[Talking about Medicine Garden] Dry goods! In-depth analysis of 500 reference preparations that failed to pass the review.

Miscellaneous talk about medicine garden 

A paradise for medical people to share and discuss pharmaceutical knowledge,

Common progress and development

9341657323461265  

In order to promote the consistency evaluation, the General Administration announced the catalogue of generic reference preparations in batches from March 17, 2017, and began to publicize the draft of the catalogue of generic reference preparations on March 28, 2019. 

In the Catalogue of Reference Preparations for Chemical Generic Drugs (25th Batch) (Draft for Comment), the list of varieties that failed to pass the review began to be updated. By the end of the Catalogue of Reference Preparations for Chemical Generic Drugs (59th Batch) (Draft for Comment), 620 failed product specifications had been updated, and 93 were reviewed by the consistency evaluation expert committee again after receiving the objection application from the enterprise. The experts maintained their original conclusions and failed the second review.

The following figure shows that the historical batches of the exposure draft have not passed the review and reference publication:

16491657323461677  

The main reasons for not passing the review are as follows:

52031657323461885  

A has no reference preparation status.

According to the Procedure for Selection and Determination of Reference Preparations for Chemical Generic Drugs, the order of selecting reference preparations is: original research imported, original research not imported, original research localized and internationally recognized drugs of the same kind.

Of the 527 failed quality regulations, 280 were rejected because they did not have the status of reference preparations. Analysis of the reasons for not having the status of reference preparation can also be divided into the following situations:

87681657323462018  

1. Clearly do not recommend reference preparations.

The reference preparation is not recommended for the trial varieties that can BE exempted or simplified in human bioequivalence (BE) issued by the National Bureau. For example, Compound Polyethylene Glycol Electrolyte Powder (V), similar varieties have been clearly not recommended in the notice (No.136, 2018) issued by the National Bureau on the exemption or simplification of human bioequivalence (BE) test varieties. It has not passed the review.

2. There is no such dosage form in the original research.

Because the reference preparations to be declared are varieties with modified specifications, the original research did not have this specification and failed to pass the review, such as acarbose chewable tablets, pantoprazole sodium enteric-coated capsules, acetaminophen dry suspension, betamethasone sodium phosphate injection, etc.

3. Compared with the published reference preparation, it has no obvious advantage.

3.1 The concentration of the reference preparation to be applied for is the same as that of the published reference preparation, but the loading quantity is different.

We can find that the specification of 4.5354g/7.5ml of Bayer Healthcare Pharmaceuticals was published in the 27th batch, and the specification of 9.0708g/15ml was published in the 28th batch.

4211657323462172  

In the Catalogue of Reference Preparations for Chemical Generic Drugs (Fifty-ninth Batch) (Draft for Comment), 1.20944g/2ml, 6.0472g/10ml, 18.1416g/30ml and 39.3068g/65ml of gadolinium butoxide injection of Bayer Healthcare Pharmaceuticals Inc were rejected because they were different from the published reference.

3.2 The published reference preparations are prescription drugs listed in the United States, and it is not recommended to add OTC drugs as reference preparations.

Omeprazole sodium bicarbonate capsules are managed separately according to prescription drugs and OTC in the United States. The published reference preparations are prescription drugs listed in the United States, and it is not recommended to add OTC drugs as reference preparations.

3.3 Compared with published reference preparations, there is no clinical advantage.

Piperacillin sodium tazobactam sodium for injection by Dapeng Chemical Industry Co., Ltd. was rejected because the powder-liquid double-chamber bag was not widely used and the cost was high. The orally disintegrating tablet of montelukast sodium from MSD Co., Ltd. was not approved because the dosage form to be applied for was orally disintegrating tablet, which only provided a choice of dosage form for clinic, and had no clinical application advantage compared with other oral preparations on the market. Cefalexin fine granules of Gonghe Chemical Industry Co., Ltd. were not approved because the published reference preparation of Cefalexin dry suspension could basically cover the usage and dosage required by children patients.

3.4 Non-original research and no reference preparation status

The metronidazole vaginal gel of Oceanside Pharmaceuticals is a generic drug authorized by the original research, but it is a generic drug listed in the United States and does not have the status of reference preparation; Pravastatin sodium tablets (4 specifications) of Teva Pharmaceuticals Usa Inc are internationally recognized as the same drug, but the reference preparation to be applied for is a generic drug listed in the United States, which does not have the status of reference preparation and is not approved.

B lack of complete and sufficient safety and effectiveness data.

A total of 104 quality regulations failed due to the lack of complete and sufficient safety and effectiveness data, of which 22 were reviewed by the consistency evaluation expert Committee again after receiving the objection application from the enterprise, and the experts maintained the original conclusion and failed the second review. 

Most of the reasons why this kind of drug failed to pass the review were that the data of safety and effectiveness provided by the applicant were not sufficient, and it was impossible to determine that it was a drug with safety, effectiveness and quality controllability. In addition, Alfasigma Romania S.R.L’ s creatine phosphate sodium for injection is the original research drug listed in China, but this product has been included in the first batch of national key monitoring drugs list, and the relevant safety and effectiveness data are limited, so the review failed; Pidotimod oral solution of Polichem S.R.L was not approved due to insufficient evidence of clinical effectiveness according to the Notice of the General Administration on Starting Clinical Efficacy Test of Pidotimod Oral Liquid (No.31 [2018] of Food and Drug Administration); Alfasigma S.p.A’ s Levocarnitine Hydrochloride Enteric-coated Tablets was declared for import in the original research, and the application materials were not enough to support the effectiveness of this product for the applied indications. The conclusion was that it was not approved and the review was not passed.

C does not meet the domestic indications, usage and dosage

There are 64 product specifications involved because they do not meet the domestic indications and usage and dosage. Subdivided into the following three reasons:

20291657323462416  

The specification of oxytocin injection of Takeda Chemical Industry Co., Ltd./ぁすかかかか Co., Ltd. is 1 unit /ml, and the specification of 1 unit /ml of this product is unreasonable, which is less than the minimum dose recommended by the instructions for single use (2.5 units/ml); The specification of Pioglitazone Hydrochloride Tablets of TAKEDA PHARMACEUTICALS USA INC is 45mg. In the past, an expert consultation meeting was held for hypoglycemic drugs. Clinical experts reported that the maximum dosage of this product used in China is usually 30mg, and the specification of the reference preparation to be applied is greater than the maximum dosage, which was not approved. Naproxen is a non-mainstream non-steroidal anti-inflammatory drug in China. Naproxen, esmomeprazole and magnesium enteric-coated tablets of Horizon Medicines LLC, the compound does not meet the requirements of domestic clinical practice and compound preparation for the time being, and the review was not passed.

D. The listed areas are not in the European Union, the United States and Japan (with relatively perfect regulatory system).

There are 46 quality regulations that have been rejected because the listed areas are not in the European Union, the United States and Japan. In order to ensure the quality of reference preparations, it is suggested that the reference preparations should be the original drugs approved for listing by institutions with relatively perfect regulatory systems such as the European Union, the United States and Japan, and the review failed.

There are mainly the following 12 listed regions that failed to pass the review:

78741657323462514  

E has certain security risks.

There are 21 quality regulations that failed due to certain safety risks, and 8 of them were reviewed by the consistency evaluation expert Committee again after receiving the objection application from the enterprise. The experts maintained the original conclusion and failed the second review.

It is worth noting that injections and eye drops without preservatives and antioxidants have more advantages as reference preparations.

80391657323462610  

F process quality does not meet the requirements.

There are 12 product specifications that failed because the process quality did not meet the requirements, and four of them were reviewed by the consistency evaluation expert Committee again after receiving the objection application from the enterprise. The experts maintained the original conclusion and failed the second review.

26791657323462765  

Oxaliplatin for injection of Sanofi-Aventis France is the reference preparation published in the 27th batch. After deliberation by the expert committee for consistency evaluation, the oxaliplatin injection prepared by terminal sterilization process can meet the requirements of product impurity control and stability, and oxaliplatin injection with terminal sterilization should be the first choice, and oxaliplatin for injection is an unreasonable dosage form, so it should be transferred. If the reference is rejected, the declared product has no possibility of approval.

69621657323462948  

tag

The selection of reference preparation is the key in the process of generic drug research and development. If the selection is wrong, the project progress will be delayed, and the blood will be lost. By studying the reasons why the reference preparation failed the audit, we can learn a lot of experience in project risk assessment and product research, and clearly judge the value orientation of the country to generic drugs. When researching products, we should not only pay attention to foreign data, but also pay attention to the performance of drugs in China. Try to avoid the embarrassment that the application for reference preparation was rejected, and pay more attention to avoid the tragedy that the selected reference preparation was transferred out of the catalogue.

Xinhua All Media+| It’s more fun to play ice and snow on campus during winter vacation.

  Xinhua News Agency, Changchun, January 29th Since the winter vacation, many places in Changchun and Shenyang have opened ice and snow custodians. Schools have built ice rinks and snow fields on campus, hired professional coaches, and provided all kinds of ice and snow sports courses for primary and secondary school students, so that students can enjoy ice and snow on campus during the winter vacation and welcome the Winter Olympics.

  In the cold winter, in the 2,400-square-meter ice rink of Pingquan Primary School in Nanguan District, Changchun City, the students learned from the skating coach in full swing.

  Students in the primary school of Changchun No.104 Middle School are learning to skate. Xinhua News Agency reporter dorri photo

  Song Haoxuan, a student in Class Two, Grade Five, Changchun No.104 Middle School, is learning skating for the first time. After three days, he has mastered the basic movements and can stand and walk on the ice. "Before the holiday, the class teacher said that there was ice and snow custody during the holiday, so I signed up. In the past, I could only do my homework at home during the holidays. It is so interesting to learn skating this time. " Song Yuxuan said.

  At the scene, the reporter saw that a shoe changing room was built around the skating rink, in which all the skating equipment was prepared for students, and each school was accompanied by leading teachers to ensure the safety of students.

  Sun Jingru, director of the Department of Physical Education, Sports, Arts and Health, Nanguan District Education Bureau, Changchun City, said that in order to create conditions for students to participate in ice and snow sports, Nanguan District Education Bureau poured an ice rink in Pingquan Primary School. Students in grades 4-8 of primary and secondary schools in the whole district took advantage of the winter vacation to participate in ice and snow custody for a total of 30 days, with about 600 participants every day. The total number of participants in the winter vacation is expected to be 18,000. The Education Bureau also hired seven professional coaches to guide students’ ice skills, so that students can master the basic skating movements and experience the fun of skating in a short period of time.

  Shoe changing room of Pingquan Primary School in Nanguan District, Changchun City. Xinhua News Agency reporter dorri photo

  In addition, other counties and cities in Changchun also provide various forms of ice and snow amusement activities for primary and secondary schools. Yushu city City, Jilin Province has poured 26 outdoor ice rinks in primary and secondary schools in towns and villages, and equipped students with PE teachers and skating equipment. Up to now, more than 10,000 people have participated in ice and snow custody.

  In the ninth primary school in Hunnan District, Shenyang City, Liaoning Province, ice and snow activities are another lively scene. The school’s snow machine makes snowflakes fly, and it is fun to have snowball fights, make snowmen and snowball. Two large indoor ski machines allow students to ski at zero distance, and more than 700 students who participate in the trusteeship can enjoy the fun of flying in the snow.

  Hou Mingfei, principal of the Ninth Primary School in Hunnan District, Shenyang, said that compared with summer classes, the school’s winter vacation trusteeship has increased the single and double snowboarding projects, and students can take skiing classes on campus.

  On the 120-square-meter indoor simulated ice rink of Heping Street No.1 Primary School in Heping District, Shenyang, the children were dressed in ice hockey equipment, and the teacher explained the technical points and basic sliding movements for the students. The slightly childish movements of the students added vitality and vitality to the winter campus.

  The school organized a winter vacation hosting service with the theme of "Harmony, Colorful Winter Holidays", and 80 students from different grades signed up to participate. The trusteeship classes were named "Bingdundun" class and "Snow Rongrong" class, and activities such as learning to sing winter Olympic songs and ice hockey experience were also carried out to cultivate students’ interest and skills in ice and snow sports.

  Students in the primary school of Changchun No.104 Middle School learn skating. Xinhua News Agency reporter dorri photo

  This school is a characteristic school of ice and snow sports on the national youth campus. Lin Yuheng, the director of teaching, said that ice hockey training in schools usually involves members of the school team, and not all students can master skills such as ice hockey and speed skating. There is plenty of hosting time in winter vacation, and for more than 80 students who participate, they can do no less than two hours of sports every day.

  In recent years, Shenyang has incorporated ice and snow projects into the teaching content of primary and secondary schools, and carried out ice and snow sports through physical education courses and comprehensive practical activities courses, and achieved remarkable results. Twenty-seven schools in the city were rated as "National Youth Campus Ice and Snow Sports Characteristic Schools" by the Ministry of Education, and 55 schools were named as municipal ice and snow characteristic schools. At present, more than 30% primary and middle school students in the city have mastered the basic skills of ice and snow. (Reporter: Li Shuangxi, dorri, Wang Ying, Wu Jiangmin)

Mila Tang Jian: Building ChatGPT in the field of life science and developing drugs with generative artificial intelligence.

"I have always been interested in biology. When I was in high school, my teacher told us that the 21st century was the century of biology. When I studied artificial intelligence, I believed that the 21st century was the century of artificial intelligence."

During the scientific lecture "Understanding the Future" hosted by the Future Forum, Tang Jian, an associate professor at the Research Center for Artificial Intelligence in Quebec, Canada (Mila) and a professor of artificial intelligence at the Canadian Institute of Advanced Studies (CIFAR), introduced the application of generative artificial intelligence in life sciences: how to build a "ChatGPT" in life sciences. He said, "Later, I felt that it might be the best choice if I could do something in the field where artificial intelligence and biology intersect."

Today, he is not only studying AI and biology at the same time, but also "left-handed scientific research and right-handed entrepreneurship". He said that he is a person who is willing to accept new things and challenges. From scientific research to entrepreneurship, many things are different, and it is difficult to carry out interdisciplinary cooperation, but this also reflects the value of doing these things.

Figure | Tang Jian (Tang Jian’s personal homepage)

According to reports, Tang Jian University studied geography at the beginning, transferred to the Department of Mathematics in his sophomore year, and successfully applied to the Department of Computer Science in his senior year. In his computer learning career, he first studied traditional machine learning, and in the last year of his doctoral degree, he turned to deep learning.

After graduating from the doctor’s degree, he officially embarked on the road of scientific research and made many achievements in the field of graphic representation learning. As one of the representative scholars in this field, his network representation learning method LINE (large-scale information network embedding) has been widely used, with more than 5,000 references.

"The double revolution of artificial intelligence and biotechnology broke out, and we are in the best era of doing research."

In 2018,Tang JianStart the research on the intersection of artificial intelligence and biology. At that time, he applied the graph representation learning technology to the research in the field of drug discovery, and did a lot of work in the prediction of three-dimensional structure of small molecules and the design of macromolecular proteins.

But a few years ago, only a few people devoted themselves to the research in this direction. In the past two years, more and more investment has been injected into this field. Tang Jian believes that the reason for this change is that artificial intelligence has brought great breakthroughs to the structural prediction and biological field in protein, and the spread of the COVID-19 epidemic has also aroused people’s focus on health and biomedicine.

"Now we are in the best era, because we are experiencing the dual technological revolution of artificial intelligence and biotechnology." Tang Jian said, "Therefore, we have seen great opportunities for generative artificial intelligence in the field of drug discovery, especially protein design."

Based on his accumulation in scientific research, he devoted himself to entrepreneurship and set up the artificial intelligence-driven biopharmaceutical company Baiao Geometry in 2022.

Build an AI macromolecular drug design platform to provide innovative drugs to save patients’ lives.

existTang JianIt seems that perhaps it is the entrepreneurial idea that has sprouted since childhood and the character of constantly seeking self-breakthrough that drives him to embark on the road of entrepreneurship.

The Baiao Geometry Company, founded by him, aims to develop a programmable protein by integrating the technologies of generative artificial intelligence and geometric deep learning, so as to overcome the problems of long cycle, high cost and low success rate of traditional macromolecular pharmacy and provide innovative drugs to save patients’ lives.

Tang Jian is mainly responsible for technical work in this company, and designs antibodies by building artificial intelligence models. As a new diffusion generation model, this model can model the amino acid sequence and three-dimensional structure of protein at the same time, and show the relationship between them, so as to generate protein with specific functions.

At present, the team has set up an AI macromolecular drug design platform, and is building a wet experiment verification platform for Qualcomm macromolecular drugs. At the same time, it also launched TorchProtein, an open source machine learning platform for macromolecules, in conjunction with companies such as NVIDIA, Intel and IBM.

"I hope that the technology I have made can really push several drugs into the clinic, solve more complicated diseases like cancer and save patients’ lives." Tang Jian said. In addition, he also said that with the development trend of intelligence, digitalization and automation in the biomedical field becoming inevitable, he expected to become a world-famous and international high-tech company in this field.

Based on generative artificial intelligence, build "ChatGPT" in life science field

In addition to starting a business, Tang Jian’s scientific research work at hand is also being carried out simultaneously. Based on generative artificial intelligence, he and his team have carried out research on three-dimensional structure prediction of small molecules and protein design of large molecules in the field of biomedicine.

In the prediction of the three-dimensional structure of small molecules, the team mainly modeled them based on the diffusion generation model. Specifically, a completely random structure is taken as the initial structure, and after several rounds of optimization, it finally converges to a stable protein structure. Each step of the optimization process is also called denoising. In addition, on the basis of expanding the research, the prediction of the complex structure was realized.

In the design of macromolecular proteins, the team proposed to design protein structure and sequence based on diffusion generation model, which not only realized the generation of antibody CDR Loop structure and sequence, but also designed α -helix transmembrane proteins with a specified number.

Not only that, the team also conducted research on antibody design and optimization. For example, it cooperated with the research team from Fudan University. Based on the antibody CR3022 obtained from newly crowned patients, it first designed the sequence with AI model, and then tested it on the wet experimental platform of Qualcomm, and finally successfully found the antibody molecule with strong affinity.

For generative artificial intelligence, its most critical ability is that it can generate new data. Then, if it is used in the biomedical field, it can help to generate a brand-new protein and help people find better drugs.

As a typical generative artificial intelligence model, ChatGPT has spread all over the world since it was introduced at the end of 2022. It can talk and communicate like a human being, and complete tasks such as writing papers and coding. "It is essentially a chat robot." Tang Jian said. As a large-scale pre-training language model, ChatGPT first pre-trains a large number of text and code data on the Internet, and then further optimizes it to enable it to be used for tasks such as dialogue.

The development of biotechnology, such as gene sequencing and gene synthesis, has brought a lot of data to the biomedical field. Therefore, Tang Jian believes that in the near future, people can also use these data to build ChatGPT in the field of life sciences.

Reporting/feedback

This year, over 30 cities have adjusted the property market purchase restriction policy: "high-frequency small-step optimization" will become a feature.

  "Cancel the recognition of housing and loan" and "encourage the elderly to buy houses with relatives" …… On March 1 this year, after Zhengzhou became the first city in China to relax the purchase restriction policy, many cities followed up and adjusted the purchase restriction policy.

  Over 30 cities adjust the purchase restriction policy

  According to the incomplete statistics of The Paper, this year, it includes Zhengzhou, Qinhuangdao, Fuzhou, Quzhou, Lanzhou, Shaoxing, Foshan, Shenyang, Huizhou, Zhongshan, Dongguan, Jurong, Changsha, Yangzhou, Hefei, Shenyang, Hangzhou, Huzhou, Yinchuan, Dalian, Harbin, Tangshan, Wuxi, Jiangmen, Guangzhou, Jiujiang, Nanjing, Wuhan.

  In these cities, some announced the abolition of the original restrictive measures, some announced the narrowing of the scope of purchase restrictions, some lowered the threshold of purchase restrictions, and some cities made it clear that families with many children and relatives could increase the number of places to buy houses.

  Take Tianjin as an example. On September 16th, according to "Tianjin Housing and Urban-Rural Development", the Tianjin Municipal Housing and Urban-Rural Development Committee and other seven departments jointly issued the Notice on Further Improving the Real Estate Regulation Policy to Promote the Healthy Development of the Real Estate Industry (hereinafter referred to as the Notice). The Notice mentioned that new citizens and college graduates who are not registered in this city and are employed in this city can buy in Tianjin with social insurance or personal income tax certificates for six consecutive months.

  According to the "Implementation Opinions on Deepening the Regulation of the Real Estate Market in Tianjin" issued by Tianjin on March 31, 2017, families with non-Tianjin household registration who purchase houses in this city need to provide proof of continuous payment of social insurance or personal income tax for more than 2 years in Tianjin within 3 years.

  In terms of supporting the demand for improved housing, the Notice proposes that families with members aged 60 and above and families with many children who have two or more children can purchase another set of housing on the basis of the original housing purchase restriction policy in Tianjin with the household registration book.

  Guan Rongxue, an analyst at Zhuge Housing Data Research Center, pointed out that in the original policy, it was clear that non-Tianjin registered residents were required to provide proof of continuous payment of social insurance or personal income tax for more than two years within three years in this city, and now it is adjusted to only provide social insurance or individual income tax for six consecutive months, which lowered the threshold for buying a house; Secondly, for families with members aged 60 and above and families with many children who have two or more children, one set can be purchased, which fully considers the housing needs of different age groups and reasonably relieves the contradiction between supply and demand.

  The policy of Suzhou and Qingdao is now "one-day tour"

  However, in the above-mentioned cities that announced the adjustment of the purchase restriction policy, there have also been cases in which policies have been introduced and adjusted.

  Taking Qingdao as an example, on September 15th, WeChat official account, the official WeChat of Qingdao Urban and Rural Construction Bureau, released "Dynamic Improvement of Real Estate Policy in Qingdao". The New Deal is clear, and the purchase restriction policy will continue to be implemented in Shinan District and Shibei District (except the original Sifang District).

  At the same time, continue to clarify the purchase of housing. For new commercial housing in the restricted area, local residents are restricted to purchase 2 sets, families with two children and three children can purchase 1 set, and foreign residents can purchase 1 set after living for half a year; Second-hand housing is no longer restricted.

  However, on the same day, Qingdao Housing and Urban-Rural Development Bureau deleted the statement that "second-hand housing is no longer restricted".

  On the afternoon of September 16th, the relevant staff of Qingdao Housing and Urban-Rural Development Bureau told The Paper that in the new policy, the restricted purchase area of second-hand houses has been adjusted, and the restricted purchase policy is still implemented for first-hand houses and second-hand houses in Shinan District and Shibei District, while the restricted purchase is released for first-hand houses and second-hand houses in other areas.

  On September 14th, market news came out that Suzhou City, Jiangsu Province has made adjustments to the purchase restriction policy, and non-Suzhou local residents can directly purchase the first suite without providing proof of social security payment.

  According to the New Deal, the six districts in Suzhou (including Xiangcheng District, gusu district District, Wuzhong District, Wujiang District, Industrial Park and High-tech Zone) have adjusted the policies for foreigners to buy the first suite, and it is no longer necessary to show social security certificates or tax certificates.

  Subsequently, The Paper confirmed from the real estate departments in various districts that the above policies were indeed adjusted. However, on September 16th, The Paper learned from the real estate departments of gusu district, Xiangcheng District, Wuzhong District, High-tech Zone and Industrial Park in Suzhou City, Jiangsu Province that the purchase restriction policies of gusu district, Xiangcheng District, Wuzhong District, High-tech Zone and Industrial Park for non-registered households have been restored to the original policy, that is, the conditions for non-registered households to purchase houses are to pay social security for six consecutive months in Suzhou within three years.

  Chen Wenjing, director of market research in the Index Division of the Central Finger Research Institute, believes that under the guidance of the central government’s orientation of "housing and not speculating", the efforts of policy optimization in first-and second-tier cities are generally weak, and high-frequency small-step optimization in various places has become a major feature of real estate policy adjustment this year.

  Chen Wenjing pointed out that the recent cancellation of the purchase restriction policies in Suzhou and Qingdao has been withdrawn, which further shows that "no speculation in housing" is still the bottom line of the policies. Among all kinds of restrictive policies, the restriction on the purchase of foreign household registration is an important firewall for core cities to achieve "housing and not speculation". In the short term, it is unlikely that hot second-tier cities will completely cancel the restriction on purchases. It is expected that more cities will gradually advance by giving priority to relaxing the restrictions on purchases in suburbs. At the same time, combined with the National Standing Committee at the end of August, "Allow local ‘ One city, one policy ’ From the expression of "flexible use of credit and other policies", it is more likely that second-tier cities will reduce the down payment ratio and optimize the "recognition of housing and loans" in the future.

  From a national perspective, Chen Xiao, a senior analyst at Zhuge Housing Search Data Research Center, pointed out that from the perspective of policy trends, policy loosening has gradually shifted from the initial stage of mild relaxation such as initial housing subsidies and relaxation of provident fund loans to a more in-depth stage, that is, the policy loosening is stronger, the coverage is deeper, and the influence is more profound. At present, many cities have released policies to loosen restrictions on purchases, including some hot second-tier cities, and the degree of loosening has gradually expanded, which will play a substantial role in boosting the property market.

  According to the monitoring data of Zhuge Housing Search Data Research Center, the sales area of new houses in 40 cities monitored in August was 14,882,000 square meters, down 10.08% from the previous month and 24.53% from the same period last year. 59,721 sets of second-hand houses were sold in 10 key cities, down 9.23% from the previous month and up 21.27% year-on-year.

Noriko Sakai abandoned the 600 million AV comeback road and concentrated on accompanying his son to be a bookboy.


Nori-P

        After a year and a month of drug abuse, Noriko Sakai, a Japanese star, has been rumored to be returning to film to earn money, and the AV industry has offered her a price of 600 million yen to lure her into the sea. A reporter blocked someone in her residence a few days ago. She was carrying her primary school son’s schoolbag, wearing a hat and sunglasses, just like a bookboy. She was kind to the media and laughed and dismissed the rumor: "I won’t come back, and I don’t want to make a movie!"

        According to Taiwan Province news, Noriko Sakai was sentenced to one year and six months’ probation and three years’ probation for possession of drugs and taking drugs last year, which severely damaged her image. Many Japanese and China porn players waved to her and asked her to take off her clothes and come back. The highest price was about 600 million yen, and it was also reported that mainland filmmakers invited her to make a new film. At the end of June, Noriko Sakai divorced successfully, ending her 11-year marriage with Gao Xiangyou, a drug addict’s husband. Some media reported that she had suspended from school and planned to make a comeback.

I was blocked when I came home from shopping, revealing that I was still in college.

        "Tokyo Sports Daily" blocked her at her Tokyo residence at 2 pm on the 1st. She was shocked at first and then showed her trademark smile. The reporter repeatedly asked her: "Have you dropped out of school? Will you return to show business? I heard that you are going to be in a movie? " She said with a cheerful smile, "No, I’m still in college, I won’t come back, and I haven’t made a film!" " She was carrying a big bag and a small bag, carrying her 11-year-old son’s schoolbag, and was asked, "Do you usually pick your own buyer’s supplies?" She immediately held up her shopping bag and said, "As you can see!"

Ji ‘na | A Review of China Sports Delegation’s Wonderful Performance Series in Paris Olympic Games

  Brilliant interpretation of China spirit in the new era by Olympic Games

  At the Paris Olympic Games, China’s sports delegation won 40 gold medals, 27 silver and 24 bronze medals, which tied for the first place with the United States in the number of gold medals, creating the best record of overseas participation. China athletes have won gold medals in sports, morality and style, and won honors for the motherland and the people, with their childlike feelings of putting the motherland first and winning glory for the country, their indomitable fighting and self-improvement beliefs, their precious qualities of unity, cooperation and fighting side by side, and their self-confidence, optimism and warm and friendly sunshine temperament.

  When receiving the China sports delegation of the 33rd Olympic Games, General Secretary of the Supreme Leader pointed out that the outstanding achievements of the China sports delegation carried forward the Chinese sports spirit and the Olympic spirit, made the Chinese national spirit and the spirit of the times complement each other, and vividly interpreted the spirit of China in the new era.

  Olympic achievements highlight China’s strength in the new era

  Sports will flourish when the country is prosperous, and sports will be strong when the country is strong.

  Since the 1984 Los Angeles Olympic Games, the China sports delegation has won 303 gold medals in the Summer Olympic Games. It took us 20 years from the first gold to the 100th gold, and it also took us 20 years from the 100th gold to the 300th gold. The sudden speed increase corresponds to the acceleration of China’s development, and also highlights the boosting force brought by China’s development.

  At the just-concluded Paris Olympic Games, the China sports delegation won 91 medals, totaling 40 gold, 27 silver and 24 bronze, which was the best result in the history of overseas participation in the Summer Olympic Games in China, and tied for the first place with the United States in the number of gold medals. At the same time, it has made historic breakthroughs in a number of projects, fully demonstrating the strength of China as a world sports power and an Olympic power, and reflecting the achievements of building a sports power and a healthy China in the new era.

  When meeting all the members of the China sports delegation of the 33rd Summer Olympic Games, the Supreme Leader General Secretary pointed out that the outstanding achievements of the China sports delegation are not only a concentrated expression of the development and progress of China’s sports undertakings, but also a microcosm of the achievements of Chinese modernization, which fully demonstrates China’s strength in the new era.

  Olympic style reflects the image of China in the new era.

  Centennial Olympics is not only the quest of mankind to break through the limit of "faster, higher and stronger", but also a stage for global cultural integration and mutual learning of civilizations to show the hope of "more unity" in the world.

  At the just-concluded Paris Olympic Games, the China sports delegation won 40 gold medals, 27 silver medals and 24 bronze medals, which was the best result in the history of overseas participation in the Summer Olympic Games in China. While achieving excellent results, China Olympic athletes won gold medals in competition, morality and style, adding oriental elegance to the Olympics.

  When meeting with the China sports delegation of the 33rd Olympic Games, General Secretary of the Supreme Leader pointed out that the China sports delegation insisted on winning the gold medal of morality, style and cleanliness, promoted the sports ethics, won wide respect and recognition, and fully demonstrated the image of China in the new era.

Heroes are the brightest coordinates of the nation —— Commemorating the 70th anniversary of Chinese people’s Volunteer Army’s war to resist US aggression and aid Korea.

The great spirit of resisting U.S. aggression and aiding Korea forged in the War to Resist U.S. Aggression and Aid Korea is precious spiritual wealth, which will inspire the people of China and the Chinese nation to overcome all difficulties and obstacles and all powerful enemies.

-On October 19th, 2020, when visiting the theme exhibition "Remembering the Great Victory and Defending Peace and Justice-Commemorating the 70th Anniversary of Chinese people’s Volunteer Army’s War to Resist US Aggression and Aid Korea", General Secretary of the Supreme Leader pointed out.

This year marks the 70th anniversary of Chinese people’s Volunteer Army’s war to resist US aggression and aid Korea. On October 19th, 1950, Chinese people’s Volunteer Army crossed the Yalu River and started the great War to Resist US Aggression and Aid Korea. On October 25, the volunteers launched the first battle into the DPRK-the two water tunnels battle and won. A year later, the people of China designated October 25th as the anniversary of Chinese people’s Volunteer Army’s War to Resist US Aggression and Aid Korea.

"valiant, spirited, across the Yalu river …"

70 years ago

There is such a group of hot-blooded China army.

Cross the Yalu River

Embark on the road to resist U.S. aggression and aid Korea and defend the country.

Volunteer troops to resist US aggression and aid Korea cross the Yalu River (Xinhua News Agency)

Battle of Shangganling (Xinhua News Agency)

In this team

There are many young people from Fujian.

They are armed with crude weapons in a foreign country.

Eating "a handful of fried noodles and a handful of snow"

Facing the "artillery rain" pouring all over the sky

Follow the big army and put the arrogant opponent.

Hit the negotiating table

Put the humiliation of China and the arrogance of the powers for more than 100 years

Smash to pieces

Meisi motherland jintanggu

I will recall the hero’s cold armor.

70 years have passed by.

We can’t forget

Veterans who joined the volunteer army without hesitation.

Although they are now in their eighties.

But just mention the bonfire years.

They will still straighten their backs.

be in high spirits

It’s like going back to the era of galloping on the battlefield …

Zhou Zhenrong (86 years old), born in Minhou County, Fuzhou City, was born in 1934. In June 1951, he joined the 25th Army of China People’s Liberation Army gloriously and officially became an army medical soldier. In August 1952, Zhou Zhenrong was ordered to "go north to build" with his army. After reorganization, the 25th Army was reorganized into the 2nd Battalion of the 217th Regiment, the 73rd Division of the 23rd Army. After a 1,800-kilometer emergency March, he arrived in Wonsan, the eastern front of Korea, and then moved to the middle line to fight side by side with the Korean people, and won two military medals.

Zheng Saizhao (91 years old), a native of Taijiang District, Fuzhou City, was born in December 1928. He joined the army in February 1950. Before joining the army, he studied in Fuzhou No.4 Middle School. In May, he studied and trained in the 20th Army Training Regiment of the Ninth Corps of the Third Field Army. In November, he participated in the War to Resist US Aggression and Aid Korea. He worked in the engineering department of the 60th Division of the 20th Army and the artillery regiment of the 60th Division of the 20th Army. He returned to China in October 1952.

Hou Yin (aged 89) now lives in Gulou District, Fuzhou, and was born in December 1930. In May 1949, he joined the China People’s Liberation Army and was a student of the Second Field Military and Political University. He has successively served as the squad leader of Wudang District in the Southern Anhui Military Region, the team leader of the Fourth Middle School of the Teaching Corps, and the trainee staff officer of the headquarters. In November, 1952, the general staff of the headquarters of the July 11th Brigade of the May 4th Division of Chinese people’s Volunteer Army entered the DPRK to fight, and participated in many military operations, such as anti-landing operations, repairing the Datong River Bridge in Pyongyang, and fighting bandits after the armistice, and won the international third-class merit once and the third-class merit four times.

Xin Shaokong (90 years old), living in Xiamen, was born in June 1930, joined the army in January 1946, worked as a nurse in the battle of Xiannan in North Korea in November 1950, and worked as a nurse in five battles in North Korea in May 1951. Because of his outstanding work performance, he completed the task well and won the second class merit. In December 1953, he worked actively in the medical team of the former Eighth Field Hospital of East China Military Region, and won a third-class merit.

Li Shuiyi (96 years old), a native of Yunxiao County, Zhangzhou City, was born in July 1924, joined the army in February 1948, served as the logistics department chief of the 27th Army of the Third Field Army, participated in War of Resistance against Japanese Aggression, the Liberation War and the Korean War successively, and was discharged in January 1955. Third class three times, fourth class three times. During his time as an ordnance officer in the War to Resist US Aggression and Aid Korea, he risked his life to protect his briefcase. More than 170 people in the whole company participated in the war, and only one of them was alive. In the early summer of 1955, he was demobilized from the 27th Army of the Third Field Army.

Ye Yinshui (89 years old), born in Changtai County, Zhangzhou City, was born in July 1931. He joined the army in Zhangzhou Uprising in 1949, was re-elected as a scout in the 271st Regiment of the 91st Division in June 1950, and joined the Party in December 1950. In April 1951, he was re-elected as the second squad leader in the guard battalion of the 148th Division of the 50th Army in Chinese people’s Volunteer Army, and in February 1953, he was re-elected as the deputy platoon leader in the 148th Division. In February 1955, he was demobilized and returned to Mingqian Township, Yanxi Town, Changtai County, where he served as the Party branch secretary, and made third-class merit three times.

Xie Ronghua (92 years old), a native of Nan ‘an, Quanzhou, was born in April 1928. In November 1950, he served as the correspondent of the 240 regiment of the Eighth Division of the Twenty-seventh Army, and joined the army to participate in the battle in the DPRK and participated in the famous Battle of Shangganling. In September 1953, he was discharged due to injury. Won the third class and the fourth class once.

Wu Qingbo (94 years old), born in Nan ‘an, Quanzhou, was born in September 1926. In June 1949, he joined the China People’s Liberation Army and joined the 93rd Regiment of the 31st Division of the 11th Army. In March 1951, the 93rd Regiment of the 31st Division of the 12th Army of the Volunteers entered the Korean War, served as a correspondent and monitor, and took part in the famous Battle of Shangganling. Won the second class once.

Zhang Zhen (94 years old), a native of Ninghua County, Sanming City, was born in May 1926. In June, 1949, he participated in the activity of "welcoming the peaceful liberation of the People’s Liberation Army in Ninghua" led by Zhang Zhinong, the Ministry of Industry of Ninghua City. In October 1949, he joined the army and studied at Nanchang Branch of Central South Military and Political University. In June, 1950, he served as the trainee operational staff of the 48th Army Command of the China People’s Liberation Army, and moved around Gannan and northern Guangdong with the army to fight bandits. In February 1951, he participated in the War to Resist US Aggression and Aid Korea, and served as a combat training staff in the headquarters of the 208th Regiment of Chinese people’s Volunteer Army Rocket (Katyusha). He was awarded the third class merit twice and won a military medal of the Democratic Republic of Korea and the title of "People’s Hero".

Lin Jinzhang (87 years old), born in Licheng District, Putian City, was born in 1933. At the age of 16, Lin Jinzhang joined the guerrillas in central Fujian as an underground liaison and joined the Communist Youth League. In April, 1950, Lin Jinzhang officially joined the army, belonging to the Independent 84th Division, and participated in the Battle of Dachen Island and Jiangshan Island. Later, Lin Jinzhang’s troops were ordered to enter the DPRK to participate in the War to Resist US Aggression and Aid Korea, participate in the Battle of Yichuan, and won the third-class merit twice. Later, they worked in the 62nd Engineering Bureau of the Ministry of Railways and returned to Putian in 1958.

Li Liumin (aged 87) now lives in Hanjiang District, Putian City and was born in February 1933. He joined the army in December 1952, and in the same year, he joined Chinese people’s Volunteer Army to go to the DPRK to participate in the war, serving as the deputy platoon leader. In September, 1955, he won the medal awarded by President People’s Republic of China (PRC), and won a third-class merit. Participated in the fifth campaign in 1953. In April 1957, he transferred to the former Fujian Tenth Construction Company, and in 1971, he was transferred to the Third Company of the Tenth Group of the Provincial Automobile Transportation Company.

Lin Jinkui (93 years old), a native of Xianyou County, Putian City, was born in October 1927, joined the army in 1948, joined the War to Resist US Aggression and Aid Korea on October 20, 1950, joined the 15th Army in the Battle of Shangganling in 1952, and then transferred to the Guard Company of the Third Corps, where he won a third class merit and returned to China in August 1955.

Mo Rubai (aged 87), born in December 1932, joined the army in January 1948. His unit was the Fourth Field Army of the Chinese People’s Liberation Army, and he joined the Communist Party of China (CPC) at the age of 17 in December 1949. He used to be an observer of a company of the 17th Regiment to Resist US Aggression and Aid Korea, and won several liberation medals and the Medal to Resist US Aggression and Aid Korea.

Wu Chuanshou (aged 89), born in Songxi County, Nanping City, was born in March 1931. He joined the army in March 1951 and joined the Second Battalion and Third Company of the 79th Division of the 27th Army. In October 1951, he participated in the War to Resist US Aggression and Aid Korea, and successively served as monitor, platoon leader and company assistant instructor. During this period, he won the second-class merit for his outstanding rodent control work in the anti-bacterial war.

李正大(现年93岁),居住于龙岩市新罗区,1927年1月出生,1949年11月参加福建军政大学,为第一期24中队学员,1950年7月分配福州警备司令部九十五师任连队宣传员。1951年1月北上抗美援朝,1952年12月在志愿军空军二十四支队警卫营任文教组长,立三等功1次。

华盛文(现年96岁),龙岩市连城县人,1924年7月出生,先后3次立功受奖,担任过战士、副班长、班长、副排长和排长等职。

刘斌(现年93岁),龙岩市长汀县人,1927年6月出生。1949年12月长汀入伍,1951年1月出国抗美援朝,1953年10月回国,1956年12月于防空部队独立四十二营退伍。在抗美援朝战斗中,他所在的高炮独立营有12门高炮驻扎在朝鲜平安大道,专门守卫大同江大桥等几座大桥的安全。1951年,获颁中国人民政治协商会议全国委员会抗美援朝纪念章。1953年,获颁中国人民赴朝慰问团抗美援朝纪念章。

林赞钦(现年90岁),宁德市蕉城区人,1930年2月出生。1949年9月参加中国人民解放军,入伍二十军六十三师一八九团。先后任炮兵团连文教,司令部管理股书记。1952年9月一八九团志愿军入朝作战,参加了金城战役等战斗,入朝参战期间,林赞钦先后担任司令部管理科书记、一八九团炮兵营参谋。1952年至1953年先后在炮兵团山炮连、炮兵团宣传股荣立三等功两次。

郑日富(现年94岁),宁德市屏南县人,1926年8月出生。1948年6月参加中国人民解放军。参加过解放战争,经历淮海战役瑶山、狼山攻击战、淮海战役围歼战、渡江战役白沙村战斗、强渡黄埔江北站等战斗,荣立三等功一次。1950年10月志愿军二十军八十九师炮兵团志愿入朝作战,参加了朝鲜二次战役社仓里战斗、朝鲜五十天阻击战等战斗,获得抗美援朝保家卫国功劳证、世界和平勋章、抗美援朝纪念勋章。

Xiao Yiwen (99 years old), a native of zhouning county, Ningde City, was born in February 1921, joined the army in June 1948, and joined the party in September 1949. He was a soldier to resist US aggression and aid Korea, and was disabled in the fourth degree because of the war. Xiao Yiwen, who participated in Liaoshen Campaign (won the "Third Class Merit"), Huaihai Campaign (won the "Second Class Merit") and Crossing the River Campaign (won the "Third Class Merit"), participated in the Fourth Battle of Korea (Battle of Tieyuan Highland in Shangganling) in 1951, and was then the squad leader of the eighth stretcher class of the 3rd Battalion of the 78th Division of the 26th Army. In order to save new soldiers, Xiao Yiwen was shot and injured, and lost one of his limbs.

Li Marong (90 years old), born in Shouning County, Ningde City, was born in January 1930. When the Korean War broke out in 1950, Li Marong merged with the People’s Liberation Army troops in Jiangshang District of Zhenghe County into the 10th Company of the 3rd Battalion of the 239th Regiment of the 80th Division of the 27th Army of Chinese people’s Volunteer Army, then entered Korea with the army, participated in the War to Resist US Aggression and Aid Korea, participated in the Battle of Xinxingli and the Battle of Wushengshan, and returned to China in 1953 after the war.

On March 28th, 2014, at Incheon International Airport, the Chinese salute held the coffin of Chinese people’s Volunteer Army’s martyr. (Xinhua News Agency)

On September 28th, 2020, the remains of the seventh batch of volunteers in Korea returned to China for burial ceremony. From 2014 to 2020, a total of 716 volunteers’ remains in Korea returned to China for burial. (CCTV News)

Review the vicissitudes of history

Some people are back.

Some people, sacrificed.

According to incomplete statistics

Since October 1950

Chinese people’s Volunteer Army went to the DPRK to fight.

The War to Resist US Aggression and Aid Korea began.

By July 1953,

The two sides signed the Korean Armistice Agreement

Victory over the War to Resist US Aggression and Aid Korea

The total number of victims in Chinese people’s Volunteer Army is 197,653.

Among them, more than 1,200 people are from Fujian.

Those martyrs who are buried in foreign countries.

The heroic spirit lives in the hearts of the people forever.

Names and deeds of heroes

It has already been written into the glorious history of the people’s army.

The heroic spirit will live on in China forever.

Due to the rush of time, long history and incomplete historical materials, it is difficult to collect personal stories. Now, according to the personal data submitted by various districts and cities in the province, some brief stories of veterans of the War to Resist US Aggression and Aid Korea are selected to look back on those passionate years to commemorate the 70th anniversary of Chinese people’s Volunteer Army’s war to resist US aggression and aid Korea abroad. )

——END——

Text finishing | Ye Mingzhu

Picture material | Integrated with various districts and cities, and partly from the Internet.

Contributed by | Supervision Committee of Ningde Municipal Commission for Discipline Inspection Shouning County Commission for Discipline Inspection

Original title: "Heroes are the brightest coordinates of the nation —— Commemorating the 70th anniversary of Chinese people’s Volunteer Army’s War to Resist US Aggression and Aid Korea"

Read the original text

Great powers take responsibility and make the world a better place.

  On the morning of March 22nd local time, the Supreme Leader of president ended his state visit to Russia.

  This is the first visit by the Chairman of the Supreme Leader after his re-election in president. Ten years ago, President Supreme Leader’s first visit to president was also Russian.

  During that visit, when it comes to the changing times, the Chairman of the Supreme Leader said this:

  We hope that the world will become better, and we have reason to believe that the world will become better.

  Believe, where does it come from? Sino-Russian relations are the coordinates of observation.

  In the past ten years, as the "best group of big power relations", China and Russia have upgraded and deepened from a comprehensive strategic cooperative partnership to a comprehensive strategic cooperative partnership in the new era.

  During this visit, the Chairman of the Supreme Leader clearly stated:

  China and Russia are each other’s largest neighbors,Consolidating and developing long-term good-neighborly and friendly relations with Russia conforms to historical logic and is China’s strategic choice, and will not change because of one thing at a time.

  △Chinese and Russian heads of state jointly met with reporters

  Why can’t Sino-Russian friendship change because of one thing at a time, and how can we make the world a better place?

  To understand these, the first question to be recognized is:

  Why is Sino-Russian relations rock solid?

  To understand the high level of Sino-Russian relations, we can look at a detail of the scene:

  During this meeting, President Putin held a grand welcoming ceremony for the Chairman of the Supreme Leader in the George Hall of the Kremlin.

  The close relationship between the Chinese and Russian heads of state runs through the visit.

  Before the trip, the Chairman of the Supreme Leader and President Putin both published signed articles in each other’s media. In the article, the two tacitly mentioned the experience of communication in the past ten years.

  Chairman of the Supreme Leader: In the past 10 years, I have visited Russia eight times, and every time I came on a whim, I returned with a full load, and together with President Putin, I opened a new chapter in Sino-Russian relations.

  President Putin: I have met and talked with the Chairman of the Supreme Leader for 40 times, and I always find time and opportunities to communicate in various formal occasions or in an informal way without a tie.

  The tacit understanding reflects the clear historical logic and endogenous motivation behind the development of Sino-Russian relations today.

  Where does the motivation come from? You can see from a detail mentioned by the Chairman of the Supreme Leader:

  During this visit, many Russians waved their hands spontaneously where our motorcade passed, which made me deeply feel that Sino-Russian relations have a deep public opinion base.

  Sino-Russian friendship is rooted in the needs of the two peoples, and it is also rooted in the fact that both Chinese and Russian people believe and respect their own paths. This is the foundation of Sino-Russian relations.

  Take your own path well, and you can also give full play to your respective advantages and learn from each other. In this meeting, there is another detail. Putin lamented that China has made great achievements in development, and the whole world is sincerely interested. We are a little envious of China.

  Mutual confidence in the road has made Sino-Russian cooperation grow against the trend.

  Despite the epidemic in the past few years, the trade volume between China and Russia increased by 29.3% last year, reaching a record $190.271 billion. From the perspective of ten years, in 2022, the bilateral trade volume between China and Russia increased by 116% compared with a decade ago.

  Sino-Russian relations have also expanded the development space that others can’t have.

  Among them, energy and high-tech cooperation attract the most attention. We saw that Russian experts participated in the construction of new nuclear power plants in China, and the two countries also explored space technology together.

  △The first highway bridge across the river between China and Russia was officially opened to traffic on June 10th, 2022.

  Ten years ago, the Chairman of the Supreme Leader visited Russia and delivered a speech in Moscow. He mentioned that the world "is increasingly becoming a community of destiny in which you have me and I have you".

  Since then, in the series of summits of the 70th anniversary of the founding of the United Nations in 2015, the G-20 Business Summit in 2016 and the Boao Forum for Asia in 2018, the Chairman of the Supreme Leader has elaborated on the community of human destiny, and "building a community of human destiny" has also been written into the United Nations resolution.

  This idea resonated with President Putin.

  The core of the community of human destiny is people, and the key lies in their development. President Putin once quoted a speech from the Chairman of the Supreme Leader, describing the goal of Russian national development:

  What’s the most important? What did China president say? — — Improve people’s lives. There are many ways to achieve the goal, but the goal is common. In Russia, we can’t have a second goal except improving the living standards of our citizens.

  The leaders of China and Russia have the same goal and the same concept, which has led the two countries to quickly realize the close connection between the Eurasian Economic Union and the "Belt and Road Initiative".

  The common concept has not only achieved a better life for the Chinese and Russian people, but also set a good example for China and Russia to get along with each other.

  Why can Sino-Russian cooperation jump out of the thinking of zero-sum game when it is also a big country?

  During this visit, Sino-Russian relations continued to deepen. The two heads of state signed two joint statements, specifying that bilateral economic cooperation will be carried out in eight key directions, and also signed a number of bilateral cooperation documents in the media and other fields.

  However, when it comes to Sino-Russian relations, some "people with a heart" seem to have grasped something and always want to understand the logic of their own "small circle".

  However, in this world, it is not only the cheating in the eyes of some countries. China and Russia have just embarked on a new road of getting along with big countries: non-alignment, non-confrontation and non-targeting at third parties.

  This is also a model of China and Russia as a new paradigm of international relations.

  Compared with the United States, which is used to holding small meetings at conferences and amplifying conflicts of opposites, China and Russia will maintain communication and coordination when there are major events, and push countries around the world to reach important consensus.

  Iran and Saudi Arabia, which have just reconciled in the last century, have just become members and dialogue partners of the Shanghai Cooperation Organization in the last two years. China and Russia are both important members of Shanghai Cooperation.

  △On September 19, 2022, Iranian President Leahy delivered a speech at the SCO summit in Samarkand.

  Earlier, the expansion of the SCO for the first time brought India and Pakistan, two "old enemies", together for the first time. After India and Pakistan joined the SCO, the Chairman of the Supreme Leader first proposed the SCO community of destiny and wrote it into the SCO joint statement.

  The expansion of the SCO vividly explains the background and attraction of democratization of international relations contained in the community of human destiny.

  So, what we saw was that on the eve of the SCO summit last year, there was even a grand occasion of "a series of countries queuing to join the organization".

  The expansion again and again shows the fission of the influence of the new paradigm of international relations led by China and Russia.

  In the future, where the world will go, China and Russia have opened up another road.

  Before the Supreme Leader went to Russia, he just put forward the global civilization initiative. He said:We should understand different civilizations’ understanding of value connotation with a broad mind, and do not impose our own values and models on others or engage in ideological confrontation.

  △High-level Dialogue between the Communist Party of China (CPC) and World Political Parties

  Not long ago, when President Putin delivered a State of the Union address to the Federal Assembly, he expressed a similar proposition: "Russia’s position is that it cannot be divided into ‘ Civilized country ’ And other countries. We are opposed to any exclusivity. "

  Under this concept, we also see that more and more countries choose to join the Shanghe and BRICS where China and Russia are located. Everyone is willing to build relations with other countries on the basis of equality and mutual respect, rather than being the object or follower of a certain country’s orders.

  Together, China and Russia are firmly defending international justice and making the space for hegemony and bullying smaller and smaller.

  What is the practical significance of the new paradigm of Sino-Russian relations for solving the current world crisis?

  On this issue, China’s actions and position on the Ukrainian crisis are the best explanation.

  During this visit, the two heads of state signed an important joint statement.

  In the joint statement, China and Russia emphasized that,Solve the Ukrainian crisis through peace talks.

  Just before the Supreme Leader’s current visit, State Councilor and Foreign Minister Qin Gang telephoned Ukrainian Foreign Minister Kuleba.

  During the call, Kuleba made a remark that is particularly noteworthy: the position paper on the political settlement of the Ukrainian crisis issued by China reflects the sincerity of promoting a ceasefire and stopping the war.

  Obviously, for both Russia and Ukraine, there is a willingness to resolve the Ukrainian crisis peacefully. The two sides are currently deadlocked, and what is lacking is a negotiating table.

  This, China see very clearly. China, too, has become the only country among the major powers that has systematically put forward a political solution to the Ukrainian crisis.

  On February 24th, on the occasion of the first anniversary of the escalation of the Ukrainian crisis, China timely issued the document "China’s Position on Political Settlement of the Ukrainian Crisis". This document has been positively evaluated by countries and international organizations such as Russia and Ukraine.

  Understanding this document, the key word is balance.

  The Ukrainian crisis is very complicated, with parties and initiators. It happened in Europe and spread all over the world. If we use the metaphor of persuasion, if we only consider the security of one side in such a complicated situation, as in the United States, we will only help the military and will only persuade the chaos. On the contrary, only by finding the greatest common denominator can we break the situation.

  Looking at China’s 12 proposals from this perspective, we will find that China’s proposals echo the concerns of all parties and reflect the peace-loving voices of developing countries and the world.

  We are not the maker of the crisis, the party to the crisis, and the behind-the-scenes pusher of delaying the conflict. However, as a peace-loving and responsible big country, China is willing to inject hope into the beauty of the world.

  Creating conditions, providing a platform and playing a constructive role are China’s position and role in the face of world conflicts. Such a role has attracted more and more attention from the world. Kissinger commented:

  China, as a peacemaker, changed the scope of international diplomacy and took an important step towards the goal of becoming a participant in creating the world order.

  Some people are making progress, while others are regressing.

  On the occasion of the meeting between Chinese and Russian leaders, Kirby, the strategic communication coordinator of the National Security Council of the White House, claimed in an interview with the US media that it would be unacceptable if the Sino-Russian meeting issued some form of ceasefire call.

  In the face of this peaceful trip, the United States is obviously in a hurry.

  China and Russia, when some countries continue to fan the flames, provide a hope that the regional crisis situation will not deteriorate and escalate.

  Ten years ago, when the Supreme Leader visited Russia for the first time, he once quoted a sentence from Chernyshevski:

  "The road of history is not the sidewalk on Neva Street. It is completely advancing in fields, sometimes through dust, sometimes through mud, sometimes across swamps, and sometimes through jungles."

  The course of history will not be smooth sailing, but blowing out other people’s lights will not make you brighter; Blocking others’ way will not make you go further.

  In the past ten years, from the "Belt and Road Initiative" to the global development initiative, the global security initiative, and then to the global civilization initiative. With the deepening of Sino-Russian relations, the concept of a community of destiny first mentioned in Russia is becoming more and more abundant.

  China and Russia have also become the most solid practitioners of these ideas.

  China and Russia will always be positive forces to make the world a better place.

Ada turned into a "panda bicycle courier" and held hands with fans to get a happy surprise.


Ada bicycle express

    Enthusiastic fans are a powerful backup for artists on the road to success. Recently, Ada, the anchor of sexy beauty, suffered a "surprise reversal" in her own special Spring Festival program, and was really moved by her own "Liusi" support group.

    Ada recorded a special program outside the Spring Festival that day to send a surprise package to enthusiastic people on a bicycle in the cold weather, but he didn’t expect that this time it was actually designed, not by himself, but by the surprise party. Ada dressed up as a lovely "Panda Express Girl" and came to the destination KTV. She called the other party to come down and pick it up, but the other party had a very bad attitude on the phone. She asked Ada to send it up in person. Although the dedicated Ada felt helpless, she smiled and agreed. When I arrived PARTY the designated room, I found myself cheated. Cake and music sounded in the private room, which was the "Sixth Anniversary of the Foundation of the Support Association" that the "Liusi" spontaneously discussed with the director. Ada was moved to tears in her eyes by the sudden surprise, and made a speech in everyone’s applause, expressing her gratitude for the support and love of the "wickers" all the time. She will definitely work harder and let everyone see more works. At everyone’s invitation, Ada happily held the hand of Liu Si and sang the songs "Sun Shangxiang" and "Unintentional Mistake" in EP "Rock Color of Ada". The fans sang along loudly, and the atmosphere was very warm.

    On that day, the temperature was very low. After Ada finished her "surprise trip", she had to rush to other programs. She reluctantly left and took photos with "Liu Si" one by one to say goodbye. Intimate Ada was afraid that fans would catch a cold because of her, and she didn’t forget to stare at everyone over and over again to put on more clothes. Don’t just be graceful and don’t be warm.

The movie version of "I have a date with a zombie" started shooting, and Bosco Wong played Kuang Tianyou, which made people look forward to it.

According to Hong Kong media reports, the film version of the classic Hong Kong drama "I have a date with zombies" and "Ma Xiaoling the Exorcist Dragon" has officially started shooting. Wu Qianyu, Jie Cai and Ziyu Liao appeared on the set. Chen Shisan, the original screenwriter and Joey Meng Yee Man’s husband, will continue to be a screenwriter and will also serve as producer and director.

I have a Date with Zombies is a TV series planned by ATV in 1998. The plot of the drama is full of imagination, and the actors are superb in acting, which caused a ratings frenzy after broadcasting. The drama version is a series of TV dramas produced by Hongkong Asia Television, directed jointly by Zhiwei Xian and Youye Tan, and starring Yin Tianzhao, Joey Meng Yee Man and Chen Qitai.

Ma Xiaoling, played by Joey Meng Yee Man, and Kuang Tianyou, played by Yin Tianzhao, won unanimous praise from the outside world, which made them soar. After that, while the iron was hot, ATV broadcasted the second and third films in 2000 and 2004, and the reputation and ratings were also very good.

Ma Xiaoling, the exorcist dragon, said that "all those who are fighting against the soldiers are in the front to punish evil". In the first part, the relationship between Joey Meng Yee Man, Kristy Yang and Yin Tianzhao was lamentable, but my favorite is the third part. Apart from zombies, love and many funny things that happened when I traveled back to the Song Dynasty to find Kuang Tianyou’s predecessor "Arrow" and "Arrow" and returned to modern society, it was definitely not because of Joey Meng Yee Man’s black leather pants.

This time, Ma Xiaoling, who is played by Wu Qianyu as a "leg expert" and "money worshipper", still makes people feel that bosco Bosco Wong, who can be "mean" and "cool", is still very much expected to play Kuang Tianyou.

Starring in the Hong Kong media exposure film:

Wu Qianyu Ma Xiaoling (originally Joey Meng Yee Man)

Bosco Wong-Kuang Tianyou (originally Yin Tianzhao)

Jie Cai Wang Zhenzhen (originally Kristy Yang)

Lv Liangwei-Kazuo Yamamoto (original Chen Qitai)

Ziyu Liao-The Future (Original Zhang Wenci)

The reporter also met Chen Shisan, so he came forward to interview him. He said that many people have been looking for him to start filming the film version and tried their best to get the copyright, but it is not convenient to disclose too much. Ask Joey Meng Yee Man if he will make a guest appearance in this film? He still didn’t answer directly. It seems that he wants to keep the film mysterious.

The so-called classic is called classic because the characters have gone deep. I hope this film can also bring a new upsurge of nostalgia for Hong Kong. After all, in the 1970s and 1990s, the glory of Hong Kong movies left many viewers with good memories.

Editor in charge: