Changsha Evening News (all-media reporter Peng Fang correspondent Chloe Wang Zeng Fan) Ms. Li, 50, has the greatest pleasure of cooking a sumptuous dinner for her family after work every day. A few days ago, Ms. Li participated in the physical examination of the unit. The results of low-dose spiral CT showed that "the space-occupying lesion of the upper lobe of the right lung does not rule out malignant lesions", and she was subsequently diagnosed as peripheral lung cancer in Hunan Cancer Hospital. Ms. Li wondered how she and her family could get lung cancer because they don’t smoke, and they usually have a healthy diet and a regular schedule. Wang Wenxiang, director and chief physician of the Second Department of Thoracic Surgery, Hunan Cancer Hospital, pointed out that in recent years, more and more patients with peripheral lung cancer were found in physical examination, and most of them were female patients who did not smoke. The academic circles thought it was related to their long-term exposure to high-temperature kitchen fumes.

　　Some surveys have found that women’s long-term exposure to high-temperature fumes will increase their risk of lung cancer by 2-3 times. Among non-smoking female lung cancer patients, more than 60% have long-term exposure to kitchen fumes; 32% women like to fry food in high-temperature oil when cooking, and the kitchen doors and windows are closed or poorly ventilated.

　　Wang Wenxiang pointed out that different cooking oils have different smoke points, and the higher the smoke point, the healthier the cooking oil. Among the commonly used edible oils, camellia seed oil has a high smoke point and can be used as a healthy first choice for cooking. In the cooking process, try to use medium fire, and control the temperature when cooking, so as not to smoke as the limit, which can not only reduce the damage of fatty acids and vitamins caused by high temperature, but also minimize the generation of smoke; Try to choose a pot with a thick bottom for cooking, so as to reduce a lot of oil smoke generated by the sharp rise of temperature in the wok; Try to use cooking methods such as steaming, boiling and stewing to reduce the oil smoke caused by frying; Ensure good ventilation in the kitchen, clean the range hood regularly, and wear a mask when necessary to reduce the smoke inhalation.

　　Wang Wenxiang reminded that the clinical cure rate of early lung cancer is over 80%, especially for women’s early lung cancer, most of which are peripheral lung cancer. Thoracoscopic surgery can achieve radical cure of lung cancer through 1 ~ 3 keyhole-sized operation incisions, and the curative effect is not inferior to that of large incision open surgery.

guide reading

On September 4th, the newly-developed recombinant novel coronavirus vaccine for inhalation (adenovirus type 5 vector) was put forward by the National Health and Wellness Commission, and was approved by National Medical Products Administration to be used as booster for emergency use, making it the first inhaled COVID-19 vaccine in the world.

On October 25th, Shanghai started the registration of intensified immunization with recombinant Covid-19 vaccine for inhalation (adenovirus type 5). On 26th, the immunization with recombinant Covid-19 vaccine (adenovirus type 5) for inhalation was started.

What is recombinant Covid-19 vaccine for inhalation? This non-injected, non-cold chain COVID-19 vaccine was called "revolutionary ideal" by Academician Chen Wei. What’s good about this "ideal" vaccine?

Chen Wei, researcher of Academy of Military Sciences, vice chairman of China Association for Science and Technology and academician of China Academy of Engineering.

↓↓↓

Studies at home and abroad have proved that enhanced immunization with Covid-19 vaccine can enhance the protection effectiveness and prolong the protection period.

The so-called atomization inhalation immunity means that the vaccine is atomized into tiny particles by an atomizer, and then enters the respiratory tract and lungs by breathing inhalation, thus stimulating mucosal immunity, which cannot be brought by intramuscular injection. Generally, intramuscular injection of COVID-19 vaccine can only induce humoral immunity and cellular immunity. In addition, immunization with atomized inhalation is painless and has higher accessibility.

Immune response and specific antibodies induced by intramuscular injection are easier to enter the blood circulation system, but their contents in nasal cavity and lungs are not high enough to achieve immune effect quickly when the virus invades. It takes a certain reaction time for these antibodies to reach the respiratory tract from the blood, but the virus invades our body and usually seizes this time difference, so many people are infected during this time.

However, this non-injected vaccine is inhaled, and only one-fifth of the dose of the vaccine is injected each time. It can also induce mucosal immunity through atomized inhalation to achieve the best effect of triple immunity, which can not only block the infection of Covid-19, but also inhibit the spread of the virus.

According to the relevant requirements of the state, citizens only need one dose of hypohomologous booster immunization or sequential booster immunization at present. When people aged 70 and over are vaccinated, they should be accompanied by family members or volunteers.

COVID-19 vaccine for inhalation 18 questions

1. What is recombinant Covid-19 vaccine for inhalation?

Answer: The recombinant Covid-19 vaccine for inhalation (adenovirus vector type 5) uses an adenovirus vector harmless to human body to deliver the genetic material expressing S protein into human body, and uses an atomizer to atomize the vaccine into tiny particles, which can reach the lung tissue through oral breathing by inhalation, thus stimulating triple immunity of mucosa, body fluid and cells.

2. What are the conditions for inoculation of recombinant Covid-19 vaccine for inhalation?

A: At this stage, the inactivated vaccine produced by Sinopharm China Biotechnology Co., Ltd., Beijing Institute of Biological Products Co., Ltd., Sinopharm China Biotechnology Co., Ltd., Wuhan Institute of Biological Products Co., Ltd. and Beijing Kexing Zhongwei Biotechnology Co., Ltd. and the intramuscular recombinant COVID-19 vaccine (adenovirus type 5) produced by Kangxinuo Biological Co., Ltd. can be used to carry out one dose of booster immunization for people aged 18 and above for six months. Recombinant Covid-19 vaccine for inhalation (adenovirus type 5 vector) is not used for basic immunization for the time being.

All kinds of people only need to be vaccinated with one dose of hypohomologous booster immunization or sequential booster immunization.

3. What is the dose of recombinant Covid-19 vaccine for inhalation?　

A: The dosage is 0.1mL each time.

4. Can people over 60 be vaccinated? Can people under 18 be vaccinated with recombinant Covid-19 vaccine for inhalation?

A: At present, the recommended vaccination population for inhalation dosage forms is people aged 18 and above.

5. How effective is the booster immunization of recombinant Covid-19 vaccine for inhalation?　

A: At present, the clinical study of sequential booster immunization with recombinant Covid-19 vaccine for inhalation and inactivated novel coronavirus vaccine in healthy adults aged 18 and above in China shows that sequential booster immunization with recombinant Covid-19 vaccine for inhalation and inactivated vaccine can significantly enhance the immune response.

6. What is the immune persistence of recombinant Covid-19 vaccine for inhalation?

A: Immunization persistence research shows that after 6 months of heterologous inoculation with recombinant Covid-19 vaccine for inhalation, the neutralizing antibody remains at a high level.

7. What is the safety of recombinant Covid-19 vaccine for inhalation?

A: A safety study conducted among tens of thousands of people showed that the recombinant Covid-19 vaccine for inhalation was safe for people over 18 years old, and no serious adverse reactions were found.

8. What are the vaccination contraindications of recombinant Covid-19 vaccine for inhalation?

Answer: (1) Those who are allergic to the active ingredients, any inactive ingredients and substances used in the production process, or those who have been allergic to similar vaccines before.

(2) Those who have had severe allergic reactions to vaccines in the past (such as acute allergic reactions, angioneurotic edema, dyspnea, etc.).

(3) Patients with uncontrolled epilepsy and other progressive nervous system diseases have a history of Guillain-Barre syndrome.

(4) People who are suffering from fever, or acute diseases, or acute attacks of chronic diseases, or patients with uncontrolled serious chronic diseases;

(5) Pregnant women.

9. Can patients with chronic diseases be vaccinated with recombinant Covid-19 vaccine for inhalation?

A: According to the Technical Guidelines for Vaccination in Covid-19 (First Edition), people with chronic diseases are at high risk of severe illness and death after being infected with Covid-19. People with chronic diseases with stable health and good drug control are recommended to be vaccinated. Vaccination is suspended when chronic diseases are in acute attack. Have a history of convulsion, epilepsy, encephalopathy or mental illness or family history; Have a history of asthma, chronic obstructive pulmonary disease, pulmonary fibrosis and other basic diseases or abnormal lung function; Use with caution in patients with impaired immune function (such as malignant tumor, nephrotic syndrome and other immunodeficiency diseases).

10. Do people cured in COVID-19 need to be vaccinated with recombinant Covid-19 vaccine for inhalation?

A: According to the Technical Guidelines for Vaccination in Covid-19 (First Edition), it is rare for Covid-19 to be reinfected within 6 months after infection. In the past, COVID-19 virus infected people (patients or asymptomatic infected people) can be vaccinated with one dose after 6 months on the basis of full notification.

11. Can people with allergies be vaccinated with recombinant Covid-19 vaccine for inhalation?

A: In the Technical Guide for Vaccination in Covid-19 (First Edition), it is clear that those who have had severe allergic reactions to vaccines in the past (such as acute allergic reactions, angioneurotic edema, dyspnea, etc.) are contraindications for vaccination of Covid-19 vaccines; In addition, the severity of allergies and allergens should be considered and implemented according to the doctor’s advice.

12. How to inoculate recombinant Covid-19 vaccine for inhalation?

A: Please practice several times before inhaling, and then start the formal vaccination.

Step 1: Take a deep breath first (do not exhale into the atomizing cup);

Step 2: hold the nozzle of the atomizing cup in your mouth, and inhale deeply until there is no fog in the cup;

Step 3: Hold your breath for more than 5 seconds (at least 5 seconds), then breathe normally, and the inoculation is over.

13. Under what circumstances should we re-inhale recombinant Covid-19 vaccine for inhalation on the spot?

Answer: (1) There is obvious misty gas in the atomizing cup after inhalation;

(2) Cough and early exhalation occur during inhalation (including 5-second breath-holding period).

Suction failure needs to inhale a dose of vaccine again, and only one repeated inhalation is allowed.

14. What should I pay attention to after vaccination with recombinant Covid-19 vaccine for inhalation?

A: You should stay on the spot for at least 30 minutes after inoculation. Avoid contact with previously known allergens and common allergens within one week after inoculation, and try not to drink alcohol, eat spicy food or seafood. It is recommended to have a light diet and drink plenty of water.

15. What adverse reactions may occur after vaccination with recombinant Covid-19 vaccine for inhalation?

A: Common systemic adverse reactions include symptoms such as fatigue, headache, fever, dry mouth and swollen throat. Generally, they can recover by themselves without special treatment.

16. Will the inoculation of recombinant Covid-19 vaccine for inhalation affect the results of nucleic acid test and antigen test?

Answer: The characteristic of adenovirus vector COVID-19 vaccine is that it only contains the gene sequence of S protein and expresses antigen in human cells, and it does not contain the open reading frame 1ab(ORF1ab) and nucleocapsid protein (N protein) at the nucleic acid detection site, so the vaccination of this vaccine will not cause COVID-19 to be positive for nucleic acid detection.

17. Can I be vaccinated during pregnancy?

A: If you are pregnant after vaccination or have been vaccinated in the case of unknown pregnancy, based on the understanding of the safety of the above vaccines, it is not recommended to take special medical measures (such as termination of pregnancy) just because you have been vaccinated with Covid-19 vaccine. It is recommended to do a good job in pregnancy examination and follow-up. For women who have a pregnancy plan, it is not necessary to delay the pregnancy plan just because of Covid-19 vaccination.

18. After three injections, do I need to get another vaccine for inhalation?

A: According to the guidelines on vaccination work, those who have already completed the booster immunization will not be given further booster immunization at this stage.

Source: The Paper, Shanghai Publishing, Jinshan CDC, Science and Technology Daily. 　 　

　　Xinhua News Agency, Tokyo, August 24th(International observation) How to talk about honesty after a long period of planning — — Before and after Japan’s decision to discharge nuclear polluted water into the sea

　　Xinhua news agency reporter

　　According to the decision of the Japanese government, Fukushima nuclear polluted water began to be discharged into the sea on August 24. This sewage disposal process will last for decades.

　　Tracing back to the whole process of Japan’s decision to discharge nuclear polluted water into the sea, we can clearly see that discharging nuclear polluted water into the sea is its long-planned "established policy", which is an out-and-out violation of international law and an extremely selfish and irresponsible state act. As a result, the cost of handling the Fukushima nuclear accident will be passed on to the whole world.

　　Nuclear polluted water has been discharged into the sea for a long time

　　Since the Fukushima Daiichi nuclear power plant suffered a serious accident in March 2011, a large amount of high-concentration nuclear polluted water has been produced every day due to the cooling of the melted core with water and the flow of rainwater and groundwater. In April 2011, Tokyo Electric Power Company, the operator of the nuclear power plant, deliberately discharged nuclear polluted water into the sea, which aroused great concern and concern in society. In December of the same year, TEPCO said that it had formulated a plan to discharge "low-concentration polluted water" into the sea.

　　In March 2013, TEPCO’s key facility "Multi-nuclide Treatment System" (ALPS) was put into trial operation, but since then, there have been many problems: frequent water leakage, and radioactive substances such as strontium in the treated water still exceeded the standard in 2018. In 2021, it was found that nearly half of the filter screen of the exhaust port for adsorbing radioactive substances was damaged & HELIP; …

　　Since ALPS was put into operation, Japan has called the treated nuclear polluted water "treated water". In fact, of the more than 1.34 million cubic meters of nuclear polluted water in the storage tank of Fukushima Daiichi Nuclear Power Plant, more than 1.33 million cubic meters have been treated by ALPS, but only about 30% have reached the standard of "treated water" defined by TEPCO, and the so-called "treated process water" that fails to meet the standard accounts for about 70%. Another 9,000 cubic meters of nuclear polluted water has not been treated by ALPS.

　　And how to solve the final destination of these "treated water"?

　　As early as December 2013, the Ministry of Economy, Trade and Industry, Japan’s nuclear energy authority, set up a working group to conduct technical discussions on the discharge of "treated water". In June 2016, the working group released a report saying that after the evaluation of five methods, such as ocean discharge, underground burial (adding cement and then burying it underground), stratum injection (injecting it into the depth of stratum by pipeline), steam release (vaporizing it into water vapor and discharging it into the atmosphere) and hydrogen release (electrolyzing it into hydrogen and discharging it into the atmosphere), it is the "lowest cost" method to dilute the "treated water" and discharge it into the sea.

　　This report set the tone for the later sea discharge plan, but it was strongly opposed by Japanese organizations such as agriculture, forestry and fisheries after its publication. Even Masayoshi Yoshino, then Japan’s minister of recovery, said that he opposed the treatment of nuclear pollution into the sea.

　　However, TEPCO and the Ministry of Economy, Trade and Industry have clearly regarded the sea-discharging plan as an "established policy". In July 2017, the Ministry of Economy, Trade and Industry held the "Local Coordination Meeting on Waste Furnace and Pollution Water Countermeasures" in Fukushima City, posing as a gesture of consultation with the local authorities. However, before the meeting, the then president of TEPCO, Takashi Kawamura, claimed to the media that TEPCO had "made a judgment" on discharging the sea, which caused widespread social dissatisfaction.

　　In order to convince the public, the Japanese government set up a committee with experts in related fields. In August 2018, the Committee held hearings in Fukushima and Tokyo, nominally to listen to the opinions of the people, but in fact it was to endorse the sea exclusion plan. At the hearing, Toyoda, then chairman of the Japan Atomic Energy Regulatory Commission, said that "discharging the sea is the only feasible option" was questioned by all parties. For example, in response to the problem of pollution water storage capacity and lack of open space raised by TEPCO, some people pointed out that 100,000-ton large-scale oil storage tanks can be considered, and the Fukushima Second Nuclear Power Plant, which has identified waste furnaces, can be used for open space. In view of the technical difficulty of nuclear pollution water treatment, it is suggested that the water vapor emission method used in the 1979 Three Mile Island nuclear accident in the United States can be adopted. It is also pointed out that the separation technology of radioactive element tritium which cannot be removed by ALPS is under study and should be discharged after the technology is mature and applied.

　　However, in February, 2020, the above-mentioned committee published a report saying that there are "many problems" in formation injection, underground burial and hydrogen release, and that sea discharge and steam release with precedents are the "realistic options", while emphasizing that sea discharge has "many benefits" over steam release.

　　In April 2021, the Japanese government unilaterally announced that it would discharge nuclear polluted water into the sea in 2023, ignoring domestic and foreign objections. Since then, the preparatory work for sea discharge has begun to advance in full swing: in December 2021, TEPCO submitted a construction plan for water discharge equipment to the Atomic Energy Regulatory Commission; In July 2022, the Atomic Energy Regulatory Commission approved the plan; On January 13 this year, the Japanese government confirmed that it will implement the sea discharge in the "spring and summer"; On June 26, TEPCO announced the completion of the construction of sea discharge equipment; On July 7, the Atomic Energy Regulatory Commission delivered the "Certificate of Acceptance" of the sea discharge facilities to TEPCO.

　　Self-directed and self-performed "authoritative certification"

　　On July 4th this year, Grossi, Director General of the International Atomic Energy Agency (IAEA), visited Japan and submitted a comprehensive assessment report on the disposal of nuclear polluted water in Fukushima to Japanese Prime Minister kishida fumio. According to the report, Japan’s sea-discharging scheme is generally "in line with international safety standards", so Japan claims that the safety of the scheme has obtained "authoritative certification".

　　However, there are many questions about the fairness and scientificity of this report.

　　First of all, the Japanese side first made a decision to discharge the sea, and then entrusted IAEA to make a safety assessment. Obviously, the purpose is not to find a scientific and reasonable solution, but to use the agency to endorse the sea discharge plan.

　　According to the contents of the report, after the Japanese government announced the decision to discharge the sea in April 2021, it signed an "authorization agreement" with IAEA in July of the same year to entrust "evaluating the safety of ALPS water treatment". The evaluation object is only limited to the sea discharge scheme and does not involve other schemes. This means that the evaluation conclusion cannot prove that the sea discharge scheme is the safest and most reliable scheme.

　　Secondly, before Japan officially authorized the IAEA evaluation, it had already started the relevant layout around the "certification card".

　　In April 2013, shortly after ALPS was put into trial operation, the Japanese government invited an IAEA delegation to Fukushima. The delegation released a report a month later, suggesting that Japan start to study the emission problem. At that time, the Director-General of IAEA was the Japanese Amano. In December 2019, Grossi succeeded Amano as the Director General of IAEA, and Japan continued to work for IAEA. In March 2021, Hiroshi Daiyama, then Japan’s Minister of Economy, Trade and Industry, held talks with Grossi, requesting the IAEA to provide support for Japan in eliminating the "reputation damage" caused by nuclear pollution water discharge. On April 14th of the same year, the day after the Japanese government announced its decision to expel the sea, Hiroshi Daishan met with Grossi again, requesting IAEA’s support in environmental monitoring and explaining to the international community.

　　"Tokyo News" reported that in the past, the Japanese government paid a huge share of expenses and other payments to the IAEA, and many departments of the Japanese government sent personnel to the IAEA. These factors will inevitably have an impact on the IAEA’s assessment of the safety of Japan’s nuclear pollution water discharge plan.

　　Members of the Common Democratic Party, the largest opposition party in South Korea, pointed out in a meeting with Grossi on July 9 that it is very regrettable that IAEA did not follow the principles of neutrality and objectivity, catered to Japan’s position of discharging nuclear pollution into the sea from beginning to end, and rushed to a conclusion regardless of the impact of this practice on neighboring countries.

　　Thirdly, at the beginning of the IAEA evaluation report, it is emphasized that the opinions in the report do not necessarily reflect the views of IAEA member States, and the report is not a recommendation or endorsement of Japan’s sea discharge plan, and IAEA and its member States are not responsible for any consequences caused by the report. This disclaimer clearly shows that the report cannot represent the opinions of the international community, nor can it prove the legitimacy and legality of Japan’s plan to discharge the sea.

　　Experts from China who participated in IAEA’s technical working group on the evaluation of Fukushima’s "ALPS treated water" for sea discharge — — Researcher Liu Senlin of China Institute of Atomic Energy told the media that the IAEA secretariat had asked for the expert opinions of the technical working group on the draft evaluation report, but the time window left for the experts was very limited, and the expert opinions were for reference only, so it was up to the IAEA secretariat to decide whether to adopt them. After receiving the feedback, the IAEA secretariat hastily released the report without discussing and negotiating with experts from all sides on the revision of the report and the adoption of opinions.

　　Li Song, China’s Permanent Representative to the United Nations and other international organizations in Vienna and Permanent Representative to the International Atomic Energy Agency, pointed out that the conclusion of the IAEA report on the safety of Japan’s sea discharge program is one-sided and lacks persuasiveness and credibility. Due to the limitation of authorization, the agency failed to assess the long-term effectiveness of the Japanese purification device, to confirm the authenticity and accuracy of the data of nuclear polluted water, to ensure that the international community can grasp the situation of excessive discharge in time, and to predict the impact of long-term accumulation and enrichment of radionuclides on the marine ecological environment, food safety and public health. "Without confirmation of accurate data, reliable equipment and effective supervision, it is impossible to draw the conclusion that it is safe to discharge more than 1.3 million tons of nuclear polluted water into the ocean within 30 years."

　　Pretending to be a show, worrying about integrity

　　The Fukushima Daiichi nuclear power plant has a marine life breeding room, which keeps the common flounder along the coast of Fukushima. One of the tanks is ordinary seawater, and the other is treated nuclear polluted water, which is called "treated water".

　　From a scientific point of view, experts and environmental protection organizations have many doubts about the nuclear pollution water treatment and other related data provided by TEPCO.

　　Professor ferenc Dalnoki-Veres, an expert in nuclear physics at Middlebury Institute of International Studies in the United States, pointed out that the data provided by Japan were "incomplete, incorrect, inconsistent and one-sided". The Japanese environmental protection group "FoE Japan" pointed out various problems in TEPCO’s statement about "treating water": some radioactive elements such as iodine 129 and strontium 90 still exceeded the standard after being "treated" by ALPS; The water samples detected by TEPCO so far only account for 3% of the stored polluted water, and the test results provided by TEPCO are not representative. The "treated water" in Fukushima is in direct contact with the melted core and cannot be compared with the normal nuclear power plant drainage … …

　　What is even more worrying is that TEPCO had a "black history" of tampering with data and concealing the safety of nuclear power plants.

　　On the third day after the Fukushima nuclear accident in March, 2011, TEPCO was able to judge the core meltdown of Units 1 to 3 according to the relevant data, but it was always whitewashed with "core damage" until two months later, when it admitted the core meltdown. TEPCO later admitted that it was intentionally concealing the truth according to the instructions of the then president. TEPCO once claimed that no new nuclear polluted water was discharged into the sea after June 2011, but with the exposure of a series of leakage incidents in 2013, TEPCO finally admitted that high-concentration nuclear polluted water leaked into the sea, saying that it was not announced in time because of fear of affecting the reputation of local fisheries; In September 2021, when TEPCO reported the damage of ALPS exhaust filter, it admitted that the same filter was damaged two years ago, but it was not reported, and the reason was not investigated. It was just a matter of replacing the filter. In October 2022, TEPCO was exposed to mislead visitors with a problematic radiation detector to prove the safety of "ALPS treating water".

　　Guan Guzhi, a scholar at the University of Tokyo, also pointed out that not only in Fukushima, but also in other nuclear power plants under TEPCO, management and safety problems are constantly occurring, which makes people unable to believe its disposal capacity. "Does TEPCO have this qualification to discharge into the ocean?"

　　The dishonesty of TEPCO and the Japanese government is also manifested in the attitude of reneging. The plan of discharging nuclear polluted water into the sea has been strongly opposed by local fishermen all over Japan, especially in Fukushima. Under this circumstance, TEPCO and the Japanese government assured the Fukushima Federation of Fishery Synergies and the Japan National Federation of Fishery Synergies in August 2015 that they would not discharge nuclear polluted water into the ocean until they were understood by fishermen and other relevant parties.

　　Although the Japanese government tried every means to convince the fishermen, it never succeeded. Since 2020, the Japan National Federation of Fishery Synergies and the Fukushima Federation of Fishery Synergies have passed special resolutions for four consecutive years, resolutely opposing the discharge of nuclear polluted water into the sea. However, regardless of opposition, the Japanese government and TEPCO violated their own commitments and insisted on promoting the sea discharge plan.

　　Yasushi Sakamoto, president of the National Federation of Fishery Cooperatives, said after meeting with Yasutoshi Nishimura, Minister of Economy, Trade and Industry, on July 14th this year that it is impossible to change the opposition position as long as we are not at ease with emissions. After exchanging views with Yasutoshi Nishimura on 11 July, Nozaki Tetsuo, president of Fukushima Fisheries Cooperative Association, stressed that the fishermen could not tolerate the discharge of nuclear polluted water into the sea, in contrast to the government’s promise of "no disposal" without the understanding of relevant parties.

　　Point the deer at the horse and pretend to be false.

　　Faced with the strong opposition at home and abroad to the discharge of nuclear polluted water into the sea, the Japanese authorities launched an intensive public relations campaign to confuse the audience and publicize the "safety theory of nuclear polluted water" as a key point of Japanese diplomacy.

　　Japanese Ministry of Foreign Affairs, Ministry of Economy, Trade and Industry, Reconstruction Agency and other government departments have set up special links on the homepage of official websites to promote the safety of ALPS "water treatment". The social media accounts of the Ministry of Foreign Affairs and the Ministry of Economy, Trade and Industry also put relevant promotional videos at the top or in a prominent position, and launched multilingual versions.

　　Japan holds the rotating presidency of the Group of Seven (G7) this year. During the G7 Climate, Energy and Environment Ministers’ Meeting in April this year, Japanese Minister of Economy, Trade and Industry Yasutoshi Nishimura declared at the press conference that "including ‘ Treated water ’ The steady progress of waste furnace work, including discharging into the sea, was welcomed. As a result, German Environment Minister Lemcke said on the spot that "discharging (nuclear polluted water) into the sea is not welcome". The Japanese side originally tried to insert "Welcome to the transparent process of discharging the sea" into the joint communique of the meeting to show "international recognition". This statement was opposed by Germany, but the Japanese side still used the host status to write "Welcome … … Japan and IAEA’s transparent efforts based on scientific evidence "and" supporting IAEA’s independent review ". The same content later appeared in the joint communique of the leaders of the Hiroshima Summit of G7 in May.

　　The Japanese side also launched a public relations offensive against Pacific island countries. These island countries suffered greatly from the nuclear test of the United States in the Pacific Ocean in the past, but now there is a strong opposition to the discharge of nuclear polluted water from Fukushima, which has become the key "appeasement" object of Japan. According to the report released by the Ministry of Economy, Trade and Industry on July 31, Japan has conducted "explanation work" for all members and regions of the Pacific Island Forum since February this year.

　　The Japanese side also frequently held briefing sessions for diplomats and foreign journalists from various countries in Japan, and tried every means to publicize the "safety" of nuclear polluted water discharging into the sea. In Japanese explanations, especially in foreign language versions, "treated water" is generally used to refer to nuclear polluted water, with the intention of diluting its pollution characteristics and potential harm to confuse people. According to some foreign journalists in Japan, once there is any content in their reports that questions the safety of nuclear polluted water discharge, TEPCO and Japanese officials will call and write to put pressure on it.

　　It is worth noting that according to the IAEA’s safety regulations on the discharge of radioactive materials into the environment, authorization for the discharge of radioactive materials should provide information and consultation to the affected stakeholders. "Some interested parties may be in other countries, especially neighboring countries." However, in the face of opposition and doubts from neighboring countries, the Japanese side did not communicate sincerely, but made a mistake and slandered the legitimate concerns of regional countries about the marine environment and food safety as "playing political cards." Some right-wing media in Japan even dressed Japan as a "victim" and angrily threatened to "counter" neighboring countries that raised objections to the discharge of nuclear polluted water into the sea.

　　On July 4th, the Embassy of China in Japan expounded China’s position on the issue of Fukushima nuclear polluted water being discharged into the sea, pointing out that Japan’s so-called "hope for dialogue and consultation with China" was insincere. So far, China has carried out exchanges with Japan in bilateral and multilateral channels and repeatedly expressed the opinions and concerns of professional departments. However, regardless of China’s position, Japan insists on promoting sea discharge according to the established timetable. "If the Japanese side regards sea exclusion as the premise of consultation and blindly imposes sea exclusion on China, what is the significance of such consultation?"

　　The discharge of Fukushima nuclear polluted water into the sea is not a private matter or a trivial matter of Japan, but a business matter and a major event related to the marine environment and human health. The Japanese government ignored the legitimate concerns of the international community, violated its due international obligations, and forced nuclear pollution water into the sea, endangering the marine environment and human health and infringing on the legitimate rights and interests of neighboring countries. It is by no means a responsible country.

Cancer, as one of the most common diseases with high mobility and high mortality in the world, the clinical treatments for its tumors generally include surgery, chemotherapy and radiotherapy. Due to the shortcomings of chemical drugs and various toxic and side effects, people have been committed to developing more effective drug delivery systems for cancer treatment, with the aim of reducing side effects and ensuring its efficacy.

With the progress and maturity of nanotechnology, its advantages are gradually reflected.

Introduction of nano-drugs

Diagram of sustained release process of nano-drugs

Nano-drug and its delivery system

Nano-medicine refers to nanoparticles or nano-carriers, which is a new product produced by the combination of nano-technology and medicine.

Nano-drug delivery system refers to the integration of small drug molecules into nano-materials by means of encapsulation or adsorption.

Advantages of nano-drugs

First, improve the solubility and absorption of drugs.

Nano-sized drugs are different from most chemotherapy drugs. Nano-sized drugs have larger specific surface area, better solubility, faster dissolution, improved absorption properties and better therapeutic effect.

At the same time, due to better solubility, the dosage of patients can also be appropriately reduced.

Second, prolong the drug’s circulation time in vivo, and enrich it to the focus.

Through some modification and treatment on the surface of nano-drugs, the circulation time of drugs in human body can be prolonged, which is beneficial for drugs to reach the lesion site, and special modification may make drugs more concentrated in the tumor site, resulting in better selectivity and targeting properties.

Nano-drugs can enter the tumor tissue through the porous blood vessels of the tumor, and achieve a high degree of penetration and retention in the tumor. Therefore, nano-preparation has excellent properties of high drug loading rate, passive targeting and controlled drug release.

Clinical application of nano-preparation.

Paclitaxel albumin nanoparticles

Paclitaxel is a commonly used anticancer drug in clinic. Here is a brief introduction to the nano-preparation of paclitaxel:

Paclitaxel, a commonly used anticancer drug

Albumin nanoparticles

Albumin nanoparticles are nano-particles based on albumin.

Albumin is an endogenous natural product with the advantages of safety, non-toxicity, non-immunogenicity, biodegradability and good biocompatibility. Moreover, the nanoparticle carrier system has unique targeting, sustained and controlled release characteristics and drug protection.

By high-pressure homogenization, paclitaxel and human serum protein preparation were made into nanometer freeze-dried powder, which can improve the solubility, avoid a large number of paclitaxel nanoparticles aggregation, and help the drug to be absorbed into tumor cells and give full play to its role.

Pharmacological action of paclitaxel

Paclitaxel is an anti-microtubule drug, which can stabilize microtubules by promoting the polymerization of tubulin dimer and inhibiting its depolymerization, thus inhibiting the normal dynamic reorganization of microtubule network during interphase and mitosis.

In addition, paclitaxel can lead to abnormal arrangement of microtubule "bundles", affect the division of tumor cells and promote tumor cell apoptosis during the whole cell cycle and cell mitosis.

indication

The application of albumin nanoparticles in the in vivo delivery of paclitaxel and cancer treatment has become a hot topic in recent years.

Albumin paclitaxel nanoparticles are mainly suitable for the treatment of metastatic breast cancer that failed in combination chemotherapy or breast cancer that recurred within 6 months after adjuvant chemotherapy.

Unless there are clinical contraindications, an anthracycline anticancer drug should be included in previous chemotherapy.

matters need attention

In the process of using paclitaxel albumin nanoparticles, it should be noted that paclitaxel for injection (albumin binding type) also has adverse drug reactions and must be used under the guidance of a doctor with chemotherapy experience.

Only with perfect diagnosis and treatment facilities can the complications and adverse reactions caused by drugs in treatment be effectively controlled.

references

[1] Jie Chen, Cao Ye, Li Shuangshuang, Luo Lailong, Yu Peng, Li Mingyuan. Research progress of novel nano-drug delivery system for tumors [J]. China Journal of Pharmacy, 2020,55(21):1749-1756.

Xin li, Zhu Dandan, Chen Yu, Lin Shuting, Han Lili, Li Ying, Liu Xiaoxuan. Research progress of nano-drug delivery system in promoting deep penetration of tumor [J]. Zhongnan Pharmacy, 2020,18(12):2009-2018.

Zhao Shuang, Zhang Shaofang, Mu Xiaoyu. Research progress of nano-drugs [J]. Tianjin Pharmacy, 2020,32(02):57-61.

Chen Dongxiao, Zhang Juanmei, Li Jianye, Xu Tianhong, Dong Yaqin, Pu Xiaohui. Research status and progress of paclitaxel albumin nanoparticles [J]. Journal of Henan University (Medical Edition), 2017,36(04):296-300.

[5] Chen Kang. Analysis of the research progress of paclitaxel pharmaceutical preparations [J]. Heilongjiang Medicine, 2019,32(06):1390-1392.

Contributed by: Song Haolin (Ruijin Intern Pharmacist)

Original title: "How do nano-warriors fight cancer-do you understand? 》

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Recently, with the overall promotion of epidemic prevention and control and economic and social development, the production and living order has been accelerated, the income growth rate of the national residents has maintained a rebound, and the consumer market has continued to rise steadily. Analysts believe that the strong resilience of China’s consumption has become an important ballast stone for China’s economy to resist the wind and waves in the first half of the year. In the second half of the year, the continuous efforts of policies such as expanding domestic demand, helping enterprises to bail out difficulties and stabilizing employment are expected to promote further compensation and recovery of consumption, thus adding more impetus to promoting the "big cycle" of domestic economy and the "double cycle" of domestic and international.

Income recovery and demand recovery

According to the latest data, in June, the total retail sales of consumer goods nationwide was 3.35 trillion yuan, down 1.8% year-on-year, and the decline narrowed for four consecutive months, with a cumulative decrease of 18.7 percentage points. From January to June, the total retail sales of social consumer goods was 17.23 trillion yuan, down 11.4% year-on-year, and the decline was 7.6 percentage points narrower than that in the first quarter.

"In the first half of the year, all localities adhered to the orientation of people’s livelihood, issued various consumer vouchers, developed the’ night economy’ through the integration of literature and tourism, helped invigorate the’ small store economy’, expanded consumption according to local conditions and took various measures to vigorously promote the recovery of household consumption. In the first half of the year, the decline in per capita consumption expenditure of the national residents narrowed significantly, with the nominal decline and the actual decline narrowing by 2.3 and 3.2 percentage points respectively compared with the first quarter. Residents’ daily necessities such as rice, flour, grain and oil, vegetables, meat, poultry and eggs were fully guaranteed, and residents’ home meals increased. In the first half of the year, the per capita expenditure on food, tobacco and alcohol increased by 5.0%, 2.9 percentage points faster than that in the first quarter. " Fang Xiaodan, director of the Household Survey Office of the National Bureau of Statistics, said.

It is worth noting that the rising growth rate of national residents’ income is inseparable from the gradual recovery of residents’ consumption level. The data shows that in the first half of the year, the per capita disposable income of the national residents was 15,666 yuan, a nominal increase of 2.4% over the same period of last year, and the nominal growth rate was 1.6 percentage points higher than that in the first quarter. After deducting the price factor, the actual decline was 2.6 percentage points narrower than that in the first quarter. At the same time, in the first half of the year, the per capita wage income of the national residents was 9010 yuan, an increase of 2.5%, 1.3 percentage points faster than that in the first quarter, and the per capita disposable income of the national residents increased by 1.4 percentage points.

Fang Xiaodan said that in terms of wage income, the resumption of work and production in various places has been solidly promoted, the vitality of economic and social development has recovered, and the economic fundamentals have laid the foundation for wage income growth; In operational income, the phased tax reduction and fee reduction, rent reduction and interest rate reduction, inclusive finance and other policy support have effectively reduced the production and operation costs of self-employed households and small and micro enterprises, and their operating conditions have improved compared with the first quarter.

There are many highlights in online consumption.

In the first half of this year, "offline limited online replenishment" became an important feature in the consumer field.

According to the data of the National Bureau of Statistics, under the prevention and control of the normalized epidemic situation, new consumption formats and new modes such as online shopping, online entertainment and online classroom are growing against the trend. For example, in the first half of the year, the number of people buying goods or services through the Internet generally increased, and the per capita postage expenditure increased by 10.8%. For another example, in order to meet the needs of home office study, the per capita spending on home desktop computers and notebook computers increased by 19.4% and 79.6% respectively in the first half of the year.

According to the Report on Economic War and Epidemic in 2020 yards jointly released by Tsinghua University China Economic and Social Research Center and Tencent Social Research Center, in the economic recovery, leisure, entertainment, restaurants, hotels and transportation rebounded most significantly, and the number of WeChat transactions increased by 7-10 times. In the last week of April, the average daily commercial transaction volume of WeChat payment has recovered to the level of the end of 2019. The report believes that the innovation of online mode under the WeChat ecosystem will further promote the upgrading of people’s lifestyles, and the depth and breadth of lifestyle online will enter a new stage, and scene, intelligence and personalization will become the development trend of lifestyle change.

Fu Yifu, a senior researcher at Suning Financial Research Institute, analyzed that in the first quarter, affected by the COVID-19 epidemic, the all-round rise of online consumption was the biggest highlight. In the second quarter, as the domestic epidemic prevention and control situation continued to improve, all walks of life resumed production and markets steadily, and the intensity of new kinetic energy for online consumption did not decrease. At the same time, offline consumption scenes such as scenic spots, restaurants and hotels also returned to the public’s field of vision, and many consumers’ consumer demand that was forced to postpone during the epidemic prevention and control period began to restart.

Zhao Ping, director of the International Trade Research Department of the China Council for the Promotion of International Trade, believes that the epidemic has further enhanced consumers’ online consumption habits, and the growth rate and proportion of online consumption have continued to increase, which has become the biggest highlight of consumption growth in the first half of the year. At the same time, online consumption has also spawned new consumption patterns such as community e-commerce, social e-commerce, community e-commerce and live delivery, thus effectively releasing the potential of online consumption.

Tamp the economic pressure resistance.

Weigh, a researcher at the Institute of World Economics of Shanghai Academy of Social Sciences, pointed out in an interview with this reporter that both the "six stability" work and the "six guarantees" task will ultimately be supported by strong consumption power. Since the beginning of this year, in the face of the great test brought by the COVID-19 epidemic, China has scientifically handled the relationship between the prevention and control of normalized epidemic and economic and social development, especially by adjusting the consumption pattern in time and effectively meeting the rigid consumption demand, thus achieving the maximum risk hedging and economic stability.

"In the process of gradually forming a new development pattern with domestic big circulation as the main body and domestic and international double circulation promoting each other, consumption is an important connection point of domestic and foreign market players and plays a very important role. Judging from the actual situation in the first half of the year, the rebound of consumer demand in China has not only become an important supporting force for China’s economy to resist all kinds of risks, but also injected strong confidence into the world economy. In the future, the role of consumption will be further highlighted. " Weighing theory.

In the eyes of many analysts, consumption is a clear manifestation of China’s economic resistance to pressure in the first half of the year. Yu Hong, a senior researcher at the Institute of East Asian Studies at the National University of Singapore, believes that China has a huge domestic market and a vibrant regional economy. In addition, the government has launched targeted fiscal, taxation and financial measures to support enterprises, which plays an important role in restoring economic growth and shows the resilience and potential of China’s economy.

Xing Ziqiang, chief economist of Morgan Stanley China, said that compared with developed countries, China’s consumption structure is currently dominated by physical consumption. In the future, as residents gradually pursue high-quality life, their consumption focus will shift from meeting basic needs to increasing life experience, and their consumption structure will also shift to service consumption. Xing Ziqiang predicts that consumption will gradually recover in the second half of this year and become the mainstay of economic growth next year, driving economic growth back to its potential level. (Reporter Wang Junling)

Legend of origin

The Dragon Boat Festival, also known as Duanyang Festival and Chung Wu Festival, is said to be the day when Qu Yuan, a great poet in ancient China, threw himself into the Guluojiang River to be martyred. For more than two thousand years, the fifth day of the fifth lunar month has become a traditional festival to commemorate Qu Yuan. According to historical records, on the fifth day of the fifth lunar month in 278 BC, Qu Yuan, a doctor and patriotic poet of the State of Chu, was filled with grief and indignation after hearing the news that Qin Jun had breached the capital of the State of Chu, and his heart ached, so he resolutely wrote Huai Sha. He threw himself into the Miluo River and died. People along the river have led boats to race to salvage, evoking souls along the water and throwing zongzi into the river to prevent fish and shrimp from eating into his body.

Today, the Dragon Boat Festival is still a festival that our people attach great importance to. On May 20th, 2006, this folk custom was approved by the State Council to be included in the first batch of national intangible cultural heritage list. Dragon Boat Festival is now a legal holiday in China.

Festival custom

01 Dragon Boat Race

Dragon boat race is the main custom of the Dragon Boat Festival. According to legend, people who originated in the ancient state of Chu were reluctant to part with the death of Qu Yuan, a sage, and many people rowed to catch up and save. They scrambled to catch up with each other and disappeared when they reached Dongting Lake. After that, I will row a dragon boat on May 5th every year to commemorate it. Dispel the fish in the river by rowing dragon boats, so as not to eat Qu Yuan’s body. The habit of racing is prevalent in Wu, Yue and Chu.

02 eat zongzi

Eating zongzi is another traditional custom of Chinese people. Zongzi, also known as "corn millet" and "zongzi". It has a long history and various patterns. From the Spring and Autumn Period to today, at the beginning of May every year, every family in China has to soak glutinous rice, wash zongzi leaves and make zongzi, with more varieties of colors. From the perspective of stuffing, there are many Beijing jujube dumplings with small dates in the north; In the south, there are many kinds of fillings, such as bean paste, fresh meat, ham and egg yolk, among which Zhejiang Jiaxing Zongzi is the representative. The custom of eating zongzi has been popular in China for thousands of years, and spread to Korea, Japan and Southeast Asian countries.

03 Artemisia argyi and calamus

A folk proverb says, "Willows are inserted in Qingming Festival, and Ai is inserted in Dragon Boat Festival". Every family sweeps the court, putting calamus and moxa sticks in the eyebrows and hanging them in the hall. Acorus calamus, Folium Artemisiae Argyi, Liuhua, Garlic and Dragon Boat Flower are made into human or tiger shapes, which are called Ai Ren and Ai Hu. It is made into garlands and ornaments, which are beautiful and fragrant, and women compete to wear them to drive away evil.

04 hanging bell statue

It is the custom of Dragon Boat Festival for Zhong Kui to catch ghosts. In the Jianghuai area, every family hangs bells and statues to ward off evil spirits. It is said that Emperor Kaiyuan of the Tang Dynasty returned to the palace from Lishan Mountain, and malaria was rampant. He dreamed that two ghosts, one big and one small, were wearing red crotch pants, stealing Yang Guifei’s sachet and Yu Di of the Ming Dynasty, and ran around the temple. GREAT GHOST wears a blue robe and hat, catches the kid, gouges out his eyes and swallows it in one gulp. When the Emperor of the Ming Dynasty asked questions, GREAT GHOST said, "My surname is Zhong Kui, that is, I am not the best in martial arts. I am willing to rid your majesty of demons." After the Ming Emperor woke up, malaria was cured, so Wu Daozi, a painter, painted a portrait of Zhong Kui catching ghosts according to what he saw in his dream, and ordered all the people to post it during the Dragon Boat Festival to exorcise evil spirits.

05 series baisuo

It is made of five-color silk, also known as Baisuo, Longevity Cord, Continuity Cord, Bing Shao, Five-color Cord, Zhu Suo and so on. Or hanging on the door, or wearing children’s neck, or tying children’s arms, or hanging on bed curtains, cradles, etc., it is said that it can avoid disasters, protect health and prolong life. In Ying Shao’s "Customs Tongyi" in the Han Dynasty, it is recorded: "On May 5, the five colors were given to continue life, and the popular saying was beneficial to human life." "The Chronicle of Jingchu’s Age" says: "It is not a disease to tie the arms with colorful silk, which is called" Bing Bing ".

06 drink realgar wine

Painting forehead is the custom of daubing children’s forehead with realgar on Dragon Boat Festival, which is said to ward off poisonous insects. The typical method is to draw the word "Wang" on children’s foreheads with realgar. One is to borrow realgar to drive away the poison, and the other is to borrow tiger’s forehead ("Wang" is like a tiger, and the tiger is the king of beasts, because it is replaced by a tiger) to suppress evil spirits. Qing Fucha Dunchong’s "Yanjing Year’s Chronicle": "From the first day of the first lunar month, take realgar and sprinkle it with wine, and apply it to the collar and nose and ears of children to avoid poison."

07 Dai Xiangbao

The sachet, also called sachet, sachet, purse, etc., is wrapped with colored silk thread and sewn with rags. It is filled with spices (made from Chinese herbal medicines, such as Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Radix Scutellariae, Herba Paicao, Rhizoma Kaempferiae, Gan Song, and Radix Kaempferiae), which is worn on the chest and smells fragrant. Chen Shiliang’s Guang Ji at the Age of Years quoted Miscellaneous Notes at the Age of Years as saying, "Duanwu is made of red and white colors, and colored lines run through it, making it look like a flower." The contents of these carry-on bags have changed from sweat-absorbing mussel powder, talisman to exorcise evil spirits, copper coins and realgar powder to sachets filled with spices, and their production has become increasingly exquisite, becoming a unique folk art of the Dragon Boat Festival.

08 collecting miscellaneous drugs

Herb picking is also one of the oldest customs of Dragon Boat Festival. "Xia Xiaozheng" contains: "Store medicine this day to remove poisonous gas." Volume 22 of "Collection of Miscellaneous Drugs" quoted the lost article of "Collection of Miscellaneous Drugs at the Age of Jingchu": "On May 5, competing for miscellaneous drugs can cure all diseases." There is a record of catching toads in May in Qi Min Yao Shu Miscellaneous Notes in the late Wei Dynasty, which is also used for pharmacy.

09 Mulan decoction

It is an ancient custom recorded in "Da Dai Li" to bathe in orchid soup at noon. At that time, orchids were not today’s orchids, but Eupatorium odoratum of Compositae, which had fragrance and could be decocted and bathed. "Nine Songs in the Cloud" also has the sentence "Bathing orchid soup will make you fragrant". "The Chronicle of Jingchu’s Age": "May 5th is called the Orchid Bathing Festival." "Five Miscellanies" records that people in the Ming Dynasty took a bath with five-colored grass at noon because "orchid soup is not available." Later, it was usually fried cattails, wormwood and other herbs to take a bath.

10 doucao

Fighting grass was popular in the Southern and Northern Dynasties, and it was called "stepping on a hundred herbs", and it was called "fighting grass" or "fighting a hundred herbs" in the Tang Dynasty. "The Story of Jingchu’s Age": "On May 5th, the four people stepped on a hundred herbs together, and there was another scene of fighting a hundred herbs." After that, it is not limited to the Dragon Boat Festival.

Original title: Chinese traditional festival-Dragon Boat Festival

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　　Xinhua News Agency, Beijing, August 20th (Reporter Xia Ke) Summer is the season of high incidence of intestinal infectious diseases, with high temperature and humidity, which is conducive to the reproduction of germs, and food is easily contaminated. People like to eat cold food to relieve summer heat, and the chances of infection are further increased. Beijing CDC reminds that attention should be paid to drinking water hygiene and food safety. High temperature can kill pathogenic microorganisms, and drinking water should be boiled before drinking. In addition, don’t use antibiotics as soon as diarrhea occurs. Abuse of antibiotics may lead to imbalance of normal intestinal flora, which is not conducive to recovery.

　　According to reports, the main manifestations of intestinal infectious diseases are diarrhea, nausea, vomiting, abdominal pain, loss of appetite, etc. Serious cases can lead to dehydration, and very few cases are even life-threatening.

　　Experts from Beijing CDC said that to prevent intestinal infectious diseases, first of all, food should be separated from raw food and cooked food to avoid cross-contamination. Leftover food should be stored in the refrigerator in time, and the storage time should not be too long. Before eating again, it needs to be heated until it is completely hot, because the low temperature of the refrigerator can only delay the growth of bacteria, but it cannot be sterilized. In addition, it is necessary to eat as little as possible foods that are easy to carry pathogenic bacteria, such as snails, shells, crabs and other aquatic products, especially seafood stalls on mobile roadsides, and products that are eaten raw or half-eaten. For families with pets, we must do a good job in pet hygiene, and at the same time, we must warn our children not to feed their pets while eating.

　　Experts suggest that if diarrhea occurs, fasting and water restriction are not recommended, and light and digestible liquid or semi-liquid food should be eaten, and the symptoms will gradually transition to a normal diet after improvement. If diarrhea is not serious, the symptoms can be improved within 2 -3 days by adjusting diet, rest and symptomatic treatment. People with severe diarrhea, especially those with dehydration symptoms, should go to the hospital intestinal clinic for medical treatment in time. In order to prevent dehydration, you should drink more sugar and salt water, and it is best to buy "oral rehydration salt" at the pharmacy; Patients who have suffered from dehydration or severe vomiting and can’t drink water should go to the hospital in time and take intravenous rehydration and other treatment measures according to the doctor’s advice.

　　Experts suggest that it is wrong for many patients to use antibiotics as soon as they have diarrhea. Because most diarrhea does not need antibiotic treatment, abuse of antibiotics may lead to imbalance of normal intestinal flora, which is not conducive to the recovery of diarrhea. If you are not sure whether antibiotics should be used, patients should go to the intestinal clinic.

　　Recently, a red-headed document with the name of "State Administration of Market Supervision" and the name of "Retirement Announcement" was circulated in the circle of friends on WeChat. For a time, the problem that the boss of Hunan Shanda Hsi Chin Financial Services Co., Ltd. (hereinafter referred to as "Shanda Hsi Chin") lost contact and was suspected of a thunderstorm surfaced.

　　Shanda Hsi Chin is a financial service intermediary company headquartered in Changsha, Hunan Province. Founded in 2011, it has never obtained a financial-related license, and has been repeatedly punished by the market supervision department for false investment and financing advertisements. But over the years, Shanda Hsi Chin has attracted a large number of customers to invest in the company with an annualized interest rate of more than 10%.

　　Recently, Jibiao Pan, the legal representative and actual controller of Shanda Hsi Chin, lost contact. As early as two months ago, some investors found that the company had been unable to pay the principal and interest. On November 19th, a manager of Shanda Hsi Chin told The Paper that the company had more than 100,000 investment customers, and at present, the unpaid investment funds of the company exceeded 10 billion. The official has not released the specific information about the number and amount involved in this matter.

　　In the early morning of 18th, Shanda Hsi Chin posted a message on its WeChat WeChat official account, saying that the above-mentioned "Retirement Announcement" was used by criminals to defraud customers’ information under the pretext of retiring. On the 19th, Shanda Hsi Chin said that due to multiple factors, the company’s assets, the project party’s assets and the assets actually controlled by affiliated companies will be preserved and disposed of for gradual repayment.

　　Recently, some investors reported to the public security organs. On November 20, the police of Xiangya Road Police Station of Changsha Public Security Bureau, who received telephone consultation from investors, said that the police were currently studying the case and had not yet filed a case. The police are highly concerned about this matter, and the parties can go to the police station in the jurisdiction to register relevant information.

　　On November 1st, Jibiao Pan said at the company meeting that he would not "run away". Video screenshot

　　As soon as the boss said "Don’t run away", he lost contact.

　　The chairman lost contact! This is like "earthquake" news for employees and customers of Shanda Hsi Chin.

　　"The boss went to Yunnan on the 4 th of this month, and he couldn’t be contacted on the 9 th." A manager of Shanda Hsi Chin told The Paper (www.thepaper.cn) that Jibiao Pan, the chairman of the company, had been missing for about ten days.

　　On November 18th, some customers came to the general manager’s office of Shanda Hsi Chin to discuss their views. The pictures in this article are all from The Paper reporter Zhu Yuanxiang (except for special labels).

　　Shanda Hsi Chin is headquartered in the 28th to 38th floors of Golden Landmark Building in Kaifu District, Changsha. On the afternoon of November 18th, a reporter from The Paper came here and found that many customers came here to ask for investment funds, and some offices were crowded with people. Most of the employees in the company don’t know where to go, and a small number of managers are repeatedly explaining to customers.

　　In the grand Hsi Chin conference room, on one side of the wall display screen, there is still a large image of Jibiao Pan — — He wore a suit and tie, his hair was neatly combed, and he looked at the front with a slight smile.

　　The image of Jibiao Pan is placed in the grand Hsi Chin conference room.

　　A manager of the marketing department of Shanda Hsi Chin introduced that Jibiao Pan is the "big boss" of the company, holding 95% of the shares. He went to Yunnan at the beginning of the month to raise money for the company. "His original words are that he has gone to make money."

　　Before Jibiao Pan lost contact, he attended a meeting of the Golden Jubilee on November 1st. On the same day, wearing a dark suit and a red tie, he appeared in the conference room on the 38th floor of the headquarters. The video shows that he speaks with a microphone, indicating that the company is listing assets and taking the initiative to "request supervision" from relevant departments. "Why did I take the initiative to request supervision? This reflects the responsibility and responsibility of me and Shanda Hsi Chin. " Jibiao Pan said at the time.

　　On November 18th, some customers who came to beg for money could not find the person in charge of Shanda Hsi Chin and stood in the corridor of the office building.

　　"Many customers and friends think that I, Jibiao Pan, will abscond with money and transfer assets," Jibiao Pan said in a high voice at the meeting. "I tell you, I have never thought of it this way!"

　　A week after this speech, employees of the company found it difficult to get in touch with Jibiao Pan. "Last Friday (November 11), the chairman’s phone could not be dialed, and WeChat did not return." An official of Shanda Hsi Chin said that 72 hours after Jibiao Pan lost contact, the company reported to the public security organ.

　　Jibiao Pan, born in 1973, is a native of Shuangpai County, Yongzhou City, Hunan Province. According to the company website information of Shanda Hsi Chin, Jibiao Pan founded Hsi Chin Credit Guarantee Company in Guangzhou in 1998 and returned to Yongzhou, Hunan Province in 2007 to "support the economic development of his hometown". In 2011, Jibiao Pan established Shanda Hsi Chin to carry out financial services in Hunan and neighboring provinces. In 2021, Jibiao Pan was elected president of Hunan Xiaoxiang Economic Promotion Association. In 2019, Jibiao Pan acquired Standard Resources Holdings, a listed company in Hong Kong, and changed its name to Hsi Chin International, with it as the chairman of the board of directors.

　　Many investors told The Paper that their trust and investment were based on the propaganda that "Shanda Hsi Chin has defaulted for more than 20 years".

　　Investor Ms. Liu’s investment receipt in Shanda Hsi Chin was provided by the interviewee.

　　Liu E (pseudonym) works in a hospital in Shuangpai County, Yongzhou City. She said that in 2016, she invested 200,000 yuan recommended by the salesman of Shanda Hsi Chin, and in November 2021, she invested another 400,000 yuan. After the previous investment of 200,000 yuan expired, she thought that her son would need money to get married. She originally wanted to "take it out", but she could not bear the salesman’s persuasion and continued to sign it for half a year.

　　"The salesman said that it is investing in medical equipment, and the robot is still awkward. Anyway, it is very promising." Liu E said that in October this year, she only received a dividend, and by November 5, the principal of 400,000 yuan that had expired could not be retrieved on time.

　　"Jibiao Pan has been back to Yongzhou and Shuangpai. He said that he will definitely return to his roots in the future. Let us rest assured that he will not treat his hometown badly." Liu Wei said.

　　Tang Fulian said that the principal she and her family invested was over one million.

　　Tang Fulian in Lengshuitan District of Yongzhou City is also a "hometown" of Jibiao Pan. She once regarded "Pan Zong" as "the pride of Yongzhou people". In 2017, Tang Fulian joined Shanda Hsi Chin as a salesman. For "performance", she encouraged her family to invest, and now the principal invested by herself and her family has reached 1.095 million yuan. "More than 600,000 yuan is borrowed, and I have no money to eat now." When interviewed by The Paper, Tang Fulian, who was begging for money at Shanda’s headquarters in Hsi Chin, cried.

　　Three years ago, Li Nanhui of Changsha Kaifu District entered the subsidiary of Shanda Hsi Chin — — Changsha Kaifu District Shengda Hsi Chin Financial Services Company became a business manager. He said that most of his customers are relatives and friends. "Now I have 70 or 80 customers, and the money invested ranges from hundreds of thousands to millions. Now, with my own money, there are more than 10 million yuan." Li Nanhui revealed that the investment amount absorbed by Hsi Chin Kaifu District Company was "nearly 150 million".

　　According to reports, the investment projects introduced by Shanda Hsi Chin to customers include coalbed methane, photovoltaic power generation, natural sand and gravel, and "medical health" and other projects. "The product projects he described to us have a good prospect," Li Nanhui said. "But most of these projects are in other places, and we don’t know how much the company actually invested."

　　The last page of a Confirmation of Rights and Interests.

　　The "Confirmation of Equity" presented by several interviewed investors shows that the "annual rate of return" of most previous investments was 14.4%, and some even reached 16%; The return on investment contracted in November this year dropped to 13.2%, still far exceeding the bank interest rate.

　　Judging from the text of the investment contract, the client did not sign an agreement with Shanda Hsi Chin directly, but paid the "joining capital" in the form of "joining the partnership". There is the official seal of the partnership enterprise on the signature of the text, and Shanda Hsi Chin seals it as a "service enterprise".

　　How many customers’ investment funds are currently owed by Shanda Hsi Chin, and how much is involved? Li Nanhui said that the information he learned from the company’s senior management team is that there are currently more than 100,000 customers involved, involving 19.4 billion yuan.

　　When meeting with customer representatives recently, Dr. Xie (name), CEO of Shanda Hsi Chin, said that 19.4 billion yuan is the data provided by the company’s finance, and there may be a small deviation in the statistics of the last three months. "Most of them are in this range, more than 19 billion yuan."

　　"Now all the data are available, but only a rough idea." An executive in Xiangbei District of Shanda Hsi Chin said, "The company has debts of more than 100 billion, involving 140,000 people." In a recent video of receiving customers, a manager of Shanda Hsi Chin introduced: "The volume of (liabilities) counted up to now is more than 20 billion … … If the income is cut off, the remaining principal will be between 8 billion and 10 billion. "

　　"False Propaganda" and Legitimacy Query

　　"Shanda Hsi Chin has about 140 subsidiaries in the country, and there are twelve or three in Changsha alone." Li Nanhui, who has worked in Shanda Hsi Chin for more than three years, said that Shanda Hsi Chin is based in Yongzhou, mainly developed in Hunan, and has also had business in Guangdong, Hubei, Jiangxi and Yunnan in recent years.

　　However, Shanda Hsi Chin, once regarded as reliable by employees and investors, was repeatedly punished for "false propaganda" in the archives of the regulatory authorities.

　　In August, 2016, the new Advertising Law was implemented for one year. At that time, the State Administration for Industry and Commerce exposed 10 typical false and illegal advertising cases, among which the illegal advertising case of Hsi Chin, Hunan Shanda was among them. According to the circular, Hunan Shanda Hsi Chin Financial Services Co., Ltd., the party concerned, used its store publicity and leaflets to publish investment and financing advertisements to the society, fabricated the main body of an enterprise group with no facts in the advertisements, and used the name and image of state organs and state functionaries, and was fined 600,000 yuan.

　　In July 2021, Changsha Kaifu District Market Supervision Administration also issued a fine of 200,000 yuan for the false advertising of Shanda Hsi Chin. The illegal facts identified by Kaifu District Market Supervision Bureau are — — Shanda Hsi Chin declared to the enterprise through its official website, WeChat official account and Hsi Chin monthly magazines: "Shanda Hsi Chin is based in China and radiates all over the world. Established branches in Hong Kong and Shenzhen. In 2019, Shanda Hsi Chin successfully acquired a Hong Kong-listed company (00091.HK), obtained a number of financial licenses and qualifications for the business development of the Hong Kong Securities Regulatory Commission, and accelerated the internationalization strategic layout. "Shanda Hsi Chin officially landed in Hong Kong and successfully obtained the No.1, No.2, No.4, No.5 and No.9 international financial licenses of the Hong Kong Securities Regulatory Commission, which means that the company has obtained the ‘ Pass ’ , officially opened a series of international capital operations. " According to the statement of the party concerned, its legal representative is the executive director and chairman of the board of directors of Hong Kong Standard Resources Holdings Limited, but the party concerned has not obtained the permission or approval to conduct financial business.

　　It was also found out that the parties advertised "Golden Plate" on the page of official website? Blue Mountain City … … Realized a net profit of 460 million, and the return on investment of shareholders was 200%. World City … … The return on investment is 342%, and the annual return of shareholders is 114%, but the "golden plate" has not been submitted. Blue Mountain City "and" Golden Plate "? Proof of the return on investment of the World City cooperation project.

　　In addition, in April and June, 2017, official website, the local financial supervision administration of Hunan Province, published two letters and replies about the illegal fund-raising of Shanda Hsi Chin.

　　All kinds of medals hanging in Shanda’s Hsi Chin office.

　　On May 25, 2017, the Financial Work Office of Hunan Provincial People’s Government replied: "Shanda Hsi Chin is an investment and financing intermediary established by private capital, not a licensed financial institution, and can’t absorb public deposits … … Even if a private financing institution is established by the relevant government departments for the record, it does not mean that the government or relevant departments will undertake any guarantee or ‘ Bottom ’ Responsibility. "

　　In the inquiry about whether Shanda Hsi Chin is illegal fund-raising, the Financial Office of the Hunan Provincial Government explained the criminal and civil meanings of illegal fund-raising in its reply on July 11, 2017, and said, "Hunan Shanda Hsi Chin Financial Services Co., Ltd. is a private investment and financing intermediary established by private capital. Whether it is suspected of illegal fund-raising in specific business activities requires investors to identify by themselves. If any illegal acts are found, they should report to the public security and other competent departments as soon as possible."

　　On November 19th, in an interview with The Paper, a manager of Shanda Hsi Chin said that the company had not obtained the relevant financial license so far, but said that "the previous policy was lenient … …” .

　　Recently, some investors reported to the public security organs that Shanda Hsi Chin was suspected of illegally absorbing public deposits and other illegal and criminal acts.

　　On November 20, the police of Xiangya Road Police Station of Changsha Public Security Bureau, who received telephone consultation from investors, said that the police were currently studying the case and had not yet filed a case. The police are highly concerned about this matter, and the parties can go to the police station in the jurisdiction to register relevant information.

　　Investors are faced with difficulties in refunding, and the company issues a repayment plan.

　　The unexpected situation of Shanda Hsi Chin caught many investors off guard.

　　Ou Qiuhong, a native of Chenzhou, Hunan, told The Paper that she invested 300,000 yuan in Shanda Hsi Chin. "Now there is no dividend, and the principal can’t be recovered." She said that she worked in Changsha over the years, working as a part-time cleaner for three times, while her husband worked as a porter on the construction site, and the whole family saved some money. In March 2021, she invested 10,000 yuan through the salesman of Shanda Hsi Chin. After receiving the dividend, she was relieved to "invest". By June 2022, she invested a total of 300,000 yuan in principal, of which 10,000 yuan was the pension money earned by her mother selling small dishes.

　　"The company said that it was investing in a wine, with a return of 14.4% a year. Dividend every quarter, deduct 1% of the handling fee. " Ou Qiuhong said that by the beginning of November this year, she had not received the dividend and the principal due was not returned.

　　Investors receive their own investment funds within the group.

　　Among the investors interviewed by The Paper, some said that they had invested more than 1 million yuan, while others said that they had invested at least 50,000 yuan. On September 30th this year, Ms. Wang of Changsha County invested 150,000 yuan through the lobbying of her neighbors upstairs as a salesman of Shanda Hsi Chin. "The salesman said that during the activities during the National Day, 50,000 three-month income was 1,800 yuan, and 100,000 three-month income was 3,600 yuan. In addition, at the end of the month, the welfare of 50,000 yuan was given to a bag of rice+a spray, and 100,000 bags of rice+a bucket of laundry detergent." Ms. Wang said that she now regrets that she was hot-headed. "My sister is now preparing for surgery on a brain tumor, and it is diagnosed as advanced lung cancer. I also borrowed 50,000 yuan from her. How can I return it to her now?" Ms. Wang said with tears.

　　A number of salesmen said that all the investment money paid by customers is to enter Shanda Hsi Chin. Judging from the transfer vouchers presented by the respondents, the money was not directly transferred to the company account. "The transfer is through the private accounts of the company’s employees, but all the money is paid to Shanda Hsi Chin’s finances." Li Nanhui said, "As for whether the money is really invested in other companies, it is unclear."

　　According to Li Nanhui, since July and August this year, there have been some problems in the payment of funds by Shanda Hsi Chin. Li Nanhui said: "The company explained to us that because the country cracked down on telecom fraud and the bank locked the card, our funds could not come out."

　　Li Nanhui said that some time ago, Shanda Hsi Chin was short of funds, and the company’s top management encouraged salesmen to pay the customers’ income and due principal. "The salesman pays ten thousand dollars in advance, and the income of one day is four or five dollars. This is the commitment of the company leaders to us. " He said that he has paid more than 200,000 yuan to customers this month.

　　Li Nanhui revealed that in August this year, the "public opinion" of Shanda Hsi Chin’s capital problem began to appear on the Internet. "Later, new customers invested less money, and old customers demanded more and more refunds." He remembers that some time ago, the company’s top management conveyed that Shanda Hsi Chin was preparing to cooperate with a policy bank, which "has a bright future". Since then, on November 10th, 2.51 billion yuan of real estate of Shanda Hsi Chin related equity projects was listed on Hunan Stock Exchange. The deadline for registration of this transaction is December 7th.

　　"On November 10th, we also reported the happy news to the chairman of the board of directors, which was officially listed. After the listing transaction, there will be funds to come down. " An official of Shanda Hsi Chin said that Jibiao Pan, the chairman of the board of directors, lost contact on November 11th before the asset transaction in December.

　　On November 14th, Hsi Chin International (stock code: 00091.HK) announced that Jibiao Pan had resigned as executive director, chairman of the board of directors and chief executive officer of the group due to "planning to spend more time on other personal affairs", with effect from now on.

　　After Jibiao Pan lost contact, Dr. Xie, the CEO of Shanda Hsi Chin, presided over the work.

　　On November 17th, a red-headed document — — The "Retirement Announcement" was spread in the WeChat circle of friends. According to the fake document, Shanda Hsi Chin cheated consumers and failed to pay them on time, and the State Administration of Markets and the third-party fund supervision institution liquidated the company and published the liquidation website.

　　A fraudulent website made by fraudsters. Network screenshot

　　The Paper reporter found that the website was a fraudulent website, requiring investors to submit five personal real information. The Paper learned from the Anti-Fraud Police Department of Changsha Public Security Bureau that in recent years, with the frequent violent thunder of illegal fund-raising cases, the corresponding fraud methods have also quickly followed. "Some victims have been psychologically hurt after being cheated on their investment, and when they hear the refund, it is like catching a lifeline … … Some were cheated again. "

　　In the early morning of 18th, Shanda Hsi Chin posted a message on its WeChat WeChat official account that the counterfeit documents such as the "Retirement Announcement" were used by criminals to defraud customers’ information under the pretext of retiring, and the company will announce the retirement plan on 19th.

　　In the early morning of November 19th, Shanda Hsi Chin released the Announcement on Relevant Matters Concerning Benign Retirement on its WeChat WeChat official account, saying that due to the economic environment, epidemic situation and the loss of the company’s actual controller, Jibiao Pan, the contract expired and was not paid. Upon the research and decision of the emergency leading group of Shanda Hsi Chin, since the date of announcement, the assets of Shanda Hsi Chin, the assets of the project party and the assets actually controlled by affiliated companies will be preserved and disposed according to laws and regulations for gradual liquidation.

　　In this announcement, Shanda Hsi Chin said that its clients would elect representatives to set up the municipal branches, provincial associations and national associations of the Investor Rights Protection Committee layer by layer to handle assets disposal and payment. In addition, the government departments will be asked to preserve the currently known assets, and then "scientifically dispose of and dissolve the stock".

　　Published almost at the same time, there is a grand Hsi Chin "independent benign repel proposal". The plan proposes that the principle of "old first and then less" and "small first and then big" should be fully considered in the payment order of investment funds. The preparatory period for repaying the loan is expected to be 12 months. For customers aged 65 and above, and customers under 65 whose principal should not exceed 30,000 yuan, they will be formally paid in December 2023, and the longest payment will be completed in 48 installments, each of which will not exceed 10,000 yuan; For other customers, it will be paid in December 2024, and the longest payment will be completed in 36 installments, and each installment will not exceed 10,000 yuan.

　　The scheme puts forward the method of "paying debts with assets": customers can choose to pay with the existing Lai Yongxing sauce and wine products. In addition, during the redemption period, "if the company’s liquidity reaches 1.1 times of the amount of principal to be repaid and the total amount of other liabilities, it will be redeemed immediately."

　　As for the above-mentioned "proposal", among the investors interviewed, some said that "it can only be like this", some held a wait-and-see attitude, while others said that it was difficult to accept: "How long has each issue not been written, which can be one month or ten years … …”

Special feature of 1905 film network After the animation film was screened in 100 cities, the title topic rushed to the top of the hot search that night.

Judging from the feedback and attention on the internet, most of the attention comes from the director of the film.

The animated film he directed seven years ago (hereinafter referred to as "The Return of the Great Sage") was never optimistic, and countless people voiced it, making it a myth of "tap water".

Box Office, Flowers, Awards … … One after another, in the eyes of everyone, this animated film is a landmark work of "the rise of the country". Countless viewers expect him to launch a sequel and turn this IP into a series of works.

But he didn’t. Instead, he buried himself in the technical research and development of a concept in The Return of the Great Sage, and co-produced a brand-new original IP animated film Deep Sea.

Yi Qiao can’t be underestimated, too. As a producer, he has released such works, and the box office and word of mouth need not be repeated.

These two animators, who have been successful in the outside world, may have already explored their own "methodology" in business, but it seems that they did not put all this on Deep Sea, but chose a new beginning.

This has also become the key to our attempt to enter the Deep Sea. Why not use the past success to create a topic for the new work and bring more box office?

In an exclusive interview with the 1905 film network, producer Yi Qiao used their answers to string together the adventures belonging to Deep Sea.

01.

Yi Qiao is a person who boasts a high tear point, but after reading the script of Deep Sea for the first time, "I cried". At that time, he decided to make this story with the animator. As for the past experience, logic and methodology, it is no longer important.

Because in Deep Sea, he saw the sincerity of the creator and Tian Xiaopeng’s self-dissection once again.

In 2015, "The Return of the Great Sage" became the key word of that summer, and the striped house film industry under Light Media also began to explore and expand the animated film market, and invested in many animated film companies in one breath, including the October culture founded by Tian Xiaopeng.

Yi Qiao and Tian Xiaopeng, then the president of the striped house film industry, visited many successful overseas animation companies, looked at the achievements of others and then looked at their own achievements. "We are all thinking that we should do something different."

Tian Xiaopeng thought of the opening title of The Return of the Great Sage, so he threw out an idea, which covered the content of China’s unique ink and wash style. Is it possible to turn it into a whole film?

After returning home, Tian Xiaopeng almost declined all kinds of invitations such as interview announcements and plunged into creation. Yi Qiao also devoted himself to the creation and development of Ne Zha and other works.

The stories of two people are not parallel lines. They still talk about stories and creations. Yi Qiao will also introduce the excellent animators he meets to each other, including the director. "They are both creators who cherish each other very much.".

Yi Qiao still remembers that when we first talked about cooperation with jiaozi, the other party was just the boss of an animation outsourcing company, and directly released the lofty ambition of "I want to make a great movie, and if I want to turn the animation upside down, I will make trouble". It’s embarrassing to dig at the ground, but it’s just enough to prove the "genius" of the creator. In the movie, he shouted the sentence, "My life is up to me."

So is Tian Xiaopeng’s creation.

In 2012, he almost sold iron to do animation. He was an animation director to the outside world, but he was a director without a masterpiece, and even worried that his children would not mention their father at school.

This sentiment was put in the movie The Return of the Great Sage — —

"Hello, Great Sage! You are the Great Sage of Qitian. I’m sorry! "

"I’m not, I can’t fly, I’m not awesome, so don’t follow me."

In Tian Xiaopeng’s mind at that time, he may have self-distrust, and he may bring down his family. If his works are smashed, he may make his children lose face in front of his classmates.

When the first preview of "The Great Sage Comes Over" came out, there were various questions on the Internet. Why is the Monkey King a horse face? Why The Journey to the West, magic change?

The first appearance of the film was in the media attention unit of the film channel of the Shanghai International Film Festival in 2015. At that time, the propagandist tried every means to invite the media rushing around in various press conferences, hoping that everyone could leave the film for 2 hours.

In the end, the film became a success, and it broke through 100 million in four days after its release.

However, this did not bring enough excitement and joy to Tian Xiaopeng. In Yi Qiao’s view, "The Return of the Great Sage has a high box office, but it has brought him a greater impact and left him in a slightly closed state." A good creator never plunges himself into the mud. "He begins to think about how to dispel the haze and what is the motivation to live after success."

This is the beginning of every project that Yi Qiao did in the past. He first asked the creator why he made this film. This time, he threw the question back to himself.

Simple and sincere expression has become the stamina given to Yi Qiao by Deep Sea. On the way home from Tian Xiaopeng’s studio, Yi Qiao is still immersed in it. The car is quiet, and the outside of the car is noisy and noisy. "I will think why I cry, why I am willing to abandon everything I have done before for it."

Thinking about it, the answer is simple, "the vitality of the director."

02.

There is no absolute conclusion about the definition of commercial film in the market, but at least from the concept of labeling, the story of Deep Sea is not commercial.

The film tells about a little girl named Betelgeuse, who represents many ordinary people in life. "We want to be an ordinary hero and express people’s inner difficulties. If we fall into darkness, what can we support to go out?"

In the whole creative process, Yi Qiao heard all kinds of negative questions more than once. Do you really want to do this? Is it too risky?

He has been working all the way from Xuanfa to now, and he is very clear that this is an adventure. However, he also understands that there is no formula for high-box-office movies. It is impossible to say that simply making a sequel will succeed. Even if you end up making "The Great Sage 2" and "Nezha 2", if you don’t have enough vitality, "it is just a simple upgrade and meaningless."

During his tenure in the striped house film industry, Yi Qiao met many animators. He said something similar to almost every co-director, "I cut all the back roads. Don’t blame me for not being so mature, and I don’t blame you for not doing it … … We must travel all over Qian Shan, and we will encounter many obstacles, but we can spend three to five years to do it. If it is, it may be that we are on the right path; It didn’t work. It must be not done well enough. The market will not live up to any good work. "

It seems so this time, but only the second half is retained. The success or failure of the adventure of Deep Sea still needs the market and audience. It’s just that "Deep Sea" lasted more than 3 or 5 years, and it was done for 7 years.

In 2017, Tian Xiaopeng invited Yi Qiao to the company and showed him the achievements of the past two years. "We have been talking about the story, but I didn’t expect him to take action. I didn’t even expect that he made the whole system. It is very touching."

It was only a 3-minute clip, and how to turn it into more than 100 minutes of content became the biggest problem faced by the team of Deep Sea. Budget, research and development, personnel … … All problems are stuck around 2020.

After finishing Ne Zha, Yi Qiao left the striped house, joined the October culture and devoted himself to the team of Deep Sea. "Reorganize and start again, and the team has expanded from 60 people to 200 people now."

In the National Day of 2020, the film Legend of Deification was released, and the audience was amazed by the eggs at the end of the film "Deep Sea". At that time, it was less than two years before the scheduled release of Deep Sea.

This process is grinding, and the team hopes to mass-produce, but if the quality can’t be guaranteed, mass production will only be empty talk. "It took almost one and a half years, and at the end of 2021, we really started to finish all the scenes and gradually entered the stage of mass production."

03.

In 2019, the phrase "My life is up to me" started the pursuit of golden sentences in the whole market, and many animated films began to pursue "burning".

"Deep Sea" didn’t, and its story was not appropriate. "This is a story about facing yourself."

Yi Qiao knows very well that after meeting the audience, this story "should cause considerable controversy." "Deep Sea" will have some thresholds, but no one can say where the thresholds will go.

In the whole creative process, Tian Xiaopeng will also consider the market and feel that it is appropriate to integrate into the joke, but Yi Qiao thinks instead, "We are not selling jokes. It is better to remove what is imposed and not affect the style of the whole film."

After the first screening of the film, as Yi Qiao predicted, some people thought the story was simple, while others were poked by stories and emotions. Just from the team’s point of view, "Tian Dao and I are both pursuing, hoping that this movie is meaningful." We hope to make a good-looking movie. "

There is no IP, no stars, and even the promotion of Deep Sea borrows from the past successful cases of two animators and faces the market with a brand-new attitude.

Now, the movie "Deep Sea" has seen the world. What will happen to the follow-up market?

Yi Qiao has no answer.

Tian Xiaopeng wrote lyrics to The Clown, the promotion song of the movie Deep Sea. There is a sentence in it, "He is very grandiose and says that he has magic. People come and go and others treat him as a joke. Don’t laugh at him."

Yes, don’t laugh at him. Deep Sea is an adventure, and adventure never has a definite answer.

　　Mo Peng

　　Every year during the Spring Festival, some newborn babies are welcomed. The "basic necessities of life" during the Spring Festival determines the health of novice mothers and babies. Mariette, the chief physician of gynecology and pediatrics of Rocket Army Characteristic Medical Center, prepared a holiday health guide for these two groups.

　　new mother

　　There are four precautions for novice mothers to celebrate the holidays.

　　First, the thickness of clothes should be moderate, especially in the north. During the Spring Festival, the weather is cold. It is best for novice mothers to dress in a loose, warm, soft, comfortable and clean manner. Clothes should be changed, washed and dried frequently. If the indoor temperature is suitable, you don’t need to wear a hat and thick cotton-padded clothes, but if you want to go out, you should keep warm and windproof. After all, the maternity who has just given birth has low resistance, so you should pay attention to preventing colds and infections.

　　Second, the diet is light and less greasy. During the Spring Festival, the dishes on the dining table are richer than usual, and big fish, big meat and fatty food can be seen everywhere. However, mothers who have just given birth can’t stand this kind of "supplement". Oily food can easily cause problems such as breast duct blockage, milk deposition, and even acute mastitis. Babies who eat breast milk may also have indigestion and diarrhea. In addition, we should avoid raw, cold, hard and spicy diets, because the hormone level and body condition of women after delivery have changed, and the gastrointestinal digestive function is in the recovery period.

　　Third, the environment is quiet and not noisy, visiting relatives and friends, congratulating the New Year, and there are many people in the family. If there are guests visiting, they should be mainly received by their families. Mothers should try not to carry their babies out of the room, because newborns have weak resistance and should avoid the risk of infection. Don’t always close the doors and windows in the living room. Open the windows for ventilation once or twice a day to avoid dirty air in the room. However, when ventilating, pay attention to avoid indoor convection wind, and don’t let the wind blow directly to the parturient and newborn.

　　Fourth, novice mothers who are moderately active in bed generally don’t travel in the second month, but they can’t stay in bed most of the time. It is necessary to get out of bed as soon as possible after delivery, which can reduce the formation of venous thrombosis and promote the discharge of lochia, which is conducive to the recovery of uterus.

　　Newborn baby

　　Babies born before and during the Spring Festival bring special joy to the family, but don’t forget to give them more careful care.

　　First, don’t cover your baby too hot. It is one of the challenges for him or her to adapt to the temperature, so it is advisable to keep the room temperature at 20-25℃ and keep the air fresh. Neonates’ thermoregulatory center is not well developed, and the subcutaneous fat layer is thin, so they are sensitive to external temperature changes. Even if the Spring Festival climate in the north is cold, you can’t cover your baby too thick. Excessive warmth will make newborns sweat a lot and lose fluids in the body. In severe cases, there will be a series of manifestations such as dehydration and hypoxia. In addition to the appropriate thickness of clothes, the quilt should not be too tight and too thick.

　　Second, don’t kiss and shake the newborn mother. Don’t let others kiss the newborn casually, lest the baby be infected with the disease. Pinch your face, a little gesture of "showing love", is also not desirable, because it may squeeze your baby’s parotid gland and parotid duct, causing diseases such as baby drooling and oral mucositis. In addition, because the baby’s brain is not well developed and the neck muscles have weak support for the head, don’t shake the newborn too much.

　　Third, use the flash carefully when taking pictures. The baby’s first Spring Festival is so meaningful that adults want to take some pictures of the baby as a souvenir. Whether it is a professional SLR camera or a smart phone, you must use the flash carefully. This strong light may cause damage to the baby’s retinal nerve cells. Just take pictures of children with natural light.

　　(Author: Rocket Army Characteristic Medical Center)