CCTV News:The 2020 APEC Business Leaders’ China Forum, hosted by China Council for the Promotion of International Trade and APEC China Business Council, was held in Beijing today (November 19th), with the theme of "Digital Productivity". Gao Yan, president of the China Council for the Promotion of International Trade, said that under the epidemic situation, the advantages of the digital economy in promoting social stability and increasing business resilience have become more prominent. China is willing to work with the economies in the Asia-Pacific region to jointly tap the potential of the digital economy, create more quality cooperation projects and share the industrial dividend of the digital economy.

　　　　　　 According to relevant data, in the first three quarters of 2020, the revenue from information technology services in China was 3,516.2 billion yuan, of which the revenue from big data services was 153 billion yuan, a year-on-year increase of 12.5%. On the consumer side, the online retail sales of physical goods increased by 15.3% year-on-year, accounting for 24.3% of the total retail sales of social consumer goods.

　　　　　　 Gao Yan said that in the long run, the digital economy, as a new economic form, has gradually merged with the real economy and become an important engine to promote the sustained and stable economic growth in China. China is willing to work with the economies in the Asia-Pacific region to jointly tap the potential of the digital economy, create more quality cooperation projects and share the industrial dividend of the digital economy.

　　　　　　 In addition, Gao Yan emphasized that economic globalization is the general trend. Although the current economic globalization is confronted with counter-current and turning back waves, and protectionism and unilateralism are on the rise, no force can stop the rolling wheel of historical progress.

　　　　　　 Gao Yan, President of China Council for the Promotion of International Trade:The business community is not an "outsider" in global economic governance, but a witness, participant and practitioner. I hope that everyone will continue to carry forward the entrepreneurial spirit, make good use of multilateral platforms such as APEC and G20, as well as the RCEP agreements that have been signed, and strive to resolve the imbalance of regional development and make the global economic governance system more open, inclusive, inclusive, balanced and win-win.

　　　　　　 In addition, Wang Shouwen, Vice Minister of Commerce and Deputy Representative of International Trade Negotiations, said that although globalization has been blocked in the past two years, there is still a bright future for APEC cooperation.

　　　　　　 Wang Shouwen said that although globalization has been blocked in the past two years, the achievements of APEC regional economic integration are still gratifying. Especially since 1994, the average tariff of APEC has decreased by 60%, the product categories enjoying zero tariff treatment have doubled, the trade and investment amount have increased by nearly 5 times and 12 times respectively, the import and export costs have decreased by 11.4% and 7.7% respectively, and the customs clearance time has been shortened by 15.6% and 14.1% respectively. The number of regional trade arrangements in which APEC economies participate has also increased eightfold.

　　　　　　 Wang Shouwen, Vice Minister of Commerce and Deputy Representative of International Trade Negotiations:Although globalization has been blocked in the past two years, there is still a bright future for APEC cooperation. This year, through the joint efforts of all parties, APEC has formulated the "Vision for Cooperation after 2020", which will serve as a programmatic document to guide cooperation in the next 20 years.

　　　　　　 According to reports, the new vision document reaffirms APEC’s support for the multilateral trading system and the WTO. China, together with other economies, will take practical actions to support the multilateral trading system under the APEC framework. The new vision document also adds the content of developing digital economy and encouraging innovation. Four days ago, the much-watched RCEP was successfully signed. Wang Shouwen said that China will work with other economies to promote the Asia-Pacific Free Trade Area from a vision to a reality.

　　　　　　 Wang Shouwen, Vice Minister of Commerce and Deputy Representative of International Trade Negotiations:China will work with other economies to narrow the regional digital divide, oppose the abuse of state power to suppress scientific and technological enterprises, strengthen confidence in the development of the digital economy, and create a new growth point for the Asia-Pacific economy.

Discover the perfect blend of luxury and sport – Porsche Macan

At the high-profile 2018 Chengdu Auto Show in the automotive industry, Porsche led the trend of mid-size SUVs with the stunning debut of the new Macan. As a member of the Porsche family, the Macan not only inherits the essence of Porsche’s design, but also shows the unique charm of its sporty SUV, fusing the fashion and functionality of a crossover.

As Porsche’s entry-level SUV, the Macan demonstrates outstanding engineering prowess with the MLB platform shared with the Audi Q5. Initially launched, the Macan offers a range of gasoline engines for consumers to choose from. The entry-level model is equipped with a 2.0-liter inline-four engine with 225 horsepower, while the slightly higher-configured model is equipped with a 3.0-liter V6 supercharged engine with 336 horsepower, showing surging power. The most anticipated is the flagship model, which is expected to use a 3.6-liter V6 twin-turbo engine with a maximum output of 395 horsepower and a peak torque of 550 Nm. The hybrid version of the Macan will also follow the market trend and follow the Q5 Hybrid powertrain, providing new options for environmentally friendly travel.

In terms of interior, the Macan’s center console design is in line with the Cayenne, presenting a simple and luxurious style. The vertical air conditioning is trended on both sides of the central display, creating a spacious and advanced driving environment. Although the specific details have not been fully exposed, we can expect the Macan to continue the Porsche interior design tradition, with exquisite and elegant details.

In terms of powertrain, the Macan will draw on the platform advantages of the Audi Q5, and at the same time make targeted adjustments to improve performance. The entry-level model will be upgraded to a 2.0T turbo engine with 220 horsepower, while the Macan S and Turbo will be equipped with a 3.6L V6 engine and a new 400 horsepower twin turbo engine respectively, demonstrating Porsche’s pursuit of extreme power handling.

In the transmission part, Macan offers a choice of 7-speed manual and 7-speed PDK automatic transmissions to meet the needs of different drivers. Whether it is a powerful Turbo or a hybrid model for green travel, Macan has shown its comprehensive competitiveness in various fields.

Miscellaneous talk about medicine garden　

A paradise for medical people to share and discuss pharmaceutical knowledge,

Common progress and development

　

In order to promote the consistency evaluation, the General Administration announced the catalogue of generic reference preparations in batches from March 17, 2017, and began to publicize the draft of the catalogue of generic reference preparations on March 28, 2019.　

In the Catalogue of Reference Preparations for Chemical Generic Drugs (25th Batch) (Draft for Comment), the list of varieties that failed to pass the review began to be updated. By the end of the Catalogue of Reference Preparations for Chemical Generic Drugs (59th Batch) (Draft for Comment), 620 failed product specifications had been updated, and 93 were reviewed by the consistency evaluation expert committee again after receiving the objection application from the enterprise. The experts maintained their original conclusions and failed the second review.

The following figure shows that the historical batches of the exposure draft have not passed the review and reference publication:

　

The main reasons for not passing the review are as follows:

　

A has no reference preparation status.

According to the Procedure for Selection and Determination of Reference Preparations for Chemical Generic Drugs, the order of selecting reference preparations is: original research imported, original research not imported, original research localized and internationally recognized drugs of the same kind.

Of the 527 failed quality regulations, 280 were rejected because they did not have the status of reference preparations. Analysis of the reasons for not having the status of reference preparation can also be divided into the following situations:

　

1. Clearly do not recommend reference preparations.

The reference preparation is not recommended for the trial varieties that can BE exempted or simplified in human bioequivalence (BE) issued by the National Bureau. For example, Compound Polyethylene Glycol Electrolyte Powder (V), similar varieties have been clearly not recommended in the notice (No.136, 2018) issued by the National Bureau on the exemption or simplification of human bioequivalence (BE) test varieties. It has not passed the review.

2. There is no such dosage form in the original research.

Because the reference preparations to be declared are varieties with modified specifications, the original research did not have this specification and failed to pass the review, such as acarbose chewable tablets, pantoprazole sodium enteric-coated capsules, acetaminophen dry suspension, betamethasone sodium phosphate injection, etc.

3. Compared with the published reference preparation, it has no obvious advantage.

3.1 The concentration of the reference preparation to be applied for is the same as that of the published reference preparation, but the loading quantity is different.

We can find that the specification of 4.5354g/7.5ml of Bayer Healthcare Pharmaceuticals was published in the 27th batch, and the specification of 9.0708g/15ml was published in the 28th batch.

　

In the Catalogue of Reference Preparations for Chemical Generic Drugs (Fifty-ninth Batch) (Draft for Comment), 1.20944g/2ml, 6.0472g/10ml, 18.1416g/30ml and 39.3068g/65ml of gadolinium butoxide injection of Bayer Healthcare Pharmaceuticals Inc were rejected because they were different from the published reference.

3.2 The published reference preparations are prescription drugs listed in the United States, and it is not recommended to add OTC drugs as reference preparations.

Omeprazole sodium bicarbonate capsules are managed separately according to prescription drugs and OTC in the United States. The published reference preparations are prescription drugs listed in the United States, and it is not recommended to add OTC drugs as reference preparations.

3.3 Compared with published reference preparations, there is no clinical advantage.

Piperacillin sodium tazobactam sodium for injection by Dapeng Chemical Industry Co., Ltd. was rejected because the powder-liquid double-chamber bag was not widely used and the cost was high. The orally disintegrating tablet of montelukast sodium from MSD Co., Ltd. was not approved because the dosage form to be applied for was orally disintegrating tablet, which only provided a choice of dosage form for clinic, and had no clinical application advantage compared with other oral preparations on the market. Cefalexin fine granules of Gonghe Chemical Industry Co., Ltd. were not approved because the published reference preparation of Cefalexin dry suspension could basically cover the usage and dosage required by children patients.

3.4 Non-original research and no reference preparation status

The metronidazole vaginal gel of Oceanside Pharmaceuticals is a generic drug authorized by the original research, but it is a generic drug listed in the United States and does not have the status of reference preparation; Pravastatin sodium tablets (4 specifications) of Teva Pharmaceuticals Usa Inc are internationally recognized as the same drug, but the reference preparation to be applied for is a generic drug listed in the United States, which does not have the status of reference preparation and is not approved.

B lack of complete and sufficient safety and effectiveness data.

A total of 104 quality regulations failed due to the lack of complete and sufficient safety and effectiveness data, of which 22 were reviewed by the consistency evaluation expert Committee again after receiving the objection application from the enterprise, and the experts maintained the original conclusion and failed the second review.　

Most of the reasons why this kind of drug failed to pass the review were that the data of safety and effectiveness provided by the applicant were not sufficient, and it was impossible to determine that it was a drug with safety, effectiveness and quality controllability. In addition, Alfasigma Romania S.R.L’ s creatine phosphate sodium for injection is the original research drug listed in China, but this product has been included in the first batch of national key monitoring drugs list, and the relevant safety and effectiveness data are limited, so the review failed; Pidotimod oral solution of Polichem S.R.L was not approved due to insufficient evidence of clinical effectiveness according to the Notice of the General Administration on Starting Clinical Efficacy Test of Pidotimod Oral Liquid (No.31 [2018] of Food and Drug Administration); Alfasigma S.p.A’ s Levocarnitine Hydrochloride Enteric-coated Tablets was declared for import in the original research, and the application materials were not enough to support the effectiveness of this product for the applied indications. The conclusion was that it was not approved and the review was not passed.

C does not meet the domestic indications, usage and dosage

There are 64 product specifications involved because they do not meet the domestic indications and usage and dosage. Subdivided into the following three reasons:

　

The specification of oxytocin injection of Takeda Chemical Industry Co., Ltd./ぁすかかかか Co., Ltd. is 1 unit /ml, and the specification of 1 unit /ml of this product is unreasonable, which is less than the minimum dose recommended by the instructions for single use (2.5 units/ml); The specification of Pioglitazone Hydrochloride Tablets of TAKEDA PHARMACEUTICALS USA INC is 45mg. In the past, an expert consultation meeting was held for hypoglycemic drugs. Clinical experts reported that the maximum dosage of this product used in China is usually 30mg, and the specification of the reference preparation to be applied is greater than the maximum dosage, which was not approved. Naproxen is a non-mainstream non-steroidal anti-inflammatory drug in China. Naproxen, esmomeprazole and magnesium enteric-coated tablets of Horizon Medicines LLC, the compound does not meet the requirements of domestic clinical practice and compound preparation for the time being, and the review was not passed.

D. The listed areas are not in the European Union, the United States and Japan (with relatively perfect regulatory system).

There are 46 quality regulations that have been rejected because the listed areas are not in the European Union, the United States and Japan. In order to ensure the quality of reference preparations, it is suggested that the reference preparations should be the original drugs approved for listing by institutions with relatively perfect regulatory systems such as the European Union, the United States and Japan, and the review failed.

There are mainly the following 12 listed regions that failed to pass the review:

　

E has certain security risks.

There are 21 quality regulations that failed due to certain safety risks, and 8 of them were reviewed by the consistency evaluation expert Committee again after receiving the objection application from the enterprise. The experts maintained the original conclusion and failed the second review.

It is worth noting that injections and eye drops without preservatives and antioxidants have more advantages as reference preparations.

　

F process quality does not meet the requirements.

There are 12 product specifications that failed because the process quality did not meet the requirements, and four of them were reviewed by the consistency evaluation expert Committee again after receiving the objection application from the enterprise. The experts maintained the original conclusion and failed the second review.

　

Oxaliplatin for injection of Sanofi-Aventis France is the reference preparation published in the 27th batch. After deliberation by the expert committee for consistency evaluation, the oxaliplatin injection prepared by terminal sterilization process can meet the requirements of product impurity control and stability, and oxaliplatin injection with terminal sterilization should be the first choice, and oxaliplatin for injection is an unreasonable dosage form, so it should be transferred. If the reference is rejected, the declared product has no possibility of approval.

　

tag

The selection of reference preparation is the key in the process of generic drug research and development. If the selection is wrong, the project progress will be delayed, and the blood will be lost. By studying the reasons why the reference preparation failed the audit, we can learn a lot of experience in project risk assessment and product research, and clearly judge the value orientation of the country to generic drugs. When researching products, we should not only pay attention to foreign data, but also pay attention to the performance of drugs in China. Try to avoid the embarrassment that the application for reference preparation was rejected, and pay more attention to avoid the tragedy that the selected reference preparation was transferred out of the catalogue.

National Highway 219 is a world-class scenic avenue, which starts from Kanas in Xinjiang in the north and ends in Dongxing in Guangxi in the south, with a total length of 10065 kilometers. It is the longest national highway in China at present. Along the way, it passes through snow-capped mountains, glaciers, alpine canyons, rivers and lakes, grassland forests, and finally goes to the sea. The rich landscape and rich folk customs are amazing, covering the border areas of Xinjiang, Xizang, Yunnan and Guangxi. It is the main artery connecting China’s western border, and is called "the road of the country" by go on road trip lovers.

G219 line is divided into old national highway 219 line and new national highway 219 line. The old national highway No.219, the new Tibet highway, starts from Yecheng County in Kashgar, Xinjiang in the north and reaches the 2140-kilometer stone tablet in Lazi County, Shigatse City, Tibet in the south, where it meets the Sino-Nepalese highway section of National Highway No.318, also known as Yela Highway. Kashgar, Hotan, Ali and Shigatse are the main transportation routes connecting Xizang and Xinjiang, and it is also the highest highway in the world, with an average elevation of more than 5,000 meters. It was opened to traffic on October 6, 1957, and has been extended and renovated for many times, with a total length of 2,140 kilometers. It is the third highway to enter Xizang after Sichuan-Tibet Highway and Qinghai-Tibet Highway. The new G219, also known as Kadong Line, was issued by the Ministry of Transport on March 5, 2018. The northern end of the original G219 was extended to Kanas in northern Xinjiang, and the southern end was rerouted to dongxing city in Guangxi. The whole highway passed through Xinjiang, Xizang, Yunnan and Guangxi provinces. The new G219 is 10065km long, which is twice as long as the National Highway 318 (5476km) and the longest national highway in China at present. This national highway not only has the landscape elements such as snow-capped mountains, grasslands, no man’s land, Yadan landform, tropical rain forest and sea, but also becomes an important border defense line in China.

G219, as the longest world-class landscape avenue in China with rich landscapes and rich folk customs along the way, is the highest highway in the world, the main artery connecting China’s western border and the land-sea Silk Road. It travels through different cultural areas in China, and along this way, you can enjoy five peaks, 16 icebergs and 44 glaciers with an altitude of over 8,000 meters … across snow-capped mountains, grasslands, deserts, Gobi, lakes, canyons and plateaus.

Go on road trip G219 starts from Kanas, Xinjiang in the north, passes through Ili along the snowy grassland, passes through the no-man’s land of Ali, Xizang, goes south along Bingchacha and Tengchong in Yunnan, reaches Pingxiang, the border city of Guangxi, and finally reaches Dongxing, where it meets the endless sea. Walking along this world-class landscape avenue, almost all the desirable landscapes are located here.

On December 5, 2020, under the guidance of the Ministry of Culture and Tourism, the cultural and tourism administrative departments of Xinjiang Uygur Autonomous Region, Xizang Autonomous Region, Guangxi Zhuang Autonomous Region and Yunnan Province jointly established the China G219 Tourism Promotion Alliance in Nanning. The establishment of the alliance conforms to the general trend of China’s tourism development, aims at promoting development through tourism, prospering the border and enriching the people, enhancing consensus, sharing experiences and deepening cooperation, and promoting the sustainable and prosperous development of tourism along G219. Since its establishment, the Alliance has organized theme promotion activities in Guangxi and Xinjiang successively. On March 16th this year, Yunnan Province, as a rotating province, will host a promotion activity in Nujiang, Yunnan Province, and organize a team of over 100 people from all over the country to experience the beautiful highway of Nujiang, Yunnan Province, National Highway 219, and feel the unique charm of the national road.

Xinjiang section of National Highway 219

The Xinjiang section of National Highway 219 is 3,216 kilometers long, passing through 8 prefectures and 7 cities in the western border of Xinjiang. It can radiate to 10 5A-level scenic spots and 25 4A-level scenic spots along the way, with beautiful scenery, all-encompassing natural landscape types and colorful humanities and history. Along the way, it includes unique natural landscapes such as snow-capped mountains, alpine meadows, grasslands, wetlands, lakes, glaciers, Gobi, deserts, etc. At the same time, it is also a great penetration from nomadic culture to oasis civilization, which combines the most typical frontier characteristics, natural geography and national customs of Xinjiang and has multiple attributes. In recent years, the strategy of rejuvenating Xinjiang through tourism has been implemented in depth, and the tourism market in Xinjiang has continued to be hot. The Xinjiang section of National Highway 219 has become the "online celebrity Highway" for national tourists to punch in.

Recommended Route 1 of Xinjiang Section of National Highway 219: Red go on road trip at Border Post.

Enter the northwest of the motherland and feel the beauty of the border; Follow the footprints of stationing troops and guarding the border, and pay tribute to the motherland in the northwest. Feel the simple patriotic feelings, visit the beautiful scenery at the port and Baymuzha, reminisce about the story of Xiaobaiyang Post, visit Sun Longzhen Martyrs Memorial Hall, and feel the frontier spirit represented by the spirit of "rooting in frontier defense and flourishing".

Red go on road trip route of border post: Urumqi-Wuerhe ghost city-Rainbow Beach Scenic Area-Burqin County-Baishahu Scenic Area of the 10th Division-185th Regiment of the First Company in Northwest China-Burqin County-Jimunai Port of the 186th Regiment of the 10th Division-165th Regiment of the 9th Division-Baymuzha Scenic Area-Xiaobaiyang Post of the 161st Regiment of the 9th Division, Sun Longzhen Martyrs Memorial Hall-Urumqi.

Recommended Route 2 of Xinjiang Section of National Highway 219: Red Tour in Southern Xinjiang

There is a natural barrier that runs through the northern and southern Xinjiang, and a memorial hall for the reclamation of the 359 brigade that feels the glorious tradition … Driving along the red army reclamation line of the Silk Road, you can feel the frontier scenery, remember the history of the Corps, carry forward the spirit of the Corps, and eulogize the cause of reclamation and frontier defense.

Southern Xinjiang Red Tour Route: Urumqi-Korla-Malan Hongshan Military Expo Park-tiemenguan-Daxi Village-Luobu Village-Luntai Western Duhufu Cultural Town-Kuqa-Aksu Monument to the People’s Heroes-Aksu Museum-First Division Aral 359 Brigade Reclamation Memorial Hall-Chinese People’s Liberation Army March into Hotan Monument.

National Highway 219 Xizang Section

Driving in the Xizang section of National Highway 219 is like walking in the clouds, with an average elevation of about 5,000 meters. The familiar landscapes such as Bangong Lake, Guge Dynasty, Mount Everest, Mabian Yongcuo, Gangrinboqi and Yarlung Zangbo Grand Canyon are all located here.

National Highway 219 is a road into Tibet paved in the air, crossing several hundreds of kilometers of no-man’s land, and the laying conditions are daunting. From "Extreme Ali" to "Zangyuan Shannan", from "Peak Dream" Shigatse to "Snowy Jiangnan" Linzhi, from the stars to the sea, from the mountains to the rivers, there are snow peaks and glaciers, winding streams and beautiful lakes.

Recommended Route 1 of Xizang Section of National Highway 219: Bingchacha Cross-sectional Imagination Road

When G219 meets G214, but Wujiao meets G318；; When the Nujiang River flows parallel to the Lancang River in a narrow place, when Bingcha agrees to Shangri-La, a new Yunnan-Tibet tourism ring line of G219 with "three G tours and three rivers flowing parallel" will be built.

The whole journey is about 1465km: Bingzhongluo (Yunnan)-—G219 National Road-Songta Village (the first village in Tibet)-ChaHuaron-Chayu County-—G559—-Ranwu-Basu-—G214—-Zuogong-Mangkang-Quzika-Deqin (Yunnan)-Shangri-La-Diqing Shangri-La Airport (flying).

Recommended Route 2 of Xizang Section of National Highway 219: Feel the dream trip of the plateau peak.

When G219 meets the highest mountain in the world, G318 holds G219 hand in hand, and the extreme border of the motherland experiences "8" and "9" without "10". I met in Lhasa and walked hand in hand into the hometown of Mount Everest. The snowy peaks are endless, the glaciers are numerous, the streams are winding, and the lakes are hidden. It is only owned by Mount Everest. This is the ultimate journey of "peak dreams and Tibetan border conventions".

The whole journey is about 1850km: Lhasa-Langkazi County-Gyangze-—G219—-Kangma County-Yadong County-Gamba County-Dingjie County-Dingri County-Mount Everest-Nyemora-Lazi-Shigatse City-Lhasa-Gongga Airport (flying).

Recommended Route 3 of Xizang Section of National Highway 219: Tour Link of Tianhu.

When G219 meets the snow-covered "Holy Lake", meets the snow-capped mountains, meets the "Holy Lake", and faces the human history, "take measures again". Encountering glaciers, snow-capped mountains, lakes and historical sites is a "trip to Tianhu" tour loop of "crossing three cities, crossing the holy lake and seeing yourself".

The whole journey is about 2200km: Lhasa-Langkazi County-—G219—-Luozha County-Kangma County-Gamba County-Dingjie County-Dingri County-Jilong County-Saga County-Zhongba County-Gaer County-Ali Kunsha Airport (flying).

Yunnan section of National Highway 219

Enter Bingzhongluo, Yunnan along Bingchacha Highway from National Highway 219, bid farewell to Xizang in the clouds and enter Yunnan in the south of colorful clouds. Here, there are Bingchacha and the mysterious Bingzhongluo, and the southwest monsoon swings in the season of Nujiang Grand Canyon. When I came to the First Bay of Nujiang River and Wuli Village not far away, the dense water vapor refracted the sun, making every corner seem to be full of "fairy spirit". The Yunnan section of National Highway 219 also connects Tengchong, which has the reputation of "the first city on the extreme edge", Lincang, a place where Wa cultures gather in China, Pu ‘er, Xishuangbanna, an emerald on the crown of plants, Honghe and Wenshan, so that tourists can enter Yunnan with spring-like seasons from the deep scenery of ice and snow and canyons.

219国道云南段推荐线路一：高黎贡山秘境之旅

怒江傈僳族自治州境内居住着傈僳族、怒族、普米族、独龙族等21个少数民族，也是我国生物多样性、文化多元性较富集的一个地方，被称为“世界物种基因库”“天然地质博物馆”“一部活的社会发展史”和“民族歌舞的海洋”。在漫长的历史发展中，各少数民族世代繁衍生息，共同耕耘劳作，用自己的血汗和智慧谱写了光辉灿烂的文化篇章，创造了丰富多彩的民族文化。怒江州是因为怒江由北向南纵贯全境而得名。怒江最佳旅游时间在每年的10月至次年4月。219国道横穿怒江州境内的泸水、福贡、贡山、丙中洛。

219国道云南段推荐线路二：保山温泉火山体验之旅

219国道从秘境怒江进入“极边第一城”的保山腾冲市。腾冲市位于云南省保山市西南部，西部与缅甸毗邻，从腾冲到克钦邦首府密支那217公里，是云南到缅甸、印度、泰国的必经地之一。腾冲在西汉时称滇越，大理国中期设腾冲府。由于地理位置重要，历代都派重兵驻守，明代还建造了石头城，称之为“极边第一城”。这里的温泉、火山、雨林与独特的边地汉文化给自驾旅行带来独特体验。219国道在保山市境内途径腾冲滇滩、明光、固东和龙陵县。

Recommended Route 3 of Yunnan Section of National Highway 219: A Tour of Primitive Tribes in Lincang Wa Township

Lincang is an ancient, mysterious and beautiful land, where 23 ethnic minorities have thrived for generations. This is the gathering place of Wa culture in China, and it is also the "eternal spring capital" with pleasant climate all year round. There is a graceful song between the lush mountains and the flowing water. Wild fruits in the mountains and fungi after the rain are natural gifts. Humanity and art achieve each other, and man and nature live in harmony, which creates the mysterious and unique beauty of Lincang. National Highway 219 will pass through three counties here: Yongde, Zhenkang and Cangyuan.

Guangxi section of National Highway 219

The section of National Highway 219 in Guangxi has a total length of 704.2 kilometers, which belongs to the border area between China and Vietnam, involving 3 cities and 8 counties on the border, with rich and unique tourism resources. G219 Guangxi section begins in dongxing city, Fangchenggang, and ends in Napo, Baise, running through the charming scenery of Guangxi’s secret land. Driving through rivers, seas and mountains, a landscape scroll stretching for more than 700 kilometers slowly extends under the wheels. All the way along the mountain and around the water, it sets off the humanities, history and scenery on both sides along the way and carries the memories from the depths of time. It is like a ribbon floating from the Beibu Gulf to the Yunnan-Guizhou Plateau, floating on the mountains and hills. This road is full of poetry and fairyland of Guangxi’s mountains and rivers, and it is also full of pictures of time and customs.

Recommended route 1 of Guangxi section of National Highway 219: Passing through Hena Expressway between landscape galleries, the charming scenery is like a fairyland.

The British "Mirror" once described it like this: "This is the most beautiful road in the world, and the charming scenery means that this may be the road to heaven." This is the Hena Expressway in Guangxi, with a total length of 503 kilometers, which consists of highway sections from Hepu to Qinzhou (142 kilometers), Qinzhou to Chongzuo (129 kilometers), Chongzuo to Jingxi (147 kilometers) and Jingxi to Napo (85 kilometers).

Self-driving route of Hena Expressway: Heiyizhuang Village in Tunlitun, Napo, Baise (the "living fossil" of Zhuang culture)-Jingxi Goose Spring (one of the three famous springs in southwest China)-Jiuzhou Ancient Town (the hometown of Chinese hydrangea)-Tongling Grand Canyon (the waterfall with the largest single-stage drop in Asia)-Detian transnational waterfall in Chongzuo (the largest transnational waterfall in Asia)-Daxin Mingshi Garden (the location of TV series Hua Qiangu)

Recommended Route 2 of Guangxi Section of National Highway 219: Self-driving Chongzuo "Drunk and Beautiful Border Customs Road" to enjoy the mystery and beauty of the border.

In Guangxi, there is a short-distance tourist scenic avenue, which covers almost all the beautiful scenery in nature. Mountains, rivers, rainforests, villages and cultural customs can be found on this line. This is the first-class tourist scenic avenue in Chongzuo, which is one of the routes that self-driving enthusiasts have to go. It has a total length of 84.17 kilometers, connecting Daxin, Longzhou and Ningming counties in Chongzuo, and a line runs through the landmark scenic spots of Chongzuo, such as Detian transnational waterfall scenic spot, Mingshi pastoral scenic spot and Zuojiang Huashan rock painting cultural landscape, and is known as "drunken beauty border customs road".

Self-driving route of the first-class tourist avenue in Chongzuo: Detian Transnational Waterfall in Chongzuo (national 5A-level tourist scenic spot, the largest transnational waterfall in Asia)-Mingshi pastoral scenic spot (location of TV series Hua Qiangu)-Huashan rock painting landscape in Zuojiang (rock painting world cultural heritage)-Nonggang National Nature Reserve (a scenic spot for birdwatchers).

Renal artery denervation (RDN) is a hot topic in the field of hypertension in recent years. Although it has not been widely used in clinic, with the release of various clinical data, more and more industries focus on RDN.

RDN targets the sympathetic nervous system, which does play a role in raising blood pressure. Therefore, RDN selectively reverses a mechanism of hypertension. But hypertension is a multifactorial disease. Is it really enough to target a single pathogenic mechanism to produce effective and sustained blood pressure reduction in a large number of hypertensive patients? Yixin specially interviewed the vice president of Hebei Provincial People’s Hospital.Professor Guo Yifang, shared his views on the future prospects of RDN.

　 One more proof of RDN’s long-term effect 　

Recently, the three-year research results of RADIANCE-HTN SOLO test were published, which confirmed that the safety and effectiveness of ultrasonic RDN lasted for 36 months.

Patients with ambulatory blood pressure ≥135/85 mmHg and < 170/105 mmHg after 4 weeks of stopping antihypertensive drugs were randomly divided into ultrasound RDN group or sham operation group. The results of 36-month follow-up showed that the systolic blood pressure and diastolic blood pressure in RDN group decreased by 17.7 mmHg and 11.3 mmHg respectively compared with baseline. In terms of safety, there were no adverse events related to equipment or operation during the follow-up period.

In response to this research result, Professor Guo Yifang pointed out that in recent years, the effectiveness and safety of RDN has been an important topic in the field of hypertension treatment, which has attracted extensive attention from scholars at home and abroad.Radiation-HTN solo research provides valuable new evidence for the instrument treatment of hypertension. However, Professor Guo is cautiously optimistic about the results of this study, considering the differences in the conclusions of several RDN studies published in recent years and the limitations of this study itself..

　 The evidence-based road of RDN 　

The basic principle of RDN is to block the afferent and efferent activities of sympathetic nerve around renal artery by radio frequency energy, ultrasonic energy or injecting heat into perivascular space, and reduce the influence of sympathetic nervous system on renal vascular resistance, renin release and sodium reabsorption. RDN blocks the signal conduction between the brain and sympathetic nerve to a certain extent, thus reducing the sympathetic nerve excitability of patients with hypertension. Theoretically, it can achieve long-term antihypertensive effect through a minimally invasive operation.

As early as 2009 and 2010, RDN completed two early clinical trials in Europe and Australia, namely Symplicity HTN-1 and HTN-2. The results of 3-year follow-up showed that the average systolic blood pressure and diastolic blood pressure of refractory hypertensive patients receiving RDN decreased by about 30 mmHg and 14 mmHg respectively, and there were no obvious adverse reactions and complications. More importantly, after three years of follow-up, these patients found no obvious signs of blood pressure rebound.

Because this is the first minimally invasive surgical technique that has been proved in history and can definitely lower patients’ blood pressure, RDN shines brilliantly after the above exploratory experiment, but the well-known sham-operated control experiment-Symplicity HTN-3 did not get positive results, which weakened people’s enthusiasm for RDN: although the research proved its safety, it did not significantly lower blood pressure compared with the control group.

On the basis of summarizing the research experience and lessons of SYMPLICITY HTN-3, the researchers subsequently carried out a new generation of randomized controlled trials, such as SPYRAL HTN-OFF MED, SPYRAL HTN-ON MED, SPYRAL HTN-OFF, etc. These studies used different techniques and methods to ablate the renal artery sympathetic nerve. The results showed that the ambulatory blood pressure and clinic blood pressure in RDN group decreased clinically regardless of whether antihypertensive drugs were used or not.

Clinical research course of RDN

(Source: Nat Rev Cardiol. 2020 Oct; 17(10):614-628. ）

In different studies, compared with sham operation group, systolic blood pressure in RDN group decreased.

The REQUIRE study aims to evaluate the effectiveness and safety of ultrasound renal artery ablation system in controlling blood pressure in patients with refractory hypertension. 143 patients with refractory hypertension (office blood pressure ≥150/90 mmHg and 24-hour SBP≥140 mmHg) were randomly assigned to RDN or sham operation group. Three months after operation, there was no significant difference in the 24-hour ambulatory systolic blood pressure between the RDN group (-6.6 mmHg) and the sham operation group (-6.5 mmHg) (P=0.971). The difference of SBP between family self-measured blood pressure and clinic blood pressure was -1.8 mmHg(P=0.488) and -2.0 mmHg(P=0.511) respectively, and there was no difference. There was no significant difference in drug load between the two groups. No major adverse events related to the operation were found.

At the EuroPCR annual meeting in 2022, a number of research data of RDN were published: Global Symplicity Registry, SPYRAL HTN-ON MED, Radiation HTN Solo & Trio, which further confirmed the potential of RDN as an adjuvant therapy for hypertension, supplemented the existing first-line therapy, and thus changed the lifestyle and drug treatment.

　 Professor Guo Yifang: RDN can be expected in the future 　

The occurrence of hypertension is a complex process, involving many mechanisms, and it is not expected to solve all patients’ problems through one drug or technology. RDN only blocks renal sympathetic innervation, and may have no therapeutic effect on other mechanisms that cause and maintain hypertension. Moreover, the antihypertensive effect of RDN is moderate, which is only equivalent to taking an antihypertensive drug.

Professor Guo Yifang talked about the future prospect of RDN. He pointed out that RDN is still in the stage of research and exploration, and it can not be used as a mature treatment technology in clinical practice. From the pathophysiological mechanism, the sympathetic nervous system plays an important role in the occurrence and maintenance of hypertension, so in theory, RDN will definitely have an ideal effect on some hypertensive patients. butThe pathophysiological mechanism of hypertension in different patients is inconsistent, the renal artery structure in different patients is obviously inconsistent, the principle of different types of RDN technology and equipment is inconsistent, and the experience and technical level of different operators are inconsistent. These four "inconsistencies" will inevitably affect the effectiveness and safety of RDN treatment and its application value and clinical status in antihypertensive treatment..

On the whole,For patients whose blood pressure can’t be satisfactorily controlled after lifestyle intervention and adequate treatment with various antihypertensive drugs, patients with obvious sympathetic hyperactivity, or patients who can’t tolerate antihypertensive drugs, it is reasonable to carry out RDN treatment in mature medical centers.. It is believed that RDN will play a more important role in the field of hypertension treatment in the future with the progress of related technologies and the continuous improvement of treatment equipment.

Expert introduction

　

Guo yifang

People’s Hospital of Hebei Province

Chief physician/professor, doctoral tutor, currently vice president of Hebei Provincial People’s Hospital. He is also the vice chairman of the Hypertension Committee of Chinese Medical Doctor Association, the vice chairman of China Society Hypertension Branch, the executive director of China Hypertension Alliance, the chairman of the Geriatrics Branch of Hebei Medical Association, the chairman of the Hypertension Professional Physician Branch of Hebei Medical Association, and the chairman of the Medical Engineering Branch of Hebei Medical Association. And the editorial boards of Chinese Journal of Internal Medicine, Chinese Journal of Geriatrics, chinese journal of cardiology and Chinese Journal of General Practitioners, and the standing editorial boards of Chinese Journal of Hypertension and chinese journal of cardiovascular medicine. Enjoy the special allowance of the State Council.

references

1. David E. Kandzari, Raymond R. Townsend, George Bakris, et al. Renal denervation in hypertension patients: Proceedings from an expert consensus roundtable cosponsored by SCAI and NKF. Catheter Cardiovasc Interv. 03 August 2021.　

2 "China cardiovascular medical device industry innovation white paper 2021"

3. Nat Rev Cardiol. 2020 Oct; 17(10):614-628.

4. C. Venkata S. Ram. Renal Denervation Therapy for Hypertension: All That Glitters Is Not Gold. Medscape. https://www.medscape.com/viewarticle/976670_1

5. Ultrasound renal denervation meets primary efficacy endpoint in RADIANCE II study. Cardiovascularnews. 26th July 2022.

6. Florian Rader, Ajay J. Kirtane, Yale Wang, et al. Durability of blood pressure reduction after ultrasound renal denervation: three-year follow-up of the treatment arm of the randomised RADIANCE-HTN SOLO trial. DOI: 10.4244/EIJ-D-22-00305

Typesetting: Yixin Editorial Department

Guangdong, a place easy to get angry.

For Cantonese people,

If you have a nosebleed

Nine times out of ten, it is getting angry.

Especially now when the weather is dry and things are dry.

Cantonese will remind you to drink herbal tea at once.

If there is a long-term nosebleed,

And it’s when there’s blood in the tears

We are about to start to be vigilant.

This could beGuangdong cancer!

nasal pharyngeal cancerIt is a malignant tumor located in the nasopharynx, also known asGuangdong cancerAccording to the statistics of the World Health Organization, there are80%Nasopharyngeal carcinoma (NPC) occurred in China, especially in Guangdong. The cancer detection data of our province released by Guangdong Provincial Center for Disease Control and Prevention in 2019 shows that at present, nasopharyngeal carcinoma ranks eighth among residents in Guangdong Province, with an incidence rate of 14.84/100,000.Far higher than the national average.

Speaking of nasopharyngeal carcinoma,

I have to mention

Epstein-Barr virus closely related to nasopharyngeal carcinoma

"Reasonable Inspection" Series No.twenty-eightperiod

Let’s have a chat.

Nasopharyngeal carcinoma and EB virus

epstein barr virus

"Good friend" of nasopharyngeal carcinoma, EB virus

Epstein-Barr virus is considered to be the strongest pathogenic factor of nasopharyngeal carcinoma at present. Epstein-Barr virus (EB virus) is one of the most widely infected herpes viruses. It is highly contagious and can be spread through droplets, kissing, sharing tableware and other behaviors, as well as through blood and semen during sexual contact, blood transfusion and organ transplantation. Epstein-Barr virus infection is very common in normal people. It is reported that more than 90% people have been infected with Epstein-Barr virus, and once infected, the antibody of Epstein-Barr virus will be carried for life.

Note: Autumn is the high incidence period of EB virus infection, so try to avoid going to crowded places to avoid cross-infection. Wear a mask when going out and take protective measures.

Then the problem is coming.

EB virus positive = nasopharyngeal carcinoma?

Epstein-Barr virus detection usually includes early antigen IgA antibody detection of Epstein-Barr virus, Rta-IgG detection of Epstein-Barr virus, and qualitative detection of Epstein-Barr virus DNA.

When EB virus antibody is positive, nasopharyngeal carcinoma can not be diagnosed. More than 90% of adults have been infected with EB virus, and only about 3%-10% of people with EB virus antibody positive will turn into nasopharyngeal carcinoma patients, indicating that the occurrence of tumors is not caused by EB virus alone, but by genetic and environmental factors.

(Source: Healthy Guangdong)

Don’t panic when you find EB virus positive in physical examination. Consult your doctor as soon as possible. The doctor can judge whether you are a high-risk patient by asking about your place of origin, family history, living habits and whether you have symptoms. According to the doctor’s advice, you may have an imaging examination for further confirmation. The 5-year survival rate of early nasopharyngeal carcinoma can reach 97%, so early detection is very important!

Epstein-Barr virus is indeed closely related to nasopharyngeal carcinoma. Accurately speaking, Epstein-Barr virus is a related substance of nasopharyngeal carcinoma, not a marker of nasopharyngeal carcinoma.

epstein barr virus

If you have the following symptoms, you should be alert to nasopharyngeal carcinoma.

VCA-lgA titer ≥ 1: 80;

All the EB virus indexes were positive;

Check the EB virus index, any one continues to rise.

When EB virus is positive, nasal congestion occurs; Reflux nasal discharge with blood; Vision loss and ghosting; Cervical lymph node enlargement; Ear buzzing and hearing loss; Headache; Facial numbness, etc., need more attention.

(Source: Healthy Guangdong)

epstein barr virus

What are the high risk factors for nasopharyngeal carcinoma?

At present, the pathogenic factors of nasopharyngeal carcinoma are not clear, except EB virus infection, which may be related to genetic factors, environmental factors, dietary factors and other factors.

01

Gender:

Nasopharyngeal carcinoma is more common in male population, which is 2~3 times higher than that in female.

02

Race:

Nasopharyngeal carcinoma is common in China, Southeast Asia and parts of North Africa. Inuit people also have a higher risk of nasopharyngeal carcinoma than other ethnic groups.

03

Region:

Guangdong, Guangxi, Fujian, Hunan, Jiangxi and other places in South China and East China belong to areas with high incidence of nasopharyngeal carcinoma, among whichPearl River DeltaThe area is particularly obvious.

04

Age:

May occur in any age group, butMostly in 30~50 years old..

(Source: Healthy Guangdong)

05

Diet:

Love foodPreserved foodSome people will also increase the incidence of nasopharyngeal carcinoma. Pickled food contains a lot ofAmmonium nitrite compoundLong-term intake can increase the incidence of nasopharyngeal carcinoma by 2~7 times.

06

Alcohol and tobacco:

manysmokeanddrink wine/alcoholIt will also increase the risk.

07

History of sinusitis and family history:

If someone in the family suffers from nasopharyngeal carcinoma, especiallydirect relativeThe risk of illness will also increase.

People who meet one or more of the above conditions are at high risk of nasopharyngeal carcinoma, so it is necessary to screen nasopharyngeal carcinoma.

epstein barr virus

Prevention: early detection+self-discipline is the key!

How to prevent nasopharyngeal carcinoma?

● Quit smoking and drinking, eat less pickled food;

● Epstein-Barr virus is mainly transmitted through saliva, and infants should not be fed mouth to mouth;

● Maintain good hygiene habits: wash your hands before meals, do not spit everywhere, and advocate the use of public chopsticks;

● If you get up every day and find that you often have a runny nose and are accompanied by bloodshot or bleeding symptoms, you must be vigilant;

(Source: Healthy Guangdong)

● In areas with high incidence of nasopharyngeal carcinoma, people with family history of nasopharyngeal carcinoma, and middle-aged and elderly people, EB virus detection should be taken as a necessary item for physical examination.

reference data

What the hell is EB virus?

https://mp.weixin.qq.com/s/I3I9u_1fsRufBIszp8OoEw

EB virus positive = nasopharyngeal carcinoma?

https://mp.weixin.qq.com/s/Z7iweJudIY9U_35Wla2Rkg

Health Science | Did you "catch" nasopharyngeal carcinoma when the physical examination found that "EB virus" was positive?

https://mp.weixin.qq.com/s/ygn4166PoefdHYrVFwHyrQ

Epstein-Barr virus positive means "Guangdong cancer"? Pay more attention to these daily situations!

https://mp.weixin.qq.com/s/6GB99I0DGXc1eX6YOEvl2A

Nosebleeds, tinnitus, neck mass, beware of "Guangdong cancer"

https://mp.weixin.qq.com/s/_YAKZlbGjfLyxNSHpfRH5w

Source | First Health Group

Editing | First Health Group

Please contact First Health Group for reprinting.

1. Cold and painful joints have nothing to do with "wind" and "wet", but it is actually caused by it.

2, 34 years old, advanced colorectal cancer! I had blood in my stool and thought it was hemorrhoids.

3, sedentary, staying up late, stressful, more than 2 million young people have a stroke every year! How does it haunt young people?

　　Recently, Tokyo Electric Power Company of Japan conducted an internal investigation on the reactor containment of Unit 1 of Fukushima Daiichi Nuclear Power Plant, and thought that the "control rod drive mechanism" at the bottom of the reactor pressure vessel might partially fall off and cause perforation at the bottom of the vessel.

　　Japan’s Kyodo News reported on the 16th that the investigation of TEPCO was carried out from March 28th to 31st, and the company put underwater robots into the containment of stagnant water. When the camera is used to photograph the surroundings, there is a space where no image is displayed, which is said to mean that the bottom of the pressure vessel is perforated. The attached blocks are considered as fuel fragments, which strongly interfere with the captured images and may have a high radiation around them. Blocks suspected of molten nuclear fuel (fuel fragments) are attached to the inner wall of the pressure vessel base. According to the analysis of TEPCO, "the heat of fuel fragments leads to the perforation of pressure vessels".

　　According to TEPCO, the control rod drive mechanism is a device that lifts the control rod from the lower side of the pressure vessel to adjust the output power of the reactor. At present, the tubular rod bundle about 4 meters long is lower than the normal position, and part of it falls to the bottom of the containment.

　　This year marks the 40th anniversary of China’s reform and opening up. 40 years of reform and opening up has made great achievements that attract worldwide attention, which has brought about earth-shaking changes in China. General Secretary of the Supreme Leader stressed that "great efforts should be made to sum up and apply the successful experience of China’s reform and opening up". It is of great theoretical and practical significance to sum up the valuable experience of China’s reform and opening up in the past 40 years to further accelerate the reform and opening up in the new era, uphold and develop Socialism with Chinese characteristics and realize the Chinese dream of the great rejuvenation of the Chinese nation.

　　The Third Plenary Session of the Eleventh Central Committee of the Party held in 1978 opened the historical journey of China’s reform and opening up. Since then, our Party has United and led the people of all ethnic groups throughout the country to make unremitting efforts, wrote a magnificent epic of the Chinese nation’s unremitting efforts to strive for self-improvement, pushed China’s economic strength, scientific and technological strength, national defense strength and comprehensive national strength into the forefront of the world, and promoted China’s international status to an unprecedented level. The face of the Party, the face of the country, the face of the people, the face of the army and the face of the Chinese nation have undergone unprecedented changes. China has accumulated a lot of experience in the 40 years of reform and opening up, and the valuable experience of fundamental significance that deserves our firm grasp mainly includes the following aspects:

　　We must adhere to the direction of Socialism with Chinese characteristics.

　　Reform and opening up is a profound revolution, and we must adhere to the correct direction and advance along the right path. Over the past 40 years, the people of China have been working hard and tenaciously, greatly liberating and developing the social productive forces, and always striving for progress and forging ahead, opening up the road of Socialism with Chinese characteristics. Over the past 40 years, China’s economic strength and comprehensive national strength have been greatly improved, people’s lives have improved significantly, its international status has been unprecedentedly improved, and its economic aggregate has leapt to the second place in the world, successfully achieving a leap from a low-income country to a middle-income country. Practice has proved that the road of Socialism with Chinese characteristics is feasible, right and good. Reform is a reform that keeps advancing on the road of Socialism with Chinese characteristics, and adhering to the direction of Socialism with Chinese characteristics is the fundamental reason for the success of China’s 40 years of reform and opening up. General Secretary of the Supreme Leader pointed out, "Our reform and opening up has a direction, a position and principles." "If we don’t implement reform and opening up, we will die, and we will deny the socialist direction &lsquo; Reform and opening up &rsquo; We say that Socialism with Chinese characteristics is socialism, that is, no matter how we reform and open up, we will always adhere to the Socialism with Chinese characteristics Road, Socialism with Chinese characteristics Theory System and Socialism with Chinese characteristics System. In the face of the actions of hostile forces in the west and some people with ulterior motives in spreading fallacies and confusing people on the reform issue, we must keep a clear head and maintain political firmness.As General Secretary of the Supreme Leader emphasized, to firmly grasp the correct direction of reform, we must stand firm and take a clear-cut stand on fundamental issues such as roads, theories and systems, and in the face of major issues.

　　We must constantly promote the China of Marxism.

　　Reform and opening up is an unprecedented innovative practice, and the process of promoting reform and opening up is a process of crossing the river by feeling the stones and constantly summarizing scientific theories in practice and guiding reform with scientific theories. In the past 40 years, China has made great achievements in reform and opening up. The key is that we not only adhere to the basic principles of Marxism, but also continue to promote the China of Marxism according to the practice of contemporary China and the development of the times, thus forming and developing the system of Socialism with Chinese characteristics Theory. Socialism with Chinese characteristics Thought of the Supreme Leader in the New Era is the latest achievement of Marxism in China and an important part of Socialism with Chinese characteristics’s theoretical system. In this thought, it is clear that the overall goal of comprehensively deepening reform is to improve and develop the Socialism with Chinese characteristics system, promote the modernization of the national governance system and governance capacity, and emphasize persisting in comprehensively deepening reform and promoting the building of a community of human destiny. An important experience of the success of China’s 40-year reform and opening-up is that it has neither lost its ancestors nor developed them, and guided the practice of China’s reform and opening-up with contemporary Marxist scientific theory in China.

　　We must uphold and improve the Communist Party of China (CPC)’s leadership.

　　The most essential feature of Socialism with Chinese characteristics is the Communist Party of China (CPC)’s leadership, and the greatest advantage of Socialism with Chinese characteristics system is the Communist Party of China (CPC)’s leadership. The Communist Party of China (CPC) is the leading core of Socialism with Chinese characteristics’s cause, and reform and opening up is a new great revolution led by the Party under the new era. China’s reform and opening-up is carried out under the condition that the productive forces are relatively backward, and there are many institutional drawbacks in the production relations and superstructure. It is the self-improvement and development of the socialist system and a profound and complicated revolution, which determines that the reform must be carried out in a planned, step-by-step and orderly manner under the leadership of the Party. Our party deeply understands that to realize the great rejuvenation of the Chinese nation, we must conform to the trend of the times, conform to the wishes of the people, be brave in reform and opening up, and make the cause of the party and the people always full of powerful motivation to forge ahead courageously. Our Party unites and leads the people to carry out the new great revolution of reform and opening up, breaks down all ideological and institutional obstacles that hinder the development of the country and the nation, opens up the road to Socialism with Chinese characteristics, and makes China catch up with the times in great strides. At the same time, with the deepening of China’s reform and opening up, party building needs to be strengthened. It is an important experience of China’s 40 years of reform and opening up to the outside world to promote the cause of China’s reform, opening up and socialist modernization by constantly strengthening and perfecting the Party’s leadership, so that the Party will always become the strong leadership core of Socialism with Chinese characteristics’s cause.

　　We must adhere to the people-centered value orientation

　　The people are the creators of history and the main force to promote reform and opening up. The General Secretary of the Supreme Leader pointed out that "reform and opening up is the cause of hundreds of millions of people, and we must persist in respecting the people’s initiative and promoting it under the leadership of the party" and "we must adhere to the unity of the people’s dominant position and the leadership of the party and rely on the people to promote reform and opening up". An important experience of China’s 40 years of reform and opening up is that our party has always adhered to taking the people as the center and respecting the people’s dominant position. Throughout the process of reform and opening up, the Party has always adhered to the basic principle of historical materialism that the people create history, represented the fundamental interests of the overwhelming majority of the people in China, and widely mobilized the enthusiasm, initiative and creativity of the people. It has always taken the people’s support or disapproval, approval or disapproval, happiness or unhappiness, and consent or disapproval as the test criteria, and has always insisted that development is for the people, development depends on the people, and development results are shared by the people. It is precisely because the party has always adhered to the people-centered political stance and value orientation, and has always regarded the people’s longing for a better life as an important goal to promote reform and opening up. Our reform and opening up has always broken through difficulties and made brilliant achievements that have attracted worldwide attention.

　　We must persist in emancipating our minds, seeking truth from facts, advancing with the times and being pragmatic.

　　The Third Plenary Session of the Eleventh Central Committee of the Party re-established the ideological line of emancipating the mind and seeking truth from facts, and opened a new era of China’s reform, opening up and socialist modernization. Since then, our Party has kept pace with the times and insisted on integrating the basic principles of Marxism with the concrete reality of China. Especially since the 18th National Congress of the Communist Party of China, the CPC Central Committee with the Supreme Leader as the core has persisted in emancipating the mind, seeking truth from facts, keeping pace with the times, seeking truth from facts and being pragmatic. With great political courage and strong responsibility, it has continuously made new breakthroughs in the journey of comprehensively deepening reform, and promoted the historic achievements and changes in the cause of the party and the country. The practice of 40 years has fully proved that China’s reform and opening-up has precisely defined the historical stage and fundamental task of China’s social development, scientifically formulated a series of principles and policies for reform, opening-up and modernization, and gradually explored a Socialism with Chinese characteristics road suitable for China’s national conditions, thus making the reform and opening-up achieve brilliant achievements.

　　We must correctly handle the relationship between reform, development and stability.

　　Reform, development and stability are inextricably linked, organically unified and indispensable. Reform is a powerful driving force for economic and social development and the foundation for achieving social stability; Development is the purpose of reform, and the key to solving all problems in China must rely on reform and development; Stability is an important prerequisite to ensure the success of reform and development. Therefore, we must make overall arrangements for reform, development and stability. Reform is the driving force, development is the goal, and stability is the premise. The relationship between reform, development and stability runs through the 40-year reform process. The experience of 40 years of reform and opening up has proved that only by correctly handling the dialectical unity relationship between reform, development and stability, consciously grasping the strength, speed and social affordability of reform, and taking continuous improvement of people’s lives as an important combination point to deal with the relationship between reform, development and stability, can we really promote reform and development while maintaining social stability, thus realizing the sustained and healthy development of China’s economy and society and continuously advancing the great process of reform, opening up and modernization.

　　(Written by Han Zhenfeng)

　　Data map. Xinhua News Agency issued Zhang Chunlei photo

　　BEIJING, Beijing, March 23 (Reporter Li Jinlei) "Let enterprises lighten their burdens a little more, and let employees get more cash", which was Li Keqiang, Premier of the State Council of the People’s Republic of China’s statement when answering questions related to "five insurances and one gold" at a Chinese and foreign press conference on March 16. The reporter of Zhongxin. com (WeChat WeChat official account: cns2012) noticed that recently, Shanghai, Guangdong, Tianjin and other places announced the reduction of social security rates.

　　In addition, streamlining the "five insurances and one gold" has also set the direction. The recently announced "Thirteenth Five-Year Plan" outlines that maternity insurance and basic medical insurance should be implemented together. This means that with the merger of maternity insurance and basic medical insurance in the future, the familiar "five insurances and one gold" will become "four insurances and one gold".

　　Help enterprises reduce costs

　　&mdash; &mdash; Reduce social security rates in many places

　　Reducing costs is one of the main tasks of China’s economic work in 2016. Under the background of high social security burden, reducing social security burden has become a practical measure for local governments to reduce costs for enterprises.

　　The reporter from Zhongxin. com found that recently, Shanghai, Guangdong, Tianjin, Yunnan, Gansu, Hangzhou, Zhejiang, Xiamen, Fujian and other regions have successively introduced new policies to reduce social security rates to varying degrees.

　　Shanghai announced on March 21 that from January 1, 2016, the unit contribution rates of employee basic endowment insurance and employee basic medical insurance will be lowered by 1 percentage point, and the unemployment insurance unit contribution rate will be lowered by 0.5 percentage point.

　　Guangdong reduced the unemployment insurance premium rate from 2% to 1% from March 1st this year, and demanded that the urban-rural integration of basic medical insurance should be promoted from the second half of 2016, and the unit premium rate should be gradually lowered to about 5.5%.

　　In early February this year, Tianjin launched the first batch of 20 policy measures to reduce the cost of enterprises in the real economy, and proposed to reduce the payment rates of unemployment, maternity and work-related injury insurance. Among them, the rate of unemployment insurance paid by enterprises has dropped from 2% to 1%; The rate of paying maternity insurance was reduced from 0.8% to 0.5%; The minimum standard for payment of work-related injury insurance is reduced from 0.5% to 0.2%, and the maximum standard is reduced from 2% to 1.9%. After adjustment, the comprehensive rate level is lowered from 0.67% to 0.54%.

　　In addition, Yunnan and Gansu have also lowered unemployment, work injury and maternity insurance rates; Hangzhou, Zhejiang Province, decided to reduce the basic medical insurance premium paid by enterprises by one month every year, the maternity insurance premium rate dropped by 0.2 percentage points, and the benchmark industrial injury insurance premium paid by enterprises dropped by 0.2 percentage points on average; Xiamen, Fujian Province also issued a notice to reduce the employer’s contribution rate of basic medical insurance for enterprise employees by 1 percentage point.

　　Data map. Photo by Zhang Yun

　　In some areas, the individual payment rate will be lowered.

　　&mdash; &mdash; The salary you get may increase.

　　It can be seen from observation that according to the local actual situation, the types of social security insurance, the rate decline and the implementation period are not consistent, and most of the downward adjustments are unit payment rates.

　　Take Shanghai as an example. This adjustment in Shanghai involves three types of insurance: pension, medical care and unemployment insurance. The overall rate has dropped by 2.5 percentage points, but only the rate of unit contributions has been reduced. According to estimates, after this rate reduction, it is estimated that the burden on enterprises will be reduced by about 13.5 billion yuan in 2016.

　　However, the reporter of Zhongxin. com noticed that Guangdong, Yunnan and other regions not only reduced the unit contribution rate, but also took into account the reduction of individual contribution rate.

　　For example, the unemployment insurance rate in Guangdong has been reduced from 2% to 1%, of which the unit rate has been reduced from 1.5% to 0.8% and the individual rate has been reduced from 0.5% to 0.2%. According to estimates, in 2016, it is estimated that the insured enterprises in the province can pay less 5.3 billion yuan, and individuals will pay less premiums of 2.4 billion yuan.

　　The payment rate of unemployment insurance in Yunnan was reduced from 3% to 2%, of which the employer’s payment rate was reduced from 2% to 1.4% and the individual’s payment rate was reduced from 1% to 0.6%.

　　This means that employees in Guangdong, Yunnan and other places may get more wages. Take Yunnan as an example. Employees of enterprises with a monthly salary of 5,000 yuan were required to pay unemployment insurance premium at 1% and 50 yuan every month. After the personal rate is lowered to 0.6%, they only need to pay 30 yuan every month, so they can get more salary 240 yuan every year.

　　On the other hand, people are generally worried about lowering the social security rate. After the social security rate is lowered, will the treatment level of the future insured also decline?

　　In this regard, Shanghai said in the policy interpretation that at present, the income and expenditure of the social insurance fund for employees in this city is good, with a certain accumulation and an annual balance. The downward adjustment of the basic old-age insurance, medical insurance and unemployment insurance rates will not affect the overall treatment level of the insured.

　　Data map. Xinhua News Agency, Fa Jing Wei, photo

　　Maternity and medical insurance will be merged.

　　&mdash; &mdash; "Five insurances and one gold" or "Four insurances and one gold"

　　In addition to lowering the social security rate, some regions also proposed to merge maternity insurance and basic medical insurance.

　　The Overall Plan for Supply-side Structural Reform in Guangdong Province (2016&mdash; In 2018), it is proposed to optimize the structure of social security insurance and promote the combined implementation of maternity insurance and basic medical insurance in accordance with the unified national deployment.

　　"Several Opinions of Hangzhou Municipal People’s Government on Reducing Costs, Reducing Burden and Removing Capacity to Promote the Healthy Development of the Real Economy in an All-round Way" also requires that maternity insurance should be incorporated into the scope of medical insurance management in a timely manner according to the unified arrangements of the state.

　　The reporter of Zhongxin. com noted that the recently announced "Thirteenth Five-Year Plan" clearly stated that maternity insurance and basic medical insurance should be combined.

　　This means that with the merger of maternity insurance and basic medical insurance in the future, the familiar "five insurances and one gold" may become "four insurances and one gold". (End)

CCTV News:Spring 2023 China Higher Education Expo was held in Chongqing International Expo Center from April 8 to 10. The theme of this year’s High-Tech Fair is "Campus-Land Convergence, Production-Education Integration: High-quality Development", with three sections: high-tech equipment exhibition, high-level conference forum, informationization and high-end achievement release. The joint research and development of scientific and technological products by many schools and enterprises has become a highlight of this exhibition.

In the high-tech equipment exhibition area, a new type of dual-arm cooperative robot attracted the attention of many exhibitors.

Yangjin, exhibitor of China Higher Education Expo:We adopt the configuration of flexible joints, which can drag the robot’s arm very flexibly, which is essentially different from our traditional robots. We cooperate with universities to introduce some of our industry applications and resources into the curriculum system, such as specialty construction and laboratory construction.

The "black technology" independently developed by many college students is also favored by exhibitors. In the booth of Shanghai Jiao Tong University, this robot for inspecting the inner wall of large containers can adsorb and move on the inner wall of steel lining through magnetic adsorption, and transmit the image back to the staff of the control station in real time through wireless transmission, thus replacing the previous manual scaffolding for inspection.

Li Tongjia, Graduate Student, School of Mechanical and Power Engineering, Shanghai Jiaotong University:In the process of developing it, I have been trained by both school tutors and enterprise tutors. On the one hand, I can apply what I have learned in school to actual production and life, on the other hand, I can understand the needs of enterprises.

Zhou Yu, Vice President of China Higher Education Society and Academician of China Academy of Engineering:Take the road of school-enterprise cooperation and integration of production and education, closely combine with the actual needs of production, extract the scientific and technological problems that enterprises need, and we will work together with schools to solve this problem.

In the newly-added college area of this high-tech fair, the achievements of 110 colleges and universities in 28 provinces (municipalities and autonomous regions) are displayed in a concentrated way. In the booth of Harbin Institute of Technology, 549 patriotic education bases and 50 national heavy equipment enterprise bases were drawn to form three maps of red resources, national heavy equipment and industry model, which effectively integrated ideological and political theory courses with practical teaching.

Yin Shengjun, Director of the Teaching and Research Section of the Ideological and Political Practice Course of Harbin Institute of Technology:On this platform, we pay special attention to the development of students’ subjectivity, that is, students participate in ideological and political courses as the main body, and more actively speak and present what they have learned through his perspective.