"Avenue of the Country": the "most beautiful" self-driving route of China G219.

National Highway 219 is a world-class scenic avenue, which starts from Kanas in Xinjiang in the north and ends in Dongxing in Guangxi in the south, with a total length of 10065 kilometers. It is the longest national highway in China at present. Along the way, it passes through snow-capped mountains, glaciers, alpine canyons, rivers and lakes, grassland forests, and finally goes to the sea. The rich landscape and rich folk customs are amazing, covering the border areas of Xinjiang, Xizang, Yunnan and Guangxi. It is the main artery connecting China’s western border, and is called "the road of the country" by go on road trip lovers.

G219 line is divided into old national highway 219 line and new national highway 219 line. The old national highway No.219, the new Tibet highway, starts from Yecheng County in Kashgar, Xinjiang in the north and reaches the 2140-kilometer stone tablet in Lazi County, Shigatse City, Tibet in the south, where it meets the Sino-Nepalese highway section of National Highway No.318, also known as Yela Highway. Kashgar, Hotan, Ali and Shigatse are the main transportation routes connecting Xizang and Xinjiang, and it is also the highest highway in the world, with an average elevation of more than 5,000 meters. It was opened to traffic on October 6, 1957, and has been extended and renovated for many times, with a total length of 2,140 kilometers. It is the third highway to enter Xizang after Sichuan-Tibet Highway and Qinghai-Tibet Highway. The new G219, also known as Kadong Line, was issued by the Ministry of Transport on March 5, 2018. The northern end of the original G219 was extended to Kanas in northern Xinjiang, and the southern end was rerouted to dongxing city in Guangxi. The whole highway passed through Xinjiang, Xizang, Yunnan and Guangxi provinces. The new G219 is 10065km long, which is twice as long as the National Highway 318 (5476km) and the longest national highway in China at present. This national highway not only has the landscape elements such as snow-capped mountains, grasslands, no man’s land, Yadan landform, tropical rain forest and sea, but also becomes an important border defense line in China.

G219, as the longest world-class landscape avenue in China with rich landscapes and rich folk customs along the way, is the highest highway in the world, the main artery connecting China’s western border and the land-sea Silk Road. It travels through different cultural areas in China, and along this way, you can enjoy five peaks, 16 icebergs and 44 glaciers with an altitude of over 8,000 meters … across snow-capped mountains, grasslands, deserts, Gobi, lakes, canyons and plateaus.

Go on road trip G219 starts from Kanas, Xinjiang in the north, passes through Ili along the snowy grassland, passes through the no-man’s land of Ali, Xizang, goes south along Bingchacha and Tengchong in Yunnan, reaches Pingxiang, the border city of Guangxi, and finally reaches Dongxing, where it meets the endless sea. Walking along this world-class landscape avenue, almost all the desirable landscapes are located here.

On December 5, 2020, under the guidance of the Ministry of Culture and Tourism, the cultural and tourism administrative departments of Xinjiang Uygur Autonomous Region, Xizang Autonomous Region, Guangxi Zhuang Autonomous Region and Yunnan Province jointly established the China G219 Tourism Promotion Alliance in Nanning. The establishment of the alliance conforms to the general trend of China’s tourism development, aims at promoting development through tourism, prospering the border and enriching the people, enhancing consensus, sharing experiences and deepening cooperation, and promoting the sustainable and prosperous development of tourism along G219. Since its establishment, the Alliance has organized theme promotion activities in Guangxi and Xinjiang successively. On March 16th this year, Yunnan Province, as a rotating province, will host a promotion activity in Nujiang, Yunnan Province, and organize a team of over 100 people from all over the country to experience the beautiful highway of Nujiang, Yunnan Province, National Highway 219, and feel the unique charm of the national road.

Xinjiang section of National Highway 219

The Xinjiang section of National Highway 219 is 3,216 kilometers long, passing through 8 prefectures and 7 cities in the western border of Xinjiang. It can radiate to 10 5A-level scenic spots and 25 4A-level scenic spots along the way, with beautiful scenery, all-encompassing natural landscape types and colorful humanities and history. Along the way, it includes unique natural landscapes such as snow-capped mountains, alpine meadows, grasslands, wetlands, lakes, glaciers, Gobi, deserts, etc. At the same time, it is also a great penetration from nomadic culture to oasis civilization, which combines the most typical frontier characteristics, natural geography and national customs of Xinjiang and has multiple attributes. In recent years, the strategy of rejuvenating Xinjiang through tourism has been implemented in depth, and the tourism market in Xinjiang has continued to be hot. The Xinjiang section of National Highway 219 has become the "online celebrity Highway" for national tourists to punch in.

Recommended Route 1 of Xinjiang Section of National Highway 219: Red go on road trip at Border Post.

Enter the northwest of the motherland and feel the beauty of the border; Follow the footprints of stationing troops and guarding the border, and pay tribute to the motherland in the northwest. Feel the simple patriotic feelings, visit the beautiful scenery at the port and Baymuzha, reminisce about the story of Xiaobaiyang Post, visit Sun Longzhen Martyrs Memorial Hall, and feel the frontier spirit represented by the spirit of "rooting in frontier defense and flourishing".

Red go on road trip route of border post: Urumqi-Wuerhe ghost city-Rainbow Beach Scenic Area-Burqin County-Baishahu Scenic Area of the 10th Division-185th Regiment of the First Company in Northwest China-Burqin County-Jimunai Port of the 186th Regiment of the 10th Division-165th Regiment of the 9th Division-Baymuzha Scenic Area-Xiaobaiyang Post of the 161st Regiment of the 9th Division, Sun Longzhen Martyrs Memorial Hall-Urumqi.

Recommended Route 2 of Xinjiang Section of National Highway 219: Red Tour in Southern Xinjiang

There is a natural barrier that runs through the northern and southern Xinjiang, and a memorial hall for the reclamation of the 359 brigade that feels the glorious tradition … Driving along the red army reclamation line of the Silk Road, you can feel the frontier scenery, remember the history of the Corps, carry forward the spirit of the Corps, and eulogize the cause of reclamation and frontier defense.

Southern Xinjiang Red Tour Route: Urumqi-Korla-Malan Hongshan Military Expo Park-tiemenguan-Daxi Village-Luobu Village-Luntai Western Duhufu Cultural Town-Kuqa-Aksu Monument to the People’s Heroes-Aksu Museum-First Division Aral 359 Brigade Reclamation Memorial Hall-Chinese People’s Liberation Army March into Hotan Monument.

National Highway 219 Xizang Section

Driving in the Xizang section of National Highway 219 is like walking in the clouds, with an average elevation of about 5,000 meters. The familiar landscapes such as Bangong Lake, Guge Dynasty, Mount Everest, Mabian Yongcuo, Gangrinboqi and Yarlung Zangbo Grand Canyon are all located here.

National Highway 219 is a road into Tibet paved in the air, crossing several hundreds of kilometers of no-man’s land, and the laying conditions are daunting. From "Extreme Ali" to "Zangyuan Shannan", from "Peak Dream" Shigatse to "Snowy Jiangnan" Linzhi, from the stars to the sea, from the mountains to the rivers, there are snow peaks and glaciers, winding streams and beautiful lakes.

Recommended Route 1 of Xizang Section of National Highway 219: Bingchacha Cross-sectional Imagination Road

When G219 meets G214, but Wujiao meets G318;; When the Nujiang River flows parallel to the Lancang River in a narrow place, when Bingcha agrees to Shangri-La, a new Yunnan-Tibet tourism ring line of G219 with "three G tours and three rivers flowing parallel" will be built.

The whole journey is about 1465km: Bingzhongluo (Yunnan)-—G219 National Road-Songta Village (the first village in Tibet)-ChaHuaron-Chayu County-—G559—-Ranwu-Basu-—G214—-Zuogong-Mangkang-Quzika-Deqin (Yunnan)-Shangri-La-Diqing Shangri-La Airport (flying).

Recommended Route 2 of Xizang Section of National Highway 219: Feel the dream trip of the plateau peak.

When G219 meets the highest mountain in the world, G318 holds G219 hand in hand, and the extreme border of the motherland experiences "8" and "9" without "10". I met in Lhasa and walked hand in hand into the hometown of Mount Everest. The snowy peaks are endless, the glaciers are numerous, the streams are winding, and the lakes are hidden. It is only owned by Mount Everest. This is the ultimate journey of "peak dreams and Tibetan border conventions".

The whole journey is about 1850km: Lhasa-Langkazi County-Gyangze-—G219—-Kangma County-Yadong County-Gamba County-Dingjie County-Dingri County-Mount Everest-Nyemora-Lazi-Shigatse City-Lhasa-Gongga Airport (flying).

Recommended Route 3 of Xizang Section of National Highway 219: Tour Link of Tianhu.

When G219 meets the snow-covered "Holy Lake", meets the snow-capped mountains, meets the "Holy Lake", and faces the human history, "take measures again". Encountering glaciers, snow-capped mountains, lakes and historical sites is a "trip to Tianhu" tour loop of "crossing three cities, crossing the holy lake and seeing yourself".

The whole journey is about 2200km: Lhasa-Langkazi County-—G219—-Luozha County-Kangma County-Gamba County-Dingjie County-Dingri County-Jilong County-Saga County-Zhongba County-Gaer County-Ali Kunsha Airport (flying).

Yunnan section of National Highway 219

Enter Bingzhongluo, Yunnan along Bingchacha Highway from National Highway 219, bid farewell to Xizang in the clouds and enter Yunnan in the south of colorful clouds. Here, there are Bingchacha and the mysterious Bingzhongluo, and the southwest monsoon swings in the season of Nujiang Grand Canyon. When I came to the First Bay of Nujiang River and Wuli Village not far away, the dense water vapor refracted the sun, making every corner seem to be full of "fairy spirit". The Yunnan section of National Highway 219 also connects Tengchong, which has the reputation of "the first city on the extreme edge", Lincang, a place where Wa cultures gather in China, Pu ‘er, Xishuangbanna, an emerald on the crown of plants, Honghe and Wenshan, so that tourists can enter Yunnan with spring-like seasons from the deep scenery of ice and snow and canyons.

219国道云南段推荐线路一:高黎贡山秘境之旅

怒江傈僳族自治州境内居住着傈僳族、怒族、普米族、独龙族等21个少数民族,也是我国生物多样性、文化多元性较富集的一个地方,被称为“世界物种基因库”“天然地质博物馆”“一部活的社会发展史”和“民族歌舞的海洋”。在漫长的历史发展中,各少数民族世代繁衍生息,共同耕耘劳作,用自己的血汗和智慧谱写了光辉灿烂的文化篇章,创造了丰富多彩的民族文化。怒江州是因为怒江由北向南纵贯全境而得名。怒江最佳旅游时间在每年的10月至次年4月。219国道横穿怒江州境内的泸水、福贡、贡山、丙中洛。

219国道云南段推荐线路二:保山温泉火山体验之旅

219国道从秘境怒江进入“极边第一城”的保山腾冲市。腾冲市位于云南省保山市西南部,西部与缅甸毗邻,从腾冲到克钦邦首府密支那217公里,是云南到缅甸、印度、泰国的必经地之一。腾冲在西汉时称滇越,大理国中期设腾冲府。由于地理位置重要,历代都派重兵驻守,明代还建造了石头城,称之为“极边第一城”。这里的温泉、火山、雨林与独特的边地汉文化给自驾旅行带来独特体验。219国道在保山市境内途径腾冲滇滩、明光、固东和龙陵县。

Recommended Route 3 of Yunnan Section of National Highway 219: A Tour of Primitive Tribes in Lincang Wa Township

Lincang is an ancient, mysterious and beautiful land, where 23 ethnic minorities have thrived for generations. This is the gathering place of Wa culture in China, and it is also the "eternal spring capital" with pleasant climate all year round. There is a graceful song between the lush mountains and the flowing water. Wild fruits in the mountains and fungi after the rain are natural gifts. Humanity and art achieve each other, and man and nature live in harmony, which creates the mysterious and unique beauty of Lincang. National Highway 219 will pass through three counties here: Yongde, Zhenkang and Cangyuan.

Guangxi section of National Highway 219

The section of National Highway 219 in Guangxi has a total length of 704.2 kilometers, which belongs to the border area between China and Vietnam, involving 3 cities and 8 counties on the border, with rich and unique tourism resources. G219 Guangxi section begins in dongxing city, Fangchenggang, and ends in Napo, Baise, running through the charming scenery of Guangxi’s secret land. Driving through rivers, seas and mountains, a landscape scroll stretching for more than 700 kilometers slowly extends under the wheels. All the way along the mountain and around the water, it sets off the humanities, history and scenery on both sides along the way and carries the memories from the depths of time. It is like a ribbon floating from the Beibu Gulf to the Yunnan-Guizhou Plateau, floating on the mountains and hills. This road is full of poetry and fairyland of Guangxi’s mountains and rivers, and it is also full of pictures of time and customs.

Recommended route 1 of Guangxi section of National Highway 219: Passing through Hena Expressway between landscape galleries, the charming scenery is like a fairyland.

The British "Mirror" once described it like this: "This is the most beautiful road in the world, and the charming scenery means that this may be the road to heaven." This is the Hena Expressway in Guangxi, with a total length of 503 kilometers, which consists of highway sections from Hepu to Qinzhou (142 kilometers), Qinzhou to Chongzuo (129 kilometers), Chongzuo to Jingxi (147 kilometers) and Jingxi to Napo (85 kilometers).

Self-driving route of Hena Expressway: Heiyizhuang Village in Tunlitun, Napo, Baise (the "living fossil" of Zhuang culture)-Jingxi Goose Spring (one of the three famous springs in southwest China)-Jiuzhou Ancient Town (the hometown of Chinese hydrangea)-Tongling Grand Canyon (the waterfall with the largest single-stage drop in Asia)-Detian transnational waterfall in Chongzuo (the largest transnational waterfall in Asia)-Daxin Mingshi Garden (the location of TV series Hua Qiangu)

Recommended Route 2 of Guangxi Section of National Highway 219: Self-driving Chongzuo "Drunk and Beautiful Border Customs Road" to enjoy the mystery and beauty of the border.

In Guangxi, there is a short-distance tourist scenic avenue, which covers almost all the beautiful scenery in nature. Mountains, rivers, rainforests, villages and cultural customs can be found on this line. This is the first-class tourist scenic avenue in Chongzuo, which is one of the routes that self-driving enthusiasts have to go. It has a total length of 84.17 kilometers, connecting Daxin, Longzhou and Ningming counties in Chongzuo, and a line runs through the landmark scenic spots of Chongzuo, such as Detian transnational waterfall scenic spot, Mingshi pastoral scenic spot and Zuojiang Huashan rock painting cultural landscape, and is known as "drunken beauty border customs road".

Self-driving route of the first-class tourist avenue in Chongzuo: Detian Transnational Waterfall in Chongzuo (national 5A-level tourist scenic spot, the largest transnational waterfall in Asia)-Mingshi pastoral scenic spot (location of TV series Hua Qiangu)-Huashan rock painting landscape in Zuojiang (rock painting world cultural heritage)-Nonggang National Nature Reserve (a scenic spot for birdwatchers).

Donghua Energy joined hands with CNNC to build a zero-carbon industrial park. The price of raw materials soared for half a year, and the net profit dropped by more than 80%.

Changjiang business news ● Changjiang Business Daily reporter Ming Hongze

Donghua Energy (002221.SZ), which constantly promotes the industrial layout, has made heavy moves again.

On the evening of September 6, Donghua Energy announced that the company will join hands with China National Nuclear Corporation to jointly promote the high-temperature gas-cooled reactor project, and it is estimated that the investment will exceed 100 billion yuan in the next five years to jointly build a zero-carbon industrial park. The two sides have also conducted in-depth cooperation in other areas.

Donghua Energy said that the above actions will be conducive to the company’s industrial transformation and upgrading, and greatly reduce the production cost of the process.

Donghua Energy was established in 1996. After more than 20 years of development, it has become one of the top 500 Chinese enterprises. The company’s main business was once dominated by trade, and it is the largest LPG trader in the world and the largest LPG importer in China. In recent years, the company has actively implemented industrial transformation, and now it has become the largest propane dehydrogenation manufacturer in the world.

In the past 10 years, Donghua Energy has achieved a continuous increase in net profit attributable to shareholders of listed companies, but since last year, net profit has declined. In the first half of this year, the company’s net profit was only 146 million yuan, down more than 80% year-on-year.

Donghua Energy explained that geographical conflicts, overlapping epidemics, soaring raw material prices and insufficient downstream demand led to a sharp drop in net profit.

Deep binding with CNNC

A paper announcement by Donghua Energy surprised the market.

According to the latest announcement, on September 6th, Donghua Energy and China National Nuclear Corporation (hereinafter referred to as "China National Nuclear Corporation") signed the Strategic Cooperation Agreement (hereinafter referred to as "Agreement"), which is valid for 10 years.

China National Nuclear Corporation (CNNC) is a super-large state-owned key enterprise directly managed by the central government and belongs to the industry giant.

According to the agreement, the two sides will jointly promote the high-temperature gas-cooled reactor project, and it is estimated that the investment will exceed 100 billion yuan in the next five years to jointly build a zero-carbon industrial park.

In addition, the two sides will jointly establish a hydrogen energy alliance, set up a hydrogen energy research institute and a pilot plant, focus on the thermochemical hydrogen production technology route in the preparation of green hydrogen, and develop solid-state storage materials and equipment for hydrogen.

At the same time, in order to build a hydrogen energy industrial chain and effectively deepen strategic cooperation, the two sides will actively promote CNNC or its member units to become strategic investors of Donghua Energy (accounting for 5%-15% of the shares), and appoint directors to participate in the management of Donghua Energy’s board of directors, so as to create a model of mixed ownership reform of "central enterprises+private enterprises". In addition, according to the principle of "giving priority to quality and price", Donghua Energy (Ningbo factory and Zhangjiagang factory) will be provided with economic and zero-carbon power supply.

The reporter of Changjiang Business Daily found that the cooperation between Donghua Energy and China National Nuclear Corporation not only involves a joint investment of 100 billion yuan in the next five years, but also involves a strategic investment in Donghua Energy, which is deeply tied with its equity relationship and has also made specific agreements on power supply. From this, it can be seen that the two are truly deepening comprehensive cooperation.

Investing 100 billion yuan in the next five years, if it is an enterprise of Donghua Energy, it is not generally difficult.

By the end of June this year, Donghua Energy’s total assets were 36.957 billion yuan, with a total market value of 15.748 billion yuan. With such a volume, it’s hard to imagine that you want to invest hundreds of billions. Holding hands with China National Nuclear Corporation, Donghua Energy will become impossible.

For the above cooperation, Donghua Energy said that the synergy effect on the company’s existing business is significant, which is conducive to the transformation and upgrading of the industry and is expected to greatly reduce the production cost of the process. If both parties cooperate on specific projects within the scope agreed in this agreement, it will have a positive impact on the company’s future performance.

Continuous large-scale investment is under financial pressure

Not only is it difficult to achieve a single investment of 100 billion yuan, but at present, Donghua Energy is also under greater financial pressure.

The semi-annual report shows that as of the end of June this year, Donghua Energy’s asset-liability ratio reached 66.43%. At the end of the period, although the company had 9.037 billion yuan of monetary funds on its books, its short-term debt reached 12.788 billion yuan, which showed obvious short-term debt repayment pressure.

Donghua Energy, originally engaged in trade business, is the largest LPG trader in the world and the largest LPG importer in China. In recent years, the company has actively implemented industrial transformation, and now it has become the largest propane dehydrogenation manufacturer in the world. Its industrial transformation is mainly implemented through investment construction and extended mergers and acquisitions.

In 2015, the first phase project of Zhangjiagang Yangzijiang Petrochemical Co., Ltd. was put into production, which is an important symbol of Donghua Energy’s strategic transformation, upgrading and layout of alkane resources comprehensive utilization industry. In that year, the production facilities of the 660,000-ton propane dehydrogenation to propylene project and the 400,000-ton/year polypropylene project were basically produced at full capacity.

Zhangjiagang Yangzijiang Petrochemical Department was established by Donghua Energy in 2011 with a capital contribution of 560 million yuan, with a shareholding ratio of 56%. In May 2015, the company acquired the remaining 44% equity at a price of 500 million yuan. From 2017 to 2019, Donghua Energy also successively acquired 100% equity of Baoying Jinfan, 100% equity of Polyentang Electronics, 100% equity of Tiansheng Port, and partial equity of Ningbo New Materials to carry out industrial transformation layout.

In 2019, the company announced that it would invest 16.67 billion yuan to build a comprehensive utilization project (Phase I) of alkane resources in Maoming. In order to strengthen the comprehensive utilization of hydrogen energy, in July last year, the company threw out acrylonitrile and its supporting projects to extend the industrial chain, with an estimated investment of more than 6.5 billion yuan.

At present, the company has three production bases in Zhangjiagang, Ningbo and Maoming, and some production capacity is still under planning and construction.

Donghua Energy said that the company will build the world’s largest olefin industrial base based on green chemicals, and plan 10 million tons of polypropylene and multi-copolymerization.

In recent years, the company’s investment cash flow has continued to flow out. From 2020 to the first half of this year, their net outflows were 1.054 billion yuan, 2.852 billion yuan and 1.911 billion yuan respectively.

Because of this, the company bears great financial pressure. In the next five years, the company and China National Nuclear Corporation will jointly invest 100 billion yuan, which will inevitably aggravate its financial pressure.

At one time, Donghua Energy showed strong profitability. In 2016, the company realized a net profit of 470 million yuan. From 2017 to 2020, its net profit increased slowly, but both exceeded 1 billion yuan. In 2021, its net profit dropped by 5.82% to 1.14 billion yuan.

However, in the first half of this year, the company’s performance fell sharply. The semi-annual report shows that its operating income was 15.192 billion yuan, up 6.54% year-on-year, the corresponding net profit was 146 million yuan, and the net profit after deducting non-recurring gains and losses was 95 million yuan, down 80.60% and 86.53% year-on-year.

Donghua Energy explained that geopolitical conflicts triggered international turmoil and superimposed global epidemics, which led to a sharp rise in propane prices. Downstream, due to the epidemic, construction was insufficient, and performance dropped significantly due to the squeeze at both ends.

Will Donghua Energy’s ability to resist risks be enhanced by accelerating industrial layout and financial pressure?

Reporting/feedback

"Enthusiasm" issued a new poster. Bo Huang and YiBo joined hands to perform hot youth


1905 movie network news The film officer announced the summer vacation and released the poster of "Hot Youth". The film is directed by, with Chen Zhixi as the chief producer and leading the street. The background of the poster is bright and colorful, like wanton youth and blood! Bo Huang and YiBo, the two leading actors, laughed shoulder to shoulder, and there was hope in their eyes. Let the audience can’t help but look forward to their stories.


The movie "Enthusiasm" tells the story of hip-hop mr. six Ding Lei (Bo Huang), who meets Chen Shuo (YiBo), a young boy who loves and pursues his dreams firmly. By chance, Chen Shuo joins the hip-hop troupe run by Ding Lei — — Exclamation mark, the master in the dance troupe is like a cloud, with different personalities, and Chen Shuo collides with different sparks and jokes. Chen Shuo enthusiastically pursued his dream and looked forward to the opportunity to play, only to find that everything was not as smooth as expected after entering the dance company. Ding Lei and Chen Shuo are facing their own difficulties in life. Can the unknown frustrations and blows make the mentoring and apprentices continue to join hands in the national competition? This mystery will be revealed after the film is released.


The poster of "Hot Youth" appeared in YiBo, Bo Huang, and the two men were blown up in the summer.


In the poster of "Hot Youth" released, the interaction of the two leading actors shoulder to shoulder caused netizens to speculate and discuss the relationship between the characters, and some netizens even used "being a teacher and a friend" to describe the status of the two characters. The background of the poster is gorgeous and unique, which belongs to the hot breath of summer, burning and warm, and you can feel youthful just by looking at the poster.


The fresh collocation of Bo Huang, a veteran actor, and YiBo, a young actor, has aroused the expectations of countless netizens for the film. One is mr. six, who has been a hip-hop coach for seven years, and the other is a new generation of actors. Their youthful "dislocation" collision in different times is bound to spark unexpected sparks.


Persistence in "enthusiasm" — — Is to pay tribute to every ordinary person who insists on loving.


The story of the film "Enthusiasm" is a gift from the master to every ordinary person who keeps loving life. Ding Lei’s persistence in winning the championship, Chen Shuo’s persistence in the stage, this kind of fighting spirit that seems to be "invincible Xiaoqiang", and his persistence in gritting his teeth in difficulties, truly pay tribute to everyone who works hard for love. Free and enthusiastic, hot and unrestrained is everyone’s attitude towards life. This story of breaking through all difficulties to pursue dreams is also a portrayal of thousands of ordinary people in Qian Qian who keep their love for their dreams.


Ding Lei and Chen Shuo met on their own dreams, and two different eras collided "enthusiastically". Survival and initial heart, friendship and reality finally gathered on one stage, and the stage of their youth never ended. Dreamcatchers of different generations encourage each other, making the film create new heights from all levels. This is exactly what director Dapeng wants to express. Youth never ends, and we will always be enthusiastic for love! Let’s meet the movie "Enthusiasm" in summer and blow it up together.


The movie "Enthusiasm" will be released in summer, so look forward to it!


[Ground Evaluation Line] Caiyun Online Review: Let the theme education release lasting effectiveness

  Duan Zongke, Special Commentator of Caiyun Online Review

  On January 8th, the educational summary meeting on the theme of "Do not forget your initiative mind, Remember Mission" was held in Beijing. General Secretary of the Supreme Leader attended the meeting and delivered an important speech. He stressed that the whole party should take this theme education as a new starting point, constantly deepen the party’s self-revolution, continue to promote the party’s Do not forget your initiative mind and keep in mind its mission.

  Summing up does not mean reaching the end, but starting a new journey on the basis of learning from experience. Theme education has a deadline, but Do not forget your initiative mind, keep in mind that the mission is never ending. General Secretary of the Supreme Leader pointed out that our party must always win the support and support of the people and write the great achievements of the Chinese nation for a thousand years, and must always bear in mind its initial heart and mission. This requires us to take Do not forget your initiative mind, bearing in mind the mission, as the eternal task of strengthening Party building, and the lifelong task of self-purification and promotion of cadres in party member, and make unremitting efforts for a long time to make the theme education release lasting effectiveness.

  Solidly summarize and improve the "storage battery"Under the strong leadership, deployment and promotion of the CPC Central Committee with the Supreme Leader as the core, and taking the lead in setting an example, the theme education of "Do not forget your initiative mind, Remember the Mission", a serious and profound baptism of party spirit, stirred up the whole party and achieved a series of major achievements. In order to release the lasting effectiveness of theme education, it is necessary to look back on the practical process in an all-round way and sum up successful experiences, so as to accumulate strong energy and lay a solid foundation for deepening the party’s self-revolution. Of course, summing up can’t be a complacent introduction of experience and a simple piling up of achievements, but should be refined and sublimated on the basis of summing up and summarizing. It is more important to look at the problem from a developmental perspective and a practical attitude. Only by constantly optimizing the measures of "keeping the original heart, taking the mission, finding the gap and grasping the implementation" can we inject lasting kinetic energy into the self-revolution.

  Ignite the long-term mechanism "engine"."Resolutely remove all factors that weaken the party’s advanced nature and damage the party’s purity, resolutely remove all cancers that breed on the party’s body, and resolutely guard against all dangers that violate the initial heart and mission and shake the party’s foundation." This is a long-term and systematic project, which must be done for a long time. It is inseparable from strong institutional guarantee to continuously promote the Do not forget your initiative mind of the whole party and keep in mind its mission. Although the theme education has come to an end, Do not forget your initiative mind’s mission needs not only immediate "immediate change", but also long-term management. Since the 18th National Congress of the Communist Party of China, the CPC Central Committee with the Supreme Leader as the core has attached great importance to institutional governance. At the Fourth Plenary Session of the 19th CPC Central Committee, it was proposed to establish a system of Do not forget your initiative mind and keeping the mission in mind. On the basis of summing up, establishing a simple, pragmatic and accurate long-term mechanism will undoubtedly ignite the engine of keeping the original heart and carrying out the mission.

  An "accelerator" to stimulate the vitality of the grassroots.General Secretary of the Supreme Leader pointed out that the mission of Do not forget your initiative mind and Mindfulness should be realized through the joint efforts of the whole Party. The key to running China well lies in the Party, and the most solid and active source of strength for the Party’s work lies in the grassroots. Doing a good job of summing up and upgrading is to start a new journey, build a long-term mechanism to promote going deep, going real and going far. Besides these, it is also essential to stimulate the vitality of the grassroots, give birth to Do not forget your initiative mind, and keep in mind the vivid and vivid grassroots innovation practice. "Bearing in mind the initial heart and mission, we must persist in serving the people wholeheartedly." Do not forget your initiative mind, whether the measures to keep in mind the mission are effective or not, and whether the results are remarkable or not, must be tested by the masses’ sense of gain. To this end, it is necessary to give full play to the initiative of grassroots innovation and creation, and to refuel and add strength to the release of lasting effectiveness of theme education with colorful grassroots practices.

  "You can’t expect to declare success through one or two educational activities. ‘ The revolution has not yet succeeded, and comrades still have to work hard ’ This sentence is always going on. " Ending is not ending, and summing up is not ending. "Do not forget your initiative mind, keep in mind the mission" is always on the road, so that the theme education will release lasting effectiveness, and our party will surely lead the great ship "China" to a brighter future.

Xinhua All Media+| It’s more fun to play ice and snow on campus during winter vacation.

  Xinhua News Agency, Changchun, January 29th Since the winter vacation, many places in Changchun and Shenyang have opened ice and snow custodians. Schools have built ice rinks and snow fields on campus, hired professional coaches, and provided all kinds of ice and snow sports courses for primary and secondary school students, so that students can enjoy ice and snow on campus during the winter vacation and welcome the Winter Olympics.

  In the cold winter, in the 2,400-square-meter ice rink of Pingquan Primary School in Nanguan District, Changchun City, the students learned from the skating coach in full swing.

  Students in the primary school of Changchun No.104 Middle School are learning to skate. Xinhua News Agency reporter dorri photo

  Song Haoxuan, a student in Class Two, Grade Five, Changchun No.104 Middle School, is learning skating for the first time. After three days, he has mastered the basic movements and can stand and walk on the ice. "Before the holiday, the class teacher said that there was ice and snow custody during the holiday, so I signed up. In the past, I could only do my homework at home during the holidays. It is so interesting to learn skating this time. " Song Yuxuan said.

  At the scene, the reporter saw that a shoe changing room was built around the skating rink, in which all the skating equipment was prepared for students, and each school was accompanied by leading teachers to ensure the safety of students.

  Sun Jingru, director of the Department of Physical Education, Sports, Arts and Health, Nanguan District Education Bureau, Changchun City, said that in order to create conditions for students to participate in ice and snow sports, Nanguan District Education Bureau poured an ice rink in Pingquan Primary School. Students in grades 4-8 of primary and secondary schools in the whole district took advantage of the winter vacation to participate in ice and snow custody for a total of 30 days, with about 600 participants every day. The total number of participants in the winter vacation is expected to be 18,000. The Education Bureau also hired seven professional coaches to guide students’ ice skills, so that students can master the basic skating movements and experience the fun of skating in a short period of time.

  Shoe changing room of Pingquan Primary School in Nanguan District, Changchun City. Xinhua News Agency reporter dorri photo

  In addition, other counties and cities in Changchun also provide various forms of ice and snow amusement activities for primary and secondary schools. Yushu city City, Jilin Province has poured 26 outdoor ice rinks in primary and secondary schools in towns and villages, and equipped students with PE teachers and skating equipment. Up to now, more than 10,000 people have participated in ice and snow custody.

  In the ninth primary school in Hunnan District, Shenyang City, Liaoning Province, ice and snow activities are another lively scene. The school’s snow machine makes snowflakes fly, and it is fun to have snowball fights, make snowmen and snowball. Two large indoor ski machines allow students to ski at zero distance, and more than 700 students who participate in the trusteeship can enjoy the fun of flying in the snow.

  Hou Mingfei, principal of the Ninth Primary School in Hunnan District, Shenyang, said that compared with summer classes, the school’s winter vacation trusteeship has increased the single and double snowboarding projects, and students can take skiing classes on campus.

  On the 120-square-meter indoor simulated ice rink of Heping Street No.1 Primary School in Heping District, Shenyang, the children were dressed in ice hockey equipment, and the teacher explained the technical points and basic sliding movements for the students. The slightly childish movements of the students added vitality and vitality to the winter campus.

  The school organized a winter vacation hosting service with the theme of "Harmony, Colorful Winter Holidays", and 80 students from different grades signed up to participate. The trusteeship classes were named "Bingdundun" class and "Snow Rongrong" class, and activities such as learning to sing winter Olympic songs and ice hockey experience were also carried out to cultivate students’ interest and skills in ice and snow sports.

  Students in the primary school of Changchun No.104 Middle School learn skating. Xinhua News Agency reporter dorri photo

  This school is a characteristic school of ice and snow sports on the national youth campus. Lin Yuheng, the director of teaching, said that ice hockey training in schools usually involves members of the school team, and not all students can master skills such as ice hockey and speed skating. There is plenty of hosting time in winter vacation, and for more than 80 students who participate, they can do no less than two hours of sports every day.

  In recent years, Shenyang has incorporated ice and snow projects into the teaching content of primary and secondary schools, and carried out ice and snow sports through physical education courses and comprehensive practical activities courses, and achieved remarkable results. Twenty-seven schools in the city were rated as "National Youth Campus Ice and Snow Sports Characteristic Schools" by the Ministry of Education, and 55 schools were named as municipal ice and snow characteristic schools. At present, more than 30% primary and middle school students in the city have mastered the basic skills of ice and snow. (Reporter: Li Shuangxi, dorri, Wang Ying, Wu Jiangmin)

Yuan Renguo, Chairman of Maotai Group: Integrating Internet thinking and big data into enterprise production.

  Cctv news (Reporter Liu Ying) On May 25th, China E-commerce Innovation and Development Summit opened in Guiyang. Yuan Renguo, chairman of China Kweichow Moutai Distillery Co., Ltd., delivered a speech at the opening ceremony. He said that integrating Internet thinking and big data into corporate strategy and production and operation, using 3-mdash; Five years to build big data Maotai, strengthen the seamless connection with consumers, and form a global big data platform such as manufacturing, trading and interactive industry chain and diversified expansion of Maotai, so that Maotai’s high-quality data can continue to be the most important data assets of the enterprise and continuously improve its core competitiveness, industrial competitiveness, brand influence and market share.

  The following is the full text of Yuan Renguo’s speech:

  Dear Governor Sun, distinguished leaders, distinguished guests, ladies and gentlemen, friends. As a leading enterprise in Guizhou Province and liquor industry, Maotai Group is honored to discuss the development of big data with industry leaders, experts, scholars and elites from the global big data field.

  Big data has brought changes to the manufacturing industry as much as the invention of steam engines and electricity has promoted the industrial revolution. In recent years, General Secretary of the Supreme Leader and Premier Li Keqiang have repeatedly given clear instructions on the implementation of the big data strategy and the internet plus Action Plan. The Guizhou Provincial Party Committee and the provincial government attached great importance to big data and made a decision to promote the strategic action of big data in the "Thirteenth Five-Year Plan". Big data has opened a brand-new era. Artificial intelligence, virtual reality technology, augmented reality technology, mixed reality technology, unmanned controllers and new sensors are on the rise. Everyone has a terminal, things can be sensed, and the Internet can be accessed everywhere. In real time, under the general trend of connected everything, data has become a valuable resource asset and production factor. The connection between Maotai and global consumers has increased the connection of big data on the basis of traditional connections, achieving zero distance from the world.

  Maotai’s craft is one of the living fossils of China’s manufacturing industry, and it is the representative of China’s traditional craftsman spirit. At present, world-renowned wine companies are carrying out big data reform, intelligent production, and informationization of the whole industry chain. Maotai deeply integrates big data, the Internet and the craftsman spirit, and leads Maotai’s innovative development with the big data revolution. First of all, Maotai built an Internet of Things cloud business platform to realize the data traceability of the whole industry chain. Maotai built the first comprehensive category trading platform integrating grassroots B2B2C, industrial financial services, collection and auction in the domestic liquor industry, and the trend of each bottle of Moutai can be quickly merged into the most valuable information of the company, which constitutes the big data of the whole industry chain of the company. At the same time, consumers can also know the production and sales links of each bottle of Moutai in their hands through the quality traceability system. We will interact with online and offline, actively and flexibly consume experiences and personalized needs.

  This year, Maotai used Internet technology to establish an information system for brewing production technology, from brewing to smart brewing. A bottle of Moutai has to go through 30 supply and demand and 165 technological links, and it will take at least five years. In the window of traditional enterprises facing the discovery and utilization of new growth drivers, under the background of Global Industry 4.0, Maotai has established an information system for collecting, counting and feeding back brewing production data.

  We will further promote the revolution and innovation of big data, better serve the global consumers from the traditional space to the Internet space, and extend the real-time interaction between service consumers and global consumers, and integrate Internet thinking and big data into corporate strategy and production and operation, using 3— Five years to build big data Maotai, strengthen the seamless connection with consumers, and form a global big data platform such as manufacturing, trading, interactive whole industry chain and diversified expansion of Maotai, so that Maotai’s high-quality data can continue to be the most important data assets of the enterprise and continuously improve its core competitiveness, industrial competitiveness, brand influence and market share. Data creates value, innovation drives the future, and the integration of knowledge and practice in Guiyang is the birthplace of philosophical thought. To make the flower of dreams bear the fruit of career, it depends on promoting knowledge with knowledge and promoting knowledge with action. Breaking can promote vitality, and innovation can promote the future. In 1995, Maotai left a much-told story in Panama. Because of breaking and innovation, Maotai has become a world-famous brand with the largest sales volume and the strongest leading ability in the world.

  Finally, welcome all of you to visit Maotai. You can appreciate the mellow taste of Maotai. Thank you!

Mila Tang Jian: Building ChatGPT in the field of life science and developing drugs with generative artificial intelligence.

"I have always been interested in biology. When I was in high school, my teacher told us that the 21st century was the century of biology. When I studied artificial intelligence, I believed that the 21st century was the century of artificial intelligence."

During the scientific lecture "Understanding the Future" hosted by the Future Forum, Tang Jian, an associate professor at the Research Center for Artificial Intelligence in Quebec, Canada (Mila) and a professor of artificial intelligence at the Canadian Institute of Advanced Studies (CIFAR), introduced the application of generative artificial intelligence in life sciences: how to build a "ChatGPT" in life sciences. He said, "Later, I felt that it might be the best choice if I could do something in the field where artificial intelligence and biology intersect."

Today, he is not only studying AI and biology at the same time, but also "left-handed scientific research and right-handed entrepreneurship". He said that he is a person who is willing to accept new things and challenges. From scientific research to entrepreneurship, many things are different, and it is difficult to carry out interdisciplinary cooperation, but this also reflects the value of doing these things.

Figure | Tang Jian (Tang Jian’s personal homepage)

According to reports, Tang Jian University studied geography at the beginning, transferred to the Department of Mathematics in his sophomore year, and successfully applied to the Department of Computer Science in his senior year. In his computer learning career, he first studied traditional machine learning, and in the last year of his doctoral degree, he turned to deep learning.

After graduating from the doctor’s degree, he officially embarked on the road of scientific research and made many achievements in the field of graphic representation learning. As one of the representative scholars in this field, his network representation learning method LINE (large-scale information network embedding) has been widely used, with more than 5,000 references.

"The double revolution of artificial intelligence and biotechnology broke out, and we are in the best era of doing research."

In 2018,Tang JianStart the research on the intersection of artificial intelligence and biology. At that time, he applied the graph representation learning technology to the research in the field of drug discovery, and did a lot of work in the prediction of three-dimensional structure of small molecules and the design of macromolecular proteins.

But a few years ago, only a few people devoted themselves to the research in this direction. In the past two years, more and more investment has been injected into this field. Tang Jian believes that the reason for this change is that artificial intelligence has brought great breakthroughs to the structural prediction and biological field in protein, and the spread of the COVID-19 epidemic has also aroused people’s focus on health and biomedicine.

"Now we are in the best era, because we are experiencing the dual technological revolution of artificial intelligence and biotechnology." Tang Jian said, "Therefore, we have seen great opportunities for generative artificial intelligence in the field of drug discovery, especially protein design."

Based on his accumulation in scientific research, he devoted himself to entrepreneurship and set up the artificial intelligence-driven biopharmaceutical company Baiao Geometry in 2022.

Build an AI macromolecular drug design platform to provide innovative drugs to save patients’ lives.

existTang JianIt seems that perhaps it is the entrepreneurial idea that has sprouted since childhood and the character of constantly seeking self-breakthrough that drives him to embark on the road of entrepreneurship.

The Baiao Geometry Company, founded by him, aims to develop a programmable protein by integrating the technologies of generative artificial intelligence and geometric deep learning, so as to overcome the problems of long cycle, high cost and low success rate of traditional macromolecular pharmacy and provide innovative drugs to save patients’ lives.

Tang Jian is mainly responsible for technical work in this company, and designs antibodies by building artificial intelligence models. As a new diffusion generation model, this model can model the amino acid sequence and three-dimensional structure of protein at the same time, and show the relationship between them, so as to generate protein with specific functions.

At present, the team has set up an AI macromolecular drug design platform, and is building a wet experiment verification platform for Qualcomm macromolecular drugs. At the same time, it also launched TorchProtein, an open source machine learning platform for macromolecules, in conjunction with companies such as NVIDIA, Intel and IBM.

"I hope that the technology I have made can really push several drugs into the clinic, solve more complicated diseases like cancer and save patients’ lives." Tang Jian said. In addition, he also said that with the development trend of intelligence, digitalization and automation in the biomedical field becoming inevitable, he expected to become a world-famous and international high-tech company in this field.

Based on generative artificial intelligence, build "ChatGPT" in life science field

In addition to starting a business, Tang Jian’s scientific research work at hand is also being carried out simultaneously. Based on generative artificial intelligence, he and his team have carried out research on three-dimensional structure prediction of small molecules and protein design of large molecules in the field of biomedicine.

In the prediction of the three-dimensional structure of small molecules, the team mainly modeled them based on the diffusion generation model. Specifically, a completely random structure is taken as the initial structure, and after several rounds of optimization, it finally converges to a stable protein structure. Each step of the optimization process is also called denoising. In addition, on the basis of expanding the research, the prediction of the complex structure was realized.

In the design of macromolecular proteins, the team proposed to design protein structure and sequence based on diffusion generation model, which not only realized the generation of antibody CDR Loop structure and sequence, but also designed α -helix transmembrane proteins with a specified number.

Not only that, the team also conducted research on antibody design and optimization. For example, it cooperated with the research team from Fudan University. Based on the antibody CR3022 obtained from newly crowned patients, it first designed the sequence with AI model, and then tested it on the wet experimental platform of Qualcomm, and finally successfully found the antibody molecule with strong affinity.

For generative artificial intelligence, its most critical ability is that it can generate new data. Then, if it is used in the biomedical field, it can help to generate a brand-new protein and help people find better drugs.

As a typical generative artificial intelligence model, ChatGPT has spread all over the world since it was introduced at the end of 2022. It can talk and communicate like a human being, and complete tasks such as writing papers and coding. "It is essentially a chat robot." Tang Jian said. As a large-scale pre-training language model, ChatGPT first pre-trains a large number of text and code data on the Internet, and then further optimizes it to enable it to be used for tasks such as dialogue.

The development of biotechnology, such as gene sequencing and gene synthesis, has brought a lot of data to the biomedical field. Therefore, Tang Jian believes that in the near future, people can also use these data to build ChatGPT in the field of life sciences.

Reporting/feedback

Vipshop will release the "2023 Beauty Awakening Trend": the trend of makeup first, refined demand and streamlined skin care is remarkable.

Wake up in the spring, and the mood of wanting to be beautiful grows wantonly in the new spring.
According to the data released by the National Bureau of Statistics, the total retail sales of social consumer goods reached 7,706.7 billion yuan in January and February 2023, a year-on-year increase of 3.5%. Among them, the total retail sales of cosmetics was 65.6 billion yuan, up 3.8% year-on-year, achieving the first positive growth since August 2022, and the cosmetics market showed obvious warming momentum.
Recently, Vipshop joined hands with many well-known beauty brands to launch a consumer survey called # Vipshop Beauty Awakening Plan #, and based on the platform sales data, brand feedback and nearly 1,500 netizens’ responses from platforms such as Weibo, Xiaohongshu, bilibili and Zhihu, it released the "2023 Beauty Awakening Trend" (hereinafter referred to as "Trend"). Trend shows that since the beginning of this year, the trend of making-up first, refined demand and streamlined skin care has been remarkable, which has brought new development space and growth point to the beauty market.
Trend 1: under the recovery of the market, make-up is the first to start.
In the vibrant spring, bright makeup makes people feel happier and more confident socially. Benefiting from the full liberalization of consumption and social scenes, makeup consumption took the lead in the first quarter of 2023, which sounded the clarion call for the recovery of the beauty market.
According to the data of Vipshop, from January to mid-March, 2023, the sales volume of platform makeup increased by 6.24% month-on-month, among which lip makeup and eye makeup products increased the most obviously, increasing by 15.3% and 18.6% month-on-month. In terms of brands, the sales of domestic beauty brands, such as Huaxizi, Kazilan and Tangduo, have increased significantly, with an increase of 17.1%, 24.9% and 20.6% respectively.
Geographically, the sales of beauty cosmetics in first-tier and new first-tier cities have increased significantly. For example, the sales of beauty cosmetics in Beijing, Shanghai, Guangzhou and Shenzhen increased by 20% to 40% month-on-month, and the growth rates of Chengdu and Chongqing, the "most beautiful cities", both exceeded 80%. Among the top ten cities in beauty sales, Xi ‘an increased by 101.9% month-on-month, ranking first in the country.
Trend 2: The consumer demand is refined, and the subdivided track is optimistic.
With the refinement of consumer demand, more and more beauty brands further expand their product lines and capture opportunities to segment the track. Taking Tangduo as an example, in 2022, innovative products, such as high-gloss capacity-repairing disk and ultra-fine eyeliner, were introduced in addition to the dominant categories such as eye shadow and blush, which formed a more perfect product layout and quickly seized the market segment.
At the same time, consumers’ awareness of cosmetics has improved rapidly, which puts forward higher requirements for the brand’s product strength. The person in charge of the Lancer brand pointed out that many "component parties" are even familiar with the basic formula and efficacy features of the products, and the beauty track will continue to "roll the efficacy" and "roll the research and development".
In addition, the refinement of demand is also reflected in the consumption scene+style. The person in charge of Maybelline brand said, "With the stratification, diversification and refinement of consumer demand, beauty care brands gradually break the circle boundary and expand brand influence through topic innovation with different emotions and scenes."
Trend 3: quality consumption prevails, and subtraction skin care becomes a hot spot.
# vipshop Beauty Awakening Plan # Consumer survey results show that nearly half of the consumers surveyed have reported that their consumption mentality has tended to be calm in the past three years, and their choices have become more rational, paying more attention to product quality. "I used to buy what I used to buy, but now I prefer to be short of it, and I will choose products that are of good quality and suitable for me."
The person in charge of Maybelline brand believes that consumers’ pursuit for the quality and details of beauty products reflects a typical attitude towards self-satisfaction.
The ever-changing lifestyle is reshaping the relationship between consumers and beauty care. A person in the beauty industry said, "Under the influence of environmental awareness and healthiness, consumers are increasingly favoring products with natural raw materials and safe ingredients. In terms of makeup, more consumers began to’ do subtraction’, praised natural and clean makeup, bid farewell to exaggeration and pursue originality. "
After more than half a year’s market downturn, the prosperity of the cosmetics industry has greatly increased. Cosmetics are selling well during Valentine’s Day 214 and Women’s Day 3.8 this year, which also makes brands optimistic about the next market trend.
The person in charge of the Orange Blossom brand said, "When the overall social mobility returns to normal, the vitality of the market is increasingly displayed. More importantly, we have seen more confidence in the industry, which comes from the supply chain, channels, consumers, and even more from various brands in the industry. This makes us look forward to the overall recovery of the beauty industry. "
The person in charge of Vipshop’s beauty cosmetics said: "As the original intention of the Spring Awakening Plan, Vipshop hopes to join hands with beauty brands in spring and start from spring."
Xinmin. com published this article for the purpose of transmitting information, and does not represent the views of this website.
Reporting/feedback

Where does RDN go to treat hypertension? Professor Guo Yifang: The future can be expected.

Renal artery denervation (RDN) is a hot topic in the field of hypertension in recent years. Although it has not been widely used in clinic, with the release of various clinical data, more and more industries focus on RDN.

RDN targets the sympathetic nervous system, which does play a role in raising blood pressure. Therefore, RDN selectively reverses a mechanism of hypertension. But hypertension is a multifactorial disease. Is it really enough to target a single pathogenic mechanism to produce effective and sustained blood pressure reduction in a large number of hypertensive patients? Yixin specially interviewed the vice president of Hebei Provincial People’s Hospital.Professor Guo Yifang, shared his views on the future prospects of RDN.

  One more proof of RDN’s long-term effect  

Recently, the three-year research results of RADIANCE-HTN SOLO test were published, which confirmed that the safety and effectiveness of ultrasonic RDN lasted for 36 months.

Patients with ambulatory blood pressure ≥135/85 mmHg and < 170/105 mmHg after 4 weeks of stopping antihypertensive drugs were randomly divided into ultrasound RDN group or sham operation group. The results of 36-month follow-up showed that the systolic blood pressure and diastolic blood pressure in RDN group decreased by 17.7 mmHg and 11.3 mmHg respectively compared with baseline. In terms of safety, there were no adverse events related to equipment or operation during the follow-up period.

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In response to this research result, Professor Guo Yifang pointed out that in recent years, the effectiveness and safety of RDN has been an important topic in the field of hypertension treatment, which has attracted extensive attention from scholars at home and abroad.Radiation-HTN solo research provides valuable new evidence for the instrument treatment of hypertension. However, Professor Guo is cautiously optimistic about the results of this study, considering the differences in the conclusions of several RDN studies published in recent years and the limitations of this study itself..

  The evidence-based road of RDN  

The basic principle of RDN is to block the afferent and efferent activities of sympathetic nerve around renal artery by radio frequency energy, ultrasonic energy or injecting heat into perivascular space, and reduce the influence of sympathetic nervous system on renal vascular resistance, renin release and sodium reabsorption. RDN blocks the signal conduction between the brain and sympathetic nerve to a certain extent, thus reducing the sympathetic nerve excitability of patients with hypertension. Theoretically, it can achieve long-term antihypertensive effect through a minimally invasive operation.

As early as 2009 and 2010, RDN completed two early clinical trials in Europe and Australia, namely Symplicity HTN-1 and HTN-2. The results of 3-year follow-up showed that the average systolic blood pressure and diastolic blood pressure of refractory hypertensive patients receiving RDN decreased by about 30 mmHg and 14 mmHg respectively, and there were no obvious adverse reactions and complications. More importantly, after three years of follow-up, these patients found no obvious signs of blood pressure rebound.

Because this is the first minimally invasive surgical technique that has been proved in history and can definitely lower patients’ blood pressure, RDN shines brilliantly after the above exploratory experiment, but the well-known sham-operated control experiment-Symplicity HTN-3 did not get positive results, which weakened people’s enthusiasm for RDN: although the research proved its safety, it did not significantly lower blood pressure compared with the control group.

On the basis of summarizing the research experience and lessons of SYMPLICITY HTN-3, the researchers subsequently carried out a new generation of randomized controlled trials, such as SPYRAL HTN-OFF MED, SPYRAL HTN-ON MED, SPYRAL HTN-OFF, etc. These studies used different techniques and methods to ablate the renal artery sympathetic nerve. The results showed that the ambulatory blood pressure and clinic blood pressure in RDN group decreased clinically regardless of whether antihypertensive drugs were used or not.

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Clinical research course of RDN

(Source: Nat Rev Cardiol. 2020 Oct; 17(10):614-628. )

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In different studies, compared with sham operation group, systolic blood pressure in RDN group decreased.

The REQUIRE study aims to evaluate the effectiveness and safety of ultrasound renal artery ablation system in controlling blood pressure in patients with refractory hypertension. 143 patients with refractory hypertension (office blood pressure ≥150/90 mmHg and 24-hour SBP≥140 mmHg) were randomly assigned to RDN or sham operation group. Three months after operation, there was no significant difference in the 24-hour ambulatory systolic blood pressure between the RDN group (-6.6 mmHg) and the sham operation group (-6.5 mmHg) (P=0.971). The difference of SBP between family self-measured blood pressure and clinic blood pressure was -1.8 mmHg(P=0.488) and -2.0 mmHg(P=0.511) respectively, and there was no difference. There was no significant difference in drug load between the two groups. No major adverse events related to the operation were found.

At the EuroPCR annual meeting in 2022, a number of research data of RDN were published: Global Symplicity Registry, SPYRAL HTN-ON MED, Radiation HTN Solo & Trio, which further confirmed the potential of RDN as an adjuvant therapy for hypertension, supplemented the existing first-line therapy, and thus changed the lifestyle and drug treatment.

  Professor Guo Yifang: RDN can be expected in the future  

The occurrence of hypertension is a complex process, involving many mechanisms, and it is not expected to solve all patients’ problems through one drug or technology. RDN only blocks renal sympathetic innervation, and may have no therapeutic effect on other mechanisms that cause and maintain hypertension. Moreover, the antihypertensive effect of RDN is moderate, which is only equivalent to taking an antihypertensive drug.

Professor Guo Yifang talked about the future prospect of RDN. He pointed out that RDN is still in the stage of research and exploration, and it can not be used as a mature treatment technology in clinical practice. From the pathophysiological mechanism, the sympathetic nervous system plays an important role in the occurrence and maintenance of hypertension, so in theory, RDN will definitely have an ideal effect on some hypertensive patients. butThe pathophysiological mechanism of hypertension in different patients is inconsistent, the renal artery structure in different patients is obviously inconsistent, the principle of different types of RDN technology and equipment is inconsistent, and the experience and technical level of different operators are inconsistent. These four "inconsistencies" will inevitably affect the effectiveness and safety of RDN treatment and its application value and clinical status in antihypertensive treatment..

On the whole,For patients whose blood pressure can’t be satisfactorily controlled after lifestyle intervention and adequate treatment with various antihypertensive drugs, patients with obvious sympathetic hyperactivity, or patients who can’t tolerate antihypertensive drugs, it is reasonable to carry out RDN treatment in mature medical centers.. It is believed that RDN will play a more important role in the field of hypertension treatment in the future with the progress of related technologies and the continuous improvement of treatment equipment.

Expert introduction

18681659483287032  

Guo yifang

People’s Hospital of Hebei Province

Chief physician/professor, doctoral tutor, currently vice president of Hebei Provincial People’s Hospital. He is also the vice chairman of the Hypertension Committee of Chinese Medical Doctor Association, the vice chairman of China Society Hypertension Branch, the executive director of China Hypertension Alliance, the chairman of the Geriatrics Branch of Hebei Medical Association, the chairman of the Hypertension Professional Physician Branch of Hebei Medical Association, and the chairman of the Medical Engineering Branch of Hebei Medical Association. And the editorial boards of Chinese Journal of Internal Medicine, Chinese Journal of Geriatrics, chinese journal of cardiology and Chinese Journal of General Practitioners, and the standing editorial boards of Chinese Journal of Hypertension and chinese journal of cardiovascular medicine. Enjoy the special allowance of the State Council.

references

1. David E. Kandzari, Raymond R. Townsend, George Bakris, et al. Renal denervation in hypertension patients: Proceedings from an expert consensus roundtable cosponsored by SCAI and NKF. Catheter Cardiovasc Interv. 03 August 2021. 

2 "China cardiovascular medical device industry innovation white paper 2021"

3. Nat Rev Cardiol. 2020 Oct; 17(10):614-628.

4. C. Venkata S. Ram. Renal Denervation Therapy for Hypertension: All That Glitters Is Not Gold. Medscape. https://www.medscape.com/viewarticle/976670_1

5. Ultrasound renal denervation meets primary efficacy endpoint in RADIANCE II study. Cardiovascularnews. 26th July 2022.

6. Florian Rader, Ajay J. Kirtane, Yale Wang, et al. Durability of blood pressure reduction after ultrasound renal denervation: three-year follow-up of the treatment arm of the randomised RADIANCE-HTN SOLO trial. DOI: 10.4244/EIJ-D-22-00305

Typesetting: Yixin Editorial Department

Lawyers interpret the ZhangJike storm: if you collude with creditors to extort Jing Tian, it will constitute an accomplice in extortion.

A few days ago, ZhangJike was exposed to a gambling debt dispute and spread private videos of others, which caused widespread concern. Seeing the rumors getting worse, ZhangJike issued a lawyer’s statement, claiming that some users’ comments had infringed on ZhangJike’s reputation, and investigation and evidence collection have been carried out. However, this did not stop the news from continuing. Well-known reporter Li Weiao subsequently published two articles, and the content of the news was more detailed and specific.

Li Wei ‘ao broke the news that the creditor who asked Jing Tian for money was sentenced. If the creditor asks Jing Tian for money by threatening the private video, and the person who gave the private video to the creditor is ZhangJike, does he need to bear legal responsibility in this case?

What kind of legal responsibility will it face to spread other people’s private videos? Will you be sentenced? If sentenced, how long will it take?

Can the celebrity accuse the gossip disseminator of infringement of his reputation right prove that the gossip spread is false? Is it true that the scandal will sue the right of reputation infringement, and the false will sue the crime of libel?

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With these questions, I consulted lawyer Li Yang of Beijing Yingke (Shanghai) Law Firm and lawyer Liang Keli of Wanshang Tianqin (Shanghai) Law Firm.

You can’t repay your gambling debts, and you use your ex-girlfriend’s private photos to pay off your debts?

At the end of March, some netizens broke the news that ZhangJike had leaked private photos of himself and his predecessor, Jing Tian, to his creditors because he had not paid his gambling debts. After the creditor got the private photos, he asked Jing Tian for money on this matter. Then Jing Tian sued the creditor.

ZhangJike Studio first issued a statement on the 30th, saying: "Mr. ZhangJike has no debt disputes, and there is no case of damaging the privacy of others in order to protect himself. The rumor is purely fabricated."

On March 31, Li Weiao, the chief reporter of Economic Observer, wrote with his real name account: "From some judicial materials I saw and mastered a few years ago, ZhangJike passed on Ms. Jing’s private video to others. This is true." .

On the same day, ZhangJike Studio entrusted a lawyer to issue a statement, saying that some users’ remarks caused ZhangJike.Infringement of reputation rightAt present, investigation and evidence collection work has been carried out, and lawsuits will be filed against key infringing users who have repeatedly published or refused to delete infringing content and caused great adverse effects.

However, ZhangJike’s lawyer’s statement did not prevent Li Wei ‘ao from publishing a message again. Li Weiao then issued two more articles, and the content of the news was more detailed and specific.

Li Weiao revealed that the judicial materials showed that there were 3 private videos of Ms. Jing and 1 video screenshot. ZhangJike admitted that he had shown others a segment of the above video. In addition, ZhangJike was sued by his creditors (and his family) a few years ago. After the prosecution, after mediation, Zhang returned the creditor (and family) 1 million yuan. However, ZhangJike’s IOU is 5 million yuan, and that IOU is still in the hands of creditors (and family members). He also said that ZhangJike’s debt and video problems were not simply "gossip" of celebrities, but caused a serious criminal case. In this case, Ms. Jing is a complete victim. ZhangJike’s creditor, who asked her for money, later pleaded guilty and is still serving his sentence.

After Li Wei ‘ao broke the news again, some media reported that he had contacted ZhangJike himself. ZhangJike denied the debt and the photos. But when asked whether there was no debt or no photos, ZhangJike hung up.

On April 2, ZhangJike’s attorney responded to the media that this matter has actually been responded. One is that the studio has completely denied it. "Another, we are entrusted to investigate the facts of infringement and are ready to sue immediately."

Lawyer’s interpretation:

Winning the case of reputation right doesn’t mean that the gossip is false, and the fake star statement may also be infringing.

Under what circumstances should I bear legal responsibility for spreading other people’s private videos?Lawyer Li Yang said to the analysis that the dissemination of other people’s private videos may constitute an infringement of others’ privacy. If the content of private videos is sensitive and the scope of dissemination is wide, it may also constitute the crime of spreading obscene articles. According to Article 364 of the Criminal Law, whoever disseminates obscene books, periodicals, films, audio-visual images, pictures or other obscene articles, if the circumstances are serious, shall be sentenced to fixed-term imprisonment of not more than two years, criminal detention or public surveillance. "If it is a small-scale spread, it is basically necessary for the victims to call the police themselves. butIf it is a large-scale dissemination of obscene articles, the police may actively intervene if they find it at work. However, the latter is unlikely. Unless the perpetrator spreads the private video on the whole network. "Lawyer Li Yang told me.

According to reporter Li Wei ‘ao, he claimed that ZhangJike’s debt and video problems were not simply "gossip" of stars, but caused a serious criminal case. In this case, Ms. Jing is a complete victim. ZhangJike’s creditor, who asked her for money, later pleaded guilty and is still serving his sentence. At the same time, Li Weiao threw a question to ZhangJike: "What role did ZhangJike play in this case, and can he respond publicly?"

If Li Wei ‘ao’s news is true, does ZhangJike need to be responsible in this case? In this regard, lawyer Li Yang said to the analysis that the creditor was criminally held accountable for asking Jing Tian for money, which probably constituted the crime of extortion.ZhangJike’s responsibility depends on whether ZhangJike forms an accomplice relationship with the creditors."For example, if ZhangJike gave private materials to creditors and colluded with them (including consulting together and directing creditors, etc.) to extort Jing Tian, although he did not participate in the extortion, it would also constitute an accomplice in extortion; On the contrary,If ZhangJike only sold or otherwise gave the private information to the creditor, but did not participate in the extortion and did not collude with the creditor, it should not be considered that he should bear criminal responsibility for this crime. "However, it is not easy to judge whether it is collusion or not, unless the creditor can provide evidence such as recording. Or if the creditor confessed that he was colluding with Zhang, and ZhangJike himself admitted it.

ZhangJike Studio issued two statements in response to the storm. In the statement issued by the studio for the first time, it was responded that some infringing users made defamatory remarks about Mr. ZhangJike’s character and private life without any factual basis, slandering him for his involvement in gambling debt disputes, fund fraud and other illegal acts. He also said: "Mr. ZhangJike has no debt disputes, and there is no situation of damaging the privacy of others in order to protect himself. The rumor is purely fabricated." The statement issued by the second entrusted lawyer did not deny the relevant rumors, saying that evidence will be obtained for the infringement of reputation rights.

Many netizens are curious about whether the statement issued by the star studio has legal effect, and whether it is necessary to bear legal responsibility if there is anything contrary to the facts in the statement. In this regard, lawyer Li Yang told the analysis that,The statement issued by the studio is generally only regarded as a public explanation. If there are fabricated facts and other plots, which have adverse effects on others, it may also infringe on the right of reputation.

Others have questioned that ZhangJike is going to sue for infringement of reputation right instead of libel. Why do stars seldom mention criminal "libel" and take civil "infringement of reputation"?Is it true that the scandal will sue the right of reputation infringement, and the false will sue the crime of libel?In this regard, lawyer Liang Yan said to the analysis that this is actually not particularly related to the "true and false gossip", mainly because of the difference between the two. The criminal and civil conditions for filing a case are different, and the requirements for the consequences caused by "insulting" behavior are different. It can be simply understood that the severity of the consequences caused by most of these "celebrity gossip" is not enough to take the criminal "libel". For example, causing someone to go insane or commit suicide because of someone else’s "libel" behavior is a serious situation.

In addition, if the scandal is true, it may involve infringement of privacy rights, etc. It should be noted that we can’t say that "if the privacy infringement is mentioned, it will prove that the scandal is true", but it still depends on the specific case.

butCan it be proved that the gossip spread is false when the star accuses the gossip disseminator of infringement of his reputation right?Lawyer Liang Yan told me that, generally speaking, when a star sues someone for infringement of his reputation, there are two main aspects, namely, whether there is slander or whether there is insult.

Even if the actor provides sufficient evidence to prove that he is spreading the true "facts", he may lose the case because of insulting behavior.At the same time, it may also involve infringing on the privacy rights of others, such as publicizing the physical defects or illness of others.

Although "winning the case of infringement of reputation right" can help us to judge the truth of "the spread scandal" to some extent. However, we can’t simply equate "winning the case" with "the gossip being spread is false", and we need to further analyze and judge rationally.