Cancer, as one of the most common diseases with high mobility and high mortality in the world, the clinical treatments for its tumors generally include surgery, chemotherapy and radiotherapy. Due to the shortcomings of chemical drugs and various toxic and side effects, people have been committed to developing more effective drug delivery systems for cancer treatment, with the aim of reducing side effects and ensuring its efficacy.

With the progress and maturity of nanotechnology, its advantages are gradually reflected.

Introduction of nano-drugs

Diagram of sustained release process of nano-drugs

Nano-drug and its delivery system

Nano-medicine refers to nanoparticles or nano-carriers, which is a new product produced by the combination of nano-technology and medicine.

Nano-drug delivery system refers to the integration of small drug molecules into nano-materials by means of encapsulation or adsorption.

Advantages of nano-drugs

First, improve the solubility and absorption of drugs.

Nano-sized drugs are different from most chemotherapy drugs. Nano-sized drugs have larger specific surface area, better solubility, faster dissolution, improved absorption properties and better therapeutic effect.

At the same time, due to better solubility, the dosage of patients can also be appropriately reduced.

Second, prolong the drug’s circulation time in vivo, and enrich it to the focus.

Through some modification and treatment on the surface of nano-drugs, the circulation time of drugs in human body can be prolonged, which is beneficial for drugs to reach the lesion site, and special modification may make drugs more concentrated in the tumor site, resulting in better selectivity and targeting properties.

Nano-drugs can enter the tumor tissue through the porous blood vessels of the tumor, and achieve a high degree of penetration and retention in the tumor. Therefore, nano-preparation has excellent properties of high drug loading rate, passive targeting and controlled drug release.

Clinical application of nano-preparation.

Paclitaxel albumin nanoparticles

Paclitaxel is a commonly used anticancer drug in clinic. Here is a brief introduction to the nano-preparation of paclitaxel:

Paclitaxel, a commonly used anticancer drug

Albumin nanoparticles

Albumin nanoparticles are nano-particles based on albumin.

Albumin is an endogenous natural product with the advantages of safety, non-toxicity, non-immunogenicity, biodegradability and good biocompatibility. Moreover, the nanoparticle carrier system has unique targeting, sustained and controlled release characteristics and drug protection.

By high-pressure homogenization, paclitaxel and human serum protein preparation were made into nanometer freeze-dried powder, which can improve the solubility, avoid a large number of paclitaxel nanoparticles aggregation, and help the drug to be absorbed into tumor cells and give full play to its role.

Pharmacological action of paclitaxel

Paclitaxel is an anti-microtubule drug, which can stabilize microtubules by promoting the polymerization of tubulin dimer and inhibiting its depolymerization, thus inhibiting the normal dynamic reorganization of microtubule network during interphase and mitosis.

In addition, paclitaxel can lead to abnormal arrangement of microtubule "bundles", affect the division of tumor cells and promote tumor cell apoptosis during the whole cell cycle and cell mitosis.

indication

The application of albumin nanoparticles in the in vivo delivery of paclitaxel and cancer treatment has become a hot topic in recent years.

Albumin paclitaxel nanoparticles are mainly suitable for the treatment of metastatic breast cancer that failed in combination chemotherapy or breast cancer that recurred within 6 months after adjuvant chemotherapy.

Unless there are clinical contraindications, an anthracycline anticancer drug should be included in previous chemotherapy.

matters need attention

In the process of using paclitaxel albumin nanoparticles, it should be noted that paclitaxel for injection (albumin binding type) also has adverse drug reactions and must be used under the guidance of a doctor with chemotherapy experience.

Only with perfect diagnosis and treatment facilities can the complications and adverse reactions caused by drugs in treatment be effectively controlled.

references

[1] Jie Chen, Cao Ye, Li Shuangshuang, Luo Lailong, Yu Peng, Li Mingyuan. Research progress of novel nano-drug delivery system for tumors [J]. China Journal of Pharmacy, 2020,55(21):1749-1756.

Xin li, Zhu Dandan, Chen Yu, Lin Shuting, Han Lili, Li Ying, Liu Xiaoxuan. Research progress of nano-drug delivery system in promoting deep penetration of tumor [J]. Zhongnan Pharmacy, 2020,18(12):2009-2018.

Zhao Shuang, Zhang Shaofang, Mu Xiaoyu. Research progress of nano-drugs [J]. Tianjin Pharmacy, 2020,32(02):57-61.

Chen Dongxiao, Zhang Juanmei, Li Jianye, Xu Tianhong, Dong Yaqin, Pu Xiaohui. Research status and progress of paclitaxel albumin nanoparticles [J]. Journal of Henan University (Medical Edition), 2017,36(04):296-300.

[5] Chen Kang. Analysis of the research progress of paclitaxel pharmaceutical preparations [J]. Heilongjiang Medicine, 2019,32(06):1390-1392.

Contributed by: Song Haolin (Ruijin Intern Pharmacist)

Original title: "How do nano-warriors fight cancer-do you understand? 》

Read the original text

　　recent days

　　Many disease control departments have issued reminders:

　　Winter is the most common season for chickenpox.

　　The disease is highly contagious.

　　The key to prevention is vaccination against varicella.

　　This is also the most economical and effective measure.

　　Chickenpox is known as "face to face biography"

　　Kindergartens and primary schools are prone to collective outbreaks.

　　Chickenpox is an acute respiratory infectious disease characterized by a rash caused by the initial infection of varicella-zoster virus.

　　The disease is highly contagious, and people are generally susceptible to chickenpox. About 90% of susceptible people get sick after contacting patients, commonly known as "face-to-face transmission", which is easy to cause outbreaks, especially in infants and school-age children.

　　Chickenpox has an acute onset, with symptoms such as fever, headache, fatigue, nausea and vomiting in the prodromal stage. After 1-2 days, a rash appears, with more on the trunk, less on the limbs, head and face, and less on the palms, soles and oral mucosa, which can be differentiated from hand, foot and mouth disease. Can be secondary to bacterial infection, pneumonia, encephalitis, hepatitis and other complications.

　　Chickenpox is a self-limited disease with a natural course of 7-10 days. After the disease, it can gain lasting immunity. Isolation treatment should be carried out after the illness, until the chickenpox and herpes are all dry and scabbed, or not less than one week after the illness.

　　Life-long immunity can be obtained after illness, sometimes the virus remains in the ganglion in a static state, and herpes zoster occurs after years of infection recurrence.

　　Vaccinate against chickenpox

　　Is the most effective means of prevention.

　　1. Vaccination can effectively prevent varicella caused by varicella-zoster virus infection. The main target of vaccination is susceptible to varicella at the age of 12 months and above. Generally, vaccination for about 2 weeks can play a protective role.

　　2 to carry out monitoring, strengthen the morning and afternoon inspection, kindergartens and schools found suspicious children should immediately take measures such as isolation, medical treatment, disinfection of supplies. Clear isolation period should be until all patients with varicella and herpes are dry and scabbed.

　　3. Teachers and staff should maintain good personal hygiene, and classrooms and dormitories should be well ventilated.

　　4. Clean and disinfect toys, personal hygiene products (cups, towels, etc.) and tableware; Disinfect activity rooms, bedrooms, classrooms, door handles, stair handrails, desktops, bathrooms, etc.

　　5. Publicity and education; Use radio, blackboard newspaper, gallery and other forms to publicize the knowledge of prevention and treatment of respiratory diseases and improve students’ awareness of self-protection.

　　Jiangsu can be vaccinated with varicella vaccine for free.

　　Chickenpox is an infectious disease caused by varicella-zoster virus, which can occur all year round and is highly contagious. In recent years, routine monitoring of infectious diseases shows that public health emergencies related to chickenpox account for more than 80% of all public health emergencies related to infectious diseases, and all of them occur in kindergartens and schools, seriously affecting children’s health and normal teaching and living order. At the same time, the chickenpox epidemic in kindergartens and schools is easy to spread to communities and families, resulting in a wider spread.

　　In order to effectively reduce the incidence of chickenpox, reduce the occurrence of public health emergencies caused by chickenpox, and prevent the cluster epidemic of chickenpox, with the consent of the provincial government, since January 1 this year, Jiangsu Province has included live attenuated chickenpox vaccine in children’s immunization program, and school-age children can be vaccinated with 2 doses of live attenuated chickenpox vaccine for free.

　　Routine immunization procedures are as follows:

　　The first dose was inoculated at the age of 12 to 18 months, and the second dose was inoculated at the age of 4. The interval between two doses of indirect inoculation is not less than 3 months.

　　All school-age children born after January 1, 2017, who are included in the management of Jiangsu Children’s Vaccination Information System and have lived for more than 2 months can be vaccinated free of charge.

　　Parents can bring their children to the vaccination clinic of the local community health service center for an appointment.

　　Synthesis: Jiangsu CDC and Nanjing CDC.

Suggestions: Suggestions on vigorously improving the local matching rate of automobile parts and enhancing the overall competitiveness of automobile industry chain.

Automobile industry is an important industry in Guangxi and a pillar industry in Liuzhou. Liuzhou is one of the important automobile industry gathering places in China, with four automobile enterprises including SAIC-GM-Wuling, Dongfeng Liuqi, faw liberation Liuzhou Branch and Guangxi Automobile Group. In 2021, the estimated output value will exceed 175 billion yuan, and the automobile production and sales will reach 1.88 million and 1.89 million respectively, among which the output of new energy vehicles will exceed 480,000, up 157.6% year-on-year.

At present, the automobile industry is facing an unprecedented change in a hundred years, and the automobile industry chain in the whole region is facing great challenges:

1. The layout of the "Three Electricity" industrial chain of new energy vehicles in Guangxi is not perfect, and the supporting system and R&D capability of the whole industrial chain of vehicles have not been upgraded. There are shortcomings in supporting local intelligence, networking, domestic chip components and intelligent driving control systems. For example, in 2021, leading enterprises in Guangxi’s new energy automobile industry, such as SAIC-GM-Wuling and Dongfeng Liuqi, are facing the problem of strong market demand but shortage of core components (control chips, power batteries, engines, etc.), and the satisfaction rate of SAIC-GM-Wuling core chips is only 30%.

Second, the core industrial chain is underdeveloped, and the localization, research and development and manufacturing capabilities of core components such as high-performance engines for passenger cars, automatic transmissions, and new energy vehicles "Three Electricity" need to be improved. The intelligent manufacturing level of local supply chain is not high, and the production operation efficiency can not meet the future competition. Take SGGM-Wuling as an example, the automation rate of its supporting suppliers in Liuzhou is about 30%, which is half that of supporting suppliers in Chongqing; The completion rate of digital factory transformation is less than 10%.

4. In recent years, Liuzhou City has successfully explored the "Liuzhou Model" for the promotion and application of new energy vehicles through the linkage between government and enterprises. In 2021, the autonomous region also introduced relevant policies for the promotion of new energy, but the promotion and application of new energy passenger cars and commercial vehicles in other cities still need to be further strengthened.

5. The competition in the new energy automobile industry will be more intense. The number of new energy automobile main engine plants has reached more than 76, and the traditional automobile giants have launched brand-new new energy vehicles. At the same time, the electric replacement models and hydrogen battery models of commercial vehicles of major automobile enterprises have also appeared. It is estimated that the output of new energy vehicles will reach 5 million in 2022.

The new energy automobile industry has become the key field of the future competition of the world automobile industry. Promoting the transformation and upgrading of the automobile industry in Guangxi is particularly important for the development of Guangxi during the "Tenth Five-Year Plan" period. It is urgent to introduce more key projects, create more competitive parts products, maintain the stable operation of the industrial chain, improve the local matching rate of automobile parts and enhance the overall competitiveness of the automobile industry chain.

To this end, it is suggested that:

First, make the industry leader bigger and stronger, and improve the driving ability and efficiency. Give full play to Liuzhou’s role as a pioneer of high-quality industrial development in the whole region, and relevant departments of the autonomous region will increase policy support and land use security to promote the strong chain, supplementary chain and extension of Liuzhou’s new energy automobile industry chain. We will increase the layout of the independent controllable capacity of the automobile industry chain led by SAIC-GM-Wuling and Dongfeng Liuqi, support the accelerated development of new energy vehicle projects, and constantly improve new energy platforms, large and medium-sized logistics vehicles, HEV energy-saving vehicles, commercial vehicles, trams and hydrogen energy commercial vehicles, enhance local basic process design, research and development capabilities and manufacturing capabilities, and consolidate the foundation of the automobile and equipment manufacturing industry chain. In five to eight years, the local matching rate will gradually increase by more than 15%, the output value of new energy automobile industry will increase by 50 billion yuan, the output value of high-tech and high value-added supply chain will increase by more than 20 billion yuan, and the total automobile production and sales will increase by 5% every year, and the market share in the country will reach more than 10%, and the total output value will increase by more than 100 billion yuan.

Second, relying on the leader to promote the gathering of industrial chain elements of the new four modernizations. In combination with the 14th Five-Year Plan of Guangxi Automobile, the relevant departments of the autonomous region, aiming at the weak points of the "new four modernizations" industrial cluster, have issued targeted policies and measures for attracting investment, carried out precise investment and special investment, attracted leading enterprises in the new energy automobile industry to settle in Liuzhou, strived to introduce a number of "three power" and intelligent networked supply chains, planned chip packaging, testing and application localization projects synchronously, and gradually built a new four modernizations with complete elements.

Third, improve the level and support the digital and intelligent upgrading of the industrial chain. Strengthen the cooperation of the government, scientific research institutions, enterprises and other parties, build leading enterprises, promote the intelligent upgrading of the industrial chain, focus on cultivating core enterprises such as SEEK Technology, focus on the upgrading of intelligent workshops and smart factories, accelerate the construction of industrial Internet, deepen the cost reduction and quality improvement of the automobile industrial chain, and enhance the competitiveness of the existing local parts market; Vigorously build a public service platform for intelligent manufacturing, support enterprises to carry out technological innovation, mechanism system innovation and business model innovation, and stimulate enterprise innovation and creativity.

Fourth, strengthen the promotion of new energy vehicles and cultivate the development environment of new energy vehicles in Guangxi. Pilot application of "Liuzhou Model for Promotion and Application of New Energy Vehicles" in various cities in the whole region, and promote and apply new energy commercial vehicles, urban logistics vehicles, special vehicles and other vehicles in ports, factories and mines and long-distance trunk transportation in conjunction with Guangxi Automobile Group, Dongfeng Liuqi and Heavy Duty Truck Transportation; Promote the application of new energy sanitation vehicles in urban and rural areas; Introduce financial leasing companies and other models, start commercialization pilots, and promote the application of new energy logistics vehicles in the fields of postal services, express delivery, and e-commerce terminal logistics; Give full play to the advantages of intelligent new energy vehicles and actively promote the transformation and upgrading of new energy commercial vehicles and special vehicles to participate in the intelligent transformation of ports, factories and mines.

Five, the implementation of the policy, increase the introduction and cultivation of high-end talents such as the "new four modernizations". Support, guide and encourage OEMs to strengthen the construction of innovative teams, implement the talent strategy of "going out" and "bringing in" in parallel, and continuously consolidate the stability and development of talent teams. On the one hand, we will build talent enclaves and R&D enclaves, break geographical restrictions, and gather industry elites to contribute to industrial chain construction. On the other hand, we will further optimize the talent introduction and education policy, improve the talent development environment, improve the talent care and protection policy, and strive to build a high-end innovative talent team with key core technologies, lead the industrial development, and promote the transformation and upgrading of the industrial chain, and strive to maintain the stability of high-end and special talents in enterprises.

Organizer: sponsored by the Department of Industry and Information Technology of the Autonomous Region, assisted by the Liuzhou Municipal People’s Government, the Science and Technology Department of the Autonomous Region and the Investment Promotion Bureau of the Autonomous Region.

Handling the reply:

Liuzhou Municipal People’s Government on the 12th CPPCC Autonomous Region

Letter of opinions of the fifth meeting on proposal No.20220291

Department of Industry and Information Technology of the Autonomous Region:

Now, we will inform you of the handling of the suggestions put forward in Proposal No.20220291 of the Fifth Session of the 12th CPPCC Autonomous Region on vigorously improving the local matching rate of auto parts and enhancing the overall competitiveness of the automobile industry chain. Please reply to the proposer together after synthesis.

I. Production and Marketing of Automobile Products in Liuzhou City

In 2021, the city’s vehicle production and sales were 1.895 million and 1.882 million respectively, up by 8.2% and 4.7% year-on-year. The growth rate of production and sales was 4.8 percentage points and 0.9 percentage points higher than that of the whole country, and the sales growth rate outperformed the national market. Among them, the production and sales volume of new energy vehicles all reached 482,000, up by 157.6% and 158.7% respectively year-on-year, and the sales volume of new energy vehicles produced in Liuzhou accounted for 13.7% of the national sales volume of new energy vehicles.

II. Answers to the suggestions made in the proposal

(A) on the "bigger and stronger industry leader, improve the driving ability and efficiency" proposal.

In recent years, the autonomous region and Liuzhou City have continuously optimized the industrial development environment, improved the policy support system, enriched the service methods of enterprises, fully supported the transformation and development of the automobile industry, and made the leading enterprises bigger and stronger. Liuzhou actively supports SAIC-GM-Wuling, Dongfeng Liuqi and other automobile main engine plants to increase the research and development of new products, and supports SAIC-GM-Wuling to implement the "two million" new energy platform project and the research and development of E-series and Hongguang MINI new energy vehicles; Support Dongfeng Liuqi to develop T5EVO, yacht, S50EV, hydrogen fuel commercial vehicle and pure electric commercial vehicle; Support the research and development of G100 new energy logistics vehicle of Guangxi Automobile Group. Actively promote the construction of the national automobile quality inspection center (Guangxi) intelligent networked automobile closed test site and Liuzhou automobile networking pilot area, and support the transformation and upgrading of automobile products of automobile OEMs. At the same time, actively assist leading automobile enterprises to explore overseas markets, the new energy automobile market in Guangxi and the northern market.

Focusing on the leading enterprises in the automobile industry, we will increase the layout of independent and controllable capabilities in the automobile industry chain. The autonomous region issued the Work Plan for Promoting the Transformation, Upgrading and Development of the Automobile Industry, the Notice on Improving the Local Matching Rate of Automobile Parts, the Notice on Printing and Distributing the Work Plan for Making SAIC-GM-Wuling Leading Enterprises Form the Whole Industry Chain of Liuzhou Automobile, and the Notice on Printing and Distributing the Work Plan for Making Dongfeng-Liuzhou Leading Enterprises Form the Whole Industry Chain of Liuzhou Automobile. Liuzhou has issued such policy documents as Implementation Plan for Transformation and Upgrading of Liuzhou Automobile Industry, Several Measures for Promoting the Development of Mould Industry in Liuzhou City and Several Measures for Promoting the Development of Casting and Forging Industry in Liuzhou City, which strongly support the construction of strengthening, supplementing and extending the chain of Liuzhou automobile industry chain.

In recent years, Liuzhou’s automobile industry has overcome the adverse effects of rising raw materials, repeated epidemics, chip shortage and power shortage, and gradually realized the transformation from traditional fuel vehicles to new energy vehicles. The production and sales volume have rebounded year by year, and the automobile production and operation of the OEM have achieved good results. In 2021, SAIC-GM-Wuling produced 1.672 million vehicles, up 8% year-on-year, of which 458,000 new energy vehicles were sold, up 157.5% year-on-year. Dongfeng Liuqi produced 200,000 vehicles in 2021, up 11.2% year-on-year, including 125,000 passenger vehicles, up 35.6% year-on-year. At present, there are E100/E200/E300 new energy automobile products produced in Liuzhou.

/E300Plus/ Hongguang MINI EV, S50EV, G100 logistics vehicles, Dongfeng Liuqi new energy power exchange vehicle, Dongfeng Liuqi hydrogen fuel commercial vehicle and other new energy vehicle products, and the products are gradually serialized.

Liuzhou plans to build a well-known domestic R&D and production base for the whole industrial chain of new energy vehicles in about five years, and build a well-known domestic new energy automobile city in Guangxi, with a production and sales scale of over 2 million vehicles and an output value of over 170 billion yuan. The production technology of complete vehicles and main parts enterprises has reached the domestic leading level. In the next step, several key projects will be implemented in the new energy automobile industry: First, the "two million" new energy automobile platform project of SAIC-GM-Wuling. Invest 30 billion yuan to build two platforms of millions of new energy vehicles, pure electric vehicles and hybrid vehicles, accelerate the localized production of the industrial chain of new energy vehicles, and realize the new output value of more than 100 billion yuan. Second, Dongfeng Liuqi new energy transformation project. Invest 4.3 billion yuan, strive to sell more than 10,000 new energy vehicles such as hydrogen fuel heavy trucks, and realize the new output value of new energy heavy trucks of more than 12 billion yuan. The third is the transformation project of new energy vehicles of Guangxi Automobile Group. Invest 3 billion yuan to develop the new energy logistics vehicle market, form three major product series of passenger cars, trucks (modified vehicles) and off-road vehicles, and at the same time promote the OEM plan of new energy passenger cars, achieving an additional output value of more than 10 billion yuan. Fourth, the new energy automobile industry chain extension and chain repair project. Invested 12 billion yuan, introduced Qingshan Ruipu power battery, United Automotive Electronic New Energy Vehicle Controller, Wuhan Yuanfeng ABS Controller and other projects, with an added output value of more than 50 billion yuan.

(B) on "relying on leading enterprises to promote the new four industrial chain elements gathering" proposal.

Liuzhou insists on promoting the electrification, intelligence and networking development of the automobile industry as an important direction to promote the transformation and upgrading of the automobile industry. Relying on the continuous improvement of the new energy automobile product market of SAIC-GM-Wuling and Dongfeng Liuqi, Liuzhou has carried out accurate investment promotion and accelerated the layout of supporting industrial chains. Liuzhou Guoxuan Hi-Tech New Energy Battery 5 GWh Project, Huating Power Battery Pack Production Line and Liuzhou Shuanglin New Energy Motor Project were completed and put into operation, SAIC-GM-Wuling built the first automobile controller production line, Sykes hybrid engine was developed, Penghui new energy storage project and Sykes Ruipu new energy battery project started construction, and the United Electronics Phase III new energy electric control drive project and Nexter new energy parts project were signed. Taking the construction of the car networking pilot area as an opportunity, we will increase investment attraction and introduce 8 industrial projects related to intelligent networking. The industrial chain construction of new energy vehicles has achieved good results, and various major core components have been put into production one after another. At present, local production of major components such as new energy power batteries, drive motors, bridges and controllers has been realized.

In the next step, in accordance with the relevant requirements of investment promotion of key industrial chains in the autonomous region and Liuzhou, we will continue to further promote the project of supplementing and strengthening the chain, especially for the upstream of new energy vehicles and intelligent network connection, and gradually build a new four-oriented industrial chain with complete elements.

(C) Suggestions on "upgrading the level and supporting the digital and intelligent upgrading of the industrial chain"

Liuzhou steadily promotes the construction of key industry platforms, with automobiles and construction machinery as the main line, and government and enterprises work together to support leading enterprises in the industry to build industry-level industrial Internet platforms and promote the digital transformation of upstream and downstream enterprises in the industrial chain. SAIC-GM-Wuling digital supply chain collaborative intelligent industrial Internet platform has been included in the pilot demonstration project of the Ministry of Industry and Information Technology for three consecutive years, and has been popularized and applied in more than 700 parts enterprises. More than 900 enterprises have carried out procurement collaboration on Guangxi machinery industry Internet platform built by Liugong. The Cheheyun Industrial Internet Platform built by Guangxi Automobile Group has been applied by more than 700 suppliers.

(D) Suggestions on "Strengthening the promotion of new energy vehicles and cultivating the development environment of new energy vehicles in Guangxi"

Liuzhou actively supports the local automobile main engine factory to carry out the promotion and application of new energy vehicles, and has formed the "Liuzhou model" for the promotion and application of new energy vehicles. In 2019, Liuzhou City and 13 other cities in Guangxi jointly launched the "Guangxi New Energy Vehicle Promotion and Exchange Series" to jointly explore and practice the "Guangxi Model" for the promotion and application of new energy vehicles, cultivate and expand the new energy vehicle market in Guangxi, and achieved remarkable results. By the end of March 2022, the total output of various new energy vehicles was 935,000 and the total sales volume was 916,500; The number of new energy vehicles is 122,700, accounting for 12.31%; Built 1016 charging pile sites and 11378 charging piles (2032 fast charging piles and 9346 slow charging piles); 530 public charging socket stations, 7041 public sockets and 17357 personal sockets have been built.

In the next step, Liuzhou will continue to accelerate the development of the new energy automobile industry, encourage SAIC-GM-Wuling and Dongfeng Liuqi to speed up the development and listing of new energy products, realize the increase in sales of new vehicles as soon as possible, and at the same time seize the favorable opportunity of the national new energy vehicles going to the countryside, accelerate the construction of charging infrastructure in counties and townships under the jurisdiction of Liuzhou, create a favorable environment for the promotion of new energy vehicles in counties and townships, and promote the extension of the promotion and application of new energy vehicles to counties and townships. At the same time, actively strive for the support of the autonomous region, increase the promotion and application of the "Liuzhou model" in the whole region, and create a good environment for the promotion and application of new energy vehicles produced in Liuzhou.

(V) Suggestions on "implementing policies and increasing the introduction and cultivation of high-end talents such as the" new four modernizations "

Liuzhou has issued some policy documents, such as "Several Measures for Accelerating the Gathering of Talents in the New Era in Liuzhou" and "Detailed Rules for the Classification of Talents and the Implementation of Incentive Subsidies in Liuzhou (Trial)", to increase the introduction of talents. From October 1, 2018, the city will achieve the goal of total talents exceeding 1 million in five years, including 100 high-end talents, 3,000 senior management talents, 3,000 doctors and masters, and high-skilled talents. According to different levels of talents, preferential treatment is given from salary, living allowance, housing purchase (rental) allowance, children’s enrollment and other aspects.

In 2022, Guangxi New Energy Automobile Laboratory settled in Liuzhou. Through joint innovation of politics and Industry-University-Research, it focused on five major sectors, namely, technical research, product development, intelligent manufacturing, industrial chain and ecological construction, and built the highest level and level of scientific and technological R&D innovation platform in Guangxi, creating a whole-chain R&D innovation base, a new highland for industrial talents training and a source of industrial ecological model in the whole region, and accelerating the "double-chain" integration of industrial chain in innovation chain. At the same time, in the process of layout of science and technology projects, guide local car companies to carry out joint research with universities, research institutes, key laboratories and other units, set up talent cultivation indicators, strengthen the construction of talent teams, and enhance the R&D and innovation capabilities of enterprises. In the introduction of high-level talents, we should pay more attention to the accurate introduction of talents, pay attention to the introduction of high-end innovative and entrepreneurial talents, achieve a benign interaction between talents and industries, and achieve a win-win situation for the development of talents and industries and enterprises. At present, four high-level talent projects in the automobile industry have been introduced to Liuzhou, including two B-type talent projects, one D-type talent project and one E-type talent project.

I am writing this letter.

the peopl citye’s government of liuzhou

June 24, 2022

On July 18, 2018, Dakar, Senegal, the Museum of Black Civilization. Xinhua News Agency reporter Yan Yanshe　　　

Seven million years ago, in the active primate community in Africa, a figure stood up and took a small step for the individual at the "fork in the road" when the apes were about to leave, but it became a big step for mankind.

Today, this "fork in the road" is located in a remote desert in Chad. The skull left by that figure has been fossilized by the years and inadvertently exposed in front of people in the sand.

"This is the earliest known ancient human," Michel Bruehne, the leader of the fossil discovery team and a professor at the Institut fran? aise, said in an interview with Xinhua News Agency recently. "His name is Toumai, which means" hope of life "in the local language.

What is Man: The Controversy Faced by Tumai

Tumai’s skull fossil was discovered by Bruehne’s team in 2001. The original is now in the National Research and Development Center of Chad, and the replicas are exhibited in the National Museum of Chad and the Senegalese Museum of Black Civilization. Aimei Contusan, the chief researcher of the Museum of Black Civilization, said: "Tumai is considered to exist between the primate chimpanzee genus and the human genus." This expression reflects the controversy that Tumai once faced.

The facial image reconstructed from Tumai’s skull can directly explain the controversy. The hair and facial features on the reconstructed head look a bit like orangutans. Experts believe that Tumai is a male, and his fossils show the mixed characteristics of apes and humans: the skull shape is similar to that of apes, the brain volume is close to that of chimpanzees, and the orbital spacing is similar to that of gorillas.

Only three months after Bruehne’s team published a paper on Tumai in the British journal Nature in July 2002, milford Wolpov of the Paleoanthropology Laboratory of the University of Michigan and others published a questioning article in Nature in October, arguing that Tumai was still an ape rather than a human being.

However, there is also a lot of evidence to support that Tumai is a human being. Bruehne published a response article in Nature in 2005. He told reporters: "Some people say that this is a gorilla, and the canine teeth will be hollow and very large, but this is the canine teeth of human beings. The position of the foramen magnum on the skull is also different from that of gorillas and chimpanzees, but it is in line with the characteristics of human legs walking upright. "

"What is a person?" Wu Xiujie, a researcher at the Institute of vertebrate paleontology and Paleoanthropology, Chinese Academy of Sciences, pointed out in an interview with Xinhua News Agency that the focus of relevant disputes is actually the definition of human beings.

"Before the 1960s, paleoanthropologists generally used whether they could make tools as the boundary between humans and apes. However, it was later discovered that making tools is not a unique ability of human beings, and animals such as chimpanzees can also make tools. Therefore, paleoanthropologists gradually adopted a new standard: habitual walking with two legs upright. "

Wu Xiujie said that the position of the foramen magnum of Tumai’s skull is as downward as ours, indicating that the skull is vertically located on the spine, indicating that it has habitually walked upright with two legs. "This is decisive evidence." She said that the current academic classification of Tumai is the Sahelian Chad species. Although it does not belong to the genus of modern people, it belongs to the human family, which is the same as other ancient humans.

On April 8, 2009, several primary school students watched the reduced image of human ancestor fossil "Lucy" at the National Museum in Addis Ababa, Ethiopia. Xinhua News Agency reporter Deng Jianshe　

"The Ape": The Fork of 7 million years ago

Since Tumai is a human being, its "age" is particularly meaningful. Bruehne’s team published a paper in the Journal of the National Academy of Sciences in 2008, saying that the dating result of Tumai skull is between 6.8 million and 7.2 million years, which is often said to be 7 million years for convenience. He said: "So far, no human beings older than this have been found."

This means that the time of human origin has been pushed forward by Tumai.

For many years, Lucy, a famous ancient human fossil, has been called "the old grandmother of mankind". This female skeleton fossil, discovered in Ethiopia in 1974, is highly valued for its completeness and antiquity. Fossils include skulls, ribs, arm bones, etc., and are the most complete fossils of their kind. Its "age" is about 3.5 million years, and it has been firmly in the top spot in the world for a long time after being discovered.

But older fossils have appeared one after another. An ancient human fossil found in Kenya in 2000 was named Millennials because of its discovery time. It was about 6 million years ago and won the throne of "the highest generation". Only one year later, Tumai was discovered in Chad, which pushed forward the time of human origin by 1 million years.

The significance of Tumai is not only in time, but also in space. Before Tumai, because important early human fossils such as Lucy were found in eastern Africa, Yves Copon, a famous French paleoanthropologist, put forward the theory of "East Story", which believed that human beings originated in the east of the Grand Canyon in East Africa. Tumai appeared in the desert of Chad in central Africa and moved about 2500 kilometers west of the Grand Canyon, breaking the theory of "East Story".

"Tumai’s discovery shows the progress of scientific research," Contusan said. "With the further development of science and technology, we may find more ancient humans."

On August 8, 2019, Michel Brunet, a professor at the French Academy, was interviewed in his office in Paris. Xinhua News Agency reporter Gao Jingshe

The blind touch the elephant: the evolutionary tree of ancestors has not yet been explored

Tumai, who stood 7 million years ago, is the earliest ancestor we can see now. Is he our ancestor?

Ordinary people may naturally have such an idea. In Chad, most people know Tumai and are proud of it. Abubakar Saleh, a citizen of Chad, said: "Tumai is the ancestor of mankind, and we are the descendants of Tumai. This is a great honor."

But in the opinion of experts, the evolutionary tree of human ancestors is far from clear. Wu Xiujie said: "Because of the scarcity of fossils, our research on the evolutionary tree of ancient humans is still blind."

Now, a mainstream view in paleoanthropology is the "African origin" of early humans, because all the ancient human fossils found 2 million years ago are in Africa. "Human beings have spent a long time in Africa," Bruehne said. From a very long time scale, "we are all Africans, and outside Africa, we are all immigrants".

However, there is still controversy in academic circles about how modern people originated in more recent places. For example, for the ancestors of Chinese, there is an international view that although there were Yuanmou people 1.7 million years ago and Peking Man 770,000 years ago, these ancient humans may not have survived the Ice Age, and another group of ancient humans came out of Africa about 60,000 years ago.

Recently, however, many new fossil evidences have been found in the paleoanthropologists in China, such as Xu Changren, Dao County Man, Huanglong Cave Man, Chongzuo Homo sapiens Cave Man, etc. about 100,000 years ago. These new fossil evidences challenge the view that there are no modern people in China earlier than 60,000 years.

Wu Xiujie said: "The evolution of ancient human branches is not an isolated and linear process, but a complex bush-like process. There may be a mixture between branches, some branches may later perish, and new branches may arise somewhere. The trunk and panorama of the human evolutionary tree have not been explored yet. "

It is not clear whether Tumai is the ancestor of today’s modern people, even the Chadians. Wu Xiujie said: "But if we look at it from a particularly long time scale, we can say that Tumai and all of us modern people are relatives."

(The original title is "Special Feature: 7 million years ago, the" fork in the road ",he went to the human side")

Every time you get a ticket, you have to go to the tax service hall.

The journey takes a long time.

Also bring the tax controller, ID card and special seal for invoice.

It’s easy to leave things behind if you’re not careful

Now these troubles can be solved.

Since June 1, 2020

Beijing Economic Development Zone Taxation Bureau

It will be a normal ticket-using enterprise in the region.

Provide through the "e-ticket delivery" mode

Free mail delivery service for receiving invoices

Yifen

How to operate this "ticket e delivery"?

Xiaoye

Xiaoye has prepared a detailed tutorial for everyone. Let’s take a look!

Detailed operation manual of "ticket e delivery"

"Ticket e-delivery" is a convenient service project of online invoice collection launched by logistics service unit entrusted by Beijing Taxation Bureau of State Taxation Administration of The People’s Republic of China. It aims to solve the problems of long journey, long time-consuming and difficult queuing for taxpayers to go to the tax service hall, and realizes the one-stop invoice collection service of "online application of taxpayers, automatic processing on cloud platform, and limited logistics delivery to the door".

one

"e-ticket delivery" feature

1. All year round, 365*24 hours service;

2. Express delivery to your door within 24 hours;

3. Coverage of the whole city, which can be delivered in Beijing area;

4. tax express through train, unlimited number of non-traffic jams;

5. Professional support team, 24-hour service hotline 4006289911 to provide follow-up guarantee;

two

Ticket e delivery qualification requirements

1. The tax registration status is business;

2. VAT taxpayers (except taxpayers who declare VAT on a per-time basis and general VAT taxpayers during the counseling period);

3. It has been included in the upgraded version of the VAT invoice system;

4. There is no internal investigation information about invoices;

three

Ticket e delivery invoice type

Five categories and seven versions of invoices can be applied for online: "two-copy and five-copy versions of general VAT invoices, three-copy and six-copy versions of special VAT invoices in Chinese, unified invoices for motor vehicle sales (computer version), roll-type invoices for taxi passengers and electronic general VAT invoices".

four

Application for online ticket collection qualification

1. Taxpayers log in to State Taxation Administration of The People’s Republic of China Beijing Electronic Taxation Bureau.

2. Click Login, enter State Taxation Administration of The People’s Republic of China Beijing Electronic Taxation Bureau, and click the "Invoice Use" module under the "I want to do tax" directory.

3. Taxpayers enter the "invoice collection" and click the "invoice distribution (e-delivery)" button to enter the "e-delivery" qualification application page (note: if you are qualified to apply for invoices online, you will directly enter the invoice application page, otherwise you will enter the online invoice application qualification application page).

4. You need to submit a qualification application for the first use. Fill in the real contact person and mobile phone number, and confirm that "our company (or individual) confirms to voluntarily use the" ticket e-delivery "service", and click the submit application button.

five

Steps to apply for invoices online

1. Taxpayers enter State Taxation Administration of The People’s Republic of China Beijing Electronic Taxation Bureau;

2. Select "Invoice Business" in the navigation bar and click "Invoice Distribution (Ticket E Delivery)" to enter the "Ticket E Delivery" page;

Step 3 fill in the application form

Enter the invoice application page and click the "New Application" button on the right side of the page.

Note: This button will only appear after the last invoice application order has been accepted successfully.

The application form is as follows. You need to fill in the number of applications, the name of the ticket holder, the mobile phone number, the location, the detailed address and the postal code. Among them, the number of applications must be an integer multiple of 5 and cannot be greater than the number of applications.

After filling out the application form, click the "Save" button. The table can be modified before it is submitted again.

4. Submit the application form

Please submit this application form when you are sure that the information filled in is correct. ("Submit" button in the action bar of the list page) After the submission is successful, please wait for the tax authorities to accept your application.

When submitting, you need to check the "Ticket E Delivery" service use confirmation form, otherwise it cannot be submitted.

5. Print the bill receipt

When the "Business Status" changes to "Package Picking Completed, Delivery Started", you can print the "Invoice Receipt Form for Online Collecting of Beijing Taxation Bureau" through the button in the operation bar of the page. The printed bill receipt needs to be stamped with official seal or special seal for invoice. When distributing the invoice, you need to receive the ticket with this receipt.

6. Sign the physical invoice

The delivery staff will contact you through the mobile phone number when submitting the application. When signing, please show the Invoice Receipt Form for Online Receipt of Invoice from Beijing Taxation Bureau, and check the invoice code and invoice number of the physical invoice. After confirmation, please give the stamped ticket receipt to the delivery staff.

END

This article was published by Yizhuang, Beijing.

Please indicate the source for reprinting.

The news comes from Beijing Economic Development Zone Taxation Bureau.

Original title: "From June 1st, tax invoices can be delivered home free of charge without queuing"

Read the original text

　　[PConline first evaluation]This generation of Turing graphics card is rarely divided into two series by NVIDIA, one is RTX 20 series graphics card which focuses on ray tracing and is aimed at higher-end players, and the other is GTX 16 series which is relatively cost-effective. The first shot of GTX 16 series was started by GTX 1660 Ti as early as last month. Its price in the early 2000 yuan is more than 30% ahead of GTX 1060, and its performance is really cost-effective. Today, GTX 16 series welcomes a new member. GTX 1660 has no Ti, so today, let’s take a look at whether the performance of GTX 16 series is satisfactory.

　　For Turing architecture graphics cards, everyone should be familiar with it. It has been half a year since the first Turing architecture graphics card RTX 2080 Ti was released. Compared with Pascal’s, SM of Turing GPU architecture has been greatly changed, reducing the number of CUDA cores in Turing SM units to 64 (Pascal is 128), but increasing the number of SM units. TU102 has 6 GPC graphics processing clusters, each with 12 groups of SM units, totaling 72 groups of SM units, while GP102 has 36 groups of SM units, and at the same time increasing the cache of each group of SM units. L0 cache is added, and L1/ shared cache is increased to 96KB, which seems to be reduced, but the allocation method is more flexible. When necessary, L1 cache is allocated to 64KB, which is 50% higher than Pascal graphics card’s 48KB.

　　For the technical analysis of product detailed analysis, you can also jump here to consult.https://diy.pconline.com.cn/1172/11720764.htmlcheckread

　　However, the Turing core used in GTX 16 series and RTX 20 series is still slightly different.

　　GTX 1660 Ti and GTX 1660 useThe redesigned TU116 coreTU116 has reduced the SM unit of GPC to 8 groups per cluster, while the core of RTX 20 series graphics cards is 12 groups. The complete TU116 core has 3 sets of GPC, including 24 sets of SM and 1536 CUDA stream processors, which is also the specification of GTX 1660 Ti, while the TU116-300 core used in GTX 1660 only castrates two sets of SM, and the number of stream processors reaches 1408.

　　In addition, RTX series graphics cards use FP16 to calculate Tensor Core, while TU116 replaces tensor Core with a dedicated FP16 computing Core.

　　Another castrated place is memory. GTX 1660 uses GDDR5 memory of the same model as GTX 1060, and the memory frequency is far less than GDDR6.

　　Detailed parameters of GTX 1660 are as follows.

　　Parameter comments:The number of GTX 1660 CUDA stream processors is 1408,It is 128 less than GTX 1660 Ti, but it will still be 128 more than GTX 1060.

　　GTX 1660 still uses GDDR5 video memory, which means that the graphics cardThe bandwidth of video memory is the same as GTX 1060, which is 50% lower than GTX 1660 Ti.

　　The core frequency of the public version is 1530-1785MHz, which is slightly higher than GTX 1660 Ti. 　

　　The TDP of the graphics card is still 120W, which means that the power consumption of the graphics card is not much different from that of GTX 1060.

　　Official guide price of GTX 1660Starting from 1799 yuan, 400 yuan less than GTX 1660 Ti, and 200 yuan less than GTX 1060 when it was first launched, so is the graphics card worth it? Just look down.

　　Let’s go directly to the testing link. Before testing, let’s briefly introduce the testing platform.

　　Since there is no public version of GTX 1660 Ti, this time we first got the Galaxy Gemini, namely GTX 1660 Master and GTX 1660 General. In the end, GTX 1660 will be appointed as the test graphics card. The core frequency of the graphics card is 1530-1830MHz, and the BOOST frequency is 45MHz higher than that of the public version. In theory, the performance will be 1~2% higher than that of the public version.

　　Many factors have been considered in the selection of the graphics card that participated in the comparison. From the specifications, we know that the performance of GTX 1660 is definitely between GTX 1660 Ti and GTX 1060 6GB, so these two graphics cards will definitely be used as a comparison. GTX 1060 6GB uses the public version, and GTX 1660 Ti also takes a model with the same frequency as the public version, just consider it as a public version.

　　AMD’s competing products chose RX 590 with the same performance between GTX 1060 and GTX 1660 Ti. Here, the 8 GB version of ASUS ROG STRIX RX 590 is used, and the public version frequency. In fact, the frequency difference of RX 590 on the market is very small, and the performance can’t be opened.

　　It is also stronger than GTX 1060 and weaker than GTX 1660 Ti, so who is better than GTX 1660 or RX 590? Let’s reveal it below.

　　As for the CPU, I 9-9900K, the strongest game CPU, is selected with two 8GB 3200MHz high-frequency memories to ensure that other hardware of the platform will not become the test bottleneck.

　　If you don’t accept it, run a score first. In addition to our commonly used Fire Strike Extreme and Fire Strike Ultra tests, there is also Time Spy for DirectX 12 benchmark performance test of game PC.

　　Summary of theoretical performance test: I don’t know, I was shocked at the test, but I didn’t expect it to be justCastrated two groups of SM units and switched to GDDR5 memory, which can reduce the FSE of Turing graphics card by nearly 1500 points!The FSE and running score of GTX 1660 are basically the same as the public version of GTX 1060 6GB, and the FSU running score is even worse, but fortunately GTX 1660 regained a city in TS running score, surpassing GTX 1060 6GB by 29%.

　　The comprehensive running score of GTX 1660 is only 7% higher than that of GTX 1060 6GB.This promotion … is … equivalent to nothing?There is also a 20% performance gap from the big brother GTX 1660 Ti.It seems that switching to GDDR5 memory is still very painful. So is GTX 1660 such a weak chicken in the game measurement? Is it a non-public GTX 1060 6GB? Let’s measure and verify it immediately.

　　This time, we expanded the lineup of evaluation games, and the number of games tested reached nine, mainly the latest and most popular 3A masterpieces, such as Assassin’s Creed: Odyssey, Subway: Leaving, Resident Evil 2 Remastered Edition, as well as classic old games, Wizard 3 and Survival of the Jedi, which made the test results more objective and convincing.

1. Tomb Raider: Shadow

　　Unconsciously, Laura has been with us for 20 years, and has developed into the 11th generation. Today, she has been able to support all kinds of latest, true and most eye-catching graphics technologies. It should be noted that Tomb Raider 11 is a game that natively supports DX12.

2. Assassin’s Creed: Odyssey

　　Assassin’s Creed: Odyssey is the 11th work in the Assassin’s Creed series, which was created by Ubisoft. In the game, players will return to ancient Greece and play a mercenary with Spartan ancestry who was sentenced to death by his family, thus starting an epic journey from a young abandoned man to a legendary hero. The game’s plot design and image quality are very brilliant, and it is a strong competitor for the best game of the year in 2018.

3. Strange Squad

　　"Strange Squad" was a game that went on the market at the end of August last year. The PC started and supported DX12 perfectly, and the Steam list was highly rated.

4. "Singularity Ash"

　　Microsoft’s personal work to promote DX12 API perfectly supports all the effects of DX12. Benchmark optimization is in place, and it is also very suitable for testing DX12 performance and graphics performance of graphics cards.

5. Resident Evil 2 Remastered Edition

　　Capcom’s latest fried cold rice, the sales volume of the game reached 3 million in just a few days, which was very popular among players. The test is based on the gas station scene at the beginning of Lyon, and the test results are recorded by running laps for 60 seconds. The game defaults to DX12 mode.

6. Battlefield V

　　Battlefield V is a hot game recently, not because it is fun, but because it is the only game that supports ray tracing on the market at present, and it is also a game promoted by NVIDIA. War stories, an African-American infantryman, was chosen as the first 30s in the test scenario, and DX11 mode was chosen in the test, because the number of game frames in DX11 mode was higher for both A card and N card.

7. "Wizard 3"

　　Super classic AAA masterpiece, needless to say. The field scene was selected for the test, and the horse rode on a fixed route for about 60 seconds to record the results.

8. Subway: Leaving

　　Although I didn’t log in on steam, Subway: Leaving is still a good game. The most amazing thing about it is its excellent picture quality. This game is also the first game with ray tracing, DLSS and Hairworks installed.

　　Because of the excellent picture quality, the game became a graphics card killer, and the number of frames of the tested graphics card was extremely low at 1080p resolution, so the test used high picture quality, not the ultimate picture quality.

9. Survival of the Jedi

　　A historic game with a record sales volume, the game of Jedi survival does not need much introduction.

　　Summary of game performance test:In order to let everyone see the performance gap between each graphics card more intuitively, Xiao Bian takesThe comprehensive performance of GTX 1060 in the above nine games is 100%., get the following chart.

　　At the resolution of 1080p, GTX 1660 can achieve 16% higher frame rate than GTX 1060, which is a big lead. Compared with competing RX 590, the performance of game frames is basically the same, but there is still a 17% gap between the graphics card and the big brother GTX 1660 Ti.

　　Because the video memory bandwidth of GTX 1660 is the same as that of GTX 1060 6GB, the gap between them is the same at 2K resolution. The gap between GTX 1660 Ti and the video memory bandwidth is naturally widened to 20%, which is also surpassed by RX 590.

　　The measured performance of the new card is still good, which is 17% stronger than GTX 1060 and basically consistent with RX 590.

　　Since it is impossible to test the power consumption of a piece of hardware alone,So the following are the power consumption of the whole machine.When the graphics card is fully loaded, the peak power consumption of the whole machine in 3DMark stress test is selected.

　　The graphics card basically maintains the same power consumption as GTX 1060 6GB, but reaches the performance of RX 590. Turing architecture +12nm technology makes the energy consumption of N card reach a new level, and the power consumption of GTX 1660 is about 130W lower than that of RX 590, which has obvious advantages.

　　Next, let’s take a look at the temperature, stability and noise performance of the Galaxy GTX 1660. These tests are related to the design skills of the manufacturer’s graphics card. Even if the same chip, different models will be very different.

3DMARK stress test results:

　　In 3DMark stress test, 97% passed,Finally, the graphics card passed the test with 97.8%, indicating that the stability of the graphics card is no problem. Graphics card in stress testThe highest instantaneous frequency is 1920MHz.This is also the characteristic of N card. The actual BOOST frequency will be much higher than the nominal frequency. Click on the image to enlarge to see the specific value.

　　By the way, I summed up the stability results of the participating graphics cards, and the performance of the Galaxy GTX 1660 is still good.

Temperature test

　　In fact, the 3DMARK stress test just now also showed this temperature performance. The temperature environment of the four graphics cards in this test is exactly the same.

　　The full-load temperature of the graphics card is not high, only 69℃.

Noise test

　　The full-load noise is only 47dB, which is basically inaudible, thanks to the new satellite obsidian radiator.

About noise:

　　0-20 decibels: very quiet, almost imperceptible; 20-40 decibels: quiet, like whispering; 40-60 decibels: general indoor conversation; 60-70 decibels: noisy: harmful to nerves; 70-90 dB: It is noisy and nerve cells are destroyed. 90-100 decibels: increased noise and hearing loss; 100-120 decibels: unbearable, temporarily deaf after staying for one minute. Above 120 decibels: extremely deaf or totally deaf; About 300 dB or above: 20km of people in Fiona Fang are irreparably deaf.

　　Finally, it is inevitable to sum up. First, a performance percentage chart is put forward, which combines the results of four graphics cards in 1080p resolution, 2K resolution and 3DMARK theory running score test. This comprehensive performance is still very important. After all, we can’t test all the games on the market, but we can get a general idea of the comprehensive performance of graphics cards in all games by combining the game performance and running score.

　　The comprehensive performance of GTX 1660 is 11% stronger than that of GTX 1060 6GB, and the performance gap is really a little small, which is 6% lower than that of competing RX 590. This is mainly because the two 3DMARK scores of GTX 1660 are so weak that the possibility of bug follow-up driving or 3dmark optimization cannot be ruled out. However, GTX 1660 Ti has been released for more than a month, which does not necessarily mean that FSE and FSU have much improvement. Can it be said that NV?

　　The performance of the graphics card is 19% worse than that of GTX 1660 Ti. Under the castration of the yellow knife method, the graphics card class of each model of N card is very fixed.

　　It is reported that GTX 1660 is the graphics card that replaces GTX 1060 6GB. It is a good thing that the inventory of GTX 1060 is finally cleared after so long.

　　The starting price of the new graphics card is 1799 yuan, which is almost the same as the starting price of GTX 1060 6GB after the mine disaster. That is to say, after two or three years, the performance of the graphics card bought by consumers with the same money is only 11~17% higher, which is far from meeting the expectations of consumers. Therefore, it is reasonable to say that the price of GTX 1660 card will continue to be reduced to around 1500 to replace GTX 1060 3GB.

GTX 1660 is a product with general competitiveness.

　　Is GTX 1660 very competitive in the market? There should be a question mark on xiaobian here. The performance of graphics card is basically the same level as RX 590, and the price is similar. At that time, RX 590 was still cost-effective because GTX 1060 sold for 1900~2100 when it came out. Now GTX 1060 has dropped to 1600~1800, and RX 580 even dropped to 1500, so the competitiveness of GTX 1660&RX 590 products is much weaker.

　　Compared with competing products at the same price, it may also be a competitor RX 590 for a long time in the future. Their performance is basically at the same level, and the bigger difference lies in other aspects.The advantage of GTX 1660 lies in its lower power consumption, which is about 140W lower than that of RX 590, which can save a lot of money on purchasing power supply and optimize the user experience in noise and heat accumulation in the chassis, while the advantage of RX 590 lies in the additional 2GB of video memory.

　　6GB of video memory is enough for playing 1080p resolution games, but playing 2K resolution games may lead to the explosion of video memory in very few games. However, in terms of the performance of these two graphics cards, it is more suitable for playing 1080p resolution games.

　　So, if you have to choose between the two,At the same price, GTX 1660 is more worth buying.And it is necessary for RX 590 to further reduce its price to maintain its competitiveness. At present, GTX 1660 wins!

　　In fact, the comparison between GTX 1660 and RX 590 is the repetition of GTX 1060 VS RX 580, which is basically the same in performance, low in power consumption of N card and larger in memory of A card.

　　Xiao Bian believes that,Graphics cards with the same materialsRX 590 is at least 100 yuan cheaper than GTX 1660, so it is worth considering which one to buy. For example, the beggar version of GTX 1660 sells for 1799, so the beggar version of RX 590 should sell for 1699.

　　This time we got the Gemini GTX 1660 Master and GTX 1660 General from Galaxy.

　　GTX 1660 is priced at 1799 yuan, while GTX 1660 uses better materials and has higher frequency, and the price naturally rises, reaching 1899 yuan.

　　Evaluation we use the GTX 1660 general, and the appearance of the graphics card is mainly blue and black, which is more eye-catching.

　　The brand-new Star Yao radiator stabilized voltage TU116-300 core, in the above evaluation, we also saw the power of this radiator.

　　The graphics card has a large-area backplane, which can assist heat dissipation and strengthen the strength of the graphics card. The whole graphics card is not thick, and it is designed for a standard 2-slot card.

　　The video output interface is 1dp+1dmi+1dvi with rich interfaces.

　　　　The measurement is 246*135*43mm, and the external power supply is 6pin, so the graphics card has good adaptability.

　　There are RGB lights on the top of the graphics card, which is full of e-sports.

　　Next, let’s take a look at the inside of the graphics card.

　　Electrical components with orderly layout.

　　High-definition codeless TU116-300 core.

　　GDDR5 memory produced by magnesium light.

　　4+1 phase power supply, which helps higher frequency on the graphics card.

　　Let’s take a look at the Xingyao radiator used in the graphics card, two 6mm nickel-plated heat pipes and nickel-plated fins, which are quite sufficient in materials.

　　The part in direct contact with GPU uses a large area of pure copper base, no wonder the graphics card is so low temperature.

　　Let’s take a look at what the non-public GTX 1660 looks like.

Colorful iGame GTX 1660 Ultra

　　GTX 1660, produced by Colorful, a graphics card manufacturer, has the same appearance as iGame GTX 1660 Ti Ultra, and the highest core frequency is 1860MHz.

Sotai GTX1660-6GD5 Destroyer OC HA

　　The MINI has a big heart, and the BOOST frequency of the graphics card core reaches 1805MHz, which is suppressed by double heat pipes and powered by 4+1 phases.

Gigabyte GeForce GTX 1660 OC

　　The cool and low-key appearance, although not the high-end model under AORUS, already feels very good.

MSI GTX 1660

　　There are many GTX 1660 models launched by MSI. Let’s count them one by one.

　　GeForce GTX 1660 AeroITX 6OGOC with single fan design is suitable for small chassis.

　　GeForce GTX 1660 Armor 6OGOC with high cost performance.

　　A new generation of magic dragon GeForce GTX 1660 GAMING X 6G to replace the classic Red Dragon series.

　　Geforce GTX 1660 Ventures XSC 6OC, which is relatively close to the people.

Gengsheng GTX 1660

　　Gengsheng also brought two non-public graphics cards.

　　The design of GTX 1660 glare radiator is very special.

　　Gengsheng GTX 1660 chasing the wind version, the red and black color matching is very e-sports.

Yingzhong GTX 1660 Black Gold Extreme Edition

　　The design of the MINI with the same body, coupled with the excellent power consumption performance of GTX 1660, Yingzhong GTX 1660 will definitely become the gospel of ITX lovers.

　　So many GTX 1660′ s are estimated to be messy. The evaluation of these graphics cards is also in progress. If you want to know which GTX 1660 is better, just keep paying attention to us.

A few days ago, the the State Council executive meeting deployed measures to increase the basic living security of the people in need, so as to secure the bottom line of people’s livelihood.

At the regular briefing on the State Council policy held by the State Council Office on August 26th, Yang Yinkai, deputy secretary general of the National Development and Reform Commission, introduced that from September this year to March next year, the linkage mechanism of price subsidies will be adjusted in stages, and the policy of "expanding the scope of protection and lowering the starting conditions" will be implemented, so as to increase the price subsidies for the needy people and effectively grasp the bottom line of people’s livelihood. It is estimated that the policy will cover 67 million people after the expansion.

One-time living allowance will be issued to people with difficulties such as the minimum living allowance, which will be fully completed by the end of August.

Since the beginning of this year, the bottom-up safeguard measures have been continuously improved, and the assistance to the people in need has also increased. By the end of June this year, 40.62 million people had received assistance from urban and rural residents, including 7 million urban residents and 33.62 million rural residents. The national urban minimum living standard is 734 yuan per person per month and the rural minimum living standard is 554 yuan per person per month; In the first half of this year, the accumulated expenditure on subsistence allowances was 92.62 billion yuan.

In order to implement the requirements of "expanding the minimum living allowance and increasing efficiency", the civil affairs department has continuously improved the minimum living allowance system. Liu Xitang, director of the Social Assistance Department of the Ministry of Civil Affairs, said that seriously ill and severely disabled people in marginal families have been included in the subsistence allowance alone, forming a combination of household insurance and personal insurance, and the system has more capacity; Encourage all localities to decentralize the examination and confirmation authority of subsistence allowances from the past counties to streets and towns to improve the efficiency of examination and verification; In addition, for low-income families whose per capita income exceeds the local minimum living standard after employment, a gradual retirement period of six months to one year will be given.

The temporary assistance system is mainly aimed at solving the sudden, urgent and temporary basic living difficulties encountered by urban and rural people. Since the beginning of this year, affected by epidemic and disaster, the number of people in need has increased. A few days ago, the the State Council executive meeting requested that the one-time living allowance issued to the needy people such as the minimum living allowance should be paid in place as soon as possible.

Residents, including migrant workers, who are unable to return to work due to the epidemic, have no income for three consecutive months, and are not included in unemployment insurance, can apply for a one-time temporary relief fund at their place of residence or domicile. Liu Xitang said that the work is progressing smoothly. Seventeen provinces in the country have all paid out, and all localities have issued an additional subsidy of 8.08 billion yuan for 40.18 million low-income recipients and extremely poor people, accounting for 90% of the total number of people in need. "It is expected that the work will be fully completed by the end of August, and the total amount of funds distributed is expected to be close to 10 billion yuan."

This year, the central government allocated 154.68 billion yuan to help the needy, an increase of 7.06 billion yuan over last year, and the local budget also increased investment accordingly. In the first half of the year, the national financial expenditure totaled more than 120 billion yuan, up 7% year-on-year.

Liu Xitang said, "Social assistance funds such as subsistence allowances are the focus of people’s livelihood security, and they are also the focus of financial support. It is no problem to implement special fund management and timely and fully distribute social assistance funds such as subsistence allowances."

The linkage mechanism of price compensation expands the scope of protection and reduces the starting conditions, which is expected to benefit about 9 million more people.

From January to July this year, China’s consumer price index (CPI) rose by 1.8% year-on-year, and rose by 2.7% year-on-year in July. Yang Yinkai said that due to factors such as imported inflationary pressure and seasonal increase in pork prices, the domestic price level may be slightly higher than that of the previous months in the latter months of this year to the first quarter of next year, which is lower than that of cardinal utility in the same period last year.

In order to alleviate the impact of rising prices on the basic livelihood of people in need, the linkage mechanism of price subsidies will be adjusted in stages from September this year to March next year.

After the adjustment, the scope of protection has been expanded. The current linkage mechanism of price compensation covers seven groups, including urban and rural minimum living allowances, destitute people, people receiving unemployment insurance benefits, special care recipients enjoying regular state pension subsidies, orphans, children who are actually left unattended and children infected with HIV, totaling about 58 million people.

On the basis of the above-mentioned seven groups, this time, two groups, namely, people receiving unemployment benefits and marginal population with minimum living allowance, will be added into the scope of protection of the linkage mechanism of price compensation. After expanding the scope of protection, it is expected to benefit about 9 million more people and cover about 67 million people in need. Conditional places can further expand the scope of protection.

Wan Jinsong, director of the Price Department of the National Development and Reform Commission, introduced that the people receiving unemployment benefits and the marginal population with low living allowances will be included in the scope of protection in stages, mainly considering that the people receiving unemployment benefits are unemployed, their income sources are unstable, and their lives are facing certain difficulties; Although the income of the marginal population is slightly higher than the minimum living standard, the living standard is generally low.

After adjustment, the starting conditions are reduced. The monthly year-on-year increase of CPI in the starting conditions of the price subsidy linkage mechanism was reduced from 3.5% to 3.0% in stages, while other starting conditions such as issuing price subsidies when the food price in CPI rose to 6% year-on-year, were kept unchanged, and the price subsidy linkage mechanism was started when any conditions were met.

"Reducing the start-up conditions is mainly due to the impact of epidemic situation and disasters. The income growth of people in need faces more difficulties, and the feeling of rising prices may be more obvious." Wan Jinsong said that after lowering the starting conditions, it is expected that the number of months and the starting area of the price subsidy linkage mechanism will increase significantly, which means that more people in need can receive price subsidies.

All localities will grant temporary price subsidies of about 20 billion yuan to people in need.

According to statistics, since 2020, local governments have distributed temporary price subsidies of about 31.5 billion yuan, benefiting 530 million people in need.

After adjusting the linkage mechanism of price subsidies in stages, it is estimated that from September this year to March next year, all localities will provide temporary price subsidies of about 20 billion yuan to the needy, of which about 7 billion yuan will be increased due to expanding the scope of protection and lowering the starting conditions.

Where does the additional funds come from? According to reports, the additional funds for those who receive unemployment insurance benefits and unemployment subsidies are paid from the unemployment insurance fund; The central government will provide subsidies to other needy people in different regions, including 30% in the eastern region, 60% in the central region and 80% in the western region.

"Temporary price subsidies are issued by the local authorities first and settled by the central government." Wan Jinsong said, in the current situation that governments at all levels are living a "tight life", the state still decided to adjust the linkage mechanism of price subsidies in stages and increase the price subsidies for the needy people, which fully demonstrated that the CPC Central Committee and the State Council always cared about and cared about the needy people, and always placed the protection of their basic livelihood in a prominent position.

Yang Yinkai said that the National Development and Reform Commission will work with relevant departments to strengthen work guidance, ensure that all the work of price subsidies is carried out in an orderly manner, and ensure that policy deployment can be fully implemented. (Reporter Lu Yanan)

Special feature of 1905 film network The spring love movie is playing continuously, and it will be broadcast for you on March 3.

Simple Cinderella, how to become the prince’s lover?

Fantasy story — — Everyone knows the ending, but it’s still attractive

As the most film in history that is not afraid of being spoiled, I’m afraid there is no one who doesn’t know the story of Cinderella. The kind Cinderella met her evil stepmother and suffered all kinds of torture. Finally, she waited for the help of the fairy, turned into a princess and finally got married with the prince.

However, it is such a perfect fairy tale that will still touch the hearts of "Cinderella" in reality, waiting for a prince who really belongs to her to come.

It is precisely because the core fairy tale dream of girls is eternal that the story of Cinderella is often shot new.

Excellent visual effects — — Reproduce the real fairy tale world

This live-action version of Cinderella reproduces a real fairy tale world with excellent visual effects and artistic design.

The scene setting in the first half maintains realistic natural scenery, beautiful countryside and dreamy castle, and has the style of pastoral naturalism. In the second half of the magic moment, the dazzling golden carriage and crystal shoes will be unveiled, which will surely impress audiences of different ages.

Especially when the door of the golden carriage is opened, as the hearts of countless girls are opened. There is also the scene where the midnight bell rings, which can be called the brilliant fireworks over the classic palace, which is dizzying.

Gorgeous costumes — — Beauty never seen in fairy tales

If you just read fairy tales, you can never imagine how beautiful those crystal shoes are, and how amazing the four-seat skirt is to match such beautiful crystal shoes. The movie didn’t live up to those romantic fantasies. Cinderella shone from head to toe and earned enough attention.

All the costumes in Cinderella were designed by designer sandy powell, and preparations were started two years before the film started.

In order to make Cinderella’s blue dancing skirt flow like water when running, sandy powell used 12 layers of blue fabrics with different shades.

She has designed nine kinds of skirts. The final version of the skirt has 12 layers from the inside out, using more than three different fabrics such as silk, nylon and polyester fiber. The skirt is decorated with countless turquoise and tens of thousands of crystals. There are tights and several layers of petticoats inside, which took 18 tailors and 500 hours to complete.

In the film, Cinderella likes to communicate with animals, and butterflies are one of them. In order to match the plot, sandy powell also decorated Cinderella’s blue dance skirt with butterflies.

In the film, Cinderella’s crystal shoes can’t be put on in reality, and only appear in close-ups. You can only wear shoes with the same shape when shooting, and then make them look like crystal shoes with special effects.

Meet the movie channel Universal Cinema at 22:20 on March 3rd.

Let Cinderella share a fairy-tale girl dream with you!

　　The the Political Bureau of the Communist Party of China (CPC) Central Committee Conference held a few days ago emphasized that "consumption should play a leading role in the economic cycle", which is an important work deployed on the basis of a comprehensive analysis of the economic situation. In connection with the "Opinions on Further Releasing Consumption Potential and Promoting Sustainable Recovery of Consumption" issued by the General Office of the State Council not long ago, 20 key measures in five aspects were put forward. The "combination boxing" to promote consumption in order to consolidate and develop the market of more than 1.4 billion people has aroused widespread concern at home and abroad.

　　From the perspective of national economic operation, consumption has a lasting driving force for economic development, is an important engine to smooth the domestic cycle, and is also a key link to form a higher level dynamic balance between demand and supply, which is related to the national economy and people’s livelihood. Judging from the current economic situation in China, the triple pressures of demand contraction, supply shock and expected weakening have not changed, and some unfavorable factors are still evolving in a complicated way, and the new downward pressure has further increased. In the face of the situation, tasks and severe tests, we should not only have a full understanding, but also have countermeasures. It is undoubtedly crucial to do everything possible and comprehensively implement policies to release consumption potential and promote sustained recovery of consumption.

　　Statistics from the National Bureau of Statistics show that in 2021, the contribution rate of China’s final consumption expenditure growth to economic growth is 65.4%, which is higher than the contribution rate of total capital formation, and it is the main driving force for the stable recovery of the national economy, and the "ballast stone" role of consumption is prominent. In the first quarter of this year, thanks to the transformation and upgrading of traditional consumption, the release of new consumption potential and the strong "blood supplement" of online consumption, the overall market sales maintained steady growth. However, since March, domestic epidemics have occurred frequently, which has had a great impact on the consumer market. In March, the total retail sales of social consumer goods decreased by 3.5% year-on-year. Residents’ trips have been significantly reduced, and contact and aggregate consumption have been greatly affected. The foundation for sustained recovery of consumption still needs to be consolidated.

　　Among the key measures put forward in the Opinions, the first one is "increasing efforts to help enterprises bail out the difficulties around the main body of the insurance market", which is a key to promoting the orderly recovery and development of consumption and thus stabilizing the basic economic disk. As the COVID-19 epidemic directly impacts the consumer, small and medium-sized enterprises and individual industrial and commercial households, it has a great impact on low-income groups and basic people’s livelihood. At present, there are more than 150 million market players in China, carrying hundreds of millions of people to find jobs and start businesses. If you keep the market players, you can keep employment; If there is employment, there will be income and consumption, which will promote economic growth. The central and local governments have introduced relief measures such as tax reduction and fee reduction, and deferred payment of social insurance premiums. Some related companies such as take-away platforms have also responded positively, helping small and medium-sized businesses tide over the difficulties by reducing commissions.

　　Practice shows that reducing taxes and fees is a direct and effective way to help enterprises get rid of difficulties. All localities should, in light of the actual situation, introduce effective measures such as tax reduction and exemption according to law, so that the intensity of tax reduction and fee reduction will only increase, so as to stabilize market expectations. In addition, the financial system should also make profits to the real economy by reducing interest rates, reducing fees and other measures, and provide financing support to enterprises in industries seriously affected by the epidemic to avoid industrial loan restriction, loan withdrawal and loan suspension.

　　Stabilizing consumption growth and promoting consumption upgrading is a systematic project. Doing a good job in ensuring the supply and price stability of basic consumer goods, promoting the upgrading of physical consumption, continuously expanding cultural tourism consumption, fully tapping the consumption potential of counties and towns, reasonably increasing public consumption, and creating a safe, secure and honest consumption environment are all important tasks to increase the weight of consumption.

　　It should be noted that the impact of the epidemic on consumption is phased. With the effective control of the epidemic and the gradual emergence of policy effects, the normal economic order will be quickly restored and consumption will gradually pick up. China has a population of more than 1.4 billion, the largest domestic market with middle-income groups in the world, and the policy support and work deployment with both far and near, and the fundamentals of long-term positive consumption will not change. We should have full confidence in this. (This article Source: Economic Daily Author: Jin Guanping)

CCTV News:Another feature of Mid-Autumn Festival tourism this year is that cultural leisure tourism is favored. All localities combine the activation of intangible heritage with immersive experience to improve people’s sense of participation and identity with intangible heritage. Many places have also launched theme tourist routes such as Mid-Autumn Festival custom experience, attracting a large number of tourists. According to the data of special survey in china tourism academy, 94.1% of tourists participated in cultural leisure during holidays, and 24.8%, 35.6% and 25.6% visited historical and cultural blocks, museums, art galleries and art galleries respectively.

Traditional culture stimulates the consumption of cultural tourism in Mid-Autumn Festival holiday.

In flying tigers Scenic Area, Zaozhuang, Shandong, a group of children, dressed in Hanfu, listened to the historical story of wickerwork’s craft, made strips with straw ropes by themselves, and wound them around wicker baskets ring by ring, patiently weaving a beautiful yearning for the future.

During the Mid-Autumn Festival holiday, in Shanghai Haichang Ocean Park, a round of "bright moon" rippled in the water. Professional synchronized swimmers dressed in ancient costumes performed a series of underwater "the Goddess Chang’e flying to the moon" cultural feasts for the audience. In addition to "the Goddess Chang’e flying to the moon", there is also a cruise full of national trends, which attracts many tourists.

Characteristic cultural activities promote "night economy"

In addition to traditional cultural tourism, immersive moon viewing has also brought fire to urban night tours. Night tourism projects such as theme park night tours, river night tours and city night sightseeing have attracted many tourists.

According to the special survey data of china tourism academy, 29.3% of tourists experienced night tours during the Mid-Autumn Festival holiday.