The Korean sex comedy "Terrible Love" starring the leading actor Lin Changzheng has been confirmed to be released in major theaters across the country on January 20th. As the first Korean film introduced this year, Lin Changzheng still plays a middle-aged "wretched man" in How Terrible Love is. After a series of experiences involving sex, he finally finds his true love … …

Sisters of "Color is Empty"

　　　 In 2002, the Korean sex comedy "Sex is Empty" was born. Although this film is not the pioneering work of Korean youth sex comedy, it has undoubtedly become the pinnacle of this kind of film. At the same time, it has also become a sexual enlightenment film for many young people in mainland China after 1980s. In this film, the "wretched man" played by the leading actor Lin Changzheng has become a classic character.

　　　 It is understood that "Love is Terrible" basically follows the original cast of "Sex is Empty", among which Jin Guili, a famous Korean actress known as the "naked queen", replaced Ha Ji Won  as the heroine. In the film, Jin Guili will play the underwear model that Lin Changzheng has a crush on. Although she has left the country with a lot of nude scenes, her graceful figure and looming curve can still arouse the audience’s infinite reverie.

Next page: the weak man rises up.

　　　 Movie network news(Compile/Ji Zhongpeng) January 9 is a traditional Japanese festival. On this day, Japan has a national holiday, and young people over the age of 20 have to take to the streets to celebrate their adulthood in colorful kimonos. There are also many artists who are about to turn 20 years old in the Japanese art circle. Based on the topic of Adult Day, Japan’s public trust list launched an online poll of "the most anticipated new adults in 2012". The results showed that Japanese golf prodigy Ishikawa Liao ranked first in the list, followed by pure beauty actress Kaho, and Atsuko Maeda, a member of the ultra-popular beautiful girl group AKB48, made it into the top three.

　　　 In addition, in the top 10 list, there are 4 beautiful girls of AKB48. Except Maeda, who ranks third, Tomomi Itano, the first one in AKB48 to fly solo, ranks fourth. Gao Qiao Minami, which has developed in various fields such as advertising, film and television dramas, ranks seventh; Ranked eighth is Kashiwagi Yuki, a lovely beauty who won the third place in the "2011 AKB48 General Election".

　　　 The selection targets are artists born between April 2, 1991 and April 1, 1992.

The following is the top ten list of "the most anticipated new adults in 2012"

1. Liao Ishikawa (golfer)

2. Kaho (actress)

3. Atsuko Maeda (actress)

4. Tomomi Itano (actress)

5. Takimoto Miori (actress)

6. Taichi Saotome (male star)

7. Gao Qiao Minami (actress)

8. Kashiwagi Yuki (actress)

9. Genki Haraguchi (professional football player)

10. Kikuchi Xiongxing (professional baseball player)

Original Zhimei Tencent Medical Code, she knows　

Fish is a good thing.

But we may not have eaten it right.

What fish do you eat? How many times a week? How much do you eat each time? How do you cook it?

These are all related to your health.

Recently, the US Food and Drug Administration (FDA) and the US Environmental Protection Agency (EPA) jointly issued the "Advice on Eating Fish", which clearly stated how to eat fish healthily.

Let’s take a look together!

(Reminder: The fish mentioned in this proposal is fish in a broad sense, and the fish in biological taxonomy, shrimp, crab and shellfish are collectively referred to as "fish")

Because there are too many benefits of eating fish!

You don’t know a lot.

Benefit 1:

Fish is so rich in nutrition that it has more advantages than pork and chicken [1,2];

① High-quality protein is high (15%~22%), with soft and tender taste, which is more digestible than livestock meat;

② Low fat content (1%~10%), mainly polyunsaturated fatty acids, especially omega-3 fatty acids (including DHA and EPA), which are beneficial to the development of nervous system, lowering blood lipid and preventing arteriosclerosis;

③ It is rich in minerals (iron, calcium, zinc, iodine, selenium, etc.) and a good source of vitamin B12, vitamin A, vitamin D and choline.

Benefit 2:

"Eating more fish in a healthy diet" is helpful to [1]:

Prevention of cardiovascular and cerebrovascular diseases;

Promote bone health and reduce the risk of hip fracture;

Reduce the risk of overweight and obesity;

Reduce the risk of colon cancer and rectal cancer;

Reduce the risk of death and prolong life;

……

("Healthy eating mode of eating more fish" means not only eating fish frequently, but also taking in enough fresh vegetables, fruits, beans and whole grains, as well as appropriate dairy products, lean meat and poultry meat, nuts and vegetable oil rich in unsaturated fatty acids.)

Benefit 3:

For some special people, eating fish in moderation brings additional benefits:

① For pregnant women, nursing women and infants, fish can provide key nutrients needed to support the brain development of fetuses and infants, especially omega-3 fatty acids [1].

② A survey of students in China found that children who eat fish have higher intelligence scores and better sleep [3].

③ A recent study by Huazhong University of Science and Technology found that eating fish for cancer patients helps to reduce the risk of death [4].

The benefits of eating fish are not limited to these, and there are many related studies. Maybe scientists will make new discoveries in two days.

No one is perfect, and so are fish.

Fish in life can’t "get out of the mud without being stained". They are easily influenced by the surrounding environment and enrich pollutants in water, especially methylmercury.

After methylmercury enters the human body, it is discharged very slowly. Excessive long-term exposure will lead to cumulative toxicity and damage to the brain and nervous system.

In 1950s, the Minamata disease in Japan was caused by methylmercury [2].

"Fish suggestion" suggests that you must choose fish with low mercury content.

According to the content of methylmercury, the safety of fish (including fish and shellfish) is divided into three grades [1]:

The best choice: low mercury, you can eat 2~3 servings a week.

Good choice: the mercury content is slightly higher than the former, and you can only eat one serving per week.

Avoid choice: the mercury content is high, so don’t eat if you can.

(How to calculate 1 copy? Adults and children are different. We will explain later. If you are in a hurry, you can slide directly to part5.)

List of fish with 3 safety levels (according to FDA recommendation)

(Don’t worry when you see a lot of fish you don’t know, and a list of fish that Chinese often eats will be given later ~)

optimum selection

Anchovy, Atlantic yellow croaker, Atlantic mackerel (mackerel), largemouth bass (California bass), golden thread fish, squid, clam, cod, crab, freshwater crayfish, flounder, haddock, hake, herring, American lobster, barracuda, and so on.

Good choice

Bamboo pod fish, buffalo fish (bull mullet), carp, Chilean sea bass/Antarctic canine fish (silver cod), grouper, halibut, dolphin,? ? ? ? Fish, rock fish, naked fish (silver cod), red bass (red snapper), snapper, mackerel, striped bass (sea water), square head fish (Atlantic Ocean), albacore/white tuna (canned, fresh and frozen), yellowfin tuna, sea fish.

Avoid choice

Atlantic mackerel, marlin (swordfish), Atlantic seabream, shark, swordfish, square head fish (Gulf of Mexico), bigeye tuna.

Based on the measured data in China, the aquatic products that Chinese eats the most every day are recommended as follows:

You can eat 2~3 servings of fish every week: hairtail, grass carp, Wuchang fish, small yellow croaker, sole, river bass, tilapia, sturgeon, cod, salmon, sardines, prawns, scallops, squid, shrimps and crabs.

You can eat 1 serving of fish every week: sea bass, mackerel, grouper, snapper, halibut, silver cod, yellow croaker, herring, silver carp, bighead carp, carp and crucian carp.

The number of so-called "one serving" fish varies with age.

(Note that 1 serving in the proposal refers to the weight of raw fish before cooking.)

1. Ordinary adults

Recommended food intake: eat 2 servings of fish a week, which is the size of two palms.

An adult serving is about 120 grams (4 ounces), which is about the size of an adult’s palm.

(Source: FDA official website)

2. Pregnant and lactating women

Suggested food intake: eat 2-3 servings of "best choice" fish per week, or 1 serving of "good choice" fish per week.

Note: it is a choice, not a "harmony" relationship.

3. Infants and children

Recommended food intake: 2 servings of "best choice" fish per week. Don’t eat "good choice" fish.

1~3 years old, about 30 grams (1 ounce)

4~7 years old, about 60 grams (2 ounces)

8~10 years old, about 90 grams (3 ounces)

11 years old and above, about 120 grams (4 ounces)

(Source: FDA official website)

In order to benefit from eating fish, the cooking method is very important.

one

Recommended practices: steaming, oven controlled baking and electric pressure cooker stewing.

Steaming is one of the best choices, which can preserve omega-3 fatty acids and multivitamins in fish.

It is also a good way to wrap it and bake it in an oven, or to stew/bake it in an electric pressure cooker.

2

Not recommended practices: roasting and frying with open fire.

Try not to bake with open fire, so as not to produce a variety of carcinogens [5].

Frying and frying are also not recommended, because omega-3 fatty acids are destroyed a lot at high temperature [6].

To braise in soy sauce and make soup, it is generally necessary to fry in oil first. It is recommended to put less oil, fry at as low a temperature as possible and for as short a time as possible.

Tips:

Freshwater fish must not be eaten raw!

Marine fish that can be eaten raw must be purchased from reliable merchants.

Pregnant women and children are not recommended to eat raw fish and aquatic products, including sushi and sashimi.

(Cooked salmon tastes good too.)

Q1

Which is better, marine fish or freshwater fish?

From a nutritional point of view, there is not much difference between the two.

In particular, the content of DHA (docosahexaenoic acid, commonly known as brain gold), which everyone is generally concerned about, does not depend entirely on whether it is river fish or deep-sea fish, but mainly on the species of fish.

For example, the DHA content of eel is as high as 471 mg /100 g, which is higher than that of small yellow croaker, hairtail, sea bass, cod and other marine fish. Bass, bighead carp, catfish and silver carp also contain more DHA [7,8].

Therefore, everyone should choose according to their own preferences.

Q2

Is there any way to reduce mercury residue?

Unfortunately, cleaning or cooking can’t reduce the residual amount of mercury, because it is dispersed in fish and very stable.

The only way to reduce the mercury intake of fish is to choose safe fish species from the "best choice" according to the above suggestions and control the food intake.

Q3

Can fish not on the list be eaten?

Can eat.

Try to choose smaller fish at the bottom of the food chain, such as freshwater bass, grass carp and Wuchang fish.

Q4

Which part of the fish can’t be eaten?

The fish in the "best choice" and "good choice" lists can be eaten regardless of the head, skin and roe.

It should be reminded that many fish gall is poisonous and can’t be eaten. For example, crucian carp, grass carp, carp, herring, silver carp, bighead carp, shad, etc., there is a toxin called "sodium carpenol sulfate" in their bile, which is very toxic and cannot be inactivated by heating [9].

Fish gall is located in the abdomen of the fish, and it is generally light bluish yellow or bluish black. It must be cleaned before cooking, and be careful not to break it.

Q5

Can you use fish oil instead of eating fish?

I can’t.

Fish oil supplements only contain omega-3 fatty acids, and do not contain nutrients such as protein, omega-6 fatty acids, vitamins and minerals. The healthy development of children is inseparable from these nutrients.

Therefore, it is suggested to obtain various nutrients including omega-3 fatty acids by eating fish instead of simply taking fish oil.

In addition, there is still some controversy about the health benefits of fish oil, and the current research results do not support the statement that taking fish oil can improve children’s IQ.

Q6

When can I start eating fish for my baby?

Babies can eat fish when they are about 6 months old and start to add complementary food.

Remember, clean the fishbone, and don’t stab the baby.

Give the baby fish. Chop up the fish and eat it slowly to avoid the risks of choking and suffocation.

Remember to forward it to the circle of friends ~

Review expert

Chen Shunsheng | Director and Professor of Aquatic Products Processing and Storage Engineering, College of Food Science, Shanghai Ocean University

references

[1]https://www.fda.gov/food/consumers/advice-about-eating-fish

[2] China Nutrition Society, Food and Health-Consensus of Scientific Evidence (2016)[M]. People’s Health Publishing House, 2016.

[3] Pennsylvania U O . Weekly fish consumption linked to better sleep, higher IQ, Penn study finds.https://www.nursing.upenn.edu/details/news.php? id=991

[4] Wang Y, Liu K, Long T, et al. Dietary fish and omega-3 polyunsaturated fatty acids intake and cancer survival: A systematic review and meta-analysis [published online ahead of print, 2022 Jan 24]. Crit Rev Food Sci Nutr. 2022; 1-17. doi:10.1080/10408398.2022.2029826.

[5] Yang Yuexin, Ge Keyou. China Nutrition Science Encyclopedia (2nd Edition). People’s Health Publishing House, 2019.

[6] Li Nannan, Fan Zhihong. The influence of cooking on the nutritional value of fish [J]. China Food and Nutrition, 2011,17(02):82-85.

[7] Yang Yuexin, editor-in-chief, China Center for Disease Control and Prevention, Institute of Nutrition and Health, China Food Composition Table (6th Edition) [M]. Peking University Medical Press, 2019.

Zuliya, Luo Junxiong, Fan Tie. Comparison of EPA and DHA contents in marine fish and freshwater fish fat [J]. China Oil, 2003(11):48-50.

Wu Hanlin, Peter Wing Ho Chin. Experimental study on acute bile poisoning in CYPRINIDAE [J]. Zoology Research, 1999(06):474-475.

Content production

Read the original text

　　China Railway Guangzhou Bureau Group Co., Ltd. continued to promote the construction of multiple ticketing systems in Spring Festival travel rush, and constantly improved the level of convenience for passengers to purchase tickets, making it easier for passengers to buy tickets. In Spring Festival travel rush this year, Guangzhou Railway Group significantly increased the number of ticket vending machines and Internet ticket collection machines at high-speed rail stations, with a total of 2,326, 211 more than that in Spring Festival travel rush last year.

　　Agency outlets extend to the countryside.

　　According to the introduction of Guangzhou Railway Passenger Transport Department, Guangzhou Railway Group has innovated the ticketing methods many times, extending the ticketing place from the ticket hall of the station, opening mobile ticketing points and temporary windows, and laying urban and rural consignment outlets. The data shows that by the end of 2018, the number of Guangzhou Railway Group’s sales outlets had reached 2,549, accounting for a quarter of the country’s total, an increase of 1,862 compared with the end of 2008. Among them, 1,130 sales outlets were set up in towns and villages in Hunan and Guangdong provinces, covering more than 50,000 people, and the ticketing terminals were directly moved to the farmers.

　　"The railway department has opened the sales outlets to towns and villages, which has done a real good thing for our migrant workers." Luo xiaoming, the manager of human resources department of Dongguan Jingmu Wood Products Co., Ltd., calculated a "time cost account" for the reporter. In the past, for the train ticket for Spring Festival travel rush’s return home, employees would not feel at ease at the end of the year, which delayed production. The company once sent three security guards to the railway station to buy tickets, even so, it was far from meeting the needs of employees.

　　Some employees have to take time off to buy tickets in order to reunite with their families.

　　This year, a train ticket sales point was opened near the company. Employees can go directly to the sales point to buy tickets in their spare time, and the number of employees taking leave is greatly reduced.

　　This year, in Spring Festival travel rush, Guangzhou Railway also increased the distribution density of sales outlets in central cities of major cities, making it convenient for citizens to buy train tickets nearby.

　　Online booking accounts for 90%

　　The proportion of Internet booking in Spring Festival travel rush is increasing. Guangzhou Railway Group has sold 14.83 million tickets through the Internet, accounting for about 90% of the number of train tickets sold.

　　Telephone booking is an important choice for many migrant workers who are not familiar with online booking, and telephone booking is a convenient measure introduced by Guangzhou Railway Group in Spring Festival travel rush in 2005. In Spring Festival travel rush in 2019, the vast number of migrant workers can book train tickets at any station in the country through the service telephone.

　　This year, in Spring Festival travel rush, Guangzhou Railway Group also added the automatic reading function of Hong Kong, Macao and Taiwan passes to relevant ticket vending machines in time according to the high proportion of Hong Kong, Macao and Taiwan passengers in the Pearl River Delta region, which greatly facilitated the self-service purchase and collection of tickets by Hong Kong, Macao and Taiwan passengers.

　　While expanding ticket sales channels, Guangzhou Railway Group also focuses on enriching supporting payment methods. It is more and more convenient for passengers to buy tickets from cash, credit card and mobile phone payment. In 2019, in Spring Festival travel rush, all stations in the whole group installed bank POS machines at the designated ticket window, and all automatic ticket vending machines have realized bank card payment. Alipay and WeChat payment methods are also gradually popularized at various stations.

　　Migrant workers and students are preferred.

　　Since Spring Festival travel rush in 1999, Guangzhou Railway Group has implemented the group ticket reservation mode for migrant workers in Spring Festival travel rush every year, and made every effort to ensure that migrant workers buy tickets to go home and return to the factory. We have started the return booking and self-organizing business of group tickets for migrant workers in Spring Festival travel rush, and this year, Spring Festival travel rush has realized separate booking for the journey and return.

　　Up to now, Guangzhou Railway has reserved 397,000 group tickets for nearly 5,000 enterprises and self-organized groups in Spring Festival travel rush. In view of the fact that some enterprises in the Pearl River Delta rushed to work at the end of the year, Guangzhou Railway also sent service teams to enterprises in Dongguan, Huizhou and other places to deliver return tickets directly to migrant workers. At the same time, according to the reservation of group tickets for migrant workers, Guangzhou Railway has arranged to run 62 special trains for migrant workers during Spring Festival travel rush this year, so that more migrant workers can enjoy the "exclusive" journey.

　　In 2019, in Spring Festival travel rush, Guangzhou Railway Group ensured that students would buy tickets to go home and go back to school to the maximum extent according to the principle of "priority sale and full guarantee". At present, the major railway stations in Guangzhou Railway have handled round-trip tickets for student groups in various ways, and the pre-sale period of student tickets has been put to the end, and the round-trip tickets for students on March 1, 2019 can be sold as far as possible.

　　Up to now, Guangzhou Railway has sold a total of 1.79 million winter vacation student tickets. There are 11 stations in Guangdong, 14 universities and colleges set up temporary ticket sales windows, and 8 stations set up 16 automatic ticket vending machines on campus.

　　According to Jin Yibing, a transportation expert in Guangdong Province, Guangzhou Railway has brought intuitive changes to Spring Festival travel rush by building a multi-system of ticket sales: it has fundamentally eased the pressure of people flow in ticket sales places, saved the time cost for the majority of passengers to purchase tickets, further demonstrated the new image of railway Spring Festival travel rush and improved the level of social public services.

Cross-border e-commerce has maintained strong growth, overseas warehouses have become an important platform, and market procurement and trade methods have developed rapidly.
Accelerate the development of new foreign trade formats and new models.

Expand the pilot scope of the cross-border e-commerce comprehensive experimental zone, actively promote the development of overseas warehouses, and support qualified places to develop offshore trade … Around accelerating the development of new foreign trade formats and new models, the the State Council executive meeting held recently determined a series of measures. Relevant persons pointed out that the new format and new mode are the effective force of China’s foreign trade development and an important trend of international trade development. The policy measures put forward at this meeting involve a variety of new formats and new models, which are highly targeted and help to further promote the upgrading of foreign trade and cultivate new competitive advantages.

The scale of cross-border e-commerce has increased nearly 10 times in five years.

In recent years, new foreign trade formats and new modes in China have developed rapidly, and cross-border e-commerce is one of them. According to the data of the General Administration of Customs, in 2020, the import and export of cross-border e-commerce in China was 1.69 trillion yuan, a year-on-year increase of 31.1%.

Since the beginning of this year, cross-border e-commerce has continued to maintain strong growth. Gao Feng, spokesman of the Ministry of Commerce, said that in the first quarter of this year, the import and export of cross-border e-commerce reached 419.5 billion yuan, a year-on-year increase of 46.5%. There are the following new features: First, from the perspective of channels, cross-border e-commerce relies mainly on third-party platforms and gradually develops various new channels such as independent websites, social networking sites and search engine marketing. Second, from the main point of view, from the early individual and trade-oriented enterprises to the integration of trade-oriented enterprises and production enterprises, many production enterprises have changed from offline to online, and the digitalization level has improved significantly. Third, from the product point of view, from simply paying attention to cost performance to paying attention to brands, quality, standards and services, customized and personalized products have grown rapidly.

"In terms of scale and speed, the development of cross-border e-commerce has maintained a double-digit growth rate in recent years. The total scale has increased nearly 10 times in five years, and its proportion in foreign trade has continued to increase, especially under the impact of the epidemic, which has played an important role in stabilizing foreign trade." Zhang Jianping, director of the Regional Economic Cooperation Research Center of the Research Institute of the Ministry of Commerce, told this reporter that in order to further promote the development of cross-border e-commerce, it is necessary to continue to increase support, such as expanding the pilot scope of the cross-border e-commerce comprehensive experimental zone, optimizing the list of cross-border e-commerce retail imports, facilitating the management of cross-border e-commerce import and export returns, and formulating guidelines for cross-border e-commerce intellectual property protection.

Improve the digital and intelligent level of overseas warehouses

In the process of cross-border e-commerce development, overseas warehouses are important support points. The data shows that there are more than 1,800 overseas warehouses of cross-border e-commerce in China, which are distributed in Russia, Japan, South Korea, the United States and other countries and regions, and the growth rate will reach 80% in 2020, covering an area of over 12 million square meters.

"Overseas warehouses have become a new type of foreign trade infrastructure supporting the development of cross-border e-commerce, and are an indispensable and important link and platform for the development of cross-border e-commerce. By setting up overseas warehouses in the destination country, and then transporting the goods in batches, sorting, packaging and transporting them according to the local market, logistics efficiency can be effectively improved and comprehensive operating costs can be reduced. Especially during the epidemic prevention and control period, the advantages of overseas warehouses are prominent, because there is sufficient stocking, and local logistics can deliver faster. " Zhang Jianping said.

The the State Council executive meeting proposed to encourage traditional foreign trade enterprises, cross-border e-commerce and logistics enterprises to participate in the construction of overseas warehouses, improve the digitalization and intelligence level of overseas warehouses, promote small and medium-sized enterprises to borrow ships to go out to sea, and drive domestic brands and dual-innovation products to expand the international market space.

Zhang Jianping said that a series of measures not only focus on promoting more market players to participate in the construction of overseas warehouses, but also emphasize the application of new technologies, which will provide more powerful support for the development of overseas warehouses. "With the increasing support from all sides, there is still a lot of room for the development of overseas warehouses in the future, especially the construction of a new generation of intelligent logistics system, which will make overseas warehouses operate more efficiently and play a more important role, thus promoting cross-border e-commerce. Make greater contributions to stabilizing foreign trade and promoting the transformation and upgrading of foreign trade."

Actively develop the way of market procurement trade.

Focusing on new formats and new models, the the State Council executive meeting proposed to actively develop market procurement trade methods.

As a new trade model created for foreign trade transactions of "multi-variety, multi-batch and small-batch" in specialized markets, market procurement trade has developed rapidly in many places in recent years. Recently, in Dongguan, Guangdong Province, the export scale of the pilot market procurement trade of Da Lang Wool Trade Center launched at the end of last year exceeded 10 billion yuan. Up to now, 1,487 pilot operators of procurement trade in Dongguan market have been registered, and the export commodities involve furniture, daily necessities, textiles and clothing, etc., and are exported to 141 countries and regions.

"Market procurement trade mode has the characteristics of fast customs clearance and convenience. Foreign trade operators can purchase goods in the approved market gathering area and go through export customs clearance procedures at the purchasing place. Accelerating the development of market procurement trade methods will help enhance the ability to collect goods and brand influence, and further tap the trade potential. " Zhang Jianping said.

In addition, the executive meeting of the State Council proposed to guide foreign trade comprehensive service enterprises to improve the efficiency and risk control level of centralized tax refund, support enterprises in comprehensive bonded areas and pilot free trade zones to carry out bonded maintenance, and support qualified places to develop offshore trade.

Zhang Jianping said: "Next, we should speed up the development of new foreign trade formats and new models, strengthen the protection of intellectual property rights, formulate relevant rules in digital trade, and further promote international exchanges and cooperation. In this process, the Pilot Free Trade Zone can play a more active role and continue to promote the high-quality development of foreign trade. " (Reporter Qiu Haifeng)

　

1905Film network feature　 Film Bureau of State Administration of Press, Publication, Radio, Film and Television2017yeartwelvemoon31The data released in the evening shows that:2017In, the total box office of national movies was559.11100 million yuan, a year-on-year increase13.45%; Among them,Domestic film box office301.04100 million yuan, accounting for the total box office53.84%The number of domestic films exceeding 100 million has reached51Department.

　

The volume of the film market is growing steadily, and the creation of film content is also moving towards quality and diversification. Looking back on another year of China’s film industry, filmmakers once again offered coverage to the audience.Action, comedy, fantasy, suspenseAnd many other types of rich masterpieces. We witnessed the box office spectacle of 10.858 billion action movies, followed comedies and walked through the spring, summer, autumn and winter with a smile, and were moved by the amazing fantasy world in the movies and the humanistic feelings of the excellent works.

　

China movies in 2017 are "exciting enough, lively enough and worth watching".

The action movie "Wolf Warriors 2" dominated by 10.85 billion yuan achieved a new height in domestic films.

　

Action movies play an important role in all kinds of movies, and only such works can give full play to the sports characteristics of movies. In 2017, 28 domestic action movies landed in mainland cinemas, which captured 10.858 billion box office in one fell swoop, including 11 movies with over 100 million yuan, followed by Wolf Warriors 2 and. This data ranks first among all types, showing the unshakable dominance of such subjects.

"Wolf Warriors 2" stills

　　

Among all these 28 works, Wolf Warriors 2, a phenomenal explosive work, has to be mentioned.5.68 billion single box office volume, nearly 160 million people watching movies.It not only helped the film successfully rank among the TOP100 in the global box office list, but also achieved a new height of domestic films from many angles. The title of the first box office in 2017 and the box office champion in mainland film history is only a part. Wolf Warriors 2 proves with its own strength that the theme of the main melody can be perfectly compatible with the creation of commercial films, and the story full of feelings for home and country can touch countless audiences. Like Wolf Warriors 2, the film "Hunting in the Sky", which focuses on the theme of military action, was released in the National Day file, and it also achieved more than 320 million success.

Stills of "England vs. England"

　

Apart from Jason Wu and his "Wolf Warriors 2", another kung fu movie star also made an eye-catching performance in the film market in 2017. He is Jackie Chan, whom we are most familiar with. The action comedy "Kung Fu Yoga" in the Spring Festival has a total box office of over 1.64 billion. Exotic family fun stories and cool kung fu fighting scenes vividly show Jackie Chan’s personal film style. On the National Day, however, he subverted the past and appeared in a slightly old-fashioned style, bringing a serious theme and a cold action style. Adding up the data of the two works, Jackie Chan’s box office contribution to the 2017 domestic action movie has exceeded 2.1 billion.

　

Comedy films are on the rise rapidly, and the explosions "Shame" and "Tianzhu" win the schedule with laughter.

　

Comedy movies have brought new changes and opportunities to China film market again and again, and created countless box office myths of "Little Soldiers Make Great Achievements". In 2017, the comedy film genre still gathered the most creativity of China filmmakers, and the number of 43 cinema films stood out among all types. At the same time, the box office is still laughing and cursing all the way, and the success of 4.338 billion yuan has increased rapidly compared with last year.

Stills of "The Iron Fist of Shame"

　

Mahua FunAge’s team, which has sprung up in the film market in the past two years, after becoming the dark horse of the year, launched the masterpiece "The Iron Fist of Shame" in the National Day of 2017. A solid script that has been tested by hundreds of drama stages, as well as wonderful interpretations by Allen, Mary, Shen Teng and others, remake a story of men and women who are not novel, giving a different feeling. During the 11th holiday, "The Iron Fist of Shame" took the lead in the film market, eventually attracting 2.2 billion yuan, and the audience scored more than 9 points, achieving a double harvest at the box office and word of mouth.

Poster of "Make a scene in Tianzhu"

　

Ranked second is the box office of nearly 720 million. This film is Wang Baoqiang’s directorial debut, and it also achieved good market response when it was released in the Spring Festival in 2017. Looking at the popular schedules of the whole year, such as the New Year’s Eve, there are many comedies. This fully shows that comedy is still the most popular theme for the audience. It not only makes us say goodbye to the past in laughter, but also makes us welcome the future with a brand-new attitude.

Next page:Fantasy type highlights the film industry level, and the volume advantage of single box office is obvious.

　　Cctv newsAccording to the "Shanghai Release" WeChat WeChat official account news, the Shanghai Central Meteorological Observatory issued a blue gale warning signal at 14: 05 on September 29, 2021: Due to strong thunderstorm clouds, it is expected that there will be 7-9 thunderstorms and strong winds in Baoshan, Jiading, Chongming, the northern part of the central city and Pudong in the next 3 hours, so please take precautions.

　　Earlier, the Shanghai Central Meteorological Observatory issued a yellow warning signal for lightning at 13: 50: It is expected that lightning activities will occur in Baoshan, downtown, Jiading, Minhang, Qingpu, Songjiang, Chongming and Pudong before midnight today, accompanied by short-term heavy precipitation with a maximum of 20-30 mm per hour, 7-9 thunderstorms and strong winds, and there may be small hail in some areas.

　　Defense guide:

　　1. Check doors and windows, reinforce clothes racks, outdoor antennas, etc., and properly place outdoor flowerpots and other items that are easy to fall.

　　2. Try not to stay near glass doors and windows or billboards when going out.

　　Defense guide:

　　1. Stop carrying out outdoor activities in open places.

　　2. Stop swimming in rivers, lakes and seas.

　　3. Stay away from trees, corners or places with prominent metal objects; Don’t hold objects with sharp metal corners in your hands or carry them on your shoulders.

　　"The earth is the cradle of human beings, but human beings cannot live in the cradle forever." This is the heroic words of tsiolkovsky, the father of modern rockets. So far, man has landed on the moon and looked at his home from another perspective. However, one big step for mankind is not far enough. The inability to support transportation and the lack of dry food supplies have restricted human beings from leaving the "cradle", realizing interstellar travel and sailing, and looking for "relatives" who go to the earth.

　　Of course, all this has been realized in science fiction movies — — In a series of sci-fi movies such as Avatar in Interstellar, astronauts use the technology of "freezing dormancy" to reduce the metabolism of their bodies and realize long-distance interstellar travel with less supplies. Recently, NASA officially announced that it will fund SpaceWorks in Atlanta to develop a similar "suspended animation" technology to put astronauts into a short-term frozen sleep state during the long interstellar travel.

　　In real space missions, the supply needed by human astronauts will have a direct impact on mission execution. Obviously, putting astronauts into a short-term frozen sleep state will make space travel go further and more efficient. ● Wang Tengteng, a reporter from Nanfang Daily in Beijing, planned and coordinated Zhang Zhichao.

　　1. Freezing dormancy improves the efficiency of space travel.

　　According to reports, during the interplanetary voyage, the frozen dormancy cabin designed by SpaceWorks will make astronauts enter an inert and numb state, that is, a short-term frozen dormancy state. In this state, the physiological activities of astronauts are reduced, usually manifested in the decrease of body temperature and metabolic rate. This will greatly reduce the astronauts’ demand for external materials, and then greatly reduce the supplies they carry.

　　John Bradford, CEO of SpaceWorks, said that the "suspended animation" of human astronauts has always been regarded as the best solution for long-term space flight. According to the design scheme, the sleeping cabin of SpaceWorks is very small, located near the central node or crew cabin of the spacecraft, allowing astronauts to enter and exit directly. Brad Ford said: "We believe that 4-mdash; The supply demand of six astronauts can be reduced to 5-mdash; 7 tons, not the current 20-mdash; 50 tons. The space required for the astronaut habitat is about 20 square meters, while most current designs require 200 square meters. "

　　When the astronauts are in a frozen hibernation state, they will be covered with various sensors, so that other awake astronauts can monitor their status at any time. Astronauts will get the nutrients needed to maintain human body function through total parenteral nutrition intravenous injection, which can be excreted with urine. Astronauts will sleep for 14 days under the low temperature induced by this drug, and then wake up for 2-mdash; Three-day shift change to meet the dormancy needs of other astronauts.

　　2. Cooling process or damage to cells

　　It can be seen that astronauts’ freezing and dormancy can maximize the space and load utilization of spacecraft. The key is to reduce the consumption of astronauts during flight, that is, to minimize the metabolic rate of the human body.

　　There is no doubt that low temperature can reduce the metabolic rate of living things. Animals such as frogs and snakes all hibernate to reduce their metabolic rate. However, it is worth noting that the freezing dormancy of astronauts is not the same as the "human freezing" technology used by Du Hong, a female writer in Chongqing, China. The first problem to be solved in astronaut’s freezing and dormancy technology is the damage caused by low temperature to astronauts’ life.

　　Technically, human freezing dormancy refers to freezing human to -196℃ in a very short time, stopping cell activity and prolonging human life cycle indefinitely. Theoretically, freezing dormancy can be done. But at present, from the technical point of view, human beings can’t freeze and sleep and wake them up. The main problem is that when the body temperature drops to -5℃, the water in the cells will freeze and form ice crystals. These ice crystals can penetrate the cell membrane and cause serious tissue damage. In other words, people who sleep through freezing will not be able to wake up again.

　　The mechanism of long-term preservation of cells at low temperature is that the metabolism of cells slows down rapidly at low temperature. The lower the storage temperature, the slower the metabolism and the longer the storage time. For example, the blood in the blood center is often stored at -5℃, and the storage time is generally one month. Of course, if the damage to cells caused by low temperature is not considered, the blood should be preserved for a longer time if it is stored at -196℃.

　　But cryopreservation itself can also kill cells and damage tissues. The SpaceWorks funded by NASA has not announced how to deal with these risks, but we might as well take a look at these risks and the current research on how to deal with them. These risks include both chemical damage and physical damage.

　　The main culprit of chemical damage is the oxygen we live on. Needless to say, the importance of oxygen, but its other side is to destroy the essence of life molecules through oxidative decomposition. Especially when cells actively use oxygen, they will generate a large number of free radicals which are more active than molecular oxygen. Under normal circumstances, cells use a series of enzymes to directly or indirectly combat the damage caused by oxygen and its free radicals. However, with the decrease of temperature, although the speed of destruction also decreases, the resistance ability accelerated by enzyme catalysis will also decrease sharply with the drastic decrease of enzyme activity, and the originally balanced chemical reaction will eventually fall to the destructive side. This cannot be ignored.

　　The second is physical damage, which mainly refers to the damage to cells caused by liquid freezing at extremely low temperature. According to the research of Liqun He, a professor at the Institute of Cryobiology, University of Science and Technology of China, the only way to achieve freezing dormancy is to treat each cell at low temperature. In practical application, the first step of cryopreservation of cells is to add cryoprotectant (CPA) to cells and then cool them safely. It is worth noting that the temperature is not low enough to meet the requirements of freezing dormancy, but -15℃— The low temperature process of -60℃ is fatal to cells.

　　3. The cooling process is difficult to operate.

　　Adding solute to water will lower the freezing point of water. Generally speaking, the higher the solute concentration, the lower the freezing point, so the first step of successful cryopreservation is to add appropriate CPA, and high concentration solute has osmotic damage to cells, so it should be appropriate. Since 50 years ago, a British research group accidentally discovered that glycerol is an effective cryoprotectant for sperm and red blood cells, although new CPAs, such as ethylene glycol, methanol, propylene glycol and dimethyl sulfoxide, are constantly emerging, and some of them are more effective, glycerol is still one of the effective CPAs.

　　According to Liqun He and others, the experiment shows that after adding CPA, the cells are dehydrated first, and the volume begins to shrink, then CPA infiltrates and the volume expands. If the concentration of CPA is too high, its volume will shrink excessively and even exceed the tolerance limit of cells, resulting in damage.

　　During the cooling process, when the temperature drops to about -5℃, the cells and transmitters around them are not frozen, and they are all in a supercooled state, at -5℃— Between -15℃, the extracellular solution begins to freeze. If it is assumed that the cell membrane prevents the ice crystals from growing into the cell, the cell is still in a supercooled state without freezing. At this time, the chemical potential of water inside the cell increases, water begins to seep out of the cell, and then freezes outside the cell, and then the reaction of the cell depends on the cooling rate. Liqun He said that if the cooling is too fast, the cells will not have enough time to maintain the osmotic pressure balance of the internal and external solutions by oozing water, so that the intracellular solutions will be too cold, and eventually the cells will start to freeze.

　　Generally speaking, cooling too fast or too slow can kill cells. At the slow cooling rate, the low-temperature damage comes from the "solution effect", which leads to severe dehydration of cells. Under rapid cooling, the low temperature damage is caused by deadly intracellular ice. For a specific cell, there must be an optimal cooling rate with the highest cell recovery rate. The cooling rate is slow enough to prevent intracellular ice and fast enough to minimize the "solution effect".

　　According to reports, in addition to the above method, there is also a cooling method to make the cytoplasm glassy at present. Using ultra-fast cooling (> 106℃/min) or using high concentration CPA, the cytoplasm will form glassy state instead of intracellular ice. However, ultra-fast cooling is technically difficult. Several CPAs that can effectively improve the cooling damage in slow cooling can also be used to promote vitrification, but the required concentration is too high and it is too toxic to cells and tissues.

　　It should be noted that the cooling rate is too high or too low relative to the water permeability of cell membrane and related to the type of cells. Different cells have different permeability to water, which leads to different optimal cooling rates for different cells. Think about it carefully, the human body is composed of countless cells, and there are many differences between brain cells and liver cells. It is very difficult to target these cells with drugs, and it needs precise control. If you don’t pay attention, you can cause irreversible damage to cells. Compared with the current difficulty of oocyte cryopreservation, sperm or blood, it is almost impossible to accurately cool different cells.

　　Whether you can wake up is the key.

　　However, it is more difficult than accurately cooling different cells to reheat them. If astronauts can’t wake up from hibernation, what’s the point of freezing hibernation? How to rewarming cells safely is the "last mile" and the key point of freezing dormancy technology.

　　As mentioned above, in the process of injecting CPA into cells to cool down, cells are easily damaged. Similarly, in the process of rewarming, CPA must be pulled out of the cell, which is also full of danger. If the CPA is excessively diluted when it is taken out, the cells will absorb too much water and expand beyond the allowable upper limit, which will also cause cell damage.

　　Liqun He said that whether the rewarming process poses a threat to the survival of cells depends first on whether the previous cooling process induces intracellular ice or cell dehydration. If there is intracellular ice, rapid rewarming can prevent ice crystals from growing and destroying cells. However, even if there is no intracellular ice formation during slow cooling, the response of cells to rewarming rate depends on freezing conditions and cell types.

　　Moreover, it is also a big problem whether the body of the astronauts after waking up will be negatively affected. When the human muscles are in a static state for a long time, their functions will inevitably deteriorate to some extent. Although the similar "suspended animation" technology developed by SpaceWorks only allows the astronauts to sleep for 14 days, I believe everyone who has experienced it knows what it feels like to lie in bed for half a month.

　　This edition of pictures: information pictures

Original editorial department Xiao Wu Chang Xiao Health included in topic # 27 medical frontiers

With the aging of the population, heart failure has become one of the main causes of death.

According to China Cardiovascular Health and Disease Report 2020, the number of patients with cardiovascular diseases in China is about 330 million, including 8.9 million patients with heart failure.

In addition, patients with heart diseases such as coronary heart disease, hypertension, valvular heart disease and cardiomyopathy are also prone to induce heart failure.

In theory, heart transplantation provides a once-and-for-all solution for these heart patients, but in reality, it is even more difficult to wait for the right donor than winning the lottery.

On March 8, 2022, the first heart patient who transplanted a pig heart also died two months after the transplant operation.

Anyone who has seen the movie "Iron Man" knows that Iron Man has a "mechanical heart" that provides him with energy continuously, which may also be another choice for these heart failure patients.

Since the heart can grow,

It will definitely be built.

This sentence comes from kolff, the father of artificial organs, and the artificial hemodialysis device (that is, "artificial kidney") comes from kolff.

The development of artificial heart has experienced three generations.

The first generation in the 1990s was a large-volume pulsating blood flow device, the second generation in the early 21st century was an axial flow device, and the latest third generation was a magnetic suspension device. At present, the third generation artificial heart has been made in China. The pump body has a diameter of 34 mm, a thickness of 26 mm and a weight of 90 g, which is almost the size of an egg. At present, many clinical operations have been completed in China, and the survival rate of one and a half years is 100%.

The principle of "artificial heart" is actually not complicated.

After being implanted into the human body, the "artificial heart" is connected in parallel with the heart, with one end connected to the left ventricle of the heart and the other end connected to the human aorta. Blood enters the artificial heart from the left ventricle through the inflow tube, and the artificial heart pushes the blood out and delivers it to the aorta through the outflow tube, thus assisting the blood circulation of patients.

Simply put, "artificial heart" is an artificially made blood pump, which can partially or completely replace the heart to do work and help maintain blood circulation throughout the body.

For a normal person, the heart beats more than 60 times per minute and pumps out 5 liters of blood. Converted to 3600 beats per hour and 86400 beats per day, a total of 7200 liters of blood is pumped. The implanted "artificial heart" can pump 1-10 liters of blood per minute, which helps the human heart function to pump blood.

Domestic "subminiature magnetic suspension centrifugal artificial heart" uses magnetic field to suspend the impeller, thus providing good blood flow performance and partially replacing the patient’s heart function. The magnetic levitation system has high efficiency and low power consumption, and can minimize the damage to blood cells, which not only solves the problem of thrombosis, but also is easier to install in the chest cavity, so that other organs are less affected and the patient’s wearing experience is more comfortable.

Of course, having an "artificial heart" has some limitations. The most important thing is to stay away from the magnetic field, and take the high-speed rail and so on.

In June 2017, Fuwai Hospital took the lead in implanting the third-generation domestic magnetic levitation artificial heart into patients and achieved success. From the follow-up results of patients with "China Heart" after operation, the quality of life of patients has been comparable to that of patients receiving heart transplantation.

The future of artificial heart

For every family of patients with heart disease, the cost of surgery is a hurdle.

It is reported that each set of artificial hearts in the United States is about 100,000 US dollars (about 700,000 yuan), and the cost of artificial heart surgery in France in 2013 is 140,000 to 180,000 euros (about 1.1-1.4 million yuan). In 2019, the cost of replacing artificial hearts in Japan will be converted into more than 1.6 million yuan. Generally speaking, the international price of a device for artificial heart is 800,000 yuan to 1 million yuan.

In an interview, Li Xinsheng, a patient who received magnetic levitation artificial heart implantation in China, said that he probably paid more than 1 million yuan for the "artificial heart" after one operation, but the subsequent expenses were very small, and the daily use of anticoagulant drugs was more than 2,000 yuan a year.

Li Xinsheng carries a battery with him.

At present, it is predicted that there are 13 million patients with heart failure in China, and there are 600,000 patients with severe end-stage heart failure who meet the standard of using artificial heart.

Although the heart is one of the most important organs in the human body, if the artificial heart costs 500 thousand yuan, the cost is still relatively high. At present, there are more than 300 thousand brain pacemakers, which are not affordable for ordinary people.

However, the launch of new medical devices is relatively expensive at first, because it has to cover the heavy research and development costs in the early stage. With the gradual increase of product output and doctors who will operate, the consumption of patients will increase, and the price will gradually decrease. This is an inevitable trend and has a natural development process.

In addition to the price, artificial heart implantation has higher requirements for hospitals and medical teams. In addition to the cooperation of doctors in cardiology, anesthesiology and cardiopulmonary bypass, doctors in cardiology and imaging departments are also needed to objectively evaluate patients, and do a good job in postoperative rehabilitation and long-term follow-up management.

The National Health and Wellness Commission issued the Management Standard of Ventricular Assisted Technology (2021 edition), and the new standard also clearly defined the technical threshold for medical institutions to carry out artificial heart implantation:

For example, medical institutions are required to carry out clinical diagnosis and treatment of cardiovascular surgery for more than 10 years, with no less than 50 beds, and no less than 1,000 cases of cardiopulmonary bypass cardiac surgery are completed every year; Doctors should have more than 10 years of experience in clinical diagnosis and treatment in the field of cardiac and great vessels, and have obtained the qualifications for professional and technical positions above the chief physician for more than 3 years.

At present, artificial hearts are mainly used in three aspects:

First, as a transitional treatment, we will strive for more time for patients to wait for a suitable transplant donor;

The second is to provide short-term replacement support for patients with acute heart failure, which will be removed after cardiac function is restored;

The third is to provide long-term replacement for patients with end-stage heart failure and support patients to carry artificial hearts for long-term survival.

Judging from the above-mentioned scenes that it can be used at present, the artificial heart that appears at present is only a transitional product and a temporary replacement, which is still a long way from the completely artificial mechanical and biocompatible permanent artificial heart.

Perhaps one day, scientists can really solve all technical problems, develop a permanent artificial heart without any side effects, and solve the problem of organ shortage. By that time, does it mean that we can achieve immortality or even immortality by relying on the "mechanical heart" of Iron Man?

Original title: "If the heart can be born, it can be rebuilt! Artificial heart saves heart failure and makes the heart beat again.

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On August 18th, the website of the State Administration of Market Supervision published a batch of vehicle recall information, involving Volvo, Ford and other brands.

01

Safety belts are at risk of failure,

Volvo recalled about 244,800 cars.

Volvo Car Sales (Shanghai) Co., Ltd. and Zhejiang Haoqing Automobile Manufacturing Co., Ltd. decided to recall the following imported and domestic Volvo cars from January 18, 2021, totaling 244,800 vehicles.

(1) Volvo Car Sales (Shanghai) Co., Ltd. (102,070 vehicles in total)

From February 7, 2006 to April 8, 2016, there were 15 S80 cars of 2007-2016;

S80L vehicles of 2009-2015 produced from August 13th, 2009 to November 21st, 2015, totaling 41,684 vehicles;

A total of 33,488 S60 cars of 2011-2018 were produced from May 21, 2010 to August 14, 2018;

From March 14th, 2007 to April 27th, 2016, there were 2 V70 cars of 2008-2016;

From June 22, 2010 to August 27, 2018, a total of 25,594 V60 cars were produced in 2011-2018;

From March 18th, 2008 to April 22nd, 2016, there were 318 XC60 cars of 2009-2016.

From December 4, 2014 to August 21, 2018, a total of 969 V60CC vehicles of 2015-2018 were produced.

(II) Zhejiang Haoqing Automobile Manufacturing Co., Ltd. (142,730 vehicles in total)

From December 13th, 2013 to December 23rd, 2019, a total of 142,730 S60L vehicles of 2014-2020 were produced.

For some vehicles within the scope of this recall, due to design reasons, if the seat belt fixing cable installed outside the front seat is in a specific position, the driver and the front passenger may cause the seat belt fixing cable to bend repeatedly and exceed the yield strength of the cable, resulting in the cable stretching, and long-term fatigue and wear may lead to the cable breaking. When a vehicle collides, it may affect the seat belt restraint function, and in extreme cases, the seat belt restraint function may fail, which increases the risk of personal injury in the accident and has potential safety hazards.

Volvo Car Sales (Shanghai) Co., Ltd. and Zhejiang Haoqing Automobile Manufacturing Co., Ltd. will replace the improved front seat outer seat belt fasteners for vehicles within the recall range free of charge to eliminate safety hazards.

In addition, official website, the State Administration of Market Supervision, showed that before the vehicle is recalled for maintenance, it is suggested that the driver and the front passenger should ensure that the seat belt fixing piece is vertical when entering the vehicle, which is consistent with the direction of the seat back, so that the seat belt fixing piece will not bend to the seat cushion when the driver and the front passenger sit in the seat, and the seat belt fixing piece can be prevented from being damaged.

02

Ford recalls some imported Lincoln cars;

Seat airbag may not work properly.

Ford Motor (China) Co., Ltd. filed a recall plan with the State Administration of Market Supervision according to the requirements of the Regulations on the Management of Defective Automobile Product Recall and the Measures for the Implementation of the Regulations on the Management of Defective Automobile Product Recall.

It is decided to recall some imported Lincoln MKX cars from May 28, 2015 to July 30, 2018 from August 21, 2020, totaling 10,649 vehicles; And some imported Lincoln Navigator cars produced from September 27, 2018 to September 30, 2019 in 2019-2020, totaling 4,010.

For some vehicles within the scope of this recall, due to the narrow gap between the front seat harness and the seat pan frame, when the seat pan angle adjustment function is used, the edge of the seat pan frame may interfere with the seat harness, which may lead to the wear of the seat harness in extreme cases, which may cause the front seat airbag system to fail to work normally and pose a safety hazard.

Ford Motor (China) Co., Ltd. will entrust Lincoln authorized dealers to install flocking tape on the exposed edge of the front seat basin frame for vehicles within the recall scope free of charge, and at the same time, check the seat harness and repair or replace it as necessary to eliminate potential safety hazards.

Source: China Economic Weekly

Original title: "@ Jiading Owner, Volvo and Ford Recall 250,000 Cars! 》

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