CCTV News:Tomorrow (June 22nd) is the Dragon Boat Festival holiday. The reporter learned from china tourism academy that this year’s Dragon Boat Festival holiday, the number of tourists is expected to exceed the level of the same period in 2019, reaching 100 million, and the holiday trips will mainly focus on Zhou Bianyou and short-distance tours.

Following the unexpected release of the "May Day" labor holiday tourism demand, the market demand for Dragon Boat Festival holiday tourism is in a warm period. The reporter learned from a number of platforms that during the Dragon Boat Festival holiday this year, the average price of hotels and air tickets in China and many popular destinations will be lower than that during the May Day holiday. Beijing, Hangzhou, Guangzhou, Chengdu and Qingdao will become popular tourist destinations in China.

Dai Bin, Dean of china tourism academy:We predict that there will be 100 million people traveling during the Dragon Boat Festival holiday this year, and there will be 37 billion yuan in tourism consumption. What does this data mean? This means that compared with the same period last year, the number of tourists will increase by 30%, while tourism consumption will increase by 43%.

China tourism academy predicted that tourists from Guangdong-Hong Kong-Macao Greater Bay Area, the Yangtze River Delta, Beijing-Tianjin-Hebei, the middle reaches of the Yangtze River and Chengdu-Chongqing urban agglomerations will circulate and interact, and a "three-hour golden tourism circle" will be formed around major tourist cities, and the popularity of tourist resorts such as Beidaihe, Songshan and Conghua will gradually become apparent.

Dai Bin, Dean of china tourism academy:Because (Dragon Boat Festival holiday) only lasts for three days, compared with "May 1" Labor Day (holiday), it is mainly short-distance travel, mainly in Zhou Bianyou; Self-driving, individual travel, family, parent-child, study and summer vacation will become the key words of holiday travel.

Shunde, Guangdong: Colorful boats compete for beauty to welcome the Dragon Boat Festival "Night Dragon Tour"

It is also a traditional festival of Dragon Boat Festival, with dumplings and dragon boat races, which has long been a lively scene all over the country. This year, the dragon boat race held in Shunde is unique and eye-catching. What kind of dragon boat race is it? Now let’s take a look with the reporters at the reception desk.

General Station reporter Qu Baiyu:This is Ronggui Street in Shunde, Guangdong. Usually, people watch dragon boats faster than others. Today, I want to show you Bimei.

At the competition site, gongs and drums were loud, waves splashed and dragon boats fought brightly. Ten dragon boats from various clubs in Rong Gui decorated their bodies with gongs and drums, umbrellas and colored lights, and they "dressed up" for a trip to show their slender posture. "Night Dragon Tour" is rare in Guangdong, which is a unique feature of traditional dragon boat culture in Rong Gui. Different from the traditional Youlong, the night dragon with lights in Rong Gui not only retains traditional elements such as gongs, drums and umbrellas, but also uses LED lights to decorate the dragon boat, innovating the form of dragon boat competition, and skillfully blending water, lights and music.

Putian, Fujian: colorful folk customs of "dragon boat climbing" at sea welcome the Dragon Boat Festival.

As the Dragon Boat Festival approaches, Fujian will carry out special folk activities in many places. These two days, in Dongpu Town, Putian City, a huge sea dragon boat race was staged.

In Putian, Fujian, dragon boat racing is also called "dragon climbing boat". On the morning of 19th, Jicheng Village, Dongpu Town, Putian City ushered in a lively Dragon Boat Climbing. On the sea, the dragon boat players follow the rhythm of drums and raise their arms to paddle hard. On the beach, citizens and tourists shouted for fun, and the scene was crowded and lively.

Tourist Liao Kajia:I like watching the Dragon Boat Festival in China very much, because it is very lively and crowded, and it is very comfortable to watch together.

According to reports, during the Dragon Boat Festival, in addition to the dragon boat race at sea, villagers in Jicheng Village will also hold dragon dances and flower drums, and the folk performance team consisting of thousands of people will stretch for miles, which is very spectacular.

Putian citizen Li Jianhuang:We rushed back to our hometown from Yunnan for the traditional Dragon Boat Festival, and we were very happy. One is to unite everyone’s cohesion, and the other is to carry forward traditional culture.

It is understood that Putian has a wide range of rivers and waters, and the Dragon Boat Festival is the most important local folk activity every year. This year, Putian Dragon Boat Race Folk Games will span many counties and districts and will last until the beginning of July.

Henan Dragon Boat Festival: Drum-beating and Paddling Dragon Boat Race for the Dragon Boat Festival.

With the approach of the Dragon Boat Festival, a Dragon Boat Culture Festival was held in Zhumadian City, Henan Province these days, and everyone welcomed the Dragon Boat Festival by way of dragon boat race.

At the Dragon Boat Culture Festival in Zhumadian City, Henan Province, the 200-meter straight race and the 300-meter straight race were set up in the dragon boat competition. On the field, drums were rumbling and cheering, and Qi Xin, a 12-player dragon boat team, joined forces to paddle and cut waves and compete. The dragon boat race attracted many citizens and tourists to watch it. People took pictures by video and recorded wonderful moments.

Meng Xin ‘ai, a citizen of Zhumadian, Henan:Everyone wants to stick to the traditional culture, so everyone is very supportive of this movement and hopes to hold more such activities in the traditional culture in the future.

　　Xinhua News Agency, Tokyo, August 24th(International observation) How to talk about honesty after a long period of planning — — Before and after Japan’s decision to discharge nuclear polluted water into the sea

　　Xinhua news agency reporter

　　According to the decision of the Japanese government, Fukushima nuclear polluted water began to be discharged into the sea on August 24. This sewage disposal process will last for decades.

　　Tracing back to the whole process of Japan’s decision to discharge nuclear polluted water into the sea, we can clearly see that discharging nuclear polluted water into the sea is its long-planned "established policy", which is an out-and-out violation of international law and an extremely selfish and irresponsible state act. As a result, the cost of handling the Fukushima nuclear accident will be passed on to the whole world.

　　Nuclear polluted water has been discharged into the sea for a long time

　　Since the Fukushima Daiichi nuclear power plant suffered a serious accident in March 2011, a large amount of high-concentration nuclear polluted water has been produced every day due to the cooling of the melted core with water and the flow of rainwater and groundwater. In April 2011, Tokyo Electric Power Company, the operator of the nuclear power plant, deliberately discharged nuclear polluted water into the sea, which aroused great concern and concern in society. In December of the same year, TEPCO said that it had formulated a plan to discharge "low-concentration polluted water" into the sea.

　　In March 2013, TEPCO’s key facility "Multi-nuclide Treatment System" (ALPS) was put into trial operation, but since then, there have been many problems: frequent water leakage, and radioactive substances such as strontium in the treated water still exceeded the standard in 2018. In 2021, it was found that nearly half of the filter screen of the exhaust port for adsorbing radioactive substances was damaged & HELIP; …

　　Since ALPS was put into operation, Japan has called the treated nuclear polluted water "treated water". In fact, of the more than 1.34 million cubic meters of nuclear polluted water in the storage tank of Fukushima Daiichi Nuclear Power Plant, more than 1.33 million cubic meters have been treated by ALPS, but only about 30% have reached the standard of "treated water" defined by TEPCO, and the so-called "treated process water" that fails to meet the standard accounts for about 70%. Another 9,000 cubic meters of nuclear polluted water has not been treated by ALPS.

　　And how to solve the final destination of these "treated water"?

　　As early as December 2013, the Ministry of Economy, Trade and Industry, Japan’s nuclear energy authority, set up a working group to conduct technical discussions on the discharge of "treated water". In June 2016, the working group released a report saying that after the evaluation of five methods, such as ocean discharge, underground burial (adding cement and then burying it underground), stratum injection (injecting it into the depth of stratum by pipeline), steam release (vaporizing it into water vapor and discharging it into the atmosphere) and hydrogen release (electrolyzing it into hydrogen and discharging it into the atmosphere), it is the "lowest cost" method to dilute the "treated water" and discharge it into the sea.

　　This report set the tone for the later sea discharge plan, but it was strongly opposed by Japanese organizations such as agriculture, forestry and fisheries after its publication. Even Masayoshi Yoshino, then Japan’s minister of recovery, said that he opposed the treatment of nuclear pollution into the sea.

　　However, TEPCO and the Ministry of Economy, Trade and Industry have clearly regarded the sea-discharging plan as an "established policy". In July 2017, the Ministry of Economy, Trade and Industry held the "Local Coordination Meeting on Waste Furnace and Pollution Water Countermeasures" in Fukushima City, posing as a gesture of consultation with the local authorities. However, before the meeting, the then president of TEPCO, Takashi Kawamura, claimed to the media that TEPCO had "made a judgment" on discharging the sea, which caused widespread social dissatisfaction.

　　In order to convince the public, the Japanese government set up a committee with experts in related fields. In August 2018, the Committee held hearings in Fukushima and Tokyo, nominally to listen to the opinions of the people, but in fact it was to endorse the sea exclusion plan. At the hearing, Toyoda, then chairman of the Japan Atomic Energy Regulatory Commission, said that "discharging the sea is the only feasible option" was questioned by all parties. For example, in response to the problem of pollution water storage capacity and lack of open space raised by TEPCO, some people pointed out that 100,000-ton large-scale oil storage tanks can be considered, and the Fukushima Second Nuclear Power Plant, which has identified waste furnaces, can be used for open space. In view of the technical difficulty of nuclear pollution water treatment, it is suggested that the water vapor emission method used in the 1979 Three Mile Island nuclear accident in the United States can be adopted. It is also pointed out that the separation technology of radioactive element tritium which cannot be removed by ALPS is under study and should be discharged after the technology is mature and applied.

　　However, in February, 2020, the above-mentioned committee published a report saying that there are "many problems" in formation injection, underground burial and hydrogen release, and that sea discharge and steam release with precedents are the "realistic options", while emphasizing that sea discharge has "many benefits" over steam release.

　　In April 2021, the Japanese government unilaterally announced that it would discharge nuclear polluted water into the sea in 2023, ignoring domestic and foreign objections. Since then, the preparatory work for sea discharge has begun to advance in full swing: in December 2021, TEPCO submitted a construction plan for water discharge equipment to the Atomic Energy Regulatory Commission; In July 2022, the Atomic Energy Regulatory Commission approved the plan; On January 13 this year, the Japanese government confirmed that it will implement the sea discharge in the "spring and summer"; On June 26, TEPCO announced the completion of the construction of sea discharge equipment; On July 7, the Atomic Energy Regulatory Commission delivered the "Certificate of Acceptance" of the sea discharge facilities to TEPCO.

　　Self-directed and self-performed "authoritative certification"

　　On July 4th this year, Grossi, Director General of the International Atomic Energy Agency (IAEA), visited Japan and submitted a comprehensive assessment report on the disposal of nuclear polluted water in Fukushima to Japanese Prime Minister kishida fumio. According to the report, Japan’s sea-discharging scheme is generally "in line with international safety standards", so Japan claims that the safety of the scheme has obtained "authoritative certification".

　　However, there are many questions about the fairness and scientificity of this report.

　　First of all, the Japanese side first made a decision to discharge the sea, and then entrusted IAEA to make a safety assessment. Obviously, the purpose is not to find a scientific and reasonable solution, but to use the agency to endorse the sea discharge plan.

　　According to the contents of the report, after the Japanese government announced the decision to discharge the sea in April 2021, it signed an "authorization agreement" with IAEA in July of the same year to entrust "evaluating the safety of ALPS water treatment". The evaluation object is only limited to the sea discharge scheme and does not involve other schemes. This means that the evaluation conclusion cannot prove that the sea discharge scheme is the safest and most reliable scheme.

　　Secondly, before Japan officially authorized the IAEA evaluation, it had already started the relevant layout around the "certification card".

　　In April 2013, shortly after ALPS was put into trial operation, the Japanese government invited an IAEA delegation to Fukushima. The delegation released a report a month later, suggesting that Japan start to study the emission problem. At that time, the Director-General of IAEA was the Japanese Amano. In December 2019, Grossi succeeded Amano as the Director General of IAEA, and Japan continued to work for IAEA. In March 2021, Hiroshi Daiyama, then Japan’s Minister of Economy, Trade and Industry, held talks with Grossi, requesting the IAEA to provide support for Japan in eliminating the "reputation damage" caused by nuclear pollution water discharge. On April 14th of the same year, the day after the Japanese government announced its decision to expel the sea, Hiroshi Daishan met with Grossi again, requesting IAEA’s support in environmental monitoring and explaining to the international community.

　　"Tokyo News" reported that in the past, the Japanese government paid a huge share of expenses and other payments to the IAEA, and many departments of the Japanese government sent personnel to the IAEA. These factors will inevitably have an impact on the IAEA’s assessment of the safety of Japan’s nuclear pollution water discharge plan.

　　Members of the Common Democratic Party, the largest opposition party in South Korea, pointed out in a meeting with Grossi on July 9 that it is very regrettable that IAEA did not follow the principles of neutrality and objectivity, catered to Japan’s position of discharging nuclear pollution into the sea from beginning to end, and rushed to a conclusion regardless of the impact of this practice on neighboring countries.

　　Thirdly, at the beginning of the IAEA evaluation report, it is emphasized that the opinions in the report do not necessarily reflect the views of IAEA member States, and the report is not a recommendation or endorsement of Japan’s sea discharge plan, and IAEA and its member States are not responsible for any consequences caused by the report. This disclaimer clearly shows that the report cannot represent the opinions of the international community, nor can it prove the legitimacy and legality of Japan’s plan to discharge the sea.

　　Experts from China who participated in IAEA’s technical working group on the evaluation of Fukushima’s "ALPS treated water" for sea discharge — — Researcher Liu Senlin of China Institute of Atomic Energy told the media that the IAEA secretariat had asked for the expert opinions of the technical working group on the draft evaluation report, but the time window left for the experts was very limited, and the expert opinions were for reference only, so it was up to the IAEA secretariat to decide whether to adopt them. After receiving the feedback, the IAEA secretariat hastily released the report without discussing and negotiating with experts from all sides on the revision of the report and the adoption of opinions.

　　Li Song, China’s Permanent Representative to the United Nations and other international organizations in Vienna and Permanent Representative to the International Atomic Energy Agency, pointed out that the conclusion of the IAEA report on the safety of Japan’s sea discharge program is one-sided and lacks persuasiveness and credibility. Due to the limitation of authorization, the agency failed to assess the long-term effectiveness of the Japanese purification device, to confirm the authenticity and accuracy of the data of nuclear polluted water, to ensure that the international community can grasp the situation of excessive discharge in time, and to predict the impact of long-term accumulation and enrichment of radionuclides on the marine ecological environment, food safety and public health. "Without confirmation of accurate data, reliable equipment and effective supervision, it is impossible to draw the conclusion that it is safe to discharge more than 1.3 million tons of nuclear polluted water into the ocean within 30 years."

　　Pretending to be a show, worrying about integrity

　　The Fukushima Daiichi nuclear power plant has a marine life breeding room, which keeps the common flounder along the coast of Fukushima. One of the tanks is ordinary seawater, and the other is treated nuclear polluted water, which is called "treated water".

　　From a scientific point of view, experts and environmental protection organizations have many doubts about the nuclear pollution water treatment and other related data provided by TEPCO.

　　Professor ferenc Dalnoki-Veres, an expert in nuclear physics at Middlebury Institute of International Studies in the United States, pointed out that the data provided by Japan were "incomplete, incorrect, inconsistent and one-sided". The Japanese environmental protection group "FoE Japan" pointed out various problems in TEPCO’s statement about "treating water": some radioactive elements such as iodine 129 and strontium 90 still exceeded the standard after being "treated" by ALPS; The water samples detected by TEPCO so far only account for 3% of the stored polluted water, and the test results provided by TEPCO are not representative. The "treated water" in Fukushima is in direct contact with the melted core and cannot be compared with the normal nuclear power plant drainage … …

　　What is even more worrying is that TEPCO had a "black history" of tampering with data and concealing the safety of nuclear power plants.

　　On the third day after the Fukushima nuclear accident in March, 2011, TEPCO was able to judge the core meltdown of Units 1 to 3 according to the relevant data, but it was always whitewashed with "core damage" until two months later, when it admitted the core meltdown. TEPCO later admitted that it was intentionally concealing the truth according to the instructions of the then president. TEPCO once claimed that no new nuclear polluted water was discharged into the sea after June 2011, but with the exposure of a series of leakage incidents in 2013, TEPCO finally admitted that high-concentration nuclear polluted water leaked into the sea, saying that it was not announced in time because of fear of affecting the reputation of local fisheries; In September 2021, when TEPCO reported the damage of ALPS exhaust filter, it admitted that the same filter was damaged two years ago, but it was not reported, and the reason was not investigated. It was just a matter of replacing the filter. In October 2022, TEPCO was exposed to mislead visitors with a problematic radiation detector to prove the safety of "ALPS treating water".

　　Guan Guzhi, a scholar at the University of Tokyo, also pointed out that not only in Fukushima, but also in other nuclear power plants under TEPCO, management and safety problems are constantly occurring, which makes people unable to believe its disposal capacity. "Does TEPCO have this qualification to discharge into the ocean?"

　　The dishonesty of TEPCO and the Japanese government is also manifested in the attitude of reneging. The plan of discharging nuclear polluted water into the sea has been strongly opposed by local fishermen all over Japan, especially in Fukushima. Under this circumstance, TEPCO and the Japanese government assured the Fukushima Federation of Fishery Synergies and the Japan National Federation of Fishery Synergies in August 2015 that they would not discharge nuclear polluted water into the ocean until they were understood by fishermen and other relevant parties.

　　Although the Japanese government tried every means to convince the fishermen, it never succeeded. Since 2020, the Japan National Federation of Fishery Synergies and the Fukushima Federation of Fishery Synergies have passed special resolutions for four consecutive years, resolutely opposing the discharge of nuclear polluted water into the sea. However, regardless of opposition, the Japanese government and TEPCO violated their own commitments and insisted on promoting the sea discharge plan.

　　Yasushi Sakamoto, president of the National Federation of Fishery Cooperatives, said after meeting with Yasutoshi Nishimura, Minister of Economy, Trade and Industry, on July 14th this year that it is impossible to change the opposition position as long as we are not at ease with emissions. After exchanging views with Yasutoshi Nishimura on 11 July, Nozaki Tetsuo, president of Fukushima Fisheries Cooperative Association, stressed that the fishermen could not tolerate the discharge of nuclear polluted water into the sea, in contrast to the government’s promise of "no disposal" without the understanding of relevant parties.

　　Point the deer at the horse and pretend to be false.

　　Faced with the strong opposition at home and abroad to the discharge of nuclear polluted water into the sea, the Japanese authorities launched an intensive public relations campaign to confuse the audience and publicize the "safety theory of nuclear polluted water" as a key point of Japanese diplomacy.

　　Japanese Ministry of Foreign Affairs, Ministry of Economy, Trade and Industry, Reconstruction Agency and other government departments have set up special links on the homepage of official websites to promote the safety of ALPS "water treatment". The social media accounts of the Ministry of Foreign Affairs and the Ministry of Economy, Trade and Industry also put relevant promotional videos at the top or in a prominent position, and launched multilingual versions.

　　Japan holds the rotating presidency of the Group of Seven (G7) this year. During the G7 Climate, Energy and Environment Ministers’ Meeting in April this year, Japanese Minister of Economy, Trade and Industry Yasutoshi Nishimura declared at the press conference that "including ‘ Treated water ’ The steady progress of waste furnace work, including discharging into the sea, was welcomed. As a result, German Environment Minister Lemcke said on the spot that "discharging (nuclear polluted water) into the sea is not welcome". The Japanese side originally tried to insert "Welcome to the transparent process of discharging the sea" into the joint communique of the meeting to show "international recognition". This statement was opposed by Germany, but the Japanese side still used the host status to write "Welcome … … Japan and IAEA’s transparent efforts based on scientific evidence "and" supporting IAEA’s independent review ". The same content later appeared in the joint communique of the leaders of the Hiroshima Summit of G7 in May.

　　The Japanese side also launched a public relations offensive against Pacific island countries. These island countries suffered greatly from the nuclear test of the United States in the Pacific Ocean in the past, but now there is a strong opposition to the discharge of nuclear polluted water from Fukushima, which has become the key "appeasement" object of Japan. According to the report released by the Ministry of Economy, Trade and Industry on July 31, Japan has conducted "explanation work" for all members and regions of the Pacific Island Forum since February this year.

　　The Japanese side also frequently held briefing sessions for diplomats and foreign journalists from various countries in Japan, and tried every means to publicize the "safety" of nuclear polluted water discharging into the sea. In Japanese explanations, especially in foreign language versions, "treated water" is generally used to refer to nuclear polluted water, with the intention of diluting its pollution characteristics and potential harm to confuse people. According to some foreign journalists in Japan, once there is any content in their reports that questions the safety of nuclear polluted water discharge, TEPCO and Japanese officials will call and write to put pressure on it.

　　It is worth noting that according to the IAEA’s safety regulations on the discharge of radioactive materials into the environment, authorization for the discharge of radioactive materials should provide information and consultation to the affected stakeholders. "Some interested parties may be in other countries, especially neighboring countries." However, in the face of opposition and doubts from neighboring countries, the Japanese side did not communicate sincerely, but made a mistake and slandered the legitimate concerns of regional countries about the marine environment and food safety as "playing political cards." Some right-wing media in Japan even dressed Japan as a "victim" and angrily threatened to "counter" neighboring countries that raised objections to the discharge of nuclear polluted water into the sea.

　　On July 4th, the Embassy of China in Japan expounded China’s position on the issue of Fukushima nuclear polluted water being discharged into the sea, pointing out that Japan’s so-called "hope for dialogue and consultation with China" was insincere. So far, China has carried out exchanges with Japan in bilateral and multilateral channels and repeatedly expressed the opinions and concerns of professional departments. However, regardless of China’s position, Japan insists on promoting sea discharge according to the established timetable. "If the Japanese side regards sea exclusion as the premise of consultation and blindly imposes sea exclusion on China, what is the significance of such consultation?"

　　The discharge of Fukushima nuclear polluted water into the sea is not a private matter or a trivial matter of Japan, but a business matter and a major event related to the marine environment and human health. The Japanese government ignored the legitimate concerns of the international community, violated its due international obligations, and forced nuclear pollution water into the sea, endangering the marine environment and human health and infringing on the legitimate rights and interests of neighboring countries. It is by no means a responsible country.

Cancer, as one of the most common diseases with high mobility and high mortality in the world, the clinical treatments for its tumors generally include surgery, chemotherapy and radiotherapy. Due to the shortcomings of chemical drugs and various toxic and side effects, people have been committed to developing more effective drug delivery systems for cancer treatment, with the aim of reducing side effects and ensuring its efficacy.

With the progress and maturity of nanotechnology, its advantages are gradually reflected.

Introduction of nano-drugs

Diagram of sustained release process of nano-drugs

Nano-drug and its delivery system

Nano-medicine refers to nanoparticles or nano-carriers, which is a new product produced by the combination of nano-technology and medicine.

Nano-drug delivery system refers to the integration of small drug molecules into nano-materials by means of encapsulation or adsorption.

Advantages of nano-drugs

First, improve the solubility and absorption of drugs.

Nano-sized drugs are different from most chemotherapy drugs. Nano-sized drugs have larger specific surface area, better solubility, faster dissolution, improved absorption properties and better therapeutic effect.

At the same time, due to better solubility, the dosage of patients can also be appropriately reduced.

Second, prolong the drug’s circulation time in vivo, and enrich it to the focus.

Through some modification and treatment on the surface of nano-drugs, the circulation time of drugs in human body can be prolonged, which is beneficial for drugs to reach the lesion site, and special modification may make drugs more concentrated in the tumor site, resulting in better selectivity and targeting properties.

Nano-drugs can enter the tumor tissue through the porous blood vessels of the tumor, and achieve a high degree of penetration and retention in the tumor. Therefore, nano-preparation has excellent properties of high drug loading rate, passive targeting and controlled drug release.

Clinical application of nano-preparation.

Paclitaxel albumin nanoparticles

Paclitaxel is a commonly used anticancer drug in clinic. Here is a brief introduction to the nano-preparation of paclitaxel:

Paclitaxel, a commonly used anticancer drug

Albumin nanoparticles

Albumin nanoparticles are nano-particles based on albumin.

Albumin is an endogenous natural product with the advantages of safety, non-toxicity, non-immunogenicity, biodegradability and good biocompatibility. Moreover, the nanoparticle carrier system has unique targeting, sustained and controlled release characteristics and drug protection.

By high-pressure homogenization, paclitaxel and human serum protein preparation were made into nanometer freeze-dried powder, which can improve the solubility, avoid a large number of paclitaxel nanoparticles aggregation, and help the drug to be absorbed into tumor cells and give full play to its role.

Pharmacological action of paclitaxel

Paclitaxel is an anti-microtubule drug, which can stabilize microtubules by promoting the polymerization of tubulin dimer and inhibiting its depolymerization, thus inhibiting the normal dynamic reorganization of microtubule network during interphase and mitosis.

In addition, paclitaxel can lead to abnormal arrangement of microtubule "bundles", affect the division of tumor cells and promote tumor cell apoptosis during the whole cell cycle and cell mitosis.

indication

The application of albumin nanoparticles in the in vivo delivery of paclitaxel and cancer treatment has become a hot topic in recent years.

Albumin paclitaxel nanoparticles are mainly suitable for the treatment of metastatic breast cancer that failed in combination chemotherapy or breast cancer that recurred within 6 months after adjuvant chemotherapy.

Unless there are clinical contraindications, an anthracycline anticancer drug should be included in previous chemotherapy.

matters need attention

In the process of using paclitaxel albumin nanoparticles, it should be noted that paclitaxel for injection (albumin binding type) also has adverse drug reactions and must be used under the guidance of a doctor with chemotherapy experience.

Only with perfect diagnosis and treatment facilities can the complications and adverse reactions caused by drugs in treatment be effectively controlled.

references

[1] Jie Chen, Cao Ye, Li Shuangshuang, Luo Lailong, Yu Peng, Li Mingyuan. Research progress of novel nano-drug delivery system for tumors [J]. China Journal of Pharmacy, 2020,55(21):1749-1756.

Xin li, Zhu Dandan, Chen Yu, Lin Shuting, Han Lili, Li Ying, Liu Xiaoxuan. Research progress of nano-drug delivery system in promoting deep penetration of tumor [J]. Zhongnan Pharmacy, 2020,18(12):2009-2018.

Zhao Shuang, Zhang Shaofang, Mu Xiaoyu. Research progress of nano-drugs [J]. Tianjin Pharmacy, 2020,32(02):57-61.

Chen Dongxiao, Zhang Juanmei, Li Jianye, Xu Tianhong, Dong Yaqin, Pu Xiaohui. Research status and progress of paclitaxel albumin nanoparticles [J]. Journal of Henan University (Medical Edition), 2017,36(04):296-300.

[5] Chen Kang. Analysis of the research progress of paclitaxel pharmaceutical preparations [J]. Heilongjiang Medicine, 2019,32(06):1390-1392.

Contributed by: Song Haolin (Ruijin Intern Pharmacist)

Original title: "How do nano-warriors fight cancer-do you understand? 》

Read the original text

Every time you get a ticket, you have to go to the tax service hall.

The journey takes a long time.

Also bring the tax controller, ID card and special seal for invoice.

It’s easy to leave things behind if you’re not careful

Now these troubles can be solved.

Since June 1, 2020

Beijing Economic Development Zone Taxation Bureau

It will be a normal ticket-using enterprise in the region.

Provide through the "e-ticket delivery" mode

Free mail delivery service for receiving invoices

Yifen

How to operate this "ticket e delivery"?

Xiaoye

Xiaoye has prepared a detailed tutorial for everyone. Let’s take a look!

Detailed operation manual of "ticket e delivery"

"Ticket e-delivery" is a convenient service project of online invoice collection launched by logistics service unit entrusted by Beijing Taxation Bureau of State Taxation Administration of The People’s Republic of China. It aims to solve the problems of long journey, long time-consuming and difficult queuing for taxpayers to go to the tax service hall, and realizes the one-stop invoice collection service of "online application of taxpayers, automatic processing on cloud platform, and limited logistics delivery to the door".

one

"e-ticket delivery" feature

1. All year round, 365*24 hours service;

2. Express delivery to your door within 24 hours;

3. Coverage of the whole city, which can be delivered in Beijing area;

4. tax express through train, unlimited number of non-traffic jams;

5. Professional support team, 24-hour service hotline 4006289911 to provide follow-up guarantee;

two

Ticket e delivery qualification requirements

1. The tax registration status is business;

2. VAT taxpayers (except taxpayers who declare VAT on a per-time basis and general VAT taxpayers during the counseling period);

3. It has been included in the upgraded version of the VAT invoice system;

4. There is no internal investigation information about invoices;

three

Ticket e delivery invoice type

Five categories and seven versions of invoices can be applied for online: "two-copy and five-copy versions of general VAT invoices, three-copy and six-copy versions of special VAT invoices in Chinese, unified invoices for motor vehicle sales (computer version), roll-type invoices for taxi passengers and electronic general VAT invoices".

four

Application for online ticket collection qualification

1. Taxpayers log in to State Taxation Administration of The People’s Republic of China Beijing Electronic Taxation Bureau.

2. Click Login, enter State Taxation Administration of The People’s Republic of China Beijing Electronic Taxation Bureau, and click the "Invoice Use" module under the "I want to do tax" directory.

3. Taxpayers enter the "invoice collection" and click the "invoice distribution (e-delivery)" button to enter the "e-delivery" qualification application page (note: if you are qualified to apply for invoices online, you will directly enter the invoice application page, otherwise you will enter the online invoice application qualification application page).

4. You need to submit a qualification application for the first use. Fill in the real contact person and mobile phone number, and confirm that "our company (or individual) confirms to voluntarily use the" ticket e-delivery "service", and click the submit application button.

five

Steps to apply for invoices online

1. Taxpayers enter State Taxation Administration of The People’s Republic of China Beijing Electronic Taxation Bureau;

2. Select "Invoice Business" in the navigation bar and click "Invoice Distribution (Ticket E Delivery)" to enter the "Ticket E Delivery" page;

Step 3 fill in the application form

Enter the invoice application page and click the "New Application" button on the right side of the page.

Note: This button will only appear after the last invoice application order has been accepted successfully.

The application form is as follows. You need to fill in the number of applications, the name of the ticket holder, the mobile phone number, the location, the detailed address and the postal code. Among them, the number of applications must be an integer multiple of 5 and cannot be greater than the number of applications.

After filling out the application form, click the "Save" button. The table can be modified before it is submitted again.

4. Submit the application form

Please submit this application form when you are sure that the information filled in is correct. ("Submit" button in the action bar of the list page) After the submission is successful, please wait for the tax authorities to accept your application.

When submitting, you need to check the "Ticket E Delivery" service use confirmation form, otherwise it cannot be submitted.

5. Print the bill receipt

When the "Business Status" changes to "Package Picking Completed, Delivery Started", you can print the "Invoice Receipt Form for Online Collecting of Beijing Taxation Bureau" through the button in the operation bar of the page. The printed bill receipt needs to be stamped with official seal or special seal for invoice. When distributing the invoice, you need to receive the ticket with this receipt.

6. Sign the physical invoice

The delivery staff will contact you through the mobile phone number when submitting the application. When signing, please show the Invoice Receipt Form for Online Receipt of Invoice from Beijing Taxation Bureau, and check the invoice code and invoice number of the physical invoice. After confirmation, please give the stamped ticket receipt to the delivery staff.

END

This article was published by Yizhuang, Beijing.

Please indicate the source for reprinting.

The news comes from Beijing Economic Development Zone Taxation Bureau.

Original title: "From June 1st, tax invoices can be delivered home free of charge without queuing"

Read the original text

　　[PConline first evaluation]This generation of Turing graphics card is rarely divided into two series by NVIDIA, one is RTX 20 series graphics card which focuses on ray tracing and is aimed at higher-end players, and the other is GTX 16 series which is relatively cost-effective. The first shot of GTX 16 series was started by GTX 1660 Ti as early as last month. Its price in the early 2000 yuan is more than 30% ahead of GTX 1060, and its performance is really cost-effective. Today, GTX 16 series welcomes a new member. GTX 1660 has no Ti, so today, let’s take a look at whether the performance of GTX 16 series is satisfactory.

　　For Turing architecture graphics cards, everyone should be familiar with it. It has been half a year since the first Turing architecture graphics card RTX 2080 Ti was released. Compared with Pascal’s, SM of Turing GPU architecture has been greatly changed, reducing the number of CUDA cores in Turing SM units to 64 (Pascal is 128), but increasing the number of SM units. TU102 has 6 GPC graphics processing clusters, each with 12 groups of SM units, totaling 72 groups of SM units, while GP102 has 36 groups of SM units, and at the same time increasing the cache of each group of SM units. L0 cache is added, and L1/ shared cache is increased to 96KB, which seems to be reduced, but the allocation method is more flexible. When necessary, L1 cache is allocated to 64KB, which is 50% higher than Pascal graphics card’s 48KB.

　　For the technical analysis of product detailed analysis, you can also jump here to consult.https://diy.pconline.com.cn/1172/11720764.htmlcheckread

　　However, the Turing core used in GTX 16 series and RTX 20 series is still slightly different.

　　GTX 1660 Ti and GTX 1660 useThe redesigned TU116 coreTU116 has reduced the SM unit of GPC to 8 groups per cluster, while the core of RTX 20 series graphics cards is 12 groups. The complete TU116 core has 3 sets of GPC, including 24 sets of SM and 1536 CUDA stream processors, which is also the specification of GTX 1660 Ti, while the TU116-300 core used in GTX 1660 only castrates two sets of SM, and the number of stream processors reaches 1408.

　　In addition, RTX series graphics cards use FP16 to calculate Tensor Core, while TU116 replaces tensor Core with a dedicated FP16 computing Core.

　　Another castrated place is memory. GTX 1660 uses GDDR5 memory of the same model as GTX 1060, and the memory frequency is far less than GDDR6.

　　Detailed parameters of GTX 1660 are as follows.

　　Parameter comments:The number of GTX 1660 CUDA stream processors is 1408,It is 128 less than GTX 1660 Ti, but it will still be 128 more than GTX 1060.

　　GTX 1660 still uses GDDR5 video memory, which means that the graphics cardThe bandwidth of video memory is the same as GTX 1060, which is 50% lower than GTX 1660 Ti.

　　The core frequency of the public version is 1530-1785MHz, which is slightly higher than GTX 1660 Ti. 　

　　The TDP of the graphics card is still 120W, which means that the power consumption of the graphics card is not much different from that of GTX 1060.

　　Official guide price of GTX 1660Starting from 1799 yuan, 400 yuan less than GTX 1660 Ti, and 200 yuan less than GTX 1060 when it was first launched, so is the graphics card worth it? Just look down.

　　Let’s go directly to the testing link. Before testing, let’s briefly introduce the testing platform.

　　Since there is no public version of GTX 1660 Ti, this time we first got the Galaxy Gemini, namely GTX 1660 Master and GTX 1660 General. In the end, GTX 1660 will be appointed as the test graphics card. The core frequency of the graphics card is 1530-1830MHz, and the BOOST frequency is 45MHz higher than that of the public version. In theory, the performance will be 1~2% higher than that of the public version.

　　Many factors have been considered in the selection of the graphics card that participated in the comparison. From the specifications, we know that the performance of GTX 1660 is definitely between GTX 1660 Ti and GTX 1060 6GB, so these two graphics cards will definitely be used as a comparison. GTX 1060 6GB uses the public version, and GTX 1660 Ti also takes a model with the same frequency as the public version, just consider it as a public version.

　　AMD’s competing products chose RX 590 with the same performance between GTX 1060 and GTX 1660 Ti. Here, the 8 GB version of ASUS ROG STRIX RX 590 is used, and the public version frequency. In fact, the frequency difference of RX 590 on the market is very small, and the performance can’t be opened.

　　It is also stronger than GTX 1060 and weaker than GTX 1660 Ti, so who is better than GTX 1660 or RX 590? Let’s reveal it below.

　　As for the CPU, I 9-9900K, the strongest game CPU, is selected with two 8GB 3200MHz high-frequency memories to ensure that other hardware of the platform will not become the test bottleneck.

　　If you don’t accept it, run a score first. In addition to our commonly used Fire Strike Extreme and Fire Strike Ultra tests, there is also Time Spy for DirectX 12 benchmark performance test of game PC.

　　Summary of theoretical performance test: I don’t know, I was shocked at the test, but I didn’t expect it to be justCastrated two groups of SM units and switched to GDDR5 memory, which can reduce the FSE of Turing graphics card by nearly 1500 points!The FSE and running score of GTX 1660 are basically the same as the public version of GTX 1060 6GB, and the FSU running score is even worse, but fortunately GTX 1660 regained a city in TS running score, surpassing GTX 1060 6GB by 29%.

　　The comprehensive running score of GTX 1660 is only 7% higher than that of GTX 1060 6GB.This promotion … is … equivalent to nothing?There is also a 20% performance gap from the big brother GTX 1660 Ti.It seems that switching to GDDR5 memory is still very painful. So is GTX 1660 such a weak chicken in the game measurement? Is it a non-public GTX 1060 6GB? Let’s measure and verify it immediately.

　　This time, we expanded the lineup of evaluation games, and the number of games tested reached nine, mainly the latest and most popular 3A masterpieces, such as Assassin’s Creed: Odyssey, Subway: Leaving, Resident Evil 2 Remastered Edition, as well as classic old games, Wizard 3 and Survival of the Jedi, which made the test results more objective and convincing.

1. Tomb Raider: Shadow

　　Unconsciously, Laura has been with us for 20 years, and has developed into the 11th generation. Today, she has been able to support all kinds of latest, true and most eye-catching graphics technologies. It should be noted that Tomb Raider 11 is a game that natively supports DX12.

2. Assassin’s Creed: Odyssey

　　Assassin’s Creed: Odyssey is the 11th work in the Assassin’s Creed series, which was created by Ubisoft. In the game, players will return to ancient Greece and play a mercenary with Spartan ancestry who was sentenced to death by his family, thus starting an epic journey from a young abandoned man to a legendary hero. The game’s plot design and image quality are very brilliant, and it is a strong competitor for the best game of the year in 2018.

3. Strange Squad

　　"Strange Squad" was a game that went on the market at the end of August last year. The PC started and supported DX12 perfectly, and the Steam list was highly rated.

4. "Singularity Ash"

　　Microsoft’s personal work to promote DX12 API perfectly supports all the effects of DX12. Benchmark optimization is in place, and it is also very suitable for testing DX12 performance and graphics performance of graphics cards.

5. Resident Evil 2 Remastered Edition

　　Capcom’s latest fried cold rice, the sales volume of the game reached 3 million in just a few days, which was very popular among players. The test is based on the gas station scene at the beginning of Lyon, and the test results are recorded by running laps for 60 seconds. The game defaults to DX12 mode.

6. Battlefield V

　　Battlefield V is a hot game recently, not because it is fun, but because it is the only game that supports ray tracing on the market at present, and it is also a game promoted by NVIDIA. War stories, an African-American infantryman, was chosen as the first 30s in the test scenario, and DX11 mode was chosen in the test, because the number of game frames in DX11 mode was higher for both A card and N card.

7. "Wizard 3"

　　Super classic AAA masterpiece, needless to say. The field scene was selected for the test, and the horse rode on a fixed route for about 60 seconds to record the results.

8. Subway: Leaving

　　Although I didn’t log in on steam, Subway: Leaving is still a good game. The most amazing thing about it is its excellent picture quality. This game is also the first game with ray tracing, DLSS and Hairworks installed.

　　Because of the excellent picture quality, the game became a graphics card killer, and the number of frames of the tested graphics card was extremely low at 1080p resolution, so the test used high picture quality, not the ultimate picture quality.

9. Survival of the Jedi

　　A historic game with a record sales volume, the game of Jedi survival does not need much introduction.

　　Summary of game performance test:In order to let everyone see the performance gap between each graphics card more intuitively, Xiao Bian takesThe comprehensive performance of GTX 1060 in the above nine games is 100%., get the following chart.

　　At the resolution of 1080p, GTX 1660 can achieve 16% higher frame rate than GTX 1060, which is a big lead. Compared with competing RX 590, the performance of game frames is basically the same, but there is still a 17% gap between the graphics card and the big brother GTX 1660 Ti.

　　Because the video memory bandwidth of GTX 1660 is the same as that of GTX 1060 6GB, the gap between them is the same at 2K resolution. The gap between GTX 1660 Ti and the video memory bandwidth is naturally widened to 20%, which is also surpassed by RX 590.

　　The measured performance of the new card is still good, which is 17% stronger than GTX 1060 and basically consistent with RX 590.

　　Since it is impossible to test the power consumption of a piece of hardware alone,So the following are the power consumption of the whole machine.When the graphics card is fully loaded, the peak power consumption of the whole machine in 3DMark stress test is selected.

　　The graphics card basically maintains the same power consumption as GTX 1060 6GB, but reaches the performance of RX 590. Turing architecture +12nm technology makes the energy consumption of N card reach a new level, and the power consumption of GTX 1660 is about 130W lower than that of RX 590, which has obvious advantages.

　　Next, let’s take a look at the temperature, stability and noise performance of the Galaxy GTX 1660. These tests are related to the design skills of the manufacturer’s graphics card. Even if the same chip, different models will be very different.

3DMARK stress test results:

　　In 3DMark stress test, 97% passed,Finally, the graphics card passed the test with 97.8%, indicating that the stability of the graphics card is no problem. Graphics card in stress testThe highest instantaneous frequency is 1920MHz.This is also the characteristic of N card. The actual BOOST frequency will be much higher than the nominal frequency. Click on the image to enlarge to see the specific value.

　　By the way, I summed up the stability results of the participating graphics cards, and the performance of the Galaxy GTX 1660 is still good.

Temperature test

　　In fact, the 3DMARK stress test just now also showed this temperature performance. The temperature environment of the four graphics cards in this test is exactly the same.

　　The full-load temperature of the graphics card is not high, only 69℃.

Noise test

　　The full-load noise is only 47dB, which is basically inaudible, thanks to the new satellite obsidian radiator.

About noise:

　　0-20 decibels: very quiet, almost imperceptible; 20-40 decibels: quiet, like whispering; 40-60 decibels: general indoor conversation; 60-70 decibels: noisy: harmful to nerves; 70-90 dB: It is noisy and nerve cells are destroyed. 90-100 decibels: increased noise and hearing loss; 100-120 decibels: unbearable, temporarily deaf after staying for one minute. Above 120 decibels: extremely deaf or totally deaf; About 300 dB or above: 20km of people in Fiona Fang are irreparably deaf.

　　Finally, it is inevitable to sum up. First, a performance percentage chart is put forward, which combines the results of four graphics cards in 1080p resolution, 2K resolution and 3DMARK theory running score test. This comprehensive performance is still very important. After all, we can’t test all the games on the market, but we can get a general idea of the comprehensive performance of graphics cards in all games by combining the game performance and running score.

　　The comprehensive performance of GTX 1660 is 11% stronger than that of GTX 1060 6GB, and the performance gap is really a little small, which is 6% lower than that of competing RX 590. This is mainly because the two 3DMARK scores of GTX 1660 are so weak that the possibility of bug follow-up driving or 3dmark optimization cannot be ruled out. However, GTX 1660 Ti has been released for more than a month, which does not necessarily mean that FSE and FSU have much improvement. Can it be said that NV?

　　The performance of the graphics card is 19% worse than that of GTX 1660 Ti. Under the castration of the yellow knife method, the graphics card class of each model of N card is very fixed.

　　It is reported that GTX 1660 is the graphics card that replaces GTX 1060 6GB. It is a good thing that the inventory of GTX 1060 is finally cleared after so long.

　　The starting price of the new graphics card is 1799 yuan, which is almost the same as the starting price of GTX 1060 6GB after the mine disaster. That is to say, after two or three years, the performance of the graphics card bought by consumers with the same money is only 11~17% higher, which is far from meeting the expectations of consumers. Therefore, it is reasonable to say that the price of GTX 1660 card will continue to be reduced to around 1500 to replace GTX 1060 3GB.

GTX 1660 is a product with general competitiveness.

　　Is GTX 1660 very competitive in the market? There should be a question mark on xiaobian here. The performance of graphics card is basically the same level as RX 590, and the price is similar. At that time, RX 590 was still cost-effective because GTX 1060 sold for 1900~2100 when it came out. Now GTX 1060 has dropped to 1600~1800, and RX 580 even dropped to 1500, so the competitiveness of GTX 1660&RX 590 products is much weaker.

　　Compared with competing products at the same price, it may also be a competitor RX 590 for a long time in the future. Their performance is basically at the same level, and the bigger difference lies in other aspects.The advantage of GTX 1660 lies in its lower power consumption, which is about 140W lower than that of RX 590, which can save a lot of money on purchasing power supply and optimize the user experience in noise and heat accumulation in the chassis, while the advantage of RX 590 lies in the additional 2GB of video memory.

　　6GB of video memory is enough for playing 1080p resolution games, but playing 2K resolution games may lead to the explosion of video memory in very few games. However, in terms of the performance of these two graphics cards, it is more suitable for playing 1080p resolution games.

　　So, if you have to choose between the two,At the same price, GTX 1660 is more worth buying.And it is necessary for RX 590 to further reduce its price to maintain its competitiveness. At present, GTX 1660 wins!

　　In fact, the comparison between GTX 1660 and RX 590 is the repetition of GTX 1060 VS RX 580, which is basically the same in performance, low in power consumption of N card and larger in memory of A card.

　　Xiao Bian believes that,Graphics cards with the same materialsRX 590 is at least 100 yuan cheaper than GTX 1660, so it is worth considering which one to buy. For example, the beggar version of GTX 1660 sells for 1799, so the beggar version of RX 590 should sell for 1699.

　　This time we got the Gemini GTX 1660 Master and GTX 1660 General from Galaxy.

　　GTX 1660 is priced at 1799 yuan, while GTX 1660 uses better materials and has higher frequency, and the price naturally rises, reaching 1899 yuan.

　　Evaluation we use the GTX 1660 general, and the appearance of the graphics card is mainly blue and black, which is more eye-catching.

　　The brand-new Star Yao radiator stabilized voltage TU116-300 core, in the above evaluation, we also saw the power of this radiator.

　　The graphics card has a large-area backplane, which can assist heat dissipation and strengthen the strength of the graphics card. The whole graphics card is not thick, and it is designed for a standard 2-slot card.

　　The video output interface is 1dp+1dmi+1dvi with rich interfaces.

　　　　The measurement is 246*135*43mm, and the external power supply is 6pin, so the graphics card has good adaptability.

　　There are RGB lights on the top of the graphics card, which is full of e-sports.

　　Next, let’s take a look at the inside of the graphics card.

　　Electrical components with orderly layout.

　　High-definition codeless TU116-300 core.

　　GDDR5 memory produced by magnesium light.

　　4+1 phase power supply, which helps higher frequency on the graphics card.

　　Let’s take a look at the Xingyao radiator used in the graphics card, two 6mm nickel-plated heat pipes and nickel-plated fins, which are quite sufficient in materials.

　　The part in direct contact with GPU uses a large area of pure copper base, no wonder the graphics card is so low temperature.

　　Let’s take a look at what the non-public GTX 1660 looks like.

Colorful iGame GTX 1660 Ultra

　　GTX 1660, produced by Colorful, a graphics card manufacturer, has the same appearance as iGame GTX 1660 Ti Ultra, and the highest core frequency is 1860MHz.

Sotai GTX1660-6GD5 Destroyer OC HA

　　The MINI has a big heart, and the BOOST frequency of the graphics card core reaches 1805MHz, which is suppressed by double heat pipes and powered by 4+1 phases.

Gigabyte GeForce GTX 1660 OC

　　The cool and low-key appearance, although not the high-end model under AORUS, already feels very good.

MSI GTX 1660

　　There are many GTX 1660 models launched by MSI. Let’s count them one by one.

　　GeForce GTX 1660 AeroITX 6OGOC with single fan design is suitable for small chassis.

　　GeForce GTX 1660 Armor 6OGOC with high cost performance.

　　A new generation of magic dragon GeForce GTX 1660 GAMING X 6G to replace the classic Red Dragon series.

　　Geforce GTX 1660 Ventures XSC 6OC, which is relatively close to the people.

Gengsheng GTX 1660

　　Gengsheng also brought two non-public graphics cards.

　　The design of GTX 1660 glare radiator is very special.

　　Gengsheng GTX 1660 chasing the wind version, the red and black color matching is very e-sports.

Yingzhong GTX 1660 Black Gold Extreme Edition

　　The design of the MINI with the same body, coupled with the excellent power consumption performance of GTX 1660, Yingzhong GTX 1660 will definitely become the gospel of ITX lovers.

　　So many GTX 1660′ s are estimated to be messy. The evaluation of these graphics cards is also in progress. If you want to know which GTX 1660 is better, just keep paying attention to us.

A few days ago, the the State Council executive meeting deployed measures to increase the basic living security of the people in need, so as to secure the bottom line of people’s livelihood.

At the regular briefing on the State Council policy held by the State Council Office on August 26th, Yang Yinkai, deputy secretary general of the National Development and Reform Commission, introduced that from September this year to March next year, the linkage mechanism of price subsidies will be adjusted in stages, and the policy of "expanding the scope of protection and lowering the starting conditions" will be implemented, so as to increase the price subsidies for the needy people and effectively grasp the bottom line of people’s livelihood. It is estimated that the policy will cover 67 million people after the expansion.

One-time living allowance will be issued to people with difficulties such as the minimum living allowance, which will be fully completed by the end of August.

Since the beginning of this year, the bottom-up safeguard measures have been continuously improved, and the assistance to the people in need has also increased. By the end of June this year, 40.62 million people had received assistance from urban and rural residents, including 7 million urban residents and 33.62 million rural residents. The national urban minimum living standard is 734 yuan per person per month and the rural minimum living standard is 554 yuan per person per month; In the first half of this year, the accumulated expenditure on subsistence allowances was 92.62 billion yuan.

In order to implement the requirements of "expanding the minimum living allowance and increasing efficiency", the civil affairs department has continuously improved the minimum living allowance system. Liu Xitang, director of the Social Assistance Department of the Ministry of Civil Affairs, said that seriously ill and severely disabled people in marginal families have been included in the subsistence allowance alone, forming a combination of household insurance and personal insurance, and the system has more capacity; Encourage all localities to decentralize the examination and confirmation authority of subsistence allowances from the past counties to streets and towns to improve the efficiency of examination and verification; In addition, for low-income families whose per capita income exceeds the local minimum living standard after employment, a gradual retirement period of six months to one year will be given.

The temporary assistance system is mainly aimed at solving the sudden, urgent and temporary basic living difficulties encountered by urban and rural people. Since the beginning of this year, affected by epidemic and disaster, the number of people in need has increased. A few days ago, the the State Council executive meeting requested that the one-time living allowance issued to the needy people such as the minimum living allowance should be paid in place as soon as possible.

Residents, including migrant workers, who are unable to return to work due to the epidemic, have no income for three consecutive months, and are not included in unemployment insurance, can apply for a one-time temporary relief fund at their place of residence or domicile. Liu Xitang said that the work is progressing smoothly. Seventeen provinces in the country have all paid out, and all localities have issued an additional subsidy of 8.08 billion yuan for 40.18 million low-income recipients and extremely poor people, accounting for 90% of the total number of people in need. "It is expected that the work will be fully completed by the end of August, and the total amount of funds distributed is expected to be close to 10 billion yuan."

This year, the central government allocated 154.68 billion yuan to help the needy, an increase of 7.06 billion yuan over last year, and the local budget also increased investment accordingly. In the first half of the year, the national financial expenditure totaled more than 120 billion yuan, up 7% year-on-year.

Liu Xitang said, "Social assistance funds such as subsistence allowances are the focus of people’s livelihood security, and they are also the focus of financial support. It is no problem to implement special fund management and timely and fully distribute social assistance funds such as subsistence allowances."

The linkage mechanism of price compensation expands the scope of protection and reduces the starting conditions, which is expected to benefit about 9 million more people.

From January to July this year, China’s consumer price index (CPI) rose by 1.8% year-on-year, and rose by 2.7% year-on-year in July. Yang Yinkai said that due to factors such as imported inflationary pressure and seasonal increase in pork prices, the domestic price level may be slightly higher than that of the previous months in the latter months of this year to the first quarter of next year, which is lower than that of cardinal utility in the same period last year.

In order to alleviate the impact of rising prices on the basic livelihood of people in need, the linkage mechanism of price subsidies will be adjusted in stages from September this year to March next year.

After the adjustment, the scope of protection has been expanded. The current linkage mechanism of price compensation covers seven groups, including urban and rural minimum living allowances, destitute people, people receiving unemployment insurance benefits, special care recipients enjoying regular state pension subsidies, orphans, children who are actually left unattended and children infected with HIV, totaling about 58 million people.

On the basis of the above-mentioned seven groups, this time, two groups, namely, people receiving unemployment benefits and marginal population with minimum living allowance, will be added into the scope of protection of the linkage mechanism of price compensation. After expanding the scope of protection, it is expected to benefit about 9 million more people and cover about 67 million people in need. Conditional places can further expand the scope of protection.

Wan Jinsong, director of the Price Department of the National Development and Reform Commission, introduced that the people receiving unemployment benefits and the marginal population with low living allowances will be included in the scope of protection in stages, mainly considering that the people receiving unemployment benefits are unemployed, their income sources are unstable, and their lives are facing certain difficulties; Although the income of the marginal population is slightly higher than the minimum living standard, the living standard is generally low.

After adjustment, the starting conditions are reduced. The monthly year-on-year increase of CPI in the starting conditions of the price subsidy linkage mechanism was reduced from 3.5% to 3.0% in stages, while other starting conditions such as issuing price subsidies when the food price in CPI rose to 6% year-on-year, were kept unchanged, and the price subsidy linkage mechanism was started when any conditions were met.

"Reducing the start-up conditions is mainly due to the impact of epidemic situation and disasters. The income growth of people in need faces more difficulties, and the feeling of rising prices may be more obvious." Wan Jinsong said that after lowering the starting conditions, it is expected that the number of months and the starting area of the price subsidy linkage mechanism will increase significantly, which means that more people in need can receive price subsidies.

All localities will grant temporary price subsidies of about 20 billion yuan to people in need.

According to statistics, since 2020, local governments have distributed temporary price subsidies of about 31.5 billion yuan, benefiting 530 million people in need.

After adjusting the linkage mechanism of price subsidies in stages, it is estimated that from September this year to March next year, all localities will provide temporary price subsidies of about 20 billion yuan to the needy, of which about 7 billion yuan will be increased due to expanding the scope of protection and lowering the starting conditions.

Where does the additional funds come from? According to reports, the additional funds for those who receive unemployment insurance benefits and unemployment subsidies are paid from the unemployment insurance fund; The central government will provide subsidies to other needy people in different regions, including 30% in the eastern region, 60% in the central region and 80% in the western region.

"Temporary price subsidies are issued by the local authorities first and settled by the central government." Wan Jinsong said, in the current situation that governments at all levels are living a "tight life", the state still decided to adjust the linkage mechanism of price subsidies in stages and increase the price subsidies for the needy people, which fully demonstrated that the CPC Central Committee and the State Council always cared about and cared about the needy people, and always placed the protection of their basic livelihood in a prominent position.

Yang Yinkai said that the National Development and Reform Commission will work with relevant departments to strengthen work guidance, ensure that all the work of price subsidies is carried out in an orderly manner, and ensure that policy deployment can be fully implemented. (Reporter Lu Yanan)

Special feature of 1905 film network The spring love movie is playing continuously, and it will be broadcast for you on March 3.

Simple Cinderella, how to become the prince’s lover?

Fantasy story — — Everyone knows the ending, but it’s still attractive

As the most film in history that is not afraid of being spoiled, I’m afraid there is no one who doesn’t know the story of Cinderella. The kind Cinderella met her evil stepmother and suffered all kinds of torture. Finally, she waited for the help of the fairy, turned into a princess and finally got married with the prince.

However, it is such a perfect fairy tale that will still touch the hearts of "Cinderella" in reality, waiting for a prince who really belongs to her to come.

It is precisely because the core fairy tale dream of girls is eternal that the story of Cinderella is often shot new.

Excellent visual effects — — Reproduce the real fairy tale world

This live-action version of Cinderella reproduces a real fairy tale world with excellent visual effects and artistic design.

The scene setting in the first half maintains realistic natural scenery, beautiful countryside and dreamy castle, and has the style of pastoral naturalism. In the second half of the magic moment, the dazzling golden carriage and crystal shoes will be unveiled, which will surely impress audiences of different ages.

Especially when the door of the golden carriage is opened, as the hearts of countless girls are opened. There is also the scene where the midnight bell rings, which can be called the brilliant fireworks over the classic palace, which is dizzying.

Gorgeous costumes — — Beauty never seen in fairy tales

If you just read fairy tales, you can never imagine how beautiful those crystal shoes are, and how amazing the four-seat skirt is to match such beautiful crystal shoes. The movie didn’t live up to those romantic fantasies. Cinderella shone from head to toe and earned enough attention.

All the costumes in Cinderella were designed by designer sandy powell, and preparations were started two years before the film started.

In order to make Cinderella’s blue dancing skirt flow like water when running, sandy powell used 12 layers of blue fabrics with different shades.

She has designed nine kinds of skirts. The final version of the skirt has 12 layers from the inside out, using more than three different fabrics such as silk, nylon and polyester fiber. The skirt is decorated with countless turquoise and tens of thousands of crystals. There are tights and several layers of petticoats inside, which took 18 tailors and 500 hours to complete.

In the film, Cinderella likes to communicate with animals, and butterflies are one of them. In order to match the plot, sandy powell also decorated Cinderella’s blue dance skirt with butterflies.

In the film, Cinderella’s crystal shoes can’t be put on in reality, and only appear in close-ups. You can only wear shoes with the same shape when shooting, and then make them look like crystal shoes with special effects.

Meet the movie channel Universal Cinema at 22:20 on March 3rd.

Let Cinderella share a fairy-tale girl dream with you!

"Chengdu decided to start the yellow warning of ozone heavy pollution weather at 0: 00 on March 6, 2023 …" On March 5, the day before the warning started, Chengdu issued the warning information of heavy pollution weather. By taking emergency control measures, Chengdu regained an excellent day-March 6, the air quality was good. Accurate and efficient early warning relies on the ecological environment monitoring network.

At present, around water, gas, soil, ecology, pollution sources and other factors, Sichuan has built more than 28,000 monitoring points, achieving full coverage of monitoring points in cities, counties, cities and major tributaries, with basically complete elements and more "hearing and seeing" in ecological environment monitoring.

Four transformations

● The transition from manual to automatic.

The number of automatic stations in our province has increased from 296 to 2,634, an increase of nearly 8 times compared with 2015, basically achieving full coverage of urban environmental air and surface water quality automatic stations in cities and counties of the province.

● Change from extensive to precise.

In terms of ambient air quality, county-level cities have monitored three indicators every month for five days, four times a day and six indicators every time at the beginning of the Thirteenth Five-Year Plan.

In terms of water environmental quality, it has been monitored once a month from the beginning of the Thirteenth Five-Year Plan to six times a day now, and 109 items of water quality in drinking water sources have been fully monitored and analyzed.

In the aspect of coordination of measurement and management, high-tech means such as radar rover and unmanned aerial vehicle are used to carry out mobile navigation of pollutants, accurately draw "pollution map trajectory" and quickly and accurately lock pollution sources.

● Transition from decentralized closure to integrated linkage.

Eco-environmental departments and meteorological departments should cooperate with each other, establish a data sharing mechanism for eco-environmental monitoring, and gradually realize the effective integration, interconnection and mutual sharing of data on environmental quality, pollution sources and ecological quality monitoring, so as to evaluate the eco-environmental quality more objectively and predict the development trend more accurately.

● Change from status quo monitoring to comprehensive prediction and early warning.

At the beginning of the "Thirteenth Five-Year Plan", our province did not have the ability to forecast water quality. After five years of construction, it can now forecast the fine cross-section of key river basins in the next three days and the trend water quality forecast in the next seven days.

How to monitor? Build a network to achieve full coverage of monitoring points in cities, counties, cities and major tributaries.

In the Key Laboratory of Atmospheric Research of Super Station on the sixth floor of Chengdu Research Institute of Environmental Protection, a large number of monitoring data such as inorganic elements, carbon components and VOCs are displayed here on a big screen. These monitoring data come from around-the-clock monitoring instruments and high-performance computers that operate continuously in the laboratory.

"This is the atmospheric particulate matter and photochemical sub-station, which is what our major usually calls a super station." Rowena, an engineer from Chengdu Academy of Environmental Sciences, told the reporter. Following Rowena to the roof of the laboratory, the reporter saw the sampling tube of the monitoring instrument. Rowena introduced that the sampling tube will sample the air like a needle, and then deliver it to the monitoring instrument for analysis after successful sampling. "These sampling and monitoring equipment are open all year round, which not only realizes real-time monitoring of 6 parameters of ambient air, but also realizes monitoring and analysis of more than 150 air pollutant indicators including volatile organic compounds." Rowena said.

In the laboratory, the reporter found that many monitoring indicators were recorded in detail by time or in the form of curves or images. What help do these images and curves have to air pollution prevention and control?

Lei Yi, deputy director of the Department of Ecology and Environment, gave the answer: these curves and images with different colors actually hide various "signs" of air pollution changes, and the causes of air pollution can be interpreted from them, which is also the difference between super stations and conventional automatic monitoring stations. According to Lei Yi, the super station can capture more and smaller pollution factors, including more than 150 indicators. By "blood test" for the atmosphere, the "cause" of air pollution can be clearly identified, so as to "prescribe the right medicine" and achieve refined control.

Without the strong support of monitoring data, the "foundation" of the battle against pollution will be unstable, and the super station is only a microcosm of the construction of Sichuan ecological environment monitoring network. The reporter learned that around water, gas, soil, ecology, pollution sources and other factors, Sichuan has built more than 28,000 monitoring points. Among them, there are nearly 25,000 environmental quality monitoring points, more than 100 ecological quality monitoring points and more than 3,000 pollution source monitoring points. Basically completed the three-year goal and task of the province’s ecological environment monitoring network construction, and achieved full coverage of monitoring points in cities, counties, cities and major tributaries, with basically complete elements.

What’s the effect? Four changes to make ecological environment monitoring smarter and more efficient.

The construction of ecological environment monitoring network makes ecological environment monitoring more intelligent and efficient.

"The first is the transition from manual to automatic." According to the relevant person in charge of the Monitoring Department of the Department of Ecology and Environment, after years of construction, the number of automatic stations in our province has increased from 296 to 2,634, an increase of nearly 8 times compared with 2015, basically achieving full coverage of urban environmental air and surface water quality automatic stations in cities and counties of the province. Taking pollution source monitoring as an example, the first and second batches of online monitoring and control systems for pollution sources were piloted in 11 cities to achieve a breakthrough in the new monitoring method of "electricity consumption monitoring". "By remotely querying the electricity consumption of enterprises, we can know whether the pollution control facilities of enterprises are operating normally, and the monitoring tentacles are further extended." The person in charge said.

Realize the transformation from extensive to accurate. "At present, the environmental monitoring method has changed from the previous situation of extensive, low frequency, few indicators and single means." According to the above-mentioned person in charge, in terms of ambient air quality, county-level cities have monitored three indicators for five days a month, four times a day and each time at the beginning of the "Thirteenth Five-Year Plan", and now they have monitored once an hour, monitoring six indicators each time; In terms of water environmental quality, from monitoring once a month at the beginning of the "Thirteenth Five-Year Plan" to monitoring six times a day now, 109 items of water quality in drinking water sources have been fully monitored and analyzed, so that ordinary people can drink clean water and feel at ease; In the aspect of coordination of measurement and management, high-tech means such as radar rover and unmanned aerial vehicle are also used to carry out mobile navigation of pollutants, accurately draw "pollution map trajectory", quickly and accurately lock pollution sources, and make environmental law enforcement targeted.

Realize the transformation from decentralized closure to integrated linkage. The reporter learned that at present, the ecological and environmental departments and meteorological departments have achieved synergy and linkage, established a data sharing mechanism for ecological environment monitoring, and gradually realized effective integration, interconnection and mutual sharing of data such as environmental quality, pollution sources and ecological quality monitoring, so as to evaluate the ecological environment quality more objectively and predict the development trend more accurately. In 2022 alone, the eco-environmental department held 23 consultations with the meteorological department and issued 15 warnings of heavy pollution.

The transition from current situation monitoring to comprehensive prediction and early warning. According to the relevant person in charge of the Monitoring Department of the Department of Ecology and Environment, at the beginning of the Thirteenth Five-Year Plan, our province did not have the ability to forecast water quality. After five years of construction, it is now possible to forecast the refinement of key river basin sections in the next three days and the trend water quality forecast in the next seven days. "It can effectively prevent and control water pollution emergencies and minimize possible losses." The person in charge said. (Reporter Tian Chengchen)

related news

Seven enterprises were selected into the list of provincial benchmark enterprises for energy saving and carbon reduction in 2022.

On March 23, the Ministry of Economy and Information Technology announced the list of provincial-level benchmark enterprises for energy saving and carbon reduction in 2022, and seven enterprises from cement, electrolytic aluminum, chemical industry, steel, ceramics and other industries were selected.

The relevant person in charge of the Department of Economics and Information Technology said that the above industries are high energy-consuming industries, and the energy efficiency level of the selected benchmark enterprises is better than the industry level by increasing energy conservation and carbon reduction in the industrial field. Taking Bazhong CONCH Co., Ltd. as an example, the company has spared no effort in environmental protection investment, persistently treating the source, reducing emissions, reducing consumption, suppressing dust, reducing noise and increasing green, and actively trying the application of new materials, new processes and new technologies in traditional fields, which has changed the production face of the traditional cement industry of "it’s cloudy in sunny days and muddy in rainy days".

Sichuan has set a goal that by 2025, the production capacity of key industries in the industrial sector will reach the benchmark level by more than 30%. The relevant person in charge of the Department of Economic and Information Technology said that relying on benchmarking activities, cities (states) should benchmark advanced practices and experiences, and guide enterprises in key areas to carry out energy-saving and carbon-reducing technological transformation in a scientific and orderly manner and promote energy efficiency. All benchmark enterprises for energy conservation and carbon reduction should actively play a leading role in demonstration, consolidate their achievements, continuously improve the level of energy conservation and carbon reduction, drive the low-carbon transformation and high-quality development of the whole industry, and help realize the peak carbon dioxide emissions in the industrial field as scheduled.

Previously, the Ministry of Industry and Information Technology, the National Development and Reform Commission and the State Administration of Markets jointly released the list of energy efficiency "leaders" enterprises in key energy-using industries in 2022, and two of the seven provincial-level benchmark enterprises in Sichuan were on the list. (Reporter Yan Minfang)

　　Cctv news(News Network): According to the latest statistics of the Central Organization Department, by the end of 2022, the total number of members of the Communist Party of China (CPC) was 98.041 million, a net increase of 1.329 million over the previous year. There are 5.065 million grass-roots organizations of the Party, a net increase of 129,000 over the previous year.

　　Party member’s total volume grew steadily. The total number of party member increased by 1.4% over the previous year. In 2001, 2.449 million party member people were newly developed, of which 51.4%, 81.2%, 45.5% and 10.5% were women with college education or above, and 1.288 million party member people were developed in production and work.

　　The team structure in party member has been continuously optimized, and the education management in party member has been further strengthened. Party organizations at all levels continue to do a good job in studying and training the Supreme Leader’s Socialism with Chinese characteristics Thought in the New Era and the Party’s Twentieth Spiritual Congress. A total of 1.284 million training courses were held throughout the year, and Party committees at or above the county level trained 5.101 million secretaries of grass-roots party organizations in rotation.

There is an unwritten "consensus" in academic circles: when Rao Yi comes out, it is a big event.

However, it happened that some people did not believe in evil and reported Rao Yi to the relevant departments. The "charge" was still the taboo of scientists: academic fraud.

Along with Rao Yi, there are also academicians Cao Xuetao of Nankai University, Pei Gang of China Academy of Sciences, Geng Meiyu of Shanghai Institute of Pharmacy of Chinese Academy of Sciences, and Professor Li Hongliang of Wuhan University … These two are well-known in the field.

It can be seen that if this report is not true, it must be "intentional".

Soon, the Ministry of Science and Technology issued a Circular on the Investigation and Handling of Papers Suspected of Falsification. The results of the Circular show that several people on the list have "misused pictures" to varying degrees, and only Pei Gang and Rao Yi are clean.

But the result, but the Rao Yi completely angered.

It took only two hours, and he wrote an open letter in reply, which was clear throughout-Pei Gang, please check yourself!

Rao Yi

Two open letters locked Pei Gang.

Rao Yi and Pei Gang’s "enemies" were forged two years ago.

At the end of 2019, a "draft letter" signed by Rao Yi was leaked. At the end of the article, three "counterfeiters" were listed by name. One of them is Pei Gang.

At that time, Rao Yi thought that a paper published by Pei Gang in 1999 contained three wrong pictures. The so-called G protein-coupled receptor (GPCR) in the paper only needed five transmembrane proteins, which was also a gimmick. If it weren’t for academic fraud, it would be impossible to finish the experiment, let alone write a serious paper.

As soon as this article came out, it almost caused a sensation in the whole "academic circle" in China. In the following two years, the main contradictions between Rao Yi and Pei Gang were almost all around this "draft" and Pei Gang’s paper.

On December 4, 2020, Rao Yi and Pei Gang were still in court for this matter.

In court, Rao Yi’s attitude was clear: If you have sufficient evidence to prove that you are not faking, you can. But under the premise of insufficient evidence, don’t let me question it. It is absolutely impossible to cover up the truth ambiguously.

Judging from the public information, Pei Gang said at that time that his lab had another article to prove his conclusion. But obviously, this answer, Rao Yi didn’t buy it. Pei Gang did not intend to "retreat once and then" on this issue, and the two sides ended in discord.

This is what happened after the Ministry of Science and Technology notified "the investigation and handling of suspected fraud in relevant papers".

Pei Gang

In fact, as long as we know a little about the cause and effect of the whole thing, we can roughly understand why Rao Yi also appeared in the list of "reported".

But after some investigation, I picked it up high and put it down gently. Rao Yi couldn’t rub the sand in his eyes.

In an open letter on January 21st, Rao Yi named and reported Pei Gang’s academic misconduct, and at the beginning of the open letter, he said: Director Pei Gang.

In addition to being a researcher at the Institute of Biochemistry and Cell Biology of China Academy of Sciences, Pei Gang is indeed the director of the Sixth Moral Construction Committee of China Academy of Sciences, focusing on the construction of scientific ethics and style of study in the department.

This move can be described as extremely lethal and ironic.

But strangely, Rao Yi’s move didn’t blow up the main Pei Gang, instead, three students from Pei Gang Lab beat him to it.

Some netizens made a simple summary of their "vocalization": First, you Rao Yi can’t repeat the experimental results of our year, which is your level; Second, you don’t do business, open letters, play from the media, and have a good rhythm. We are ashamed of ourselves.

Scientists can’t write open letters?

The experimental details involved in the debate between Rao Yi and Pei Gang are inconclusive for the time being, and it is difficult to evaluate the level of both sides. However, compared with some scientific workers, Rao Yi really loves to write open letters. It’s just that his original intention of writing letters is rarely for himself.

While working in the United States that year, Rao Yi noticed that it was difficult for Asian scientists to gain a leading position in the academic circles in the United States. Working in this academic environment for a long time is false to say that it is not depressing.

Rao Yi began to write to the American Society of Biochemistry and Molecular Biology (ASBMB), reminding them that in the history of the Society for more than 100 years, there were few Asian leaders;

He wrote a letter to the American Neurological Society, pointing out that there is not a scholar from Chinese mainland in the hundreds of various leadership positions of the Society;

He also wrote to the editor-in-chief of CELL at that time, suggesting that the proportion of Asian scientists should be increased.

With the efforts of Rao Yi, Professor Wang Xiaofan later became the deputy editor-in-chief of the academic journal JBC; Lu Bai was successfully elected to the cadre selection Committee of the American Neurological Society; Luo Liqun was elected as a member of the procedural Committee of the annual meeting of the American Neurological Association.

At the beginning of this year, Rao Yi wrote to the Massachusetts Institute of Technology, where Chen Gang worked, about the accusation and arrest of Chinese-American Professor Chen Gang by the United States, hoping that MIT, as a beacon of academic excellence and academic freedom, could hold its head high and show its backbone in front of the Boston FBI and its agents to protect Chen Gang.

MIT did, too.

They responded positively and explained the FBI’s accusation against Chen Gang, and also called on all China and Chinese alumni of MIT to care for and respect each other. According to the latest news, at present, Chen Gang has been released on bail.

Rao Yi’s way of doing things by "writing a letter and remonstrating directly" certainly offended a group of people. We can see the clue from the "Pei Gang Incident" which continues to ferment.

But anyone who knows Rao Yi knows that he is that kind of person.

Shi Yigong, an old friend, once commented on him like this: Rao Yi, a scientist who cares about the country and the people, an open and honest man, a modern Lu Xun who is sharp in honest and frank, and a semi-old urchin who goes his own way. Whether you like him or not, Rao Yi is enlightening China society in his own way and is destined to leave an important influence.

But beyond Rao Yi, what we prefer to see is that more and more people take the initiative to "get ahead" in order to establish a better academic atmosphere. Because the optimization of any kind of system and environment is not the responsibility of one person.

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