Beijing, Jan 21st (Reporter Zhang Ni): Starting today, the Spring Festival travel rush will be officially opened in 2019. In the next 40 days, the number of passengers sent nationwide is expected to reach 2.99 billion. At the same time, the four major changes in Spring Festival travel rush this year will also make the journey home more comfortable and convenient.

　　It is estimated that 2.99 billion passengers will be sent, and the demand for railway and civil aviation transportation will grow rapidly.

　　According to the data from the National Development and Reform Commission, in 2019, the number of passengers sent by Spring Festival travel rush will reach 2.99 billion, an increase of 0.6% over the previous year in Spring Festival travel rush.

　　Among them, the number of road trips was 2.46 billion, down by 0.8%; 413 million railway passengers, an increase of 8.3%; 73 million passengers in civil aviation, an increase of 12%; 43 million passengers were transported by water, basically the same as last year.

　　On the whole, the growth rate of total passenger traffic has slowed down but the structure has changed, and the demand for railway and civil aviation transportation has maintained rapid growth. Before the holiday, the student flow and the work flow are superimposed on each other, and the peak of passenger flow comes early and lasts for a long time, while the passenger flow after the holiday is relatively flat.

　　In terms of railways, Spring Festival travel rush’s transport capacity will increase by 5.3% this year. Among them, 4,787 pairs of passenger trains were arranged before the festival, an increase of 468 pairs year-on-year, with an average daily transportation capacity of 9.42 million seats, an increase of 5.4%; After the festival, 4,860 pairs of passenger trains were arranged, an increase of 460 pairs compared with the same period of last year, and the average daily transportation capacity was 9.64 million seats, an increase of 5.2%.

　　In terms of civil aviation, in order to avoid congestion and high fares in hot spots, the Civil Aviation Administration has launched pilot projects to extend the running time of domestic flights at 10 hot airports, including Pudong in Shanghai, Shuangliu in Chengdu and Fenghuang in Sanya, which has increased the flexibility of airlines’ overall capacity arrangement. It is expected that 35,000 overtime flights will be arranged during the Spring Festival this year.

　　Data Map: Hulk, a new member of Fuxing family, arrived in Shanghai to start debugging and will be put into operation during its stay in Spring Festival travel rush. Photo by Zhang Hengwei

　　Four New Changes in Spring Festival travel rush in 2019

　　— — New models unveiled to improve ride experience.

　　During Spring Festival travel rush in 2019, the railway department will further optimize the operation organization and open more passenger trains to meet the travel needs of passengers. Among them, the number of "Fuxing" will increase from 291.5 pairs to 400 pairs, and high-speed trains such as Jingha, Beijing-Guangzhou, Shanghai-Kunming and Chongqing-Guizhou will be added at night, and 180 newly purchased EMUs with a speed of 350 kilometers per hour will be put into operation, and many new lines such as Hanghuang and Huaiheng will be opened.

　　In addition, since the implementation of the new train diagram on the 5 th of this month, new members of the "Fuxing" family have met with passengers one after another.

　　On the 5th, 17 grouped super-long "Fuxing" EMUs were officially put into operation on the Beijing-Shanghai high-speed railway. The number of passengers on the EMU is 1,283, and the passenger capacity is increased by 90 people, or 7.5%, compared with the 16 formed trains.

　　In addition, the "Fuxing" EMU, known as the "Hulk" with a speed of 160 kilometers per hour, will also meet with the public.

　　The EMU has two models: short marshalling and long marshalling. The short marshalling consists of 9 cars with a capacity of 720 people, while the long marshalling consists of 11 to 20 cars with a maximum capacity of 1,102 people.

　　Compared with the traditional locomotive traction bus, the driver of this vehicle is more convenient and quick to operate, the passengers are safer and more comfortable to ride, the transportation organization is more efficient, the existing maintenance resources can be fully utilized, and the basic investment and equipment maintenance cost can be reduced.

　　After the "Hulk" is put into operation, some ordinary speed lines will enter the era of moving trains.

　　— — The new line ushered in the first Spring Festival travel rush "final exam"

　　This year, a number of new railway lines will be put into Spring Festival travel rush for the first time.

　　For example, the Jiangzhan Railway and Kunchu Railway, which were opened in July 2018, and the Guangzhou-Shenzhen-Hong Kong High-speed Railway and Hajia Railway, which were opened in September 2018, will usher in their first "big exam" in Spring Festival travel rush.

　　In addition, 10 new railway lines from Hangzhou to Huangshan, Chengde to Shenyang, Xinmin to Tongliao, Harbin to Mudanjiang, Jinan to Qingdao, Qingdao to Yancheng, Nanping to Longyan, Huaihua to Hengyang, Tongren to Yuping and Chengdu to Ya ‘an, which were opened at the end of 2018, will also serve Spring Festival travel rush passengers for the first time.

　　— — The new service is online to facilitate passengers’ travel.

　　This year, in Spring Festival travel rush, besides the choice of new models and routes, passengers can also enjoy more convenient new services.

　　From December 27, 2018, the railway department selected the long-distance section of the train with a tight capacity in Spring Festival travel rush in 2019 on the website of Railway 12306 and the mobile phone client, and launched the pilot service of standby ticket purchase to further improve the passenger ticket purchase experience.

　　With this service, passengers can submit their ticket purchase requirements by date, train number and seat, and after paying the ticket in advance, the ticketing system will automatically arrange online queuing. When the tickets available for sale are generated for the corresponding trains and seats due to refund or change of tickets, the system will automatically cash the tickets and inform the passengers of the purchase results.

　　In addition, the railway department is still vigorously exploring "paperless" services. Since November 22, 2018, the railway department has implemented an e-ticket service pilot in Hainan’s high-speed rail around the island, making it easier and faster for passengers to purchase tickets, check in tickets and ride.

　　— — New regulations regulate travel order

　　In 2018, people were impressed by the appearance of "bully man" and "bully woman". However, during this year’s Spring Festival travel rush, the implementation of the new regulations will strictly restrict this behavior.

　　Previously, the National Development and Reform Commission and other nine departments issued the Opinions on Doing a Good Job in Spring Festival travel rush in 2019. The "Opinions" pointed out that it is necessary to severely punish serious uncivilized behaviors of passengers such as "car troubles", "machine troubles" and "high-speed rail hegemony" in accordance with the law and maintain a good travel order.

　　The transportation department should strengthen the education and training of drivers and passengers and improve the ability to deal with uncivilized behavior; Encourage passengers to participate in transportation safety, and dare to stop illegal acts of passengers that affect the normal driving of drivers and disturb the safety of public transportation; Cooperate with the public security department to punish suspected illegal and criminal acts according to law.

　　Civil aviation and railway departments should take disciplinary measures to restrict the use of planes and trains within a certain period of time against untrustworthy people who seriously disrupt the transportation order and endanger the transportation safety according to laws and regulations.

　　The Opinions on Appropriately Restricting Certain Serious Untrustworthy Persons to Take Civil Aircraft to Promote the Construction of Social Credit System, which was implemented in May 2018, also made it clear that nine types of serious "airplane-troubled" passengers, such as seizing seats on the plane, impacting the apron, fabricating false terror information about flight safety and fighting on the plane, will be "banned from flying" for one year. (End)

　　Cctv newsAccording to the "Shanghai Release" WeChat WeChat official account news, the Shanghai Central Meteorological Observatory issued a blue gale warning signal at 14: 05 on September 29, 2021: Due to strong thunderstorm clouds, it is expected that there will be 7-9 thunderstorms and strong winds in Baoshan, Jiading, Chongming, the northern part of the central city and Pudong in the next 3 hours, so please take precautions.

　　Earlier, the Shanghai Central Meteorological Observatory issued a yellow warning signal for lightning at 13: 50: It is expected that lightning activities will occur in Baoshan, downtown, Jiading, Minhang, Qingpu, Songjiang, Chongming and Pudong before midnight today, accompanied by short-term heavy precipitation with a maximum of 20-30 mm per hour, 7-9 thunderstorms and strong winds, and there may be small hail in some areas.

　　Defense guide:

　　1. Check doors and windows, reinforce clothes racks, outdoor antennas, etc., and properly place outdoor flowerpots and other items that are easy to fall.

　　2. Try not to stay near glass doors and windows or billboards when going out.

　　Defense guide:

　　1. Stop carrying out outdoor activities in open places.

　　2. Stop swimming in rivers, lakes and seas.

　　3. Stay away from trees, corners or places with prominent metal objects; Don’t hold objects with sharp metal corners in your hands or carry them on your shoulders.

CCTV News:On May 5th, WeChat official account, the "China Medicine News", issued a notice from the General Department of National Medical Products Administration on the establishment of a GAP expert working group on Chinese herbal medicines.

All provinces, autonomous regions, municipalities directly under the central government and the drug administration of Xinjiang Production and Construction Corps, and all relevant units:

According to the Notice of National Medical Products Administration on Printing and Distributing Several Measures to Further Strengthen the Scientific Supervision of Traditional Chinese Medicine and Promote the Inheritance, Innovation and Development of Traditional Chinese Medicine (No.1 [2023] of the State Drug Administration), in order to promote the standardized development of traditional Chinese medicine, promote the orderly implementation of GAP (hereinafter referred to as GAP), strengthen the quality control of traditional Chinese medicine, promote the construction of traceability system of traditional Chinese medicine, improve the quality of traditional Chinese medicine from the source, and further play the guiding and supporting role of technical experts in the industry, National Medical Products Administration decided to set up a GAP expert working group on traditional Chinese medicine.

First, the members of the expert group are composed of professionals engaged in the research, planting/breeding, harvesting and processing, quality control, quality evaluation and administration of Chinese herbal medicines. They are required to have high academic attainments and professional level, and in principle they are not over 60 years old.

Two, National Medical Products Administration is responsible for the selection, addition and replacement of members of the expert group, formulate and adjust the work responsibilities and work requirements of the expert group.

National Medical Products Administration Verification Center set up an expert group office, which is responsible for the daily work of the expert group. The members of the office are composed of relevant departments of National Medical Products Administration, relevant staff members of directly affiliated units such as the Central Inspection Institute, Pharmacopoeia Committee and Verification Center.

Three, the expert group consists of 1 leader and 3 deputy heads. The term of office of all members is five years, and the members of the expert group can be supplemented and adjusted according to the needs of work and the wishes of experts. See the annex for the list of members of the first phase expert group. The expert group leader is Huang Luqi, the executive deputy leader is Wei Jianhe, and the deputy leaders are Guo Lanping and Gao Tianbing.

IV. Following the principles of scientificity, legality, openness, impartiality and objectivity, the expert group provides technical support and decision-making suggestions for the quality and safety supervision of Chinese herbal medicine production, promotes the standardized development of Chinese herbal medicines and promotes the implementation of GAP in Chinese herbal medicines. The specific responsibilities are as follows:

(a) to provide support for National Medical Products Administration to study and formulate technical guidance documents such as technical guidelines, inspection procedures and inspection and evaluation standards to promote the implementation of GAP in Chinese herbal medicines, and directly participate in the drafting of relevant documents when necessary.

(two) to provide technical advice for National Medical Products Administration to study and improve the standardization, industrialization and moderate scale development of Chinese herbal medicines, and to strengthen the management policy of quality and safety supervision of Chinese herbal medicines.

(three) according to the arrangement of National Medical Products Administration, to participate in the supervision and inspection of the GAP conformity inspection and causal inspection of Chinese herbal medicines related to the extended inspection of Chinese herbal medicines.

(four) according to the arrangement of National Medical Products Administration, to provide technical guidance for promoting the implementation of GAP in Chinese herbal medicines throughout the country and promoting the standardized production of Chinese herbal medicines.

(five) according to the arrangement of National Medical Products Administration, to provide opinions on the major disputes that may exist in the implementation and inspection of GAP in Chinese herbal medicines.

(VI) Investigate, collect, summarize and analyze the problems and risks in the implementation, inspection and standardized production of Chinese herbal medicines, and put forward solutions to National Medical Products Administration.

(seven) other technical consulting work related to the quality management of standardized production of Chinese herbal medicines.

5. Members of the expert group shall attend meetings and GAP-related inspections of Chinese herbal medicines according to the arrangement of National Medical Products Administration; Provide specific and clear professional opinions and suggestions objectively, fairly and rigorously; Take the initiative to avoid related activities that I have an interest in; Not to participate in standardized production of Chinese herbal medicines, GAP implementation of Chinese herbal medicines and other related commercial activities in the name of members of the expert group; Undertake the obligation of confidentiality according to the law and regulations.

Six, members of the expert group have the right to independently and fully express their personal opinions and suggestions within the scope of performing their duties as members, receive corresponding labor remuneration in accordance with relevant regulations, and resign according to their own wishes.

Seven, the provincial drug regulatory authorities can be combined with the actual development of Chinese herbal medicines in their respective administrative areas, study and set up a GAP expert group of Chinese herbal medicines in their respective administrative areas, and guide and promote the standardized development of Chinese herbal medicines in their respective administrative areas.

Attachment: List of GAP Expert Working Groups of Chinese Herbal Medicine in National Medical Products Administration (Phase I)

　　"The earth is the cradle of human beings, but human beings cannot live in the cradle forever." This is the heroic words of tsiolkovsky, the father of modern rockets. So far, man has landed on the moon and looked at his home from another perspective. However, one big step for mankind is not far enough. The inability to support transportation and the lack of dry food supplies have restricted human beings from leaving the "cradle", realizing interstellar travel and sailing, and looking for "relatives" who go to the earth.

　　Of course, all this has been realized in science fiction movies — — In a series of sci-fi movies such as Avatar in Interstellar, astronauts use the technology of "freezing dormancy" to reduce the metabolism of their bodies and realize long-distance interstellar travel with less supplies. Recently, NASA officially announced that it will fund SpaceWorks in Atlanta to develop a similar "suspended animation" technology to put astronauts into a short-term frozen sleep state during the long interstellar travel.

　　In real space missions, the supply needed by human astronauts will have a direct impact on mission execution. Obviously, putting astronauts into a short-term frozen sleep state will make space travel go further and more efficient. ● Wang Tengteng, a reporter from Nanfang Daily in Beijing, planned and coordinated Zhang Zhichao.

　　1. Freezing dormancy improves the efficiency of space travel.

　　According to reports, during the interplanetary voyage, the frozen dormancy cabin designed by SpaceWorks will make astronauts enter an inert and numb state, that is, a short-term frozen dormancy state. In this state, the physiological activities of astronauts are reduced, usually manifested in the decrease of body temperature and metabolic rate. This will greatly reduce the astronauts’ demand for external materials, and then greatly reduce the supplies they carry.

　　John Bradford, CEO of SpaceWorks, said that the "suspended animation" of human astronauts has always been regarded as the best solution for long-term space flight. According to the design scheme, the sleeping cabin of SpaceWorks is very small, located near the central node or crew cabin of the spacecraft, allowing astronauts to enter and exit directly. Brad Ford said: "We believe that 4-mdash; The supply demand of six astronauts can be reduced to 5-mdash; 7 tons, not the current 20-mdash; 50 tons. The space required for the astronaut habitat is about 20 square meters, while most current designs require 200 square meters. "

　　When the astronauts are in a frozen hibernation state, they will be covered with various sensors, so that other awake astronauts can monitor their status at any time. Astronauts will get the nutrients needed to maintain human body function through total parenteral nutrition intravenous injection, which can be excreted with urine. Astronauts will sleep for 14 days under the low temperature induced by this drug, and then wake up for 2-mdash; Three-day shift change to meet the dormancy needs of other astronauts.

　　2. Cooling process or damage to cells

　　It can be seen that astronauts’ freezing and dormancy can maximize the space and load utilization of spacecraft. The key is to reduce the consumption of astronauts during flight, that is, to minimize the metabolic rate of the human body.

　　There is no doubt that low temperature can reduce the metabolic rate of living things. Animals such as frogs and snakes all hibernate to reduce their metabolic rate. However, it is worth noting that the freezing dormancy of astronauts is not the same as the "human freezing" technology used by Du Hong, a female writer in Chongqing, China. The first problem to be solved in astronaut’s freezing and dormancy technology is the damage caused by low temperature to astronauts’ life.

　　Technically, human freezing dormancy refers to freezing human to -196℃ in a very short time, stopping cell activity and prolonging human life cycle indefinitely. Theoretically, freezing dormancy can be done. But at present, from the technical point of view, human beings can’t freeze and sleep and wake them up. The main problem is that when the body temperature drops to -5℃, the water in the cells will freeze and form ice crystals. These ice crystals can penetrate the cell membrane and cause serious tissue damage. In other words, people who sleep through freezing will not be able to wake up again.

　　The mechanism of long-term preservation of cells at low temperature is that the metabolism of cells slows down rapidly at low temperature. The lower the storage temperature, the slower the metabolism and the longer the storage time. For example, the blood in the blood center is often stored at -5℃, and the storage time is generally one month. Of course, if the damage to cells caused by low temperature is not considered, the blood should be preserved for a longer time if it is stored at -196℃.

　　But cryopreservation itself can also kill cells and damage tissues. The SpaceWorks funded by NASA has not announced how to deal with these risks, but we might as well take a look at these risks and the current research on how to deal with them. These risks include both chemical damage and physical damage.

　　The main culprit of chemical damage is the oxygen we live on. Needless to say, the importance of oxygen, but its other side is to destroy the essence of life molecules through oxidative decomposition. Especially when cells actively use oxygen, they will generate a large number of free radicals which are more active than molecular oxygen. Under normal circumstances, cells use a series of enzymes to directly or indirectly combat the damage caused by oxygen and its free radicals. However, with the decrease of temperature, although the speed of destruction also decreases, the resistance ability accelerated by enzyme catalysis will also decrease sharply with the drastic decrease of enzyme activity, and the originally balanced chemical reaction will eventually fall to the destructive side. This cannot be ignored.

　　The second is physical damage, which mainly refers to the damage to cells caused by liquid freezing at extremely low temperature. According to the research of Liqun He, a professor at the Institute of Cryobiology, University of Science and Technology of China, the only way to achieve freezing dormancy is to treat each cell at low temperature. In practical application, the first step of cryopreservation of cells is to add cryoprotectant (CPA) to cells and then cool them safely. It is worth noting that the temperature is not low enough to meet the requirements of freezing dormancy, but -15℃— The low temperature process of -60℃ is fatal to cells.

　　3. The cooling process is difficult to operate.

　　Adding solute to water will lower the freezing point of water. Generally speaking, the higher the solute concentration, the lower the freezing point, so the first step of successful cryopreservation is to add appropriate CPA, and high concentration solute has osmotic damage to cells, so it should be appropriate. Since 50 years ago, a British research group accidentally discovered that glycerol is an effective cryoprotectant for sperm and red blood cells, although new CPAs, such as ethylene glycol, methanol, propylene glycol and dimethyl sulfoxide, are constantly emerging, and some of them are more effective, glycerol is still one of the effective CPAs.

　　According to Liqun He and others, the experiment shows that after adding CPA, the cells are dehydrated first, and the volume begins to shrink, then CPA infiltrates and the volume expands. If the concentration of CPA is too high, its volume will shrink excessively and even exceed the tolerance limit of cells, resulting in damage.

　　During the cooling process, when the temperature drops to about -5℃, the cells and transmitters around them are not frozen, and they are all in a supercooled state, at -5℃— Between -15℃, the extracellular solution begins to freeze. If it is assumed that the cell membrane prevents the ice crystals from growing into the cell, the cell is still in a supercooled state without freezing. At this time, the chemical potential of water inside the cell increases, water begins to seep out of the cell, and then freezes outside the cell, and then the reaction of the cell depends on the cooling rate. Liqun He said that if the cooling is too fast, the cells will not have enough time to maintain the osmotic pressure balance of the internal and external solutions by oozing water, so that the intracellular solutions will be too cold, and eventually the cells will start to freeze.

　　Generally speaking, cooling too fast or too slow can kill cells. At the slow cooling rate, the low-temperature damage comes from the "solution effect", which leads to severe dehydration of cells. Under rapid cooling, the low temperature damage is caused by deadly intracellular ice. For a specific cell, there must be an optimal cooling rate with the highest cell recovery rate. The cooling rate is slow enough to prevent intracellular ice and fast enough to minimize the "solution effect".

　　According to reports, in addition to the above method, there is also a cooling method to make the cytoplasm glassy at present. Using ultra-fast cooling (> 106℃/min) or using high concentration CPA, the cytoplasm will form glassy state instead of intracellular ice. However, ultra-fast cooling is technically difficult. Several CPAs that can effectively improve the cooling damage in slow cooling can also be used to promote vitrification, but the required concentration is too high and it is too toxic to cells and tissues.

　　It should be noted that the cooling rate is too high or too low relative to the water permeability of cell membrane and related to the type of cells. Different cells have different permeability to water, which leads to different optimal cooling rates for different cells. Think about it carefully, the human body is composed of countless cells, and there are many differences between brain cells and liver cells. It is very difficult to target these cells with drugs, and it needs precise control. If you don’t pay attention, you can cause irreversible damage to cells. Compared with the current difficulty of oocyte cryopreservation, sperm or blood, it is almost impossible to accurately cool different cells.

　　Whether you can wake up is the key.

　　However, it is more difficult than accurately cooling different cells to reheat them. If astronauts can’t wake up from hibernation, what’s the point of freezing hibernation? How to rewarming cells safely is the "last mile" and the key point of freezing dormancy technology.

　　As mentioned above, in the process of injecting CPA into cells to cool down, cells are easily damaged. Similarly, in the process of rewarming, CPA must be pulled out of the cell, which is also full of danger. If the CPA is excessively diluted when it is taken out, the cells will absorb too much water and expand beyond the allowable upper limit, which will also cause cell damage.

　　Liqun He said that whether the rewarming process poses a threat to the survival of cells depends first on whether the previous cooling process induces intracellular ice or cell dehydration. If there is intracellular ice, rapid rewarming can prevent ice crystals from growing and destroying cells. However, even if there is no intracellular ice formation during slow cooling, the response of cells to rewarming rate depends on freezing conditions and cell types.

　　Moreover, it is also a big problem whether the body of the astronauts after waking up will be negatively affected. When the human muscles are in a static state for a long time, their functions will inevitably deteriorate to some extent. Although the similar "suspended animation" technology developed by SpaceWorks only allows the astronauts to sleep for 14 days, I believe everyone who has experienced it knows what it feels like to lie in bed for half a month.

　　This edition of pictures: information pictures

Liu Yabin preached in primary school.

CCTV News:Liu Yabin is the squadron leader of the intelligence squadron of the Criminal Police Brigade of Cangzhou Canal Branch, Hebei Province. After graduating from college, he briefly worked as a teacher for three years, but out of love for criminal investigation, in 2005, he gave up his stable job and was admitted to the Canal Branch to become a criminal policeman.

There is a lot of pressure at the grassroots level and little room for promotion, but since the police, Liu Yabin has been working at the grassroots level. He firmly believes in "empty talk about making mistakes in the country and prospering the country by hard work". In the past 14 years, he has started as an ordinary investigator and served as a detective, deputy squadron leader, instructor and squadron leader. From cracking the theft case of several hundred yuan to the biggest fraud case in China, he recovered more than 3 billion yuan for the masses step by step, which was well received by the leaders.

Defend people’s safety regardless of safety

Criminal investigation is a hard and dangerous job, which requires patience, care and extraordinary courage. During his years as a criminal police officer, Liu Yabin has caught pickpockets in the street and desperate drug dealers. When there is a dangerous incident, he always rushes to the front line.

Liu Yabin is a famous anti-pickpocketing expert in the city bureau. He has basically caught the old thieves in Cangzhou, whether they are in the mall or on the bus, playing with blades or carrying bags directly. When asked why he can catch thieves that others can’t catch, he said: "Anti-pickpocketing is hard work, as long as you are not afraid of hard work, there is no thief that can’t be caught. At the peak of work, most people are on their way home. I stand next to the bus stop sign and stare at the thief who follows the car. On Saturday and Sunday, when others are at home with my wife and children, I take a camera near the mall to take photos for evidence. That’s all. "

Relatively speaking, anti-pickpocketing may be the least dangerous in Liu Yabin’s work. Drug control is also one of his daily work, and because transporting and selling one kilogram of ice is enough to sentence the suspect to death, the suspect often struggles desperately. In November 2016, when Liu Yabin led a team to arrest drug trafficking suspects, he was fiercely resisted. The suspects even rushed to try to snatch the guns of the police. The two sides fought until they collapsed, and finally captured them.

There are many similar dangerous cases. For example, on one occasion, a time bomb tied with a petrol tank was found in Bohai Commercial Building. In the face of the bomb that may explode at any time, Liu Yabin did not hesitate, and immediately transferred the bomb to the safety zone of Cangxian County with his colleagues. Just as they had just arrived at their destination, waiting for the arrival of bomb squad, the bomb suddenly exploded and the explosion-proof blankets were blown up. If they had been transported to a slower speed, the consequences would have been unimaginable. Thinking of this, Liu Yabin also felt scared. However, whenever he thinks of the trust and satisfaction of the people behind him when he carries away the bomb, his heart will feel very full.

Innovative thinking to combat new crimes

With the popularization of information technology, all kinds of new crimes emerge in an endless stream, and all kinds of information-based investigation and solving methods have sprung up. Liu Yabin is keenly aware that informatization is the direction of future investigation and solving cases. Since then, he has devoted himself to studying the theory of information-based crime solving, seriously studying the methods of information-based crime solving in advanced provinces and cities, and actively exploring the means of information-based crime solving, and soon became an expert in this field.

As early as 2008, Liu Yabin discovered a loophole in the system through the study of the escape system: many suspects surf the Internet in many places, but the case-handling unit does not necessarily know. Through comparison, he compared more than 3,000 fugitives who were released on bail nationwide at one time, more than a squadron caught in 30 years. Driven by this comparison work, the Hebei Provincial Public Security Department has specially carried out a special action to compare fugitives and normalized this action.

In 2012, the Canal Public Security Bureau found that the number of cases reported by leasing companies accepted by the branch was on the rise, and many vehicles were resold or mortgaged at low prices after being leased by suspects, and almost all the vehicles used by suspects were from leasing companies. In this regard, the Canal Public Security Bureau decided to take the management and service of car rental industry as the starting point and explore a new way in the informationization of criminal investigation basic work. After Liu Yabin was appointed as the person in charge of the project, he first went deep into various car rental companies to understand the vehicles and operating conditions, sorted out and registered the car rental companies and vehicles in the city one by one, and established data files. Subsequently, according to the data and current situation, he independently developed the information management system of car rental industry, and started it in 24 rental companies in the urban area at the same time.

This management system soon came in handy. On September 20, 2012, the Canal Branch received a request from Dacheng County Public Security Bureau for investigation, claiming that a suspected vehicle was heading for Cangzhou, hoping that the Branch would investigate the track of the suspected vehicle in Cangzhou. Upon hearing the case, Liu Yabin immediately inquired about the vehicles during the incident period through the bayonet system of the Municipal Bureau. After the inquiry was fruitless, he immediately inquired about the vehicles of Cangzhou urban leasing company through the car rental industry management system and found that a car had been to the scene at the time of the crime. The lessee of the car is called Yan, and he often rents a car with Yan.

By analyzing the GPS trajectory of the suspect’s rented vehicle, Liu Yabin finally found the location where Yan and others hid the stolen goods. Through the car rental industry management system all the way, Yan, who returned from the crime, was arrested, and four mahogany chairs and two mahogany coffee tables were seized on the spot, with a case value of 200,000 yuan.

Due to his outstanding achievements in information-based crime solving, Liu Yabin was selected into the talent pool of information experts of the Provincial Public Security Department in 2012, the talent pool of anti-fraud experts of the Provincial Public Security Department in 2013, and the first batch of information-based crime solving experts of the Criminal Investigation Bureau of the Ministry of Public Security in 2015.

Be a preacher of safe Cangzhou

It is important to combat crime, but nip in the bud is the foundation of building a peaceful society. Since 2009, Liu Yabin has given full play to the advantages of being a teacher, and has organized primary and secondary school students and community residents to study many times to explain the knowledge of preventing telecom fraud and drug control. He coordinated the city post office to print a letter to all students and parents by greeting card, which included 16 common types of telecom fraud and preventive measures. He also contacted a total of 25,152 students from 26 primary schools in Canal District to carry out the interactive activity of "I study with my parents", and made students become propagandists to prevent telecom fraud crimes by playing promotional videos and conducting micro-classes. This activity was also selected as "the most satisfying thing for the masses".

In addition, Liu Yabin also opened the WeChat official account of Canal Interpol in Cangzhou Bar and Sina Weibo. Practice has proved that the opening of WeChat official account has played a positive role in the control of online public opinion, the early warning of high-incidence cases, the collection of criminal information and many other aspects. Up to now, the police have obtained more than 30 valuable clues through communication with netizens, and have cracked more than 20 cases accordingly.

Due to his outstanding work achievements, Liu Yabin has been awarded the third-class merit three times since 2005, and has been awarded the honorary titles of "Strike Hard Advanced Individual", "Excellent Investigator" and "Informatization Advanced Individual" by Cangzhou Municipal Party Committee, Municipal Government and Municipal Public Security Bureau in successive years. "Public security work is not just a job to make a living, it is also a glorious cause. The crackdown is the main business of public security, and criminal police are the main force of this work, so I will still choose to stick to the front line of criminal investigation. " Liu Yabin said. (Source: Hebei Provincial Federation of Trade Unions)

Original editorial department Xiao Wu Chang Xiao Health included in topic # 27 medical frontiers

With the aging of the population, heart failure has become one of the main causes of death.

According to China Cardiovascular Health and Disease Report 2020, the number of patients with cardiovascular diseases in China is about 330 million, including 8.9 million patients with heart failure.

In addition, patients with heart diseases such as coronary heart disease, hypertension, valvular heart disease and cardiomyopathy are also prone to induce heart failure.

In theory, heart transplantation provides a once-and-for-all solution for these heart patients, but in reality, it is even more difficult to wait for the right donor than winning the lottery.

On March 8, 2022, the first heart patient who transplanted a pig heart also died two months after the transplant operation.

Anyone who has seen the movie "Iron Man" knows that Iron Man has a "mechanical heart" that provides him with energy continuously, which may also be another choice for these heart failure patients.

Since the heart can grow,

It will definitely be built.

This sentence comes from kolff, the father of artificial organs, and the artificial hemodialysis device (that is, "artificial kidney") comes from kolff.

The development of artificial heart has experienced three generations.

The first generation in the 1990s was a large-volume pulsating blood flow device, the second generation in the early 21st century was an axial flow device, and the latest third generation was a magnetic suspension device. At present, the third generation artificial heart has been made in China. The pump body has a diameter of 34 mm, a thickness of 26 mm and a weight of 90 g, which is almost the size of an egg. At present, many clinical operations have been completed in China, and the survival rate of one and a half years is 100%.

The principle of "artificial heart" is actually not complicated.

After being implanted into the human body, the "artificial heart" is connected in parallel with the heart, with one end connected to the left ventricle of the heart and the other end connected to the human aorta. Blood enters the artificial heart from the left ventricle through the inflow tube, and the artificial heart pushes the blood out and delivers it to the aorta through the outflow tube, thus assisting the blood circulation of patients.

Simply put, "artificial heart" is an artificially made blood pump, which can partially or completely replace the heart to do work and help maintain blood circulation throughout the body.

For a normal person, the heart beats more than 60 times per minute and pumps out 5 liters of blood. Converted to 3600 beats per hour and 86400 beats per day, a total of 7200 liters of blood is pumped. The implanted "artificial heart" can pump 1-10 liters of blood per minute, which helps the human heart function to pump blood.

Domestic "subminiature magnetic suspension centrifugal artificial heart" uses magnetic field to suspend the impeller, thus providing good blood flow performance and partially replacing the patient’s heart function. The magnetic levitation system has high efficiency and low power consumption, and can minimize the damage to blood cells, which not only solves the problem of thrombosis, but also is easier to install in the chest cavity, so that other organs are less affected and the patient’s wearing experience is more comfortable.

Of course, having an "artificial heart" has some limitations. The most important thing is to stay away from the magnetic field, and take the high-speed rail and so on.

In June 2017, Fuwai Hospital took the lead in implanting the third-generation domestic magnetic levitation artificial heart into patients and achieved success. From the follow-up results of patients with "China Heart" after operation, the quality of life of patients has been comparable to that of patients receiving heart transplantation.

The future of artificial heart

For every family of patients with heart disease, the cost of surgery is a hurdle.

It is reported that each set of artificial hearts in the United States is about 100,000 US dollars (about 700,000 yuan), and the cost of artificial heart surgery in France in 2013 is 140,000 to 180,000 euros (about 1.1-1.4 million yuan). In 2019, the cost of replacing artificial hearts in Japan will be converted into more than 1.6 million yuan. Generally speaking, the international price of a device for artificial heart is 800,000 yuan to 1 million yuan.

In an interview, Li Xinsheng, a patient who received magnetic levitation artificial heart implantation in China, said that he probably paid more than 1 million yuan for the "artificial heart" after one operation, but the subsequent expenses were very small, and the daily use of anticoagulant drugs was more than 2,000 yuan a year.

Li Xinsheng carries a battery with him.

At present, it is predicted that there are 13 million patients with heart failure in China, and there are 600,000 patients with severe end-stage heart failure who meet the standard of using artificial heart.

Although the heart is one of the most important organs in the human body, if the artificial heart costs 500 thousand yuan, the cost is still relatively high. At present, there are more than 300 thousand brain pacemakers, which are not affordable for ordinary people.

However, the launch of new medical devices is relatively expensive at first, because it has to cover the heavy research and development costs in the early stage. With the gradual increase of product output and doctors who will operate, the consumption of patients will increase, and the price will gradually decrease. This is an inevitable trend and has a natural development process.

In addition to the price, artificial heart implantation has higher requirements for hospitals and medical teams. In addition to the cooperation of doctors in cardiology, anesthesiology and cardiopulmonary bypass, doctors in cardiology and imaging departments are also needed to objectively evaluate patients, and do a good job in postoperative rehabilitation and long-term follow-up management.

The National Health and Wellness Commission issued the Management Standard of Ventricular Assisted Technology (2021 edition), and the new standard also clearly defined the technical threshold for medical institutions to carry out artificial heart implantation:

For example, medical institutions are required to carry out clinical diagnosis and treatment of cardiovascular surgery for more than 10 years, with no less than 50 beds, and no less than 1,000 cases of cardiopulmonary bypass cardiac surgery are completed every year; Doctors should have more than 10 years of experience in clinical diagnosis and treatment in the field of cardiac and great vessels, and have obtained the qualifications for professional and technical positions above the chief physician for more than 3 years.

At present, artificial hearts are mainly used in three aspects:

First, as a transitional treatment, we will strive for more time for patients to wait for a suitable transplant donor;

The second is to provide short-term replacement support for patients with acute heart failure, which will be removed after cardiac function is restored;

The third is to provide long-term replacement for patients with end-stage heart failure and support patients to carry artificial hearts for long-term survival.

Judging from the above-mentioned scenes that it can be used at present, the artificial heart that appears at present is only a transitional product and a temporary replacement, which is still a long way from the completely artificial mechanical and biocompatible permanent artificial heart.

Perhaps one day, scientists can really solve all technical problems, develop a permanent artificial heart without any side effects, and solve the problem of organ shortage. By that time, does it mean that we can achieve immortality or even immortality by relying on the "mechanical heart" of Iron Man?

Original title: "If the heart can be born, it can be rebuilt! Artificial heart saves heart failure and makes the heart beat again.

Read the original text

General Office of the State Council on Printing and Distributing

Notice of National Nutrition Plan (2017-2030)
Guo Ban Fa [2017] No.60

People’s governments of all provinces, autonomous regions and municipalities directly under the Central Government, ministries and commissions and institutions directly under the State Council:

The National Nutrition Plan (2017-2030) has been approved by the State Council and is hereby issued to you, please implement it carefully.

　　　　　　　　　　　　　　　　　　　　　　　　　　the General Office of the State Council

　　　　　　　　　　　　　　　　　　　　　　　　　　June 30, 2017

(This piece is publicly released)

National Nutrition Plan (2017-2030)

Nutrition is an important material basis for human beings to maintain life, growth and health, and national nutrition is related to the improvement of national quality and economic and social development. In recent years, the living standards of Chinese people have been continuously improved, the nutrition supply capacity has been significantly enhanced, and the nutritional health status of the people has been significantly improved. However, it still faces problems such as the coexistence of insufficient nutrition and excessive nutrition, frequent nutrition-related diseases, and the lack of universal nutrition and healthy lifestyle, which has become an important factor affecting national health. This plan is formulated in order to implement the Outline of Healthy China 2030 and improve the national nutrition and health level.

I. General requirements

(1) Guiding ideology.We will fully implement the spirit of the 18th CPC National Congress and the Third, Fourth, Fifth and Sixth Plenary Sessions of the 18th CPC Central Committee, thoroughly implement the spirit of the series of important speeches by the Supreme Leader General Secretary and the new ideas, ideas and strategies for governing the country, closely focus on promoting the overall layout of the "five in one" and coordinating the promotion of the "four comprehensive" strategic layout, conscientiously implement the decision-making arrangements of the CPC Central Committee and the State Council, firmly establish and implement the new development concept, and persist in taking people’s health as the center. Focusing on popularizing nutrition and health knowledge, optimizing nutrition and health services, perfecting nutrition and health system, building a nutrition and health environment and developing nutrition and health industry, based on the present situation and focusing on the long-term, we should pay attention to nutrition and health in the whole life cycle and health process of the people, integrate nutrition into all health policies, continuously meet the nutritional and health needs of the people, improve the health level of the whole people, and lay a solid foundation for building a healthy China.

(2) Basic principles.

Adhere to government guidance. Pay attention to overall planning, integrate resources, improve the system and perfect the system, give full play to the role of the market in allocating nutritional resources and providing services, and create a policy environment for the whole society to participate in the national nutrition and health work.

Adhere to scientific development. Explore and grasp the law of healthy development of nutrition, give full play to the leading role of science and technology, strengthen the research and development and application of appropriate technologies, improve the national nutrition and health literacy, and enhance the scientific level of nutrition work.

Adhere to innovation and integration. Reform and innovation will drive the transformation and upgrading of nutritious agriculture, food processing industry and catering industry, enrich the supply of nutritious and healthy products, and promote the integration of nutrition and health with industrial development.

Adhere to co-construction and sharing. Give full play to the important role of nutrition-related professional academic groups, industry associations and other social organizations, as well as enterprises and individuals in the implementation of the national nutrition plan, and promote the benign interaction, orderly participation and responsibility of all parties in society, so that everyone can enjoy health and well-being.

(3) Main objectives.

By 2020, the standard system of nutrition laws and regulations will be basically perfect; The nutrition work system is basically sound, the nutrition work system of provinces, cities and counties is gradually improved, and the nutrition work at the grassroots level is strengthened; The food nutrition and health industry has developed rapidly, and traditional food and nutrition services have become increasingly rich; The level of nutrition and health informatization has been gradually improved; The malnutrition status of key populations has been significantly improved, the healthy lifestyle of eating balance has been further popularized, and the nutritional and health literacy of residents has been significantly improved. Achieve the following objectives:

-reduce the anemia rate of the population. The anemia rate of children under 5 years old is controlled below 12%; The anemia rate of pregnant women dropped below 15%; The anemia rate of the elderly population dropped below 10%; The anemia rate of people in poor areas should be controlled below 10%.

—— The folic acid deficiency rate of pregnant women should be controlled below 5%; The exclusive breastfeeding rate of infants aged 0-6 months is over 50%; The growth retardation rate of children under 5 years old should be controlled below 7%.

-the growth retardation rate of rural primary and secondary school students should be kept below 5%, so as to narrow the height difference between urban and rural students; The rising trend of students’ obesity rate slowed down.

-improve the nutrition screening rate of inpatients and the proportion of nutritional treatment for malnourished inpatients.

-the awareness rate of residents’ nutrition and health knowledge has increased by 10% on the existing basis.

By 2030, the standard system of nutrition laws and regulations will be more perfect, the nutrition work system will be more perfect, the food nutrition and health industry will continue to develop healthily, the traditional food and nutrition services will be more abundant, the intelligent application of "internet plus Nutrition and Health" will be widely promoted, the nutrition and health literacy of residents will be further improved, and the nutrition and health status will be significantly improved. Achieve the following objectives:

-further reduce the anemia rate of key populations. The anemia rate of children under 5 years old and the anemia rate of pregnant women should be controlled below 10%.

-the growth retardation rate of children under 5 years old has dropped to below 5%; The exclusive breastfeeding rate of infants aged 0-6 months will increase by 10% on the basis of 2020.

-further narrowing the height difference between urban and rural students; The rising trend of students’ obesity rate has been effectively controlled.

-further improve the nutrition screening rate of inpatients and the proportion of malnutrition inpatients.

-The awareness rate of residents’ nutrition and health knowledge will continue to increase by 10% on the basis of 2020.

-The daily salt intake per capita in China has been reduced by 20%, and the growth rate of overweight and obesity among residents has slowed down significantly.

Second, improve the implementation strategy

(1) Improve the standard system of nutrition laws, regulations, policies and standards.

Promote nutrition legislation and policy research. Carry out research work on nutrition-related legislation and further improve the system of nutrition laws and regulations. To study and formulate rules and regulations on clinical nutrition management and nutrition monitoring management. Formulate and improve policies related to nutrition and health. Study and establish nutrition and health steering committees at all levels, and strengthen technical consultation and guidance on nutrition and health regulations, policies and standards.

Improve the standard system. Strengthen the basic research and measures to ensure the formulation of standards, and improve the ability of standard formulation and revision. Scientifically and timely formulate nutrition and health standards based on food safety. To formulate and revise the industry standards of China residents’ dietary nutrient reference intake, dietary survey methods, population malnutrition risk screening, dietary guidance for diabetics, and population nutrition survey. Study and formulate the general rules of nutritious food for the elderly, nutrition labeling of catering food and other standards, and speed up the revision of important national food safety standards such as general rules of nutrition labeling, standards for the use of food nutrition fortifiers and infant formula food in prepackaged foods.

(2) Strengthen the building of nutrition capacity.

Strengthen the capacity building of nutrition scientific research. Accelerate the research and formulation of reference intake of dietary nutrients based on Chinese population data, change the status quo of relying on foreign population research results, and give priority to the study of important nutrient requirements such as iron and iodine. Study and improve the techniques and methods of food and population nutrition monitoring and evaluation. Study and formulate prevention and control technologies and strategies for nutrition-related diseases. Carry out economic research on nutrition and health, nutrition and social development. Strengthen the construction of national nutrition and health research institutions, and establish 3-5 regional nutrition innovation platforms and 20-30 provincial-level nutrition special key laboratories based on national and provincial nutrition professional institutions.

Strengthen the cultivation of nutrition talents. Strengthen professional education and high-level personnel training of nutrition talents, and promote nutrition training for clinicians in hospitals, maternal and child health care institutions, primary health care institutions, and catering personnel in centralized catering units. Carry out the training of nutritionists, nutrition caterers and other talents, and promote qualified schools, kindergartens, pension institutions and other places to equip or hire nutritionists. Make full use of social resources and carry out nutrition education and training.

(3) Strengthen the monitoring and evaluation of nutrition and food safety.

Regularly monitor the nutritional status of the population. Regularly monitor the nutritional health status and food consumption status of the national representative population, and collect information such as food consumption, nutrient intake, physical measurement and laboratory testing. According to the regional characteristics, the monitoring area and the monitoring population will be gradually expanded according to the needs.

Strengthen the monitoring of food ingredients. Expand the monitoring content of food ingredients, carry out regular monitoring, and collect data on nutritional ingredients, functional ingredients, ingredients related to special diseases, and harmful ingredients. Continuously update and improve the national food ingredient database. Establish laboratory reference system and strengthen quality control.

Carry out comprehensive evaluation and evaluation. Rescue historical investigation data, collect and systematically sort out all kinds of monitoring data in time, and establish a database. Carry out the evaluation of the nutritional health status of the population and the nutritional value of food. Risk-benefit assessment of dietary nutrient intake, pollutants and other harmful substances exposure was carried out to provide basis for formulating scientific dietary guidance.

Strengthening iodine nutrition monitoring and prevention and treatment of iodine deficiency disorders. We will continue to monitor the urine iodine, water iodine and salt iodine of people and investigate the iodine in key foods, gradually expand the coverage areas and people, and establish a database of iodine nutrition status of China residents. To study and formulate scientific evaluation techniques and indicators of iodine nutrition status of the population. Formulate differentiated iodine intervention measures and implement accurate iodine supplementation.

(4) Developing food nutrition and health industry.

Intensify efforts to promote the production of nutritious and high-quality edible agricultural products. Prepare guidance on improving the nutritional quality of edible agricultural products, improve the nutritional level of high-quality agricultural products, and increase the overall proportion of "three products and one standard" (pollution-free agricultural products, green food, organic agricultural products and geographical indications of agricultural products) in similar agricultural products to more than 80%. Establish a nutritional agricultural product extension system, promote the nutrition upgrade and expansion of high-quality edible agricultural products, and promote the safe and nutritious agricultural products in poverty-stricken areas to go out. Research and build a continuously rolling national agricultural product nutrition quality database and a food nutrition supply and demand balance decision support system.

Standardize and guide the development of food nutrition and health industry to meet different needs. Develop and utilize China’s rich characteristic agricultural products resources, and focus on developing new nutritious and healthy foods such as health food, nutrition-fortified food and double protein food according to the health needs of different groups of people. Strengthen industrial guidance, standardize market order, scientifically guide consumption, and promote the coordinated development of production, consumption, nutrition and health.

Carry out demonstration and promotion of healthy cooking mode and balanced nutrition catering. Strengthen the nutritional transformation of traditional cooking methods and develop healthy cooking models. Combined with the nutritional needs of the population and the characteristics of regional food resources, a systematic study on balanced nutrition catering was carried out. Establish a national food nutrition education demonstration base, carry out the construction of demonstration healthy canteens and healthy restaurants, and promote healthy cooking mode and balanced nutrition catering.

Strengthen the implementation of major projects such as nutritious staple food and double protein project. Continue to promote the research and development of potato staple food products and consumer guide, focusing on traditional popular, regional characteristic, leisure and functional products, and carry out demonstration and guidance of nutritious staple food. With high-quality animal and plant protein as the main nutritional base, we will intensify our efforts to innovate basic research and processing technology, and carry out the transformation and promotion of key products of double protein engineering.

Accelerate the nutritional transformation of food processing. Priority should be given to the study of the amount of oil, salt and sugar in processed foods and their correlation with health, and timely control measures for oil, salt and sugar in processed foods should be introduced. Put forward the path of nutritional transformation of food processing technology, and integrate the technical system to reduce nutrient loss and avoid the production of toxic and harmful substances. To study the effects of different storage and transportation conditions on food nutrients and control the nutritional loss during food storage and transportation.

(5) Vigorously develop traditional feeding and maintenance services.

Strengthen the guidance of traditional food and nutrition. Give full play to the advantages of traditional Chinese medicine, formulate guidelines for residents’ food and nutrition in line with China’s current situation, and guide the development of food and nutrition habits in line with the dietary characteristics of different regions in China. Promote the spread of traditional food and nutrition knowledge through various forms, and promote the effective integration of traditional food and nutrition with modern nutrition and physical fitness. Carry out food support guidance for the elderly, children, pregnant women and people with chronic diseases, and improve residents’ food support literacy. Implement the health project of preventing diseases with traditional Chinese medicine, and further improve the food and nutrition system suitable for national health needs.

Carry out monitoring and evaluation of traditional health-preserving ingredients. Establish a monitoring and evaluation system of traditional health-preserving ingredients, carry out monitoring and safety evaluation of effective components and pollutants in ingredients, and further improve the list of items that are both food and Chinese herbal medicines in China. In-depth investigation, screening a number of traditional ingredients and compatibility with certain use history and empirical basis, and making an empirical study on their health-preserving effects. Construction of health food database and information sharing platform.

Promote the research and development of traditional food and nutrition products and industrial upgrading. Combine modern food processing industry with traditional food products and formulas, promote the standardization of products and formulas, promote industrial scale, and form a number of food products with great social and economic value. Establish a resource monitoring network covering the main producing areas of health-preserving ingredients in China, grasp the dynamic changes of resources, and provide timely information services for research and development, production and consumption.

(6) Strengthen the sharing and utilization of basic data on nutrition and health.

Vigorously promote the sharing of nutrition and health data. Relying on the existing information platform, strengthen the information construction of nutrition and health, and improve the food composition and population health monitoring information system. Establish information sharing and exchange mechanism to promote interconnection and data sharing. Collaborative sharing of environment, agriculture, food and drug, medical care, education, sports and other information and data resources, the construction of cross-industry integration, cross-regional sharing, cross-business application of the basic data platform. Establish a nutrition and health data standard system and an electronic certification service system to effectively improve information security capabilities. Actively promote the "Nutrition and Health in internet plus" service and promote the pilot demonstration of big data application, so as to drive the development of nutrition and health-oriented information technology industry.

Comprehensively deepen data analysis and intelligent application. Establish a directory system of nutrition and health data resources, formulate management norms for hierarchical authorization, classified application and safety review, promote the open sharing of data resources, and strengthen the innovative application of data resources in various fields. Promote comprehensive analysis and mining of multi-domain data, carry out research on application scenarios of data analysis, build models of correlation analysis, trend prediction, scientific early warning and decision support, promote an integrated big data-driven service system, support business integration, inter-departmental collaboration, social services and scientific decision-making, and realize accurate government management and efficient services.

Vigorously carry out information service for the benefit of the people. Develop wearable devices and mobile terminals (APPs) that gather nutrition, sports and health information, promote the integration of internet plus, big data frontier technology and nutrition and health, develop personalized and differentiated electronic products of nutrition and health, such as nutrition calculator, mobile application of dietary nutrition and sports health guidance, and provide convenient and accessible health information technology products and services.

(7) Popularize nutrition and health knowledge.

Improve the supply and dissemination of nutrition and health science information. Around the needs of national nutrition and food safety science popularization, combined with local food resources and eating habits, combined with the traditional concept of food support, we compiled nutrition and food safety science popularization materials suitable for residents in different regions and different groups, so as to make the science popularization work better. Innovate the expression forms of popular science information, expand communication channels, and establish a national nutrition and food safety popular science platform for free sharing. Adopt a variety of communication methods and channels to spread popular science information to the target population in a targeted and accurate way. Strengthen the construction of popular science teams in nutrition and food safety. Give full play to the positive role of the media, resolutely oppose pseudoscience, crack down on and deal with various forms of rumors according to law, find and correct false nutrition propaganda in time, and avoid misleading nutrition information.

Promote the normalization of nutrition and health science education activities. Take the National Nutrition Week, the National Food Safety Publicity Week, the "May 20" National Student Nutrition Day and the "May 15" National Iodine Deficiency Disorders Prevention Day as opportunities to vigorously carry out popular science education activities and promote the normalization of education activities. Promote the awareness rate of national nutrition and food safety knowledge into the assessment indicators of healthy cities and healthy villages and towns. The establishment of nutrition, food safety science demonstration workplace, such as nutrition, food safety science hut. Regularly evaluate the effect of popular science propaganda, timely guide and adjust the contents and methods of propaganda, and enhance the pertinence and effectiveness of propaganda work. Carry out public opinion monitoring, respond to social concerns, reasonably guide public opinion, and solve doubts and doubts for the public.

Third, carry out major actions

(1) Nutrition and Health Action for 1000 Days in Early Life.

Carry out nutritional evaluation and dietary guidance before and during pregnancy. Promote maternal and child health care institutions at or above the county level to provide nutritional guidance to pregnant women, and incorporate nutritional evaluation and dietary guidance into pre-pregnancy and pregnancy examinations in China. Carry out nutritional screening and intervention for pregnant women to reduce the birth rate of low birth weight infants and macrosomia. Establish a 1000-day nutrition consultation platform for early life.

Implement the nutrition intervention plan for women and children. We will continue to promote the project of folic acid supplementation for rural women to prevent neural tube defects, actively guide pregnant women to strengthen the supplementation of various micronutrients including folic acid and iron, reduce the anemia rate of pregnant women, and prevent nutritional deficiency in children. On the basis of reasonable diet, we will promote the intervention project of pregnant women in nutrition package.

Improve breastfeeding rate and cultivate scientific feeding behavior. Further improve the breastfeeding security system, improve the breastfeeding environment, and establish maternal and child rooms in public places, institutions, enterprises and institutions. Study and formulate scientific feeding strategies for infants and young children, and publicize and guide reasonable complementary feeding. Strengthen the monitoring and early warning of infant diarrhea and malnutrition cases, and study and formulate and implement prevention and control strategies for food-borne diseases (diarrhea, etc.) in infants.

Improve the quality and safety of infant food and promote the healthy development of the industry. Strengthen the monitoring of nutritional components and key pollutants of infant formula and supplementary food, and revise and improve the standards of infant formula and supplementary food in a timely manner. Improve research and development capabilities and continuously improve the quality of infant formula food and supplementary food.

(2) Student nutrition improvement actions.

Instruct students to have a nutritious meal. Encourage local governments to formulate recipe guides to meet the nutritional needs of students of different ages according to local conditions, and guide students to eat scientifically and nutritionally. Formulate and implement the nutrition operation norms of collective feeding units.

Intervention on overweight and obesity of students. Carry out the weight management and intervention strategy of "exercise plus nutrition" for students, carry out balanced diet and nutrition education for students, and enhance students’ physical exercise. Strengthen the management of food sales in and around the campus. Strengthen the monitoring and evaluation of students’ overweight and obesity, analyze the influencing factors such as family, school and society, and put forward targeted comprehensive intervention measures.

Carry out nutrition and health education for students. Promote primary and secondary schools to strengthen nutrition and health education. Combined with the characteristics of students of different ages, various forms of nutrition and health education activities are carried out in and out of class.

(3) Nutrition improvement actions for the elderly.

To monitor and evaluate the nutritional status of the elderly. Relying on the national gerontology research institutions and primary health care institutions, establish and improve the nutrition screening and evaluation system for the elderly in China, compile the nutrition health status evaluation guide, and develop appropriate nutrition screening tools. Pilot the monitoring, screening and evaluation of the nutritional status of the elderly population and form a regional demonstration, gradually covering more than 80% of the elderly population in China, and basically grasping the nutritional health status of the elderly population in China.

Establish nutrition improvement measures to meet the needs of different elderly people and promote "healthy aging". Relying on primary medical and health institutions, provide dietary guidance and consultation for the elderly at home. Introduce the standard of nutritional diet for the elderly, and guide the nutritional catering in hospitals, community canteens, medical and nursing institutions and pension institutions. Develop food products suitable for the nutrition and health needs of the elderly. Special nutrition intervention should be given to the elderly with low weight to gradually improve the overall health level of the elderly population.

Establish a nutrition and health management and care system for the elderly. Gradually incorporate the nutritional health status of the elderly into the residents’ health records to achieve seamless docking and effective management. Relying on the existing work foundation, nutrition work should be included in family health care services. Promote the multi-sectoral cooperation mechanism and realize the effective connection between nutrition work and the service content of medical care.

(4) Clinical nutrition action.

Establish and improve the clinical nutrition work system. Through the pilot demonstration, we will further promote the clinical nutrition work in an all-round way, strengthen the construction of clinical nutrition departments, make the ratio of clinical nutritionists to beds reach 1∶150, increase the multidisciplinary diagnosis and treatment mode, set up a nutrition support team, carry out nutritional treatment, and gradually expand the pilot scope.

Carry out nutritional screening, evaluation, diagnosis and treatment for inpatients. Gradually carry out nutritional screening for inpatients to understand their nutritional status. Establish a standardized clinical nutrition treatment path based on nutrition screening, evaluation, diagnosis and treatment, and provide nutrition treatment for malnourished inpatients according to the principle of nutrition ladder treatment, and regularly evaluate its effect.

Promote nutrition prevention and treatment of nutrition-related chronic diseases. Formulate and improve clinical nutrition intervention guidelines for chronic diseases such as hypertension, diabetes, stroke and cancer. Carry out nutrition evaluation work for inpatients with nutrition-related chronic diseases and implement classified guidance treatment. Establish a long-term nutrition management model for patients with nutrition-related chronic diseases from hospitals, communities to families, and carry out nutrition grading treatment.

Promote the standardized application of formula food and therapeutic diet for special medical purposes. Further study and improve the standard of formula food for special medical use, refine product classification, and promote the research and development and production of formula food for special medical use. Establish a unified nutritional standard for clinical therapeutic diet and gradually improve the formula of therapeutic diet. Strengthen the training of medical staff related knowledge.

(5) Nutrition interventions in poverty-stricken areas.

Incorporate nutrition intervention into health poverty alleviation work, and carry out nutrition and dietary guidance according to local conditions. Piloting the monitoring of nutritional health status, food consumption patterns, main nutritional components and pollutants in food for all kinds of people. Formulate dietary nutrition guidance programs according to local conditions, and carry out regional accurate classification guidance and publicity and education. In order to improve the nutritional status of residents and reduce the risk of specific pollutants intake, the feasibility of agricultural planting and breeding and the adjustment of residents’ dietary structure was studied, and solutions and specific measures were put forward, which were piloted in conditional areas.

Implement nutrition intervention for key populations in poverty-stricken areas. We will continue to promote the implementation of the nutrition improvement plan for rural compulsory education students and the nutrition improvement project for children in poverty-stricken areas, and gradually cover all key counties for poverty alleviation and development and counties in concentrated contiguous poverty-stricken areas. Encourage schools in poverty-stricken areas to combine local resources and carry out reasonable catering according to local conditions, and improve students’ dining conditions at school. Continue to monitor and evaluate the nutritional health status and food safety risks of students in poverty-stricken areas. According to the nutritional needs of people in poor areas, formulate and improve nutrition and health policies and standards. Monitoring nutrition intervention products and regularly evaluating the improvement effect.

Strengthen the monitoring and prevention of food-borne diseases in poverty-stricken areas, and reduce the nutritional deficiency caused by food-borne diseases. Strengthen the construction of food-borne disease monitoring network and reporting system in poverty-stricken areas, understand the main food-borne diseases in poverty-stricken areas, epidemic trends, and their impact on the nutrition and health status of local residents, focus on strengthening diarrhea monitoring and traceability investigation, and master the sources and transmission routes of food pollution. According to the key points of food-borne diseases, the prevention and control strategies are formulated. Carry out publicity and education on the integration of nutrition and health.

(6) eat dynamic balance action.

Promote a healthy lifestyle. Actively promote the healthy lifestyle of the whole people, and extensively carry out special actions focusing on "three reductions and three health" (reducing salt, oil and sugar, healthy mouth, healthy weight and healthy bones). Popularize and apply the Dietary Guidelines for China Residents to guide the daily diet, control the salt intake, gradually quantify the use of salt and oil, and reduce the hidden salt intake. Advocate the basic principle of balanced diet, adhere to the dietary pattern of diverse foods and cereals, and promote the formation and consolidation of healthy eating habits of the people. Propagandize the concept of scientific exercise, cultivate the habit of exercise and fitness, strengthen personal weight management, and intervene in diet and exercise for adults who are overweight and obese. Regularly revise and publish dietary guidelines for residents and physical activity guidelines for adults.

Improve the nutritional support ability and effect of sports people. Establish a nutrition network information service platform for sports people, build a sports nutrition prescription library, promote accurate nutrition guidance for sports people, and reduce the risk of sports injuries. Revise the national standards and industry standards related to sports nutritious food in time, improve the research and development ability of sports nutritious food technology, and promote industrial development.

Promote the integration of sports and medicine. To investigate the nutritional status and exercise behavior of people with nutrition-related chronic diseases such as diabetes, obesity and bone diseases, and to construct a health management model of nutrition exercise with prevention as the main factor and prevention as the combination. To study and establish the path of exercise intervention for nutrition-related chronic diseases. Construct a model of integration of physical education and medicine, and play an active role of exercise intervention in the prevention and rehabilitation of nutrition-related chronic diseases.

Fourth, strengthen organization and implementation

(1) Strengthen organizational leadership.Local governments at all levels should combine local conditions, strengthen organizational guarantee, make overall plans and coordinate, formulate implementation plans, refine work measures, and incorporate the implementation of the national nutrition plan into government performance evaluation to ensure effective results. Health and family planning departments at all levels should work with relevant departments to clarify the division of responsibilities, strengthen supervision and evaluation, and implement all tasks.

(2) Guarantee the investment of funds.It is necessary to increase investment in the national nutrition plan, fully rely on all sources of funds, guide social forces to participate extensively and diversify their investment, and strengthen fund supervision.

(3) Extensive publicity and mobilization.It is necessary to organize professional organizations, trade associations, associations and news media to carry out multi-channel and multi-form thematic publicity activities, enhance the general awareness of the national nutrition plan in the whole society, win the support of all parties, and promote the participation of the whole people.

(4) Strengthening international cooperation.Strengthen exchanges with international organizations and relevant national nutrition professional institutions, and enhance China’s international influence in the field of nutrition and health through project cooperation, education and training, and academic seminars.

recent days

Official website, General Administration of Market Supervision

Issue 4 recall notices

Take a quick look

01

Kawasaki Motorcycle (Shanghai) Co., Ltd. recalled some imported ZR900 motorcycles.

A few days ago, Kawasaki Motorcycle (Shanghai) Co., Ltd. filed a recall plan with the State Administration of Market Supervision according to the requirements of the Regulations on the Management of Defective Automobile Product Recall and the Measures for the Implementation of the Regulations on the Management of Defective Automobile Product Recall. From now on, some imported ZR900 motorcycles produced between September 5, 2023 and September 7, 2023 will be recalled, totaling 10 motorcycles.

For vehicles within the scope of this recall, the inner wall of the tire may bulge due to the delamination of the tire cord, which may not meet the relevant requirements and pose a safety hazard.

Kawasaki Motorcycle (Shanghai) Co., Ltd. will inspect the tire batches for vehicles within the recall range free of charge, and replace the tires if they belong to defective batches to eliminate potential safety hazards.

Kawasaki Motorcycle (Shanghai) Co., Ltd. will entrust an authorized dealer to notify relevant users by registered mail or telephone. Users can call the after-sales service hotline: 400-920-1068 to learn more about this recall.

02

Ford Motor (China) Co., Ltd. recalled some imported sixth-generation Mustang cars.

Recently, Ford Motor (China) Co., Ltd. filed a recall plan with the State Administration of Market Supervision according to the requirements of the Regulations on the Management of Defective Automobile Product Recall, the Implementation Measures for the Regulations on the Management of Defective Automobile Product Recall and the Regulations on the Management of Motor Vehicle Emission Recall. It is decided to recall some imported sixth-generation Mustang cars produced between March 5, 2021 and October 10, 2022, totaling 2,371 vehicles, from May 27, 2024.

For vehicles within the scope of this recall, there may be slight leakage in the low-pressure fuel pipeline that provides fuel for the high-pressure fuel pump, and there is an unreasonable emission risk.

Ford Motor (China) Co., Ltd. will replace the low-pressure fuel pipeline for the vehicles within the recalled scope free of charge by authorizing the dealers of imported cars, so as to eliminate the unreasonable emission risk.

Ford Motor (China) Co., Ltd. will notify relevant users by registered mail, etc., and authorized dealers of Ford imported cars will take the initiative to contact users to arrange free maintenance. Users can call the customer center hotline of Ford Motor (China) Co., Ltd. at 400-690-1886 to get relevant information about this recall.

03

Chongqing Changan Automobile Co., Ltd. recalled some second-generation CS55PLUS cars.

A few days ago, Chongqing Changan Automobile Co., Ltd. filed a recall plan with the State Administration of Market Supervision according to the requirements of the Regulations on the Management of Defective Automobile Product Recall and the Measures for the Implementation of the Regulations on the Management of Defective Automobile Product Recall. It is decided to recall some second-generation CS55PLUS vehicles produced from July 8, 2021 to March 14, 2023, with a total of 203,414 vehicles.

Due to the deviation of the software of the infotainment control unit, the image display of some vehicles within the scope of this recall may be abnormal, which may affect the driver’s vision when reversing, increase the risk of vehicle collision, and have potential safety hazards.

Chongqing Changan Automobile Co., Ltd. will upgrade the software for vehicles within the scope of recall free of charge through OTA technology, so that users can complete the software upgrade without going to the store to eliminate potential safety hazards.

This recall was carried out under the condition that the State Administration of Market Supervision initiated a defect investigation. Affected by the investigation, Chongqing Changan Automobile Co., Ltd. decided to take recall measures to eliminate potential safety hazards.

Chongqing Changan Automobile Co., Ltd. will notify the relevant owners of the recall by registered mail or telephone. Car owners can call Changan Automobile Service Hotline: 951999 (by mobile phone or landline) or visit the official website of Changan Automobile (https://www.changan.com.cn) for relevant information.

04

Anhui JAC Automobile Group Co., Ltd. recalled some JAC iEVA50 pure electric vehicles.

A few days ago, Anhui Jianghuai Automobile Group Co., Ltd. filed a recall plan with the State Administration of Market Supervision according to the requirements of the Regulations on the Management of Defective Automobile Product Recall and the Measures for the Implementation of the Regulations on the Management of Defective Automobile Product Recall. It is decided to recall 1,266 JAC iEVA50 pure electric vehicles produced from February 14, 2019 to June 18, 2019 from now on.

Due to the software strategy problems of battery management system in some vehicles within the scope of this recall, under the condition that the vehicles have not been in the store for a long time, the internal cell pressure difference of some power batteries gradually increases, and the pressure difference exceeds the design value, which may lead to the limited power driving of the vehicles. In extreme cases, high-voltage power failure may occur, and the vehicles lose power, which may pose a safety hazard.

This recall was carried out under the condition that the State Administration of Market Supervision initiated a defect investigation. Affected by the investigation, Anhui Jianghuai Automobile Group Co., Ltd. will upgrade the battery management system software for vehicles within the scope of recall free of charge to eliminate potential safety hazards.

Anhui Jianghuai Automobile Group Co., Ltd. will notify the owners of the recall by registered mail, telephone and SMS. Users can call JAC customer service hotline: 400-888-9933, or consult JAC authorized dealers.

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Xinghua released the video number

Source: Website of State Administration of Market Supervision

Editor: Zhu Nan

Audit: Fan Meng

Issued by Shen Chen

Copyright statement: [The articles, pictures and music used in Xinghua’s release belong to the relevant obligee. For objective reasons, if there is any improper use, please contact us at any time to deal with it in time. 】

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Original title: "Emergency recall! Involving multiple brands "

Read the original text

City Express-Orange Persimmon Interactive News, last night (December 3), a message attracted attention on the Internet-

At noon, in the underground parking lot of a home square in Shangcheng District, Hangzhou, when a new energy taxi was charging, the driver lost consciousness in the car. When he was discovered by his peers, he was suspected to have died suddenly.

Several passing network car drivers took many videos at the scene.

The video shows: a blue new energy taxi, with Zhejiang A license plate hanging, with the door wide open and the green signboard behind the windshield of the cab still on.

There were many people on the scene watching, the police lights flashed and the police and security guards rushed to the scene to maintain order.

A network car driver at the scene revealed that "(he) stayed up late for a long time and died suddenly. There are dozens of missed calls, and there are no people. Many of us are still eating next to him.

I’ve been online for 18 hours a day, which is really expensive. I basically spend 18 hours a day, and I also get a car online. "

The driver of the network car judged, "This should be due to excessive fatigue for a long time and no good rest, resulting in sudden death due to imbalance in heart rate. I used to drive a taxi, and I really took time to exchange money. I didn’t have a good rest, and I owed rent if I didn’t go out. I can’t run."

Orange Persimmon Interactive noticed that there was a landline number on the taxi door of the accident, which was the customer service phone number of Hangzhou Taxi Group.

The reporter contacted the taxi group, and the staff said, "If the family is not authorized, it is not convenient for us to disclose this information at present."

The staff of the home square told Orange Persimmon Interactive, "After the accident, it was the colleague of this taxi driver who first discovered it. At present, the police station in the jurisdiction is investigating. "

This incident has caused many online car or taxi drivers to discuss it on the Internet.

"This kind of thing happens every winter. Drivers and friends who open a car and taxi should not fight so hard, and their health is more important."

"18 hours is not unusual. If you are tired, go to the airport to queue up for a few hours to take a nap, take a shower and go to the public toilet. It is not fatal to ask for money."

"When I am most tired, I can only sleep for 3 to 4 hours a day from purchasing goods, processing and selling. When I drive, I sleep while driving. I almost drove into the ditch and hit the tree pole several times."

"I leave at 6: 30 in the morning and come back at 11: 00. I am really tired and can’t earn a few money. Running the net to get a car is running with your life. It is better than this to go to the factory to screw. "

Some passengers saw this video and commented, "Today, on Zhijiang Road, I saw a network car master fall asleep, and when I was waiting for the traffic lights, I cried at that moment …"

Orange persimmon interactive learned that at present, the police have ruled out criminal cases after investigation, and the incident is being further processed.

Original title: Yesterday, in an underground parking lot in Hangzhou, a taxi driver was found dead in the car by his peers …

Editor: Yang Yanlin

Editor: Wu Zhonglan

Audit: Feng Fei

() The business review of the Board of Directors in 2021 is as follows:

　　I. Industry situation of the company during the reporting period

　　(A) the macro environment facing the industry

　　2021 is the first year of the 14th Five-Year Plan, and the macro environment continues to change. China’s economy continues to repair in the context of the epidemic, GDP is growing steadily, and the economy is developing to high quality; Medical reform policies are frequent, and the state has implemented the healthy China strategy in depth to promote the balanced distribution of high-quality medical resources; The process of population aging has gradually accelerated, and the "three-child" policy has been fully liberalized, which has increased the market demand for health industry and the old-age service industry that combines medical care and health care, and the demand for children’s medication. With the release of the Outline of Guangdong-Hong Kong-Macao Greater Bay Area’s Development Plan, a number of policies have provided new dividends for Greater Bay Area’s medical and health construction.

　　(two) the basic situation, development stage and cyclical characteristics of the industry.

　　In 2021, the scale of the pharmaceutical market continued to grow, the linkage reform of "three medicines" continued to deepen, and the policies of the pharmaceutical industry were intensively introduced, which ushered in greater challenges and opportunities for the pharmaceutical industry.

　　1. Development of medical terminal market

　　In 2021, the growth of the medical terminal market picked up, but the development of the medical terminal market continued to be under pressure due to factors such as the multi-point spread of the epidemic and the accelerated promotion of centralized procurement.

　　PDB (data released by China Pharmaceutical Industry Information Center) Statistics of domestic sample hospital market show that the market size of sample hospitals rose by 10.24% in the first three quarters of 2021 compared with the same period in 2020. However, due to the low base in 2020, the growth rate of hospital market continued to slow down due to factors such as epidemic situation and centralized procurement, and only increased by 1.86% in the third quarter of 2021 compared with the second quarter. The annual hospital market sales in 2021 remained the same as that in 2011.

　　Zhongkang CMH retail data shows that in the first three quarters of 2021, the sales scale of retail pharmacies nationwide increased by 3.0%. In the second half of 2021, due to the repeated epidemic situation in some parts of China, the prevention and control measures of epidemic situation in retail pharmacies in some areas became stricter, the drugs related to the epidemic situation were banned, and some patients returned to hospitals and primary medical institutions under the influence of centralized procurement by medical institutions, and the passenger flow in retail pharmacies was challenged, with an increase of only 0.3% in the third quarter.

　　2, the pharmaceutical industry policy and influence

　　In 2021, the pharmaceutical industry policies were introduced intensively, and the linkage reform of "three doctors" continued to deepen. In medicine, it mainly involves many policies such as drug registration and approval, raw materials, drug patents, drug vigilance, development of traditional Chinese medicine and formula granules; In terms of medical insurance, there are mainly policies such as purchasing with quantity, adjusting and negotiating medical insurance catalogue, dual-channel medical insurance, DRG/DIP payment method, and medical insurance for urban and rural residents. Medical treatment mainly includes long-term prescription, public hospital reform, graded diagnosis and treatment, medical and health service reform and popularization of Sanming medical reform experience.

　　(1) The normalization and institutionalization of quantity procurement and the gradual expansion of its coverage have a great impact on the pharmaceutical industry.

　　The centralized drug collection organized by the state has been carried out in 6 batches, and a total of 234 kinds of drugs have been purchased. The market amount involved accounts for about 30% of the purchase amount of chemical drugs and biological drugs in public medical institutions. In 2021, the special procurement of insulin was carried out, and the centralized collection was expanded from chemical drugs to biological drugs for the first time. The collection of high-value medical consumables focuses on cardiology and orthopedics, two areas that the masses are most concerned about. The centralized procurement of cardiac stents has been running smoothly for one year, and the total number of selected stents is 1.69 million, which is nearly 1.6 times of the annual agreed procurement. In 2021, the state organized the collection of artificial joints for more complex orthopedic consumables, which further expanded the coverage of the reform.

　　The influence of quantity procurement on pharmaceutical business: the decline of sales revenue and gross profit margin has a great impact on the income growth and profit space of commercial companies; With the increase of distribution cost, the distribution frequency of centralized procurement products is often higher, especially in the newly opened primary medical institutions, which presents the phenomenon of small single purchase volume and high distribution frequency, which obviously increases the distribution cost; The gap between pharmaceutical commercial enterprises is widening, and the variety of centralized procurement is increasing, which also brings challenges and opportunities to commercial enterprises: due to factors such as scale, collectivization, informationization and capital chain, weak commercial enterprises can no longer support and bear the burden of purchasing with quantity. Large pharmaceutical commercial enterprises have a large variety of reserves, strong financial strength, fast delivery capacity, and a wide range of hospital customers, which provide convenient conditions for enterprises. Although the gross profit of overall distribution has declined, the industry position has been further consolidated due to the scale effect of purchasing with quantity, which can digest some costs.

　　The influence of quantity procurement on pharmaceutical retail: the winning varieties were shortlisted for price reduction, and the prices of pharmacy operating varieties were upside down, facing the pressure of price reduction. Even if you participate in centralized purchasing and solve channel problems, you still face price pressure; Monomer pharmacies lose their competitive advantage under the trend of centralized purchasing, accelerate the merger and acquisition of pharmacies, and further improve the chain rate of pharmacies; Accelerate the online layout, reduce the price of drugs, increase the operating cost of pharmacies, and gradually develop online business in pharmacies.

　　(2) Promote graded diagnosis and treatment and the construction of medical associations, and gradually open the grassroots market.

　　On November 4, 2021, the National Health and Wellness Commission issued the Work Plan for Improving the Comprehensive Capacity of County Hospitals under the "Thousand Counties Project" (2021-2025), aiming at meeting the medical service needs of the people in the county, consolidating and expanding the achievements of poverty alleviation and effectively connecting with rural revitalization, accelerating the improvement of the graded diagnosis and treatment system, and pushing county hospitals into a new stage of high-quality development. Through five years’ efforts, at least 1000 county hospitals in China will reach the level of medical service capacity of tertiary hospitals, laying a solid foundation for solving common diseases in cities and counties.

　　On November 22, 2021, the General Office of the National Health and Wellness Commission issued the Notice on Promoting the Experience of Classified Diagnosis and Treatment and the Construction of Medical Consortium in Sanming City, and put forward eight key tasks to promote the graded diagnosis and treatment and the construction of medical consortia with the goal of building a pattern of primary diagnosis, two-way referral, rapid and slow division and treatment, and linkage up and down, with the focus on promoting the high-quality development of public hospitals.

　　Graded diagnosis and treatment and the construction of medical associations have pushed the joint procurement of hospitals and the control of medical insurance fees to the ground. First of all, unify the catalogue, and the general minimum threshold for drugs to enter the catalogue will be price; Expanding the promotion coverage and entering the medical association procurement catalogue means that the products have entered many hospitals within the medical association, and the crowd tactics that every hospital used to run in the past are expected to reduce costs. Secondly, unified distribution, the initiative of medical institutions to upstream distribution businesses and pharmaceutical companies has been greatly improved. Whether it is secondary bargaining, distribution or payment, the trend of medical institutions suppressing upstream and downstream industries and businesses is even more difficult to reverse. Finally, on the basis of purchasing with quantity, linking quantity with price, reducing price with quantity and centralized purchasing, all medical associations further bargain with quantity to form a second bargaining.

　　(3) "dual channels" help negotiate the landing of drugs, which is beneficial to the development of retail business.

　　The dual-channel policy accelerates the circulation of prescriptions and the separation of medicines, and transfers part of the functions of the original in-hospital management of medicines to the outside of the hospital, so as to ensure that the compliance institutions in and outside the hospital enjoy equal medical insurance payment rules; Relevant national conferences also show that the supervision of medical insurance funds will be strengthened with the prescription circulation center as the core. In the future, under the background of higher and higher requirements for policy guidance, compliance and professionalism, the competitiveness of leading pharmaceutical enterprises will be strengthened and the industry concentration will be further enhanced.

　　

　　II. Main businesses of the Company during the reporting period

　　(1) The company’s main business includes pharmaceutical distribution and retail, as follows:

　　1. In the field of pharmaceutical distribution, it is mainly based on Guangdong and Guangxi, and the scale of pharmaceutical distribution business in Guangdong and Guangxi is leading.

　　As of December 31, 2021, there were 1092 secondary and tertiary medical institutions; 7870 primary medical clients; There are 6,414 retail terminal customers (chain pharmacies, single stores and self-funded pharmacies in hospitals). Sinopharm consistently distributes Guangdong and Guangxi regional market segments, including drug distribution and equipment consumables, retail direct sales and retail diagnosis and treatment, drug and machinery linkage, retail development, and the whole business keeps a relatively leading position in the industry; Innovate business, constantly explore new customer cooperation modes, and become a medical supply chain management solution and service provider; Improve domestic logistics planning and construction, provide third-party logistics professional services, and build leading logistics and supply chain service capabilities. By continuously integrating the distribution and logistics business, deeply penetrating the terminal market, perfecting the ladder distribution network, and building an intelligent supply chain, we are committed to becoming the provider of medical and health products and services with the strongest influence, the highest share, the most complete variety, the best service and the fastest delivery in China Southern District.

　　2. In the field of pharmaceutical retail, Guoda Pharmacy under the company is a leading pharmaceutical retail enterprise in China.

　　By the end of 2021, Guoda Pharmacy had 8,798 stores in 20 provinces, autonomous regions and municipalities directly under the Central Government, forming a pharmacy network covering coastal urban agglomerations in East China, North China and South China, and gradually spreading into the northwest, Central Plains and inland urban agglomerations, with a sales scale of over 22 billion, keeping the sales scale ahead of the industry; Guoda’s pharmacy business mainly relies on social retail pharmacies, and pays attention to developing a professional service system with medical resources as its core competitiveness, and creates a number of retail clinics and hospitals that integrate medical services and health product sales. At the same time, Guoda Pharmacy actively expands innovative business, actively explores and enriches new business channels, enhances professional service capabilities, and is committed to the transformation from traditional pharmaceutical retail enterprises to innovative service-oriented enterprises. Guoda Pharmacy promotes the cooperation between key brands and suppliers to tap the potential, speeds up the establishment and improvement of DTP business and continues the health service system, and builds the industry-leading professional service capability through regular retail management.

　　(2) Business model

　　1. Distribution business

　　(1) Procurement mode

　　The company has established a "foreground-background" division of labor and cooperation procurement mechanism, which effectively reduces the procurement cost. The "front desk" is the purchasing department, which, according to business requirements, looks for the source of goods, establishes the first variety, and conducts price comparison and business negotiations on product quality requirements, supply cycle, supply price and payment cycle. Effectively manage suppliers, including supplier qualification, service quality, integrity, etc., establish supplier files and organize supplier evaluation. The "background" is the supply chain department, which is responsible for integrating the resources of supply chain links, grasping the supply chain information as a whole, realizing professional division of labor, promoting integrated management, creating an integrated service background, assisting the "front desk" business front line and making daily purchase contract orders.

　　(2) Sales model

　　In terms of sales model, the company carried out transformation and innovation according to the strategy of "one body and two wings" in the distribution sector.

　　For the traditional business, the distribution implements the business model of "network sinking" in the southern district of China, which is the main channel supplier of drugs in Guangdong and Guangxi, and realizes the full coverage of the national drug market. At the same time, we will create special businesses such as equipment, medical beauty, medical care, Chinese herbal pieces, and import, and vigorously expand the terminal markets such as primary medical institutions and private hospitals to improve product supply guarantee and grassroots network coverage.

　　The retail direct selling business undertakes the company’s strategy of "integration of wholesale and retail", promotes the layout of retail terminals nationwide, and is based on the distribution network of top 100+professional DTP pharmacies, project centralized procurement and third terminal agents in China, deeply cultivating South China and radiating the whole country;

　　At the same time, the company provides customers with one-stop overall solutions and diversified value-added services and innovative services; 1) Through hospital supply chain projects, equipment SPD, regional distribution, regional medical services (inspection and disinfection), prescription dispensing and undertaking, etc., the innovative mode of medical services will be promoted. Its subsidiaries, Sinopharm Guangzhou Medical Technology Co., Ltd., Sinopharm Guangzhou Medical Management Co., Ltd. and Sinopharm Guangzhou Medical Supply Chain Service Co., Ltd., have carried out effective business development and practice on professional service products such as medical equipment life cycle management, reagent consumables and disinfection business. 2) In terms of third-party logistics business, it undertakes warehousing, distribution and other value-added services of third-party customers such as medical equipment manufacturers, medical equipment businesses, disease control centers and vaccine manufacturers, and provides professional third-party logistics solutions for integrated services such as third-party bonded logistics and national warehousing and distribution logistics services.

　　(3) Logistics distribution mode

　　After long-term development and accumulation, the logistics center has established a perfect modern medical logistics service system, integrated warehousing and distribution and intelligent supply chain service capabilities. The logistics center has a storage area of more than 180,000 square meters and more than 260 self-operated transport vehicles in Guangdong and Guangxi. Customer types of services include upstream and downstream customers of distribution and operation headquarters, and third-party logistics customers include innovative pharmaceutical companies, disease control customers, pharmaceutical machinery manufacturers and commercial companies, vaccine manufacturers, etc. The distribution scope is the whole country. Distribution terminals include hospital direct sales customers, primary medical customers, small social medical customers, commercial customers, retail direct sales customers, CDC and individuals. The logistics center relies on the national logistics resources of Sinopharm Holdings and combines the carrier resources to achieve full coverage of medical logistics in urban and rural areas across the country. The company’s logistics products mainly include: warehousing inspection service, storage service, delivery service, insurance and supply chain optimization and other value-added services; Value-added services such as transportation medicine city distribution service, medicine special car service, medicine express service and supply chain optimization.

　　2. Retail business

　　(1) Procurement mode

　　The procurement mode of Guoda pharmacy is divided into centralized procurement and local procurement; The purchasing methods of centralized purchasing are divided into unified signing and separate purchasing and unified signing and unified purchasing; Three-party contracts (headquarters, regional companies and suppliers) are signed by the headquarters, and regional companies directly purchase goods from suppliers. Unified signing and unified procurement is signed by the headquarters and suppliers, and the headquarters will concentrate on purchasing goods, and then the headquarters will distribute them to regional companies for sales. The procurement method of local procurement is that the regional company directly signs a contract with the supplier, and the region purchases and sells itself. In 2021, the sales of centralized mining accounted for 44%, and the local mining accounted for 56%.

　　(2) Sales model

　　The retail business of Guoda Pharmacy is mainly carried out in the form of chain operation, covering two parts: direct operation and joining. By December 2021, there were 8,798 total stores, 7,257 direct stores and 1,541 franchise stores, with 20 provincial markets. Mainly engaged in Chinese and western medicines, Chinese herbal pieces, medical equipment, health food, health food and supplies; Actively promote the () intercommunication of medicines in internet plus in business mode, and open up "5+X" retail diagnosis and treatment innovative stores in combination with Chinese medicine, western medicine, rehabilitation physiotherapy and other services. At the same time, we continue to optimize the new mode of chronic disease diagnosis and treatment and member management. At present, we have nearly 24 million effective members, establish health records for chronic patients, follow up for a long time, and cooperate with domestic and foreign head suppliers to continuously improve the professional pharmacy service ability, provide quality health products and services for the broad masses of the people, and practice the social responsibility of state-owned enterprises.

　　(3) Logistics distribution mode

　　There are two main types of logistics warehouse management modes for the headquarters and subsidiaries of Guoda Pharmacy. One is the self-management logistics mode, that is, the subsidiaries rent warehouses for the warehouse operation and distribution services of stores and external customers, and the other is the logistics distribution mode of entrusting the state-controlled system, that is, the subsidiaries entrust local state-controlled companies for storage and transportation based on factors such as cost or resource sharing. At present, the proportion of entrusted distribution is 27%. There are three modes of transportation, self-operated distribution, the second is entrusted to the third party, and the third is mixed transportation management, self-operated+entrusted mode.

　　(III) The Company’s annual performance and main work in 2021

　　The year 2021 is a significant moment for the Communist Party of China (CPC)’s centenary birthday and a key node for the historical intersection of "two centennials". Domestic epidemic prevention and control and economic and social development are under pressure. Sinopharm consistently adheres to the guidance of Socialism with Chinese characteristics Thought, the supreme leader in the new era, thoroughly implements the spirit of the 19th National Congress of the Communist Party of China and the previous plenary sessions of the 19th National Congress, fully implements the general requirements for party building and the party’s organizational line in the new era, and conscientiously implements the deployment requirements of Sinopharm Group and Sinopharm Holdings. Focusing on the strategic policy of "technology empowerment, service upgrade, integration of wholesale and retail, and dual drive of industry and finance", Sinopharm continued to push forward the "14 th Five-Year Plan" of "1-2-6" with one core, two networks and six platforms. Under the annual work idea of "building a new development pattern and sustained high-quality development", Sinopharm has made concerted efforts with 40,000 employees to achieve a new start in the first year of the "14 th Five-Year Plan"

　　Operation in 2021

　　In 2021, under the influence of the epidemic situation in COVID-19, centralized drug collection and other policies, Sinopharm faced the pressure unanimously, took various measures simultaneously and made great efforts to start. In the whole year, the accumulated operating income was 68.358 billion yuan, a year-on-year increase of 14.60%; Operating profit was 1.952 billion yuan, down 9.77% year-on-year; The net profit attributable to shareholders of listed companies was 1.336 billion yuan, a year-on-year decrease of 4.67%. The decline in profit was mainly due to the results of the company’s impairment test of goodwill and intangible assets this year.

　　Following the principle of prudence, provision for impairment of goodwill and intangible assets (brand use right and sales network) is made for Shanghai Dingqun Enterprise Management Consulting Co., Ltd. (and Sinopharm Holdings Tianhe Jilin Pharmaceutical Co., Ltd.). At the same time, the retail sector opened 1155 new direct-operated stores in 2021. The initial investment in new stores was large, and the benefits have not yet appeared. Due to the multiple influences of industry policies and epidemics, the profit space has narrowed.

　　In 2021, Sinopharm’s consistent distribution business completed a total operating income of 46.833 billion yuan, up 14.03% year-on-year, and realized a net profit of 947 million yuan, up 10.74% year-on-year. Among them: the income from traditional medical direct selling business was 31.9 billion yuan, up 15% year-on-year; Retail direct sales revenue was 6.2 billion, a year-on-year increase of 1%; Retail medical income was 2 billion, a year-on-year increase of 19%; The income from commercial distribution business was 5.2 billion yuan, a year-on-year increase of 19%.

　　In 2021, Guoda Pharmacy completed a total operating income of 22.478 billion yuan, up 15.64% year-on-year, and realized a net profit of 184 million yuan, down 61.38% year-on-year. The net profit of returning to the mother was 65 million yuan, a year-on-year decrease of 80.88%. Among them: the revenue of retail formats (including direct stores and franchise stores) was 17.99 billion, up 16.3% year-on-year; Distribution revenue was 4.1 billion, up 15% year-on-year.

　　In 2021, the company’s accumulated investment income in joint ventures was 333 million yuan, down 5.91% year-on-year.

　　1. gather strength to fight the epidemic and show the responsibility of central enterprises.

　　By December 2021, Sinopharm’s subsidiaries at all levels had obtained 67 qualifications such as medicine and epidemic materials reserve (including 2 qualifications for central medicine reserve; 12 provincial and municipal qualifications; The number of central direct fund reserves is 25; The government has 28 qualifications for epidemic prevention and control and special procurement), and has successively completed the emergency distribution of materials in several epidemic areas in Guangdong and Guangxi.

　　Undertaking the storage and distribution of disease control vaccines in Guangdong and Guangxi, setting up a special vaccine command team/operation team, responding quickly on duty 24 hours a day, investing nearly 2,000 square meters in cold storage and 120 refrigerated trucks, undertaking 60% of COVID-19 vaccine storage and distribution services in Guangdong Province, and signing 40 disease control contracts, covering about 1,700 inoculation sites; More than 3.4 million COVID-19 vaccines were distributed in Guangxi, covering more than 130 inoculation sites.

　　In response to the local government’s requirements for epidemic prevention and control, the emergency mode of "Enterprise WeChat customer service guidance+store order taking+logistics car delivery" was launched in the closed environment of the epidemic outbreak isolation area, and it was open all day, providing professional consultation and medicine delivery services for chronic patients in the epidemic isolation area; Assist the hospital to open an Internet prescription circulation channel to meet the online follow-up and medication needs of patients in epidemic isolation areas. Many subsidiaries of the company won the anti-epidemic awards issued by the government and industry associations, and the advanced deeds of fighting the COVID-19 epidemic were included in the briefing on the study and education of party history carried out by the state-owned assets system of Guangdong Province and the Guangdong Provincial Committee of the Communist Youth League.

　　2. Consistent distribution business of Sinopharm: Consolidate traditional business, develop innovative business, and continuously improve market competitiveness.

　　(1) Traditional business:

　　Traditional business further stimulates vitality, becomes stronger and bigger, and leads the industry. Consistent distribution of Sinopharm actively grasps the opportunity of centralized procurement policy and fully obtains the distribution right of centralized varieties. In the year, the distribution rate of all countries and provinces in Guangdong and Guangxi exceeded 95%, ranking first in the distribution rate; At the same time, we actively seize the opportunity of dual-channel market and strive for the distribution right of dual-channel products. The entrusted distribution rate of products exceeds 80%. Purchase and sales linkage, accelerate the upstream and downstream icebreaking, and continuously improve the market share; Promote marketing transformation, build a professional marketing team in the field of cancer and chronic diseases, and carry out CSO cooperation mode in depth; Strengthen the development and introduction of new potential suppliers, continuously optimize the hierarchical management of suppliers, institutionalize the development of supplier cooperation projects, and introduce 700 new products through multiple channels.

　　The winning rate of Chinese herbal pieces in hospitals has increased, and the market expansion of refined herbal pieces has achieved initial results, with the overall business increasing by 45% year-on-year; Medical beauty opens the C-end marketing model.

　　(2) Retail direct selling:

　　Promote the national top 100 chain projects, deepen cooperation and enhance product introduction. To speed up the network layout of member stores, the total number of member stores has reached 1313, with sales increasing by 66% year-on-year. Continue to give full play to the advantages of e-commerce B2B, optimize online platform services, increase online saleable product specifications, promote targeted product specifications, and increase the frequency of customers’ online orders.

　　(3) Retail diagnosis and treatment:

　　Continue to speed up the layout of retail clinics in Guangdong and Guangxi. There are 120 large pharmacies controlled by Sinopharm in Guangdong and Guangxi (with a net increase of 20 stores in the whole year), including 91 in Guangdong and 29 in Guangxi; 35 stores with "dual-channel" qualification have been obtained, and the brand advantages of "medical insurance+commercial insurance" have been continuously exerted, and the sales have shown a steady growth trend. There were 31 prescription circulation projects, and the total circulation increased by 124%.

　　(4) Equipment consumables business:

　　Actively expand to build a commercial platform with upstream manufacturers, open a device experience center, explore the marketing model of household devices, set up a clinical service team, realize the extension of the service function of the commercial platform, explore the cooperation model of medical devices with large access, and develop the integration of medical devices in the whole province.

　　(5) Innovative business:

　　Actively promote the service transformation, and develop to C logistics/services in the hospital, home and community medical care and health care, medical association/medical community primary medical services, retail diagnosis and treatment/retail direct sales and other directions. Integrate resources, promote the specialization and platform construction of innovative business, and set industry benchmarks. Many projects have won the top ten demonstration cases and excellent cases of service innovation in pharmaceutical supply chain.

　　(6) the third party logistics:

　　Vigorously develop third-party logistics services, and add state-controlled Guangzhou and Shanghai equipment warehouses and Sinopharm Holdings Guangzhou public bonded warehouses. The disease control business increased by 197% year-on-year, the innovative pharmaceutical business increased by 201% year-on-year, and the pharmaceutical machinery business increased by 15% year-on-year. The vaccine business maintains a leading position in the regional market.

　　3. Guoda pharmacy business: focus on strategy, improve quality and efficiency, consolidate the scale of existing business and explore innovative business development.

　　(1) Accelerate the network layout of the whole network and promote the expansion and sinking of stores.

　　By the end of 2021, the total number of pharmacy stores in Guoda was 8,798, an increase of 1,138 compared with the beginning of the year, including 1,155 newly opened direct-operated stores, 244 newly added through mergers and acquisitions, and 93 newly joined stores, with a total increase of 1,138 after deducting the impact of store closure and store transfer.

　　(2) Focus on building a self-operated e-commerce platform and continue to promote online and offline integration.

　　Focus on the development and construction of self-operated platforms, which have been launched in 26 regional companies and over 6,000 stores. To build a self-media platform for Guoda Pharmacy, 14 regional subsidiaries have opened 28 video numbers. Improve the quality of third-party O2O operations, increase the number of online stores to 7,000, increase the number of operating products to 2,000 SKU//store, and continuously improve the gross profit margin of O2O. The O2O business introduces traffic platforms such as Ping An Good Doctor to sell drugs at night. The annual sales of e-commerce business (including B2C) reached 2.23 billion, a year-on-year increase of 99.6%.

　　(3) Continue to innovate business models and create new retail of medicine.

　　1) Actively carry out the prescription outflow project and build an Internet hospital: in response to the "dual-channel" policy of medical insurance, 13 new medical insurance stores were added throughout the year; In cooperation with 16 Internet hospital platforms, prescription outflow projects have been carried out in Shenzhen, Inner Mongolia, Xinjiang, Jilin and Shenyang, creating a one-stop service of "Internet diagnosis and treatment+prescription online circulation+drug delivery to home"; Jiaren Medical Health (Hainan) Co., Ltd., a newly established joint venture, has obtained the license of Internet Hospital and completed the system docking.

　　2) Create a new retail model and promote service upgrade: create the first new concept store with SPS+ great health integration, and the store design won the "Top Ten Pharmacy Retail Model Innovation Award"; 340 stores are open 24 hours a day to provide night medicine purchase service; Set up 217 panda self-service medicine vending machines to provide intelligent service of self-service medicine purchase.

　　3) Explore the construction of digital intelligent unattended pharmacy: actively explore various digital application scenarios such as digital shelf+machine vision+multi-sensor fusion technology to realize non-inductive payment, artificial intelligence to assist in-store customers and drug purchase tracking, and pilot "non-inductive payment" in Shenzhen Guoda Pharmacy and "code scanning payment" in Shanghai Longhua East Road Store.

　　(4) Continue to pay attention to the improvement of gross profit, and set up a gross profit improvement project team (procurement, commodities, private brands, marketing and operation), focusing on the adjustment of sales structure and the control of gross profit margin of commodities themselves; The main index of gross profit margin basically achieved the annual task.

　　(5) Vigorously promote the systematic development of private brands.

　　We promoted the systematic construction of our own brand business, and protected our own brand and "China-made" products at home. The OEM business increased by 115% year-on-year. Create a new model, create new growth points, create a sales model of drainage products "Jiebaonuo" cotton tablets, and an innovative development model of industrial and commercial cooperation in the Chinese medicine system.

　　(6) Continue to build a professional pharmacy service system.

　　Carry out training on drug information platform, covering 31,863 shop assistants and managers nationwide, and carry out training around five modules: professional foundation, patient education, practical application, chronic disease goods and related goods; Organized the training of licensed pharmacists, and 476 employees obtained the qualification of licensed pharmacists; Provide health management services, and provide professional services for over 7 million chronically ill members by means of health testing, member filing, health education and medication guidance; To improve the viscosity of members, Guoda Pharmacy cooperated with the third party Yiyouhui to build a member platform, and has launched several cooperation projects with a number of foreign-funded manufacturers.

　　4. Improve quality, increase efficiency and seek benefits

　　Normalization promotes the special work of improving quality and increasing efficiency. Improve the concentration of funds, enjoy tax incentives, revitalize resources and save costs. Human resources investment and business have maintained a benign synergy, and the scale of personnel has been continuously and dynamically optimized. The growth rate of team size is much lower than that of revenue. Accelerate the continuous optimization of the company’s business structure and continue to carry out the "two gold" pressure control. Take one enterprise and one policy for subordinate loss-making enterprises, refine the measures to turn losses into losses, and increase the intensity of special assessment.

　　5. Continue to promote comprehensive digital transformation.

　　Promote integrated information management, and continuously optimize management processes and business links with digital projects. Strengthen basic information management, establish a stable and efficient basic equipment support system, carry out database inspection and optimization, and complete the construction of Guangzhou-Shenzhen disaster recovery platform. Promote the digital project of management platform and business system, improve the financial sharing platform, switch the NC unified financial platform to the national pharmacy, and pilot the online financial robot. Distribution revolves around the strategic deployment of "one body and two wings", and carries out the docking of supply chain automation, micro-shopping malls, dual channels and prescription circulation; Guoda Pharmacy promotes the establishment of several digital transformation projects, such as unmanned intelligent pharmacy, business system optimization, unified DTP system online use, online mall system and OMS system optimization and construction, etc.

　　6. Empowering science and technology to optimize supply chain efficiency

　　Continue to promote logistics network planning. At present, the company has 61 self-operated+entrusted logistics centers, with a total area of 370,000 square meters. It has established an index system to carry out national supply chain logistics monitoring, and carried out national logistics planning and B2B2C planning integrating wholesale and retail, breaking the decentralized layout of "one place and one warehouse" and improving the efficiency of warehouse network; Layout logistics wholesale and retail integration, joint supply, joint inventory, joint network.

　　Promote the intelligent transformation of the number of logistics warehouses, and create the 3A intelligent logistics solution (AS/RS+AMR+AI). By using OCR+AI visual identification system, the state-controlled Guangdong Logistics introduced intelligent equipment such as robotic arms and AGV smart cars to get through the logistics management system, which increased the warehouse storage density by 10% and the overall efficiency by 25%. AGV unmanned warehouse realizes its own FYWMS system docking AGV scheduling, realizes multi-floor intelligent equipment scheduling, and effectively improves the efficiency of supply chain.

　　7. Continue to promote the core strategy of wholesale and retail integration.

　　Dig deep into the connotation and value of "wholesale and retail integration" and promote the extension of resources to the upstream and downstream of the industrial chain. Start the expansion of the pilot area of wholesale and retail integration, and select 10 regions including Shanxi and Inner Mongolia for promotion, totaling 15 regions. On the basis of "one place, one policy", we will continue to promote it dynamically and rely on the operational characteristics of various places to export effective business models and profit models. Guangdong province’s wholesale and retail collaborative sales reached 1.03 billion.

　　During the reporting period, the operation of retail stores:

　　1. By the end of 2021, Guoda Pharmacy had 7,257 directly operated stores, with a sales income of 16.64 billion yuan; There are 1541 franchise stores, with a distribution income of 1.34 billion yuan.

　　Remarks: North: Liaoning, Shanxi, Inner Mongolia, Beijing, Tianjin, Hebei, Jilin;

　　East China: Shanghai, Jiangsu, Anhui, Shandong, Fujian, Zhejiang;

　　South China: Guangdong and Guangxi;

　　Central China: Henan and Hunan;

　　Northwest: Ningxia and Xinjiang;

　　Southwest: Yunnan.

　　(1) In 2021, 1,155 directly operated stores were opened and 347 stores were closed, with a net increase of 808 stores.

　　(2) The store’s medical insurance qualification.

　　By December 31st, 2021, the company had 7,257 direct chain stores, and 6,338 pharmacies had obtained the qualification of "designated retail pharmacies for medical insurance", accounting for 87% of the total number of pharmacies in the company.

　　2. Changes of main sales indicators

　　(1) Store operation by region

　　(2) The operating efficiency of the company’s direct stores during the reporting period.

　　Average daily operating income = operating income including tax of the store in the current year/business days of the store in the current year.

　　3, the top ten stores operating income.

　　4. Category structure of retail terminal

　　5. Procurement and suppliers

　　The commodity suppliers of Guoda Pharmacy are mainly external suppliers, assisting some affiliated enterprises and their own brands of Sinopharm Group. Top 5 suppliers in 2021:

　　6. Member management and service business

　　In 2021, the company’s member sales accounted for 67%, which was unchanged from that in 2020. At the same time, the number of member transactions in 2021 increased by 25% compared with 2020. The proportion of member transactions in the total number of transactions increased from 56% in 2018 to 64% in 2021. In the process of continuous sales improvement in the past three years, the number of member transactions has maintained a steady growth every year, which has played a key supporting role in the steady improvement of the company’s performance.

　　By optimizing the product structure, the company can improve its operating efficiency. In 2021, the unit price of the company’s member customers will be 108 yuan, and the unit price of non-member customers will be 82 yuan. The main difference between members and non-members lies in the degree of brand recognition and the differentiation of the types of goods purchased.

　　7. Warehousing and logistics during the reporting period

　　By the end of 2021, Guoda Pharmacy has 33 logistics centers/distribution centers in 20 provinces (including 9 entrusted logistics and 24 self-owned logistics), and the total area of its own warehouses is 190,000 square meters; Among them, the cold storage area is 1463 square meters, and the cold storage volume is 3880 cubic meters, which is used for the storage and circulation of normal temperature, cool and refrigerated goods, ensuring the distribution of all customers’ goods; There are 173 self-owned logistics vehicles in China, including 20 refrigerated trucks; The number of logistics employees in NUS is 1387; In China, 20.49 million pieces were swallowed and 98.86 million orders were made.

　　8. On-line sales during the reporting period

　　In 2021, online sales increased by 56% year-on-year, of which self-operated platform business increased by 33%, third-party O2O business increased by 93%, and B2C business increased by 8%. The O2O network layout covers over 7,000 stores in 23 provinces across the country.

　　9, to undertake prescription outflow and chronic disease management

　　With the continuous deepening of the national medicine reform, drugs have collapsed on the basis of medicine-supporting medical model through policies such as purchasing with quantity, centralized bidding and dual channels, and prescription outflow has gradually become a trend. In 2021, the overall prescription sales of pharmacies in Guoda were 9.98 billion (including DTP), up 21.3% year-on-year. Among them, represented by Xinjiang, the sales of prescription drugs in 2021 were 720 million (including DTP), up 60% year-on-year. The sales of prescription drugs have brought great influence to chain pharmacies.

　　In order to better undertake the outflow of prescriptions, it is necessary to strengthen the professional service ability and establish a chronic disease management team. In 2021, Guoda Pharmacy organized online study for diabetes specialists and hypertension specialists every week, covering 26 regions, and actually trained 2,593 diabetes specialists and 2,568 hypertension specialists; Accumulated 1.01 million diabetes members and 970,000 hypertension members were filed, and the sales of diabetes and hypertension products increased by 11.7% and 14.2% year-on-year.

　　10. Development of innovative business

　　In 2021, the innovative business of Guoda Pharmacy will be driven by the business model of "medicine+medicine+insurance". In November 2021, Jialong Health, a shareholder of Guoda Pharmacy, obtained the qualification of Hainan Internet Hospital, laying the foundation for Guoda Pharmacy to realize online service and medical care. In terms of commercial insurance, sales in 2021 increased by 159% year-on-year, involving various types of fund insurance, serious illness, chronic illness and other multi-faceted business attempts. E-commerce business continued to maintain rapid growth in the self-operated platform construction and O2O. The self-operated platform realized the mode of dividing employees’ commission, and introduced some large health products for online distribution. In 2021, Guoda Pharmacy achieved a breakthrough in self-media and live broadcast business, and completed more than 340 live broadcast businesses throughout the year, and jointly created short videos and other publicity with Meituan, Hungry and cooperative brands to enhance the overall brand image of the company. At the same time, since 2019, the self-service drug purchasing machine business has achieved a good breakthrough in 2021. At the end of 2021, 217 self-service drug purchasing machines were laid in airports, stations, hospitals, enterprises, parks, pharmacies and other channels.

　　

　　Third, the core competitiveness analysis

　　1. Strong network coverage and layout

　　Sinopharm has consistently relied on a sound distribution network and variety resources to do a good job in the integration of wholesale and retail resources. The company has a complete drug distribution network and sales in all formats have achieved steady growth.

　　(1) 27 prefecture-level cities in Guangdong and Guangxi have strong netcom in regional distribution business, covering all levels of medical institutions, small-scale social medical offices and retail chain single-store terminals; In terms of retail diagnosis and treatment, there are 120 DTP and hospital-side pharmacies (Sinopharm Holding Pharmacy);

　　(2) Guoda Pharmacy has 8798 retail stores, and its chain network covers 20 provinces, municipalities and autonomous regions, covering more than 150 cities in China.

　　2. Rich variety resources

　　After years of hard work, the company’s distribution business has rich variety resources in many fields such as medicines and consumables, and has established extensive cooperative relations with thousands of domestic manufacturers and commercial enterprises, and established stable business relations with hundreds of imported and joint venture manufacturers, with an overall operating product specification of more than 60,000.

　　Guoda Pharmacy operates nearly 180,000 kinds of product specifications. With a relatively complete procurement network and many years of experience in commodity operation, Guoda Pharmacy has established a commodity system with wide coverage, high specialization and rich varieties.

　　3. Perfect logistics distribution system

　　In terms of distribution, warehousing and transportation network, the logistics center has a storage area of more than 180,000 square meters in Guangdong and Guangxi, with 5 logistics centers, 23 distribution centers and 1 transfer station, forming a stepped logistics distribution network. Relying on the national logistics resources of Sinopharm Holdings and combining the resources of carriers, we will realize the full coverage of medical logistics in urban and rural areas throughout the country. In terms of informationization and automation, it has a modern logistics management system, including WMS warehouse management system, TMS intelligent dispatching system, logistics visualization system, AGV goods-to-people system, robotic arm and five-sided code scanning instrument, so as to realize digitalization and intelligence of logistics, continuously improve the efficiency and quality of logistics services. In terms of operation management, unified standardized operation norms and management, integrated quality management system, integrated information management and integrated operation management are implemented. Unified planning, unified deployment and unified management are implemented in logistics resource management.

　　Guoda Pharmacy has a modern logistics distribution system covering domestic scope. Guoda Pharmacy has 33 large and small logistics warehouses in 20 provinces, with a total storage area of over 190,000 square meters. Headquarters logistics management is the highest logistics management institution, which is responsible for the management of logistics warehouses of all subsidiaries in China, the planning and construction of logistics networks, and the information collection and analysis of warehouses. Headquarters logistics provides trunk distribution of centralized goods to warehouses, and regional subsidiaries provide all goods distribution to local stores and external customers. Companies with wholesale qualifications can also provide wholesale distribution between warehouses.

　　4. Medical insurance resources and advantages of dual-channel stores

　　In terms of distribution and retail, by the end of 2021, it has obtained the qualification of "dual-channel" pharmacy in 24 cities and 37 pharmacies in Guangdong and Guangxi. Among them, a total of 25 stores in 14 cities in Guangdong Province have obtained the qualification of "dual-channel" pharmacies, and have served more than 100,000 insured persons. Their professional and meticulous services have been repeatedly recognized by local insured persons, medical insurance, hospitals and industry associations.

　　In terms of the development of pharmaceutical retail, the subsidiaries of Guoda Pharmacy generally have a high ability to obtain medical insurance resources, with a relatively high proportion of medical insurance sales and stable operation. By the end of 2021, there were 6,338 medical insurance stores, and the tax-included sales of direct medical insurance stores was 16.69 billion yuan, up 17% year-on-year. The tax-included sales of direct medical insurance cards reached 7.4 billion yuan, up 26% year-on-year. There are 102 dual-channel stores with a cumulative sales of 2.8 billion yuan.

　　5. Compliance advantages

　　The company strictly adheres to the requirements of legal compliance in the process of operation and management, and has great advantages in the face of stricter policy supervision.

　　6. An influential brand of Chinese medicine.

　　The company’s brand and retail and distribution sub-brands are in the same strain as the brands of controlling shareholders and actual controllers. Relying on the strong influence of central enterprises, the company’s popularity and influence in the industry are increasingly prominent.

IV. Prospects for the future development of the company

　　(A) the industry pattern and trends

　　1. The concentration of the pharmaceutical industry will increase, and the business model will be reconstructed. According to the Guiding Opinions of the Ministry of Commerce on Promoting the High-quality Development of the Pharmaceutical Circulation Industry during the Tenth Five-Year Plan period, the overall goal by 2025 is to cultivate and form 1-3 large-scale digital and comprehensive pharmaceutical circulation enterprises exceeding 500 billion yuan and 5-10 enterprises exceeding 100 billion yuan, and the retail chain rate of pharmaceuticals is close to 70%. From this, it can be seen that the state supports and encourages the formation of national and regional leading patterns, whether it is the upstream original research drugs, generic drug manufacturers or the middle-stream circulation enterprises, which will accelerate the leap of centralized measurement level in the market, and the small and medium-sized circulation enterprises with weak comprehensive strength will be eliminated and the business model of the circulation industry will be reconstructed.

　　2. Centralized mining speeds up the expansion, and the gross profit space is further compressed. The scope of centralized procurement with quantity will continue to expand, the price of drugs will be further reduced, and the gross profit space will be further compressed. The three major sectors of chemical medicine, Chinese patent medicine and biological medicine will carry out centralized procurement in all directions, and high-value medical consumables will focus on orthopedic consumables, drug balloons, dental implants and other varieties. At the same time, cross-regional alliance with quantity procurement will gradually become a trend; At the same time, more and more varieties of Chinese patent medicines and biological agents will be brought into centralized collection. With the further expansion of centralized purchasing, the gross profit margin of pharmaceutical consumables will further decline.

　　3. Innovation, transformation and upgrading of the pharmaceutical market, and accelerated reshuffle of the industry. With the medical reform entering the deep water area, the quantity procurement and medical insurance negotiation have greatly changed the medical ecology. Policies encourage innovation. Facing the new pattern, traditional pharmaceutical companies seek transformation in marketing model, R&D strategy and overseas layout, so as to cope with or lead the development of industrial trends. According to the national policy guidance and the increasingly fierce competition among circulation enterprises, circulation enterprises will continue to promote business model innovation and service innovation, and improve their business performance by steadily developing their scale.

　　4. The market demand for pharmaceutical consumption and diversified payment funds will jointly support the scale and volume of the pharmaceutical retail market. According to the forecast of Minenet, by 2029, the drug market scale of retail pharmacy terminals alone will reach 1.15 trillion yuan.

　　5. Innovative drugs, traditional Chinese medicine and other categories will become the main force driving the increment of China’s pharmaceutical retail market. According to the "14th Five-Year Plan for Pharmaceutical Industry Development" jointly issued by nine departments in January, 2022, the innovation-driven development pattern will be fully formed, and the number of original new drugs and "leading" products will increase, and China will become an important source of pharmaceutical innovation in the world. According to IQVIA’s forecast, in the next five years, driven by the increase in the number and dosage of innovative new drugs, China’s drug expenditure will increase by 3.8% CAGR, and the main contribution to the growth will be the original brand drugs, and the CAGR will be 10.4% in 2022-2026. Retail pharmacies will enjoy this wave of innovative drugs out-of-hospital market dividends through the "dual-channel" qualification.

　　6. With the "three-medical linkage" reform, the drug price has dropped in an all-round way, and retail pharmacies urgently need to accelerate the development and transformation driven by innovative services and cultivate new income growth points. Based on the innovative ideas of the transformation of world-class enterprises and the health service strategy of Wobolian (), we will vigorously develop medical and health clinic services such as VillageMD and HealthCorner.

　　(2) Possible risks

　　1, novel coronavirus epidemic continued to affect. Although the domestic COVID-19 epidemic has been effectively controlled, it is still sporadic. Once there is an outbreak in the company’s business area, under the current strict prevention and control measures, the decline in hospital outpatient service and outpatient drug use still has a noticeable impact on the company’s business.

　　2. Policy risk: National policies have direct guidance and influence on the development of pharmaceutical retail industry. Under the premise of medical insurance cost control, the centralized procurement of drugs with quantity is normalized and institutionalized, and the price of drugs has dropped overall; In addition to the comprehensive spread of the variety of drugs collected, the drug price linkage mechanism has also landed in some areas. The supply chain capacity and profitability of retail pharmacies are facing challenges. At the same time, the supervision of medical insurance funds is becoming stricter in an all-round way. The construction of medical insurance informatization will be accelerated in an all-round way, and a unified national medical insurance information platform will be built. In the future, the unified national medical insurance information platform will be vertically connected, horizontally connected, internally and externally interconnected, and ecologically integrated, and the medical insurance information will be fully transparent. The supervision of medical insurance fund will be upgraded in an all-round way, the requirements for compliance operation of pharmacies will be improved, and the compliance cost of pharmacies will increase. The related policies of Internet diagnosis and treatment norms have been issued, and strict restrictions have been imposed on such behaviors as prescribing for the first visit, unifying prescriptions and supplementing prescriptions. Online diagnosis and treatment of pharmacies, medical e-commerce and other business operations are also facing greater compliance requirements.

　　3. Market changes and market competition risks: the pharmaceutical retail industry has entered a stage of high-quality development, the growth rate of market scale has slowed down, and the overall number of stores is still expanding. In this environment, the competition in the industry has intensified, and major chains are seizing the opportunity to expand their store size and scramble for land through self-opening, joining and mergers and acquisitions, and the industry concentration has been continuously improved. The passenger flow in offline pharmacies is blocked, which is not only squeezed by online channels, but also affected by the return of some patients to the hospital due to centralized purchase. Retail pharmacies are facing challenges from peer competition, online channel competition and medical institutions, especially primary medical institutions. Guoda Pharmacy, as a leading chain pharmacy enterprise in the industry, has a network of stores covering 20 provinces and cities across the country, backed by Sinopharm Holdings and Sinopharm Consistency, and has competitive advantages in terms of supply chain capability, hospital channel resources, brand value and logistics capability. However, with the intensification of industry competition, how to maintain the leading position, scale and competitive advantage of the industry is still facing challenges.

　　4. Risk of public opinion: The popularity of the Internet leads to the rapid spread of network information. With the continuous expansion of social networks online, the spread of information is not only through traditional media, but also through the dynamics shared by social accounts, and public opinion has become a more important risk point.

　　5. Compliance risk: In recent years, drug management has become stricter, and GSP regulations have become stricter. For example, the appearance of traditional Chinese medicine decoction pieces does not meet the requirements, as well as mildew and moth-eaten. Penalties for violations have increased. In addition to the gradual increase in exposure and fines, penalties such as revocation of medical insurance qualifications have also occurred from time to time. The implementation of the new version of the Drug Administration Law faces the most severe punishment under the strongest supervision. Government market management behaviors such as supervision, inspection and punishment, such as cooperation with epidemic management, are also becoming more and more frequent.

　　6. Risk of impairment of goodwill: On December 31, 2021, the book value of goodwill in the company’s consolidated financial statements was RMB 2.776 billion, which was allocated to the asset groups corresponding to the distribution segment and the retail segment. According to the provisions of the Accounting Standards for Business Enterprises, the company conducts impairment test on goodwill every year. (For the disclosure of impairment of goodwill, please refer to Notes III, 17 and 33 and Notes V and 18 in Section X of the Financial Report. )

　　(3) The company’s business plan

　　In 2022, Sinopharm will continue to comprehensively strengthen the party’s leadership, accurately grasp the new development stage, thoroughly implement the new development concept, accelerate the construction of a new development pattern, take high-quality development as the main line goal, take the "14 th Five-Year Plan" as the guide, focus on customer value, and take "technology empowerment, service upgrade, integration of wholesale and retail, and dual drive of industry and finance" as the core development measures. Build a "1-2-6" digital medical and health service system based on omni-channel, all categories and full life cycle, keep a close eye on the development, changes and trends of national medical reform policies, strengthen the research and judgment of industry policy trends, and make overall plans to promote steady growth, adjust structure, promote innovation, strengthen science and technology, prevent risks, "seek change in stability" and "seek innovation in change" to achieve high-quality development.

　　1. Pay equal attention to both endogenous and exogenous development, and maintain the leading industry scale.

　　Strengthen the guidance of strategic planning, while steadily developing traditional businesses, do a good job in endogenous innovation development and extension of mergers and acquisitions, and continuously increase market share. Strengthen the distribution sector and consolidate the leading position; Expand the retail sector and enhance profitability.

　　2. Benchmarking first-class management to enhance the competitiveness of enterprises.

　　Make up the shortcomings, deepen organizational change and management innovation, promote the modernization of management capabilities and management systems, and enhance the support for strategic landing and business transformation. Focus on the efficiency and benefit of human resources, optimize the development of management, talents and organizations, and maintain a high matching degree and high supply rate between talents and strategies and businesses. Customer-oriented, adhere to management improvement and value creation. Focusing on customer needs and combining business scenarios, we will accelerate the application of technologies such as big data and artificial intelligence, strengthen the promotion of digital transformation projects, and drive innovative services and supply chain upgrades with numbers.

　　3. Adjust the structure to promote transformation and build a new value-driven business model.

　　Grasp the demand changes in the upstream and downstream of the industrial chain, build an omni-channel, whole industrial chain and whole life cycle service system around the customer value orientation, and win the development opportunity in the innovative service track.

　　4. The consistent distribution of Sinopharm focuses on the strategy of "one body and two wings" and continues to transform and innovate.

　　Strengthen the strategic goal orientation, face the change directly, focus on the share and improve the efficiency. Continue to develop retail business, improve the network, enrich varieties, cooperate with wholesale and retail, develop with characteristics, and strengthen and upgrade the competitive advantage. Establish a marketing service system, integrate wholesale and retail network resources, expand CSO product projects, promote marketing system and team building, and improve the marketing service capabilities of medical institutions and end consumers.

　　Continue to promote business transformation and innovation, integrate digital transformation and supply chain optimization into the business, and achieve model breakthrough and scale improvement of innovative business. Provide a comprehensive 4D overall service solution to enhance the integrated service capability; Continue to expand the leading edge of SPD business and promote the upgrade of service platform and operation and maintenance capability; Continue to promote the upgrading of third-party logistics value-added services, and explore the ability to build warehouse distribution+cold chain +SPD+2C+ logistics services.

　　5. The pharmacy of Guoda quickly becomes large-scale, deepening the market and improving the efficiency.

　　Strengthen strategic guidance, further intensify regional business integration, speed up the merger and acquisition of intentional cooperation projects, enhance the cooperation of opening stores and joining, speed up the national retail layout, further fill the blank market and expand the new provincial market layout. Continue to promote national integrated operation, enhance the advantages of economies of scale, and build the core competitiveness of NUS. Strengthen the online layout, focus on the construction of self-operated platforms and Internet hospitals, and explore the layout of commercial health insurance. Actively respond to the "dual-channel" policy and strive to achieve full coverage of all provinces and cities in dual-channel designated pharmacies. Strengthen the breakthrough of all products, linkage of purchase and sale, systematically promote the increase of gross profit margin, and continuously promote the development of self-owned brand product series and the construction of marketing system. Promote the integration of retail brand resources in an orderly manner and strengthen the influence of retail brands of "Guoda Pharmacy". Continue to promote digital transformation and continuously improve professional service capabilities.

　　6. Full coverage of wholesale and retail, and exploration and operation of various modes.

　　We will continue to promote the integration of wholesale and retail of Chinese medicine, and export effective business models and profit models according to the model of "one place, one policy and dynamic promotion" and relying on the operational characteristics of various places. On the basis of the original 15 pilot areas, 13 areas will be added to achieve full coverage of 28 areas in the country. Encourage regional exploration of business integration, equity integration, organizational integration, member stores and other model operations, and continue to promote the all-round cooperation of wholesale and retail through business cooperation, logistics cooperation, zero-machinery cooperation and management cooperation.

　　7. High-quality Party building leads to create a clean and healthy development environment.

　　Comprehensively strengthen the party’s political and ideological construction and adhere to the integration of party leadership and corporate governance. Deepen the construction of grassroots party organizations and deepen the comprehensive and strict management of the party. Cultivate and build a corporate culture with temperature, depth, breadth and height, which is consistent with the development of the "14 th Five-Year Plan" of Sinopharm and helps the development of enterprises.