[Ground Evaluation Line] Caiyun Online Review: Let the theme education release lasting effectiveness

  Duan Zongke, Special Commentator of Caiyun Online Review

  On January 8th, the educational summary meeting on the theme of "Do not forget your initiative mind, Remember Mission" was held in Beijing. General Secretary of the Supreme Leader attended the meeting and delivered an important speech. He stressed that the whole party should take this theme education as a new starting point, constantly deepen the party’s self-revolution, continue to promote the party’s Do not forget your initiative mind and keep in mind its mission.

  Summing up does not mean reaching the end, but starting a new journey on the basis of learning from experience. Theme education has a deadline, but Do not forget your initiative mind, keep in mind that the mission is never ending. General Secretary of the Supreme Leader pointed out that our party must always win the support and support of the people and write the great achievements of the Chinese nation for a thousand years, and must always bear in mind its initial heart and mission. This requires us to take Do not forget your initiative mind, bearing in mind the mission, as the eternal task of strengthening Party building, and the lifelong task of self-purification and promotion of cadres in party member, and make unremitting efforts for a long time to make the theme education release lasting effectiveness.

  Solidly summarize and improve the "storage battery"Under the strong leadership, deployment and promotion of the CPC Central Committee with the Supreme Leader as the core, and taking the lead in setting an example, the theme education of "Do not forget your initiative mind, Remember the Mission", a serious and profound baptism of party spirit, stirred up the whole party and achieved a series of major achievements. In order to release the lasting effectiveness of theme education, it is necessary to look back on the practical process in an all-round way and sum up successful experiences, so as to accumulate strong energy and lay a solid foundation for deepening the party’s self-revolution. Of course, summing up can’t be a complacent introduction of experience and a simple piling up of achievements, but should be refined and sublimated on the basis of summing up and summarizing. It is more important to look at the problem from a developmental perspective and a practical attitude. Only by constantly optimizing the measures of "keeping the original heart, taking the mission, finding the gap and grasping the implementation" can we inject lasting kinetic energy into the self-revolution.

  Ignite the long-term mechanism "engine"."Resolutely remove all factors that weaken the party’s advanced nature and damage the party’s purity, resolutely remove all cancers that breed on the party’s body, and resolutely guard against all dangers that violate the initial heart and mission and shake the party’s foundation." This is a long-term and systematic project, which must be done for a long time. It is inseparable from strong institutional guarantee to continuously promote the Do not forget your initiative mind of the whole party and keep in mind its mission. Although the theme education has come to an end, Do not forget your initiative mind’s mission needs not only immediate "immediate change", but also long-term management. Since the 18th National Congress of the Communist Party of China, the CPC Central Committee with the Supreme Leader as the core has attached great importance to institutional governance. At the Fourth Plenary Session of the 19th CPC Central Committee, it was proposed to establish a system of Do not forget your initiative mind and keeping the mission in mind. On the basis of summing up, establishing a simple, pragmatic and accurate long-term mechanism will undoubtedly ignite the engine of keeping the original heart and carrying out the mission.

  An "accelerator" to stimulate the vitality of the grassroots.General Secretary of the Supreme Leader pointed out that the mission of Do not forget your initiative mind and Mindfulness should be realized through the joint efforts of the whole Party. The key to running China well lies in the Party, and the most solid and active source of strength for the Party’s work lies in the grassroots. Doing a good job of summing up and upgrading is to start a new journey, build a long-term mechanism to promote going deep, going real and going far. Besides these, it is also essential to stimulate the vitality of the grassroots, give birth to Do not forget your initiative mind, and keep in mind the vivid and vivid grassroots innovation practice. "Bearing in mind the initial heart and mission, we must persist in serving the people wholeheartedly." Do not forget your initiative mind, whether the measures to keep in mind the mission are effective or not, and whether the results are remarkable or not, must be tested by the masses’ sense of gain. To this end, it is necessary to give full play to the initiative of grassroots innovation and creation, and to refuel and add strength to the release of lasting effectiveness of theme education with colorful grassroots practices.

  "You can’t expect to declare success through one or two educational activities. ‘ The revolution has not yet succeeded, and comrades still have to work hard ’ This sentence is always going on. " Ending is not ending, and summing up is not ending. "Do not forget your initiative mind, keep in mind the mission" is always on the road, so that the theme education will release lasting effectiveness, and our party will surely lead the great ship "China" to a brighter future.

Xinhua All Media+| It’s more fun to play ice and snow on campus during winter vacation.

  Xinhua News Agency, Changchun, January 29th Since the winter vacation, many places in Changchun and Shenyang have opened ice and snow custodians. Schools have built ice rinks and snow fields on campus, hired professional coaches, and provided all kinds of ice and snow sports courses for primary and secondary school students, so that students can enjoy ice and snow on campus during the winter vacation and welcome the Winter Olympics.

  In the cold winter, in the 2,400-square-meter ice rink of Pingquan Primary School in Nanguan District, Changchun City, the students learned from the skating coach in full swing.

  Students in the primary school of Changchun No.104 Middle School are learning to skate. Xinhua News Agency reporter dorri photo

  Song Haoxuan, a student in Class Two, Grade Five, Changchun No.104 Middle School, is learning skating for the first time. After three days, he has mastered the basic movements and can stand and walk on the ice. "Before the holiday, the class teacher said that there was ice and snow custody during the holiday, so I signed up. In the past, I could only do my homework at home during the holidays. It is so interesting to learn skating this time. " Song Yuxuan said.

  At the scene, the reporter saw that a shoe changing room was built around the skating rink, in which all the skating equipment was prepared for students, and each school was accompanied by leading teachers to ensure the safety of students.

  Sun Jingru, director of the Department of Physical Education, Sports, Arts and Health, Nanguan District Education Bureau, Changchun City, said that in order to create conditions for students to participate in ice and snow sports, Nanguan District Education Bureau poured an ice rink in Pingquan Primary School. Students in grades 4-8 of primary and secondary schools in the whole district took advantage of the winter vacation to participate in ice and snow custody for a total of 30 days, with about 600 participants every day. The total number of participants in the winter vacation is expected to be 18,000. The Education Bureau also hired seven professional coaches to guide students’ ice skills, so that students can master the basic skating movements and experience the fun of skating in a short period of time.

  Shoe changing room of Pingquan Primary School in Nanguan District, Changchun City. Xinhua News Agency reporter dorri photo

  In addition, other counties and cities in Changchun also provide various forms of ice and snow amusement activities for primary and secondary schools. Yushu city City, Jilin Province has poured 26 outdoor ice rinks in primary and secondary schools in towns and villages, and equipped students with PE teachers and skating equipment. Up to now, more than 10,000 people have participated in ice and snow custody.

  In the ninth primary school in Hunnan District, Shenyang City, Liaoning Province, ice and snow activities are another lively scene. The school’s snow machine makes snowflakes fly, and it is fun to have snowball fights, make snowmen and snowball. Two large indoor ski machines allow students to ski at zero distance, and more than 700 students who participate in the trusteeship can enjoy the fun of flying in the snow.

  Hou Mingfei, principal of the Ninth Primary School in Hunnan District, Shenyang, said that compared with summer classes, the school’s winter vacation trusteeship has increased the single and double snowboarding projects, and students can take skiing classes on campus.

  On the 120-square-meter indoor simulated ice rink of Heping Street No.1 Primary School in Heping District, Shenyang, the children were dressed in ice hockey equipment, and the teacher explained the technical points and basic sliding movements for the students. The slightly childish movements of the students added vitality and vitality to the winter campus.

  The school organized a winter vacation hosting service with the theme of "Harmony, Colorful Winter Holidays", and 80 students from different grades signed up to participate. The trusteeship classes were named "Bingdundun" class and "Snow Rongrong" class, and activities such as learning to sing winter Olympic songs and ice hockey experience were also carried out to cultivate students’ interest and skills in ice and snow sports.

  Students in the primary school of Changchun No.104 Middle School learn skating. Xinhua News Agency reporter dorri photo

  This school is a characteristic school of ice and snow sports on the national youth campus. Lin Yuheng, the director of teaching, said that ice hockey training in schools usually involves members of the school team, and not all students can master skills such as ice hockey and speed skating. There is plenty of hosting time in winter vacation, and for more than 80 students who participate, they can do no less than two hours of sports every day.

  In recent years, Shenyang has incorporated ice and snow projects into the teaching content of primary and secondary schools, and carried out ice and snow sports through physical education courses and comprehensive practical activities courses, and achieved remarkable results. Twenty-seven schools in the city were rated as "National Youth Campus Ice and Snow Sports Characteristic Schools" by the Ministry of Education, and 55 schools were named as municipal ice and snow characteristic schools. At present, more than 30% primary and middle school students in the city have mastered the basic skills of ice and snow. (Reporter: Li Shuangxi, dorri, Wang Ying, Wu Jiangmin)

Yuan Renguo, Chairman of Maotai Group: Integrating Internet thinking and big data into enterprise production.

  Cctv news (Reporter Liu Ying) On May 25th, China E-commerce Innovation and Development Summit opened in Guiyang. Yuan Renguo, chairman of China Kweichow Moutai Distillery Co., Ltd., delivered a speech at the opening ceremony. He said that integrating Internet thinking and big data into corporate strategy and production and operation, using 3-mdash; Five years to build big data Maotai, strengthen the seamless connection with consumers, and form a global big data platform such as manufacturing, trading and interactive industry chain and diversified expansion of Maotai, so that Maotai’s high-quality data can continue to be the most important data assets of the enterprise and continuously improve its core competitiveness, industrial competitiveness, brand influence and market share.

  The following is the full text of Yuan Renguo’s speech:

  Dear Governor Sun, distinguished leaders, distinguished guests, ladies and gentlemen, friends. As a leading enterprise in Guizhou Province and liquor industry, Maotai Group is honored to discuss the development of big data with industry leaders, experts, scholars and elites from the global big data field.

  Big data has brought changes to the manufacturing industry as much as the invention of steam engines and electricity has promoted the industrial revolution. In recent years, General Secretary of the Supreme Leader and Premier Li Keqiang have repeatedly given clear instructions on the implementation of the big data strategy and the internet plus Action Plan. The Guizhou Provincial Party Committee and the provincial government attached great importance to big data and made a decision to promote the strategic action of big data in the "Thirteenth Five-Year Plan". Big data has opened a brand-new era. Artificial intelligence, virtual reality technology, augmented reality technology, mixed reality technology, unmanned controllers and new sensors are on the rise. Everyone has a terminal, things can be sensed, and the Internet can be accessed everywhere. In real time, under the general trend of connected everything, data has become a valuable resource asset and production factor. The connection between Maotai and global consumers has increased the connection of big data on the basis of traditional connections, achieving zero distance from the world.

  Maotai’s craft is one of the living fossils of China’s manufacturing industry, and it is the representative of China’s traditional craftsman spirit. At present, world-renowned wine companies are carrying out big data reform, intelligent production, and informationization of the whole industry chain. Maotai deeply integrates big data, the Internet and the craftsman spirit, and leads Maotai’s innovative development with the big data revolution. First of all, Maotai built an Internet of Things cloud business platform to realize the data traceability of the whole industry chain. Maotai built the first comprehensive category trading platform integrating grassroots B2B2C, industrial financial services, collection and auction in the domestic liquor industry, and the trend of each bottle of Moutai can be quickly merged into the most valuable information of the company, which constitutes the big data of the whole industry chain of the company. At the same time, consumers can also know the production and sales links of each bottle of Moutai in their hands through the quality traceability system. We will interact with online and offline, actively and flexibly consume experiences and personalized needs.

  This year, Maotai used Internet technology to establish an information system for brewing production technology, from brewing to smart brewing. A bottle of Moutai has to go through 30 supply and demand and 165 technological links, and it will take at least five years. In the window of traditional enterprises facing the discovery and utilization of new growth drivers, under the background of Global Industry 4.0, Maotai has established an information system for collecting, counting and feeding back brewing production data.

  We will further promote the revolution and innovation of big data, better serve the global consumers from the traditional space to the Internet space, and extend the real-time interaction between service consumers and global consumers, and integrate Internet thinking and big data into corporate strategy and production and operation, using 3— Five years to build big data Maotai, strengthen the seamless connection with consumers, and form a global big data platform such as manufacturing, trading, interactive whole industry chain and diversified expansion of Maotai, so that Maotai’s high-quality data can continue to be the most important data assets of the enterprise and continuously improve its core competitiveness, industrial competitiveness, brand influence and market share. Data creates value, innovation drives the future, and the integration of knowledge and practice in Guiyang is the birthplace of philosophical thought. To make the flower of dreams bear the fruit of career, it depends on promoting knowledge with knowledge and promoting knowledge with action. Breaking can promote vitality, and innovation can promote the future. In 1995, Maotai left a much-told story in Panama. Because of breaking and innovation, Maotai has become a world-famous brand with the largest sales volume and the strongest leading ability in the world.

  Finally, welcome all of you to visit Maotai. You can appreciate the mellow taste of Maotai. Thank you!

Mila Tang Jian: Building ChatGPT in the field of life science and developing drugs with generative artificial intelligence.

"I have always been interested in biology. When I was in high school, my teacher told us that the 21st century was the century of biology. When I studied artificial intelligence, I believed that the 21st century was the century of artificial intelligence."

During the scientific lecture "Understanding the Future" hosted by the Future Forum, Tang Jian, an associate professor at the Research Center for Artificial Intelligence in Quebec, Canada (Mila) and a professor of artificial intelligence at the Canadian Institute of Advanced Studies (CIFAR), introduced the application of generative artificial intelligence in life sciences: how to build a "ChatGPT" in life sciences. He said, "Later, I felt that it might be the best choice if I could do something in the field where artificial intelligence and biology intersect."

Today, he is not only studying AI and biology at the same time, but also "left-handed scientific research and right-handed entrepreneurship". He said that he is a person who is willing to accept new things and challenges. From scientific research to entrepreneurship, many things are different, and it is difficult to carry out interdisciplinary cooperation, but this also reflects the value of doing these things.

Figure | Tang Jian (Tang Jian’s personal homepage)

According to reports, Tang Jian University studied geography at the beginning, transferred to the Department of Mathematics in his sophomore year, and successfully applied to the Department of Computer Science in his senior year. In his computer learning career, he first studied traditional machine learning, and in the last year of his doctoral degree, he turned to deep learning.

After graduating from the doctor’s degree, he officially embarked on the road of scientific research and made many achievements in the field of graphic representation learning. As one of the representative scholars in this field, his network representation learning method LINE (large-scale information network embedding) has been widely used, with more than 5,000 references.

"The double revolution of artificial intelligence and biotechnology broke out, and we are in the best era of doing research."

In 2018,Tang JianStart the research on the intersection of artificial intelligence and biology. At that time, he applied the graph representation learning technology to the research in the field of drug discovery, and did a lot of work in the prediction of three-dimensional structure of small molecules and the design of macromolecular proteins.

But a few years ago, only a few people devoted themselves to the research in this direction. In the past two years, more and more investment has been injected into this field. Tang Jian believes that the reason for this change is that artificial intelligence has brought great breakthroughs to the structural prediction and biological field in protein, and the spread of the COVID-19 epidemic has also aroused people’s focus on health and biomedicine.

"Now we are in the best era, because we are experiencing the dual technological revolution of artificial intelligence and biotechnology." Tang Jian said, "Therefore, we have seen great opportunities for generative artificial intelligence in the field of drug discovery, especially protein design."

Based on his accumulation in scientific research, he devoted himself to entrepreneurship and set up the artificial intelligence-driven biopharmaceutical company Baiao Geometry in 2022.

Build an AI macromolecular drug design platform to provide innovative drugs to save patients’ lives.

existTang JianIt seems that perhaps it is the entrepreneurial idea that has sprouted since childhood and the character of constantly seeking self-breakthrough that drives him to embark on the road of entrepreneurship.

The Baiao Geometry Company, founded by him, aims to develop a programmable protein by integrating the technologies of generative artificial intelligence and geometric deep learning, so as to overcome the problems of long cycle, high cost and low success rate of traditional macromolecular pharmacy and provide innovative drugs to save patients’ lives.

Tang Jian is mainly responsible for technical work in this company, and designs antibodies by building artificial intelligence models. As a new diffusion generation model, this model can model the amino acid sequence and three-dimensional structure of protein at the same time, and show the relationship between them, so as to generate protein with specific functions.

At present, the team has set up an AI macromolecular drug design platform, and is building a wet experiment verification platform for Qualcomm macromolecular drugs. At the same time, it also launched TorchProtein, an open source machine learning platform for macromolecules, in conjunction with companies such as NVIDIA, Intel and IBM.

"I hope that the technology I have made can really push several drugs into the clinic, solve more complicated diseases like cancer and save patients’ lives." Tang Jian said. In addition, he also said that with the development trend of intelligence, digitalization and automation in the biomedical field becoming inevitable, he expected to become a world-famous and international high-tech company in this field.

Based on generative artificial intelligence, build "ChatGPT" in life science field

In addition to starting a business, Tang Jian’s scientific research work at hand is also being carried out simultaneously. Based on generative artificial intelligence, he and his team have carried out research on three-dimensional structure prediction of small molecules and protein design of large molecules in the field of biomedicine.

In the prediction of the three-dimensional structure of small molecules, the team mainly modeled them based on the diffusion generation model. Specifically, a completely random structure is taken as the initial structure, and after several rounds of optimization, it finally converges to a stable protein structure. Each step of the optimization process is also called denoising. In addition, on the basis of expanding the research, the prediction of the complex structure was realized.

In the design of macromolecular proteins, the team proposed to design protein structure and sequence based on diffusion generation model, which not only realized the generation of antibody CDR Loop structure and sequence, but also designed α -helix transmembrane proteins with a specified number.

Not only that, the team also conducted research on antibody design and optimization. For example, it cooperated with the research team from Fudan University. Based on the antibody CR3022 obtained from newly crowned patients, it first designed the sequence with AI model, and then tested it on the wet experimental platform of Qualcomm, and finally successfully found the antibody molecule with strong affinity.

For generative artificial intelligence, its most critical ability is that it can generate new data. Then, if it is used in the biomedical field, it can help to generate a brand-new protein and help people find better drugs.

As a typical generative artificial intelligence model, ChatGPT has spread all over the world since it was introduced at the end of 2022. It can talk and communicate like a human being, and complete tasks such as writing papers and coding. "It is essentially a chat robot." Tang Jian said. As a large-scale pre-training language model, ChatGPT first pre-trains a large number of text and code data on the Internet, and then further optimizes it to enable it to be used for tasks such as dialogue.

The development of biotechnology, such as gene sequencing and gene synthesis, has brought a lot of data to the biomedical field. Therefore, Tang Jian believes that in the near future, people can also use these data to build ChatGPT in the field of life sciences.

Reporting/feedback

Vipshop will release the "2023 Beauty Awakening Trend": the trend of makeup first, refined demand and streamlined skin care is remarkable.

Wake up in the spring, and the mood of wanting to be beautiful grows wantonly in the new spring.
According to the data released by the National Bureau of Statistics, the total retail sales of social consumer goods reached 7,706.7 billion yuan in January and February 2023, a year-on-year increase of 3.5%. Among them, the total retail sales of cosmetics was 65.6 billion yuan, up 3.8% year-on-year, achieving the first positive growth since August 2022, and the cosmetics market showed obvious warming momentum.
Recently, Vipshop joined hands with many well-known beauty brands to launch a consumer survey called # Vipshop Beauty Awakening Plan #, and based on the platform sales data, brand feedback and nearly 1,500 netizens’ responses from platforms such as Weibo, Xiaohongshu, bilibili and Zhihu, it released the "2023 Beauty Awakening Trend" (hereinafter referred to as "Trend"). Trend shows that since the beginning of this year, the trend of making-up first, refined demand and streamlined skin care has been remarkable, which has brought new development space and growth point to the beauty market.
Trend 1: under the recovery of the market, make-up is the first to start.
In the vibrant spring, bright makeup makes people feel happier and more confident socially. Benefiting from the full liberalization of consumption and social scenes, makeup consumption took the lead in the first quarter of 2023, which sounded the clarion call for the recovery of the beauty market.
According to the data of Vipshop, from January to mid-March, 2023, the sales volume of platform makeup increased by 6.24% month-on-month, among which lip makeup and eye makeup products increased the most obviously, increasing by 15.3% and 18.6% month-on-month. In terms of brands, the sales of domestic beauty brands, such as Huaxizi, Kazilan and Tangduo, have increased significantly, with an increase of 17.1%, 24.9% and 20.6% respectively.
Geographically, the sales of beauty cosmetics in first-tier and new first-tier cities have increased significantly. For example, the sales of beauty cosmetics in Beijing, Shanghai, Guangzhou and Shenzhen increased by 20% to 40% month-on-month, and the growth rates of Chengdu and Chongqing, the "most beautiful cities", both exceeded 80%. Among the top ten cities in beauty sales, Xi ‘an increased by 101.9% month-on-month, ranking first in the country.
Trend 2: The consumer demand is refined, and the subdivided track is optimistic.
With the refinement of consumer demand, more and more beauty brands further expand their product lines and capture opportunities to segment the track. Taking Tangduo as an example, in 2022, innovative products, such as high-gloss capacity-repairing disk and ultra-fine eyeliner, were introduced in addition to the dominant categories such as eye shadow and blush, which formed a more perfect product layout and quickly seized the market segment.
At the same time, consumers’ awareness of cosmetics has improved rapidly, which puts forward higher requirements for the brand’s product strength. The person in charge of the Lancer brand pointed out that many "component parties" are even familiar with the basic formula and efficacy features of the products, and the beauty track will continue to "roll the efficacy" and "roll the research and development".
In addition, the refinement of demand is also reflected in the consumption scene+style. The person in charge of Maybelline brand said, "With the stratification, diversification and refinement of consumer demand, beauty care brands gradually break the circle boundary and expand brand influence through topic innovation with different emotions and scenes."
Trend 3: quality consumption prevails, and subtraction skin care becomes a hot spot.
# vipshop Beauty Awakening Plan # Consumer survey results show that nearly half of the consumers surveyed have reported that their consumption mentality has tended to be calm in the past three years, and their choices have become more rational, paying more attention to product quality. "I used to buy what I used to buy, but now I prefer to be short of it, and I will choose products that are of good quality and suitable for me."
The person in charge of Maybelline brand believes that consumers’ pursuit for the quality and details of beauty products reflects a typical attitude towards self-satisfaction.
The ever-changing lifestyle is reshaping the relationship between consumers and beauty care. A person in the beauty industry said, "Under the influence of environmental awareness and healthiness, consumers are increasingly favoring products with natural raw materials and safe ingredients. In terms of makeup, more consumers began to’ do subtraction’, praised natural and clean makeup, bid farewell to exaggeration and pursue originality. "
After more than half a year’s market downturn, the prosperity of the cosmetics industry has greatly increased. Cosmetics are selling well during Valentine’s Day 214 and Women’s Day 3.8 this year, which also makes brands optimistic about the next market trend.
The person in charge of the Orange Blossom brand said, "When the overall social mobility returns to normal, the vitality of the market is increasingly displayed. More importantly, we have seen more confidence in the industry, which comes from the supply chain, channels, consumers, and even more from various brands in the industry. This makes us look forward to the overall recovery of the beauty industry. "
The person in charge of Vipshop’s beauty cosmetics said: "As the original intention of the Spring Awakening Plan, Vipshop hopes to join hands with beauty brands in spring and start from spring."
Xinmin. com published this article for the purpose of transmitting information, and does not represent the views of this website.
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Where does RDN go to treat hypertension? Professor Guo Yifang: The future can be expected.

Renal artery denervation (RDN) is a hot topic in the field of hypertension in recent years. Although it has not been widely used in clinic, with the release of various clinical data, more and more industries focus on RDN.

RDN targets the sympathetic nervous system, which does play a role in raising blood pressure. Therefore, RDN selectively reverses a mechanism of hypertension. But hypertension is a multifactorial disease. Is it really enough to target a single pathogenic mechanism to produce effective and sustained blood pressure reduction in a large number of hypertensive patients? Yixin specially interviewed the vice president of Hebei Provincial People’s Hospital.Professor Guo Yifang, shared his views on the future prospects of RDN.

  One more proof of RDN’s long-term effect  

Recently, the three-year research results of RADIANCE-HTN SOLO test were published, which confirmed that the safety and effectiveness of ultrasonic RDN lasted for 36 months.

Patients with ambulatory blood pressure ≥135/85 mmHg and < 170/105 mmHg after 4 weeks of stopping antihypertensive drugs were randomly divided into ultrasound RDN group or sham operation group. The results of 36-month follow-up showed that the systolic blood pressure and diastolic blood pressure in RDN group decreased by 17.7 mmHg and 11.3 mmHg respectively compared with baseline. In terms of safety, there were no adverse events related to equipment or operation during the follow-up period.

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In response to this research result, Professor Guo Yifang pointed out that in recent years, the effectiveness and safety of RDN has been an important topic in the field of hypertension treatment, which has attracted extensive attention from scholars at home and abroad.Radiation-HTN solo research provides valuable new evidence for the instrument treatment of hypertension. However, Professor Guo is cautiously optimistic about the results of this study, considering the differences in the conclusions of several RDN studies published in recent years and the limitations of this study itself..

  The evidence-based road of RDN  

The basic principle of RDN is to block the afferent and efferent activities of sympathetic nerve around renal artery by radio frequency energy, ultrasonic energy or injecting heat into perivascular space, and reduce the influence of sympathetic nervous system on renal vascular resistance, renin release and sodium reabsorption. RDN blocks the signal conduction between the brain and sympathetic nerve to a certain extent, thus reducing the sympathetic nerve excitability of patients with hypertension. Theoretically, it can achieve long-term antihypertensive effect through a minimally invasive operation.

As early as 2009 and 2010, RDN completed two early clinical trials in Europe and Australia, namely Symplicity HTN-1 and HTN-2. The results of 3-year follow-up showed that the average systolic blood pressure and diastolic blood pressure of refractory hypertensive patients receiving RDN decreased by about 30 mmHg and 14 mmHg respectively, and there were no obvious adverse reactions and complications. More importantly, after three years of follow-up, these patients found no obvious signs of blood pressure rebound.

Because this is the first minimally invasive surgical technique that has been proved in history and can definitely lower patients’ blood pressure, RDN shines brilliantly after the above exploratory experiment, but the well-known sham-operated control experiment-Symplicity HTN-3 did not get positive results, which weakened people’s enthusiasm for RDN: although the research proved its safety, it did not significantly lower blood pressure compared with the control group.

On the basis of summarizing the research experience and lessons of SYMPLICITY HTN-3, the researchers subsequently carried out a new generation of randomized controlled trials, such as SPYRAL HTN-OFF MED, SPYRAL HTN-ON MED, SPYRAL HTN-OFF, etc. These studies used different techniques and methods to ablate the renal artery sympathetic nerve. The results showed that the ambulatory blood pressure and clinic blood pressure in RDN group decreased clinically regardless of whether antihypertensive drugs were used or not.

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Clinical research course of RDN

(Source: Nat Rev Cardiol. 2020 Oct; 17(10):614-628. )

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In different studies, compared with sham operation group, systolic blood pressure in RDN group decreased.

The REQUIRE study aims to evaluate the effectiveness and safety of ultrasound renal artery ablation system in controlling blood pressure in patients with refractory hypertension. 143 patients with refractory hypertension (office blood pressure ≥150/90 mmHg and 24-hour SBP≥140 mmHg) were randomly assigned to RDN or sham operation group. Three months after operation, there was no significant difference in the 24-hour ambulatory systolic blood pressure between the RDN group (-6.6 mmHg) and the sham operation group (-6.5 mmHg) (P=0.971). The difference of SBP between family self-measured blood pressure and clinic blood pressure was -1.8 mmHg(P=0.488) and -2.0 mmHg(P=0.511) respectively, and there was no difference. There was no significant difference in drug load between the two groups. No major adverse events related to the operation were found.

At the EuroPCR annual meeting in 2022, a number of research data of RDN were published: Global Symplicity Registry, SPYRAL HTN-ON MED, Radiation HTN Solo & Trio, which further confirmed the potential of RDN as an adjuvant therapy for hypertension, supplemented the existing first-line therapy, and thus changed the lifestyle and drug treatment.

  Professor Guo Yifang: RDN can be expected in the future  

The occurrence of hypertension is a complex process, involving many mechanisms, and it is not expected to solve all patients’ problems through one drug or technology. RDN only blocks renal sympathetic innervation, and may have no therapeutic effect on other mechanisms that cause and maintain hypertension. Moreover, the antihypertensive effect of RDN is moderate, which is only equivalent to taking an antihypertensive drug.

Professor Guo Yifang talked about the future prospect of RDN. He pointed out that RDN is still in the stage of research and exploration, and it can not be used as a mature treatment technology in clinical practice. From the pathophysiological mechanism, the sympathetic nervous system plays an important role in the occurrence and maintenance of hypertension, so in theory, RDN will definitely have an ideal effect on some hypertensive patients. butThe pathophysiological mechanism of hypertension in different patients is inconsistent, the renal artery structure in different patients is obviously inconsistent, the principle of different types of RDN technology and equipment is inconsistent, and the experience and technical level of different operators are inconsistent. These four "inconsistencies" will inevitably affect the effectiveness and safety of RDN treatment and its application value and clinical status in antihypertensive treatment..

On the whole,For patients whose blood pressure can’t be satisfactorily controlled after lifestyle intervention and adequate treatment with various antihypertensive drugs, patients with obvious sympathetic hyperactivity, or patients who can’t tolerate antihypertensive drugs, it is reasonable to carry out RDN treatment in mature medical centers.. It is believed that RDN will play a more important role in the field of hypertension treatment in the future with the progress of related technologies and the continuous improvement of treatment equipment.

Expert introduction

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Guo yifang

People’s Hospital of Hebei Province

Chief physician/professor, doctoral tutor, currently vice president of Hebei Provincial People’s Hospital. He is also the vice chairman of the Hypertension Committee of Chinese Medical Doctor Association, the vice chairman of China Society Hypertension Branch, the executive director of China Hypertension Alliance, the chairman of the Geriatrics Branch of Hebei Medical Association, the chairman of the Hypertension Professional Physician Branch of Hebei Medical Association, and the chairman of the Medical Engineering Branch of Hebei Medical Association. And the editorial boards of Chinese Journal of Internal Medicine, Chinese Journal of Geriatrics, chinese journal of cardiology and Chinese Journal of General Practitioners, and the standing editorial boards of Chinese Journal of Hypertension and chinese journal of cardiovascular medicine. Enjoy the special allowance of the State Council.

references

1. David E. Kandzari, Raymond R. Townsend, George Bakris, et al. Renal denervation in hypertension patients: Proceedings from an expert consensus roundtable cosponsored by SCAI and NKF. Catheter Cardiovasc Interv. 03 August 2021. 

2 "China cardiovascular medical device industry innovation white paper 2021"

3. Nat Rev Cardiol. 2020 Oct; 17(10):614-628.

4. C. Venkata S. Ram. Renal Denervation Therapy for Hypertension: All That Glitters Is Not Gold. Medscape. https://www.medscape.com/viewarticle/976670_1

5. Ultrasound renal denervation meets primary efficacy endpoint in RADIANCE II study. Cardiovascularnews. 26th July 2022.

6. Florian Rader, Ajay J. Kirtane, Yale Wang, et al. Durability of blood pressure reduction after ultrasound renal denervation: three-year follow-up of the treatment arm of the randomised RADIANCE-HTN SOLO trial. DOI: 10.4244/EIJ-D-22-00305

Typesetting: Yixin Editorial Department

Lawyers interpret the ZhangJike storm: if you collude with creditors to extort Jing Tian, it will constitute an accomplice in extortion.

A few days ago, ZhangJike was exposed to a gambling debt dispute and spread private videos of others, which caused widespread concern. Seeing the rumors getting worse, ZhangJike issued a lawyer’s statement, claiming that some users’ comments had infringed on ZhangJike’s reputation, and investigation and evidence collection have been carried out. However, this did not stop the news from continuing. Well-known reporter Li Weiao subsequently published two articles, and the content of the news was more detailed and specific.

Li Wei ‘ao broke the news that the creditor who asked Jing Tian for money was sentenced. If the creditor asks Jing Tian for money by threatening the private video, and the person who gave the private video to the creditor is ZhangJike, does he need to bear legal responsibility in this case?

What kind of legal responsibility will it face to spread other people’s private videos? Will you be sentenced? If sentenced, how long will it take?

Can the celebrity accuse the gossip disseminator of infringement of his reputation right prove that the gossip spread is false? Is it true that the scandal will sue the right of reputation infringement, and the false will sue the crime of libel?

……

With these questions, I consulted lawyer Li Yang of Beijing Yingke (Shanghai) Law Firm and lawyer Liang Keli of Wanshang Tianqin (Shanghai) Law Firm.

You can’t repay your gambling debts, and you use your ex-girlfriend’s private photos to pay off your debts?

At the end of March, some netizens broke the news that ZhangJike had leaked private photos of himself and his predecessor, Jing Tian, to his creditors because he had not paid his gambling debts. After the creditor got the private photos, he asked Jing Tian for money on this matter. Then Jing Tian sued the creditor.

ZhangJike Studio first issued a statement on the 30th, saying: "Mr. ZhangJike has no debt disputes, and there is no case of damaging the privacy of others in order to protect himself. The rumor is purely fabricated."

On March 31, Li Weiao, the chief reporter of Economic Observer, wrote with his real name account: "From some judicial materials I saw and mastered a few years ago, ZhangJike passed on Ms. Jing’s private video to others. This is true." .

On the same day, ZhangJike Studio entrusted a lawyer to issue a statement, saying that some users’ remarks caused ZhangJike.Infringement of reputation rightAt present, investigation and evidence collection work has been carried out, and lawsuits will be filed against key infringing users who have repeatedly published or refused to delete infringing content and caused great adverse effects.

However, ZhangJike’s lawyer’s statement did not prevent Li Wei ‘ao from publishing a message again. Li Weiao then issued two more articles, and the content of the news was more detailed and specific.

Li Weiao revealed that the judicial materials showed that there were 3 private videos of Ms. Jing and 1 video screenshot. ZhangJike admitted that he had shown others a segment of the above video. In addition, ZhangJike was sued by his creditors (and his family) a few years ago. After the prosecution, after mediation, Zhang returned the creditor (and family) 1 million yuan. However, ZhangJike’s IOU is 5 million yuan, and that IOU is still in the hands of creditors (and family members). He also said that ZhangJike’s debt and video problems were not simply "gossip" of celebrities, but caused a serious criminal case. In this case, Ms. Jing is a complete victim. ZhangJike’s creditor, who asked her for money, later pleaded guilty and is still serving his sentence.

After Li Wei ‘ao broke the news again, some media reported that he had contacted ZhangJike himself. ZhangJike denied the debt and the photos. But when asked whether there was no debt or no photos, ZhangJike hung up.

On April 2, ZhangJike’s attorney responded to the media that this matter has actually been responded. One is that the studio has completely denied it. "Another, we are entrusted to investigate the facts of infringement and are ready to sue immediately."

Lawyer’s interpretation:

Winning the case of reputation right doesn’t mean that the gossip is false, and the fake star statement may also be infringing.

Under what circumstances should I bear legal responsibility for spreading other people’s private videos?Lawyer Li Yang said to the analysis that the dissemination of other people’s private videos may constitute an infringement of others’ privacy. If the content of private videos is sensitive and the scope of dissemination is wide, it may also constitute the crime of spreading obscene articles. According to Article 364 of the Criminal Law, whoever disseminates obscene books, periodicals, films, audio-visual images, pictures or other obscene articles, if the circumstances are serious, shall be sentenced to fixed-term imprisonment of not more than two years, criminal detention or public surveillance. "If it is a small-scale spread, it is basically necessary for the victims to call the police themselves. butIf it is a large-scale dissemination of obscene articles, the police may actively intervene if they find it at work. However, the latter is unlikely. Unless the perpetrator spreads the private video on the whole network. "Lawyer Li Yang told me.

According to reporter Li Wei ‘ao, he claimed that ZhangJike’s debt and video problems were not simply "gossip" of stars, but caused a serious criminal case. In this case, Ms. Jing is a complete victim. ZhangJike’s creditor, who asked her for money, later pleaded guilty and is still serving his sentence. At the same time, Li Weiao threw a question to ZhangJike: "What role did ZhangJike play in this case, and can he respond publicly?"

If Li Wei ‘ao’s news is true, does ZhangJike need to be responsible in this case? In this regard, lawyer Li Yang said to the analysis that the creditor was criminally held accountable for asking Jing Tian for money, which probably constituted the crime of extortion.ZhangJike’s responsibility depends on whether ZhangJike forms an accomplice relationship with the creditors."For example, if ZhangJike gave private materials to creditors and colluded with them (including consulting together and directing creditors, etc.) to extort Jing Tian, although he did not participate in the extortion, it would also constitute an accomplice in extortion; On the contrary,If ZhangJike only sold or otherwise gave the private information to the creditor, but did not participate in the extortion and did not collude with the creditor, it should not be considered that he should bear criminal responsibility for this crime. "However, it is not easy to judge whether it is collusion or not, unless the creditor can provide evidence such as recording. Or if the creditor confessed that he was colluding with Zhang, and ZhangJike himself admitted it.

ZhangJike Studio issued two statements in response to the storm. In the statement issued by the studio for the first time, it was responded that some infringing users made defamatory remarks about Mr. ZhangJike’s character and private life without any factual basis, slandering him for his involvement in gambling debt disputes, fund fraud and other illegal acts. He also said: "Mr. ZhangJike has no debt disputes, and there is no situation of damaging the privacy of others in order to protect himself. The rumor is purely fabricated." The statement issued by the second entrusted lawyer did not deny the relevant rumors, saying that evidence will be obtained for the infringement of reputation rights.

Many netizens are curious about whether the statement issued by the star studio has legal effect, and whether it is necessary to bear legal responsibility if there is anything contrary to the facts in the statement. In this regard, lawyer Li Yang told the analysis that,The statement issued by the studio is generally only regarded as a public explanation. If there are fabricated facts and other plots, which have adverse effects on others, it may also infringe on the right of reputation.

Others have questioned that ZhangJike is going to sue for infringement of reputation right instead of libel. Why do stars seldom mention criminal "libel" and take civil "infringement of reputation"?Is it true that the scandal will sue the right of reputation infringement, and the false will sue the crime of libel?In this regard, lawyer Liang Yan said to the analysis that this is actually not particularly related to the "true and false gossip", mainly because of the difference between the two. The criminal and civil conditions for filing a case are different, and the requirements for the consequences caused by "insulting" behavior are different. It can be simply understood that the severity of the consequences caused by most of these "celebrity gossip" is not enough to take the criminal "libel". For example, causing someone to go insane or commit suicide because of someone else’s "libel" behavior is a serious situation.

In addition, if the scandal is true, it may involve infringement of privacy rights, etc. It should be noted that we can’t say that "if the privacy infringement is mentioned, it will prove that the scandal is true", but it still depends on the specific case.

butCan it be proved that the gossip spread is false when the star accuses the gossip disseminator of infringement of his reputation right?Lawyer Liang Yan told me that, generally speaking, when a star sues someone for infringement of his reputation, there are two main aspects, namely, whether there is slander or whether there is insult.

Even if the actor provides sufficient evidence to prove that he is spreading the true "facts", he may lose the case because of insulting behavior.At the same time, it may also involve infringing on the privacy rights of others, such as publicizing the physical defects or illness of others.

Although "winning the case of infringement of reputation right" can help us to judge the truth of "the spread scandal" to some extent. However, we can’t simply equate "winning the case" with "the gossip being spread is false", and we need to further analyze and judge rationally.

This year, over 30 cities have adjusted the property market purchase restriction policy: "high-frequency small-step optimization" will become a feature.

  "Cancel the recognition of housing and loan" and "encourage the elderly to buy houses with relatives" …… On March 1 this year, after Zhengzhou became the first city in China to relax the purchase restriction policy, many cities followed up and adjusted the purchase restriction policy.

  Over 30 cities adjust the purchase restriction policy

  According to the incomplete statistics of The Paper, this year, it includes Zhengzhou, Qinhuangdao, Fuzhou, Quzhou, Lanzhou, Shaoxing, Foshan, Shenyang, Huizhou, Zhongshan, Dongguan, Jurong, Changsha, Yangzhou, Hefei, Shenyang, Hangzhou, Huzhou, Yinchuan, Dalian, Harbin, Tangshan, Wuxi, Jiangmen, Guangzhou, Jiujiang, Nanjing, Wuhan.

  In these cities, some announced the abolition of the original restrictive measures, some announced the narrowing of the scope of purchase restrictions, some lowered the threshold of purchase restrictions, and some cities made it clear that families with many children and relatives could increase the number of places to buy houses.

  Take Tianjin as an example. On September 16th, according to "Tianjin Housing and Urban-Rural Development", the Tianjin Municipal Housing and Urban-Rural Development Committee and other seven departments jointly issued the Notice on Further Improving the Real Estate Regulation Policy to Promote the Healthy Development of the Real Estate Industry (hereinafter referred to as the Notice). The Notice mentioned that new citizens and college graduates who are not registered in this city and are employed in this city can buy in Tianjin with social insurance or personal income tax certificates for six consecutive months.

  According to the "Implementation Opinions on Deepening the Regulation of the Real Estate Market in Tianjin" issued by Tianjin on March 31, 2017, families with non-Tianjin household registration who purchase houses in this city need to provide proof of continuous payment of social insurance or personal income tax for more than 2 years in Tianjin within 3 years.

  In terms of supporting the demand for improved housing, the Notice proposes that families with members aged 60 and above and families with many children who have two or more children can purchase another set of housing on the basis of the original housing purchase restriction policy in Tianjin with the household registration book.

  Guan Rongxue, an analyst at Zhuge Housing Data Research Center, pointed out that in the original policy, it was clear that non-Tianjin registered residents were required to provide proof of continuous payment of social insurance or personal income tax for more than two years within three years in this city, and now it is adjusted to only provide social insurance or individual income tax for six consecutive months, which lowered the threshold for buying a house; Secondly, for families with members aged 60 and above and families with many children who have two or more children, one set can be purchased, which fully considers the housing needs of different age groups and reasonably relieves the contradiction between supply and demand.

  The policy of Suzhou and Qingdao is now "one-day tour"

  However, in the above-mentioned cities that announced the adjustment of the purchase restriction policy, there have also been cases in which policies have been introduced and adjusted.

  Taking Qingdao as an example, on September 15th, WeChat official account, the official WeChat of Qingdao Urban and Rural Construction Bureau, released "Dynamic Improvement of Real Estate Policy in Qingdao". The New Deal is clear, and the purchase restriction policy will continue to be implemented in Shinan District and Shibei District (except the original Sifang District).

  At the same time, continue to clarify the purchase of housing. For new commercial housing in the restricted area, local residents are restricted to purchase 2 sets, families with two children and three children can purchase 1 set, and foreign residents can purchase 1 set after living for half a year; Second-hand housing is no longer restricted.

  However, on the same day, Qingdao Housing and Urban-Rural Development Bureau deleted the statement that "second-hand housing is no longer restricted".

  On the afternoon of September 16th, the relevant staff of Qingdao Housing and Urban-Rural Development Bureau told The Paper that in the new policy, the restricted purchase area of second-hand houses has been adjusted, and the restricted purchase policy is still implemented for first-hand houses and second-hand houses in Shinan District and Shibei District, while the restricted purchase is released for first-hand houses and second-hand houses in other areas.

  On September 14th, market news came out that Suzhou City, Jiangsu Province has made adjustments to the purchase restriction policy, and non-Suzhou local residents can directly purchase the first suite without providing proof of social security payment.

  According to the New Deal, the six districts in Suzhou (including Xiangcheng District, gusu district District, Wuzhong District, Wujiang District, Industrial Park and High-tech Zone) have adjusted the policies for foreigners to buy the first suite, and it is no longer necessary to show social security certificates or tax certificates.

  Subsequently, The Paper confirmed from the real estate departments in various districts that the above policies were indeed adjusted. However, on September 16th, The Paper learned from the real estate departments of gusu district, Xiangcheng District, Wuzhong District, High-tech Zone and Industrial Park in Suzhou City, Jiangsu Province that the purchase restriction policies of gusu district, Xiangcheng District, Wuzhong District, High-tech Zone and Industrial Park for non-registered households have been restored to the original policy, that is, the conditions for non-registered households to purchase houses are to pay social security for six consecutive months in Suzhou within three years.

  Chen Wenjing, director of market research in the Index Division of the Central Finger Research Institute, believes that under the guidance of the central government’s orientation of "housing and not speculating", the efforts of policy optimization in first-and second-tier cities are generally weak, and high-frequency small-step optimization in various places has become a major feature of real estate policy adjustment this year.

  Chen Wenjing pointed out that the recent cancellation of the purchase restriction policies in Suzhou and Qingdao has been withdrawn, which further shows that "no speculation in housing" is still the bottom line of the policies. Among all kinds of restrictive policies, the restriction on the purchase of foreign household registration is an important firewall for core cities to achieve "housing and not speculation". In the short term, it is unlikely that hot second-tier cities will completely cancel the restriction on purchases. It is expected that more cities will gradually advance by giving priority to relaxing the restrictions on purchases in suburbs. At the same time, combined with the National Standing Committee at the end of August, "Allow local &lsquo; One city, one policy &rsquo; From the expression of "flexible use of credit and other policies", it is more likely that second-tier cities will reduce the down payment ratio and optimize the "recognition of housing and loans" in the future.

  From a national perspective, Chen Xiao, a senior analyst at Zhuge Housing Search Data Research Center, pointed out that from the perspective of policy trends, policy loosening has gradually shifted from the initial stage of mild relaxation such as initial housing subsidies and relaxation of provident fund loans to a more in-depth stage, that is, the policy loosening is stronger, the coverage is deeper, and the influence is more profound. At present, many cities have released policies to loosen restrictions on purchases, including some hot second-tier cities, and the degree of loosening has gradually expanded, which will play a substantial role in boosting the property market.

  According to the monitoring data of Zhuge Housing Search Data Research Center, the sales area of new houses in 40 cities monitored in August was 14,882,000 square meters, down 10.08% from the previous month and 24.53% from the same period last year. 59,721 sets of second-hand houses were sold in 10 key cities, down 9.23% from the previous month and up 21.27% year-on-year.

[Li Xiang China] Correctly understand and grasp the socialist nature of Chinese modernization.

1661136875848

  Author: Huang Kun, Deputy Director and Professor of Chinese Modernization Research Center of the Party School of the Central Committee of the Communist Party of China (National School of Administration)

  On July 26th, 2022, General Secretary of the Supreme Leader emphasized at the seminar for leading cadres at the provincial and ministerial levels on "Learning the spirit of the important speech of General Secretary of the Supreme Leader and Meeting the 20th Party Congress" that "the modernization we are advancing is the socialist modernization led by the Communist Party of China (CPC), and we must persist in promoting the great rejuvenation of the Chinese nation with Chinese modernization", and clearly pointed out the socialist nature of Chinese modernization. Scientific understanding and grasping the socialist nature of Chinese-style modernization is of great significance to deeply understand Chinese-style modernization and ensure its stability and far-reaching development.

  Adhering to Chinese modernization to promote the great rejuvenation of the Chinese nation has made it clear that only socialism can save China and only socialism can develop China.

  Exploring the road of national rejuvenation has started since the Chinese nation faced the invasion of western powers in modern times, which is manifested in the hard exploration of utensils, systems and ideas in order to save the weak China. Due to class attributes and historical limitations, these explorations ended in failure. The real opening of the road to national rejuvenation began with the founding of the Communist Party of China (CPC) and the struggle for national independence and people’s liberation. Since its birth, the Communist Party of China (CPC) has devoted himself to the prosperity of the country, the happiness of the people and the rejuvenation of the nation. The dream of rejuvenation and modernization runs through the whole century of party history and has become the biggest theme of the Communist Party of China (CPC)’s century-long struggle.

  During the period of the new-democratic revolution, the Communist Party of China (CPC) fought for national independence and people’s liberation through arduous armed struggle, united and led the people of the whole country to overthrow the three mountains of imperialism, feudalism and bureaucratic capitalism, and established a new China, which created fundamental social conditions for realizing Chinese modernization and promoting the great rejuvenation of the Chinese nation. During the period of socialist revolution and construction, the party led the people to overcome a series of severe challenges in politics, economy and military affairs, successfully completed socialist transformation, realized the transformation from new democracy to socialism, established a brand-new socialist system with strong vitality on the ancient land of China, and laid a fundamental political premise and institutional foundation for realizing Chinese modernization and promoting the great rejuvenation of the Chinese nation. In the new era of reform, opening-up and socialist modernization, the Party United and led the whole Party and the people of all ethnic groups throughout the country, made a historic decision to shift the work center of the Party and the state to economic construction and carry out reform and opening-up, successfully created Socialism with Chinese characteristics, and provided new and energetic institutional guarantee and rapid development material conditions for realizing Chinese modernization and promoting the great rejuvenation of the Chinese nation. Since the 18th National Congress of the Communist Party of China, Socialism with Chinese characteristics has entered a new era. With great historical initiative, great political courage and strong responsibility, our party has provided a more perfect institutional guarantee, a more solid material foundation and a more active spiritual force for realizing Chinese modernization and promoting the great rejuvenation of the Chinese nation. The great rejuvenation of the Chinese nation has shown unprecedented bright prospects.

  It is through the unremitting struggle and exploration in the past century that we have found the correct way to realize the great rejuvenation of the Chinese nation, that is, the road of modernization in Socialism with Chinese characteristics and China. "Promoting the great rejuvenation of the Chinese nation with Chinese modernization" is an important experience for the success of our cause. In essence, Chinese-style modernization is socialist modernization, the concretization of Socialism with Chinese characteristics’s development path and the realistic path of the great rejuvenation of the Chinese nation. Chinese-style modernization, like Socialism with Chinese characteristics, is the inevitable result of the historical logic, theoretical logic and practical logic of China people’s long-term struggle in modern times, which has a profound historical origin and a broad realistic foundation. Historical facts show that the closed and rigid old road is a dead end, and the evil road of changing the flag is a dead end. Only the Socialism with Chinese characteristics road and the Chinese modernization road are the new road, the right road and the main road to develop and strengthen China and prosper and stabilize China. Only socialism can save China and only socialism can develop China. Socialism with Chinese characteristics and Chinese modernization not only point out the direction for realizing the Chinese dream of national rejuvenation, but also provide the fundamental guarantee for realizing the Chinese dream of national rejuvenation. The great practice of modernization in Socialism with Chinese characteristics and China has not only enabled our country to develop rapidly, improved the living standards of our people, and enabled the Chinese nation to catch up with the trend of the times and usher in the bright future of great rejuvenation, but also enabled the people of China and the Chinese nation to make great contributions to world peace and development. As it turns out,To build a powerful socialist modernization country in an all-round way and realize the great rejuvenation of the Chinese nation, we must unswervingly adhere to and develop Socialism with Chinese characteristics and Chinese modernization.

  Adhere to the leadership of the Communist Party of China (CPC), and clarify the essential characteristics and fundamental guarantee of Chinese modernization.

  The party’s leadership is the root and lifeline of the party and the country, and it is the interest and destiny of the people of all ethnic groups in the country. The Communist Party of China (CPC)’s leadership is the most essential feature of Socialism with Chinese characteristics, and it is also the most essential feature of Chinese modernization. Adhering to the party’s leadership over Chinese modernization is fundamentally related to the future and destiny of Chinese modernization and the fundamental guarantee for Chinese modernization to adhere to the socialist direction.

  Chinese-style modernization is a modernization with a specific development process, stages and social attributes, which is different from both western developed countries and other developing countries. Its task is more arduous, its course is more complicated and its nature is more special. From the development process, Chinese modernization is a "parallel" modernization. Different from the "series" modernization development process in western developed countries, industrialization, urbanization, agricultural modernization and informatization develop in sequence, while China’s modernization is the "parallel" superposition development of industrialization, informatization, urbanization and agricultural modernization, with multiple modernization processes developing in coordination and multiple modernization goals being realized simultaneously. From the development stage, Chinese modernization is catch-up modernization. As a developing country, China’s modernization was launched only after the success of modernization in developed countries. The problems it encountered were very different from the international environment, and even faced with the obstruction and containment of developed countries. The tasks it faced were more arduous and special, and the development environment was more complicated and uncertain. In particular, the world today is experiencing a great change that has never happened in a hundred years. China’s socialist modernization is facing a more severe domestic and international situation, and the risks and challenges are obviously increasing. From the perspective of social attributes, Chinese modernization is socialist modernization. The nature of socialism is the most remarkable and fundamental social attribute that China’s modernization is different from the western modernization.China’s socialist modernization can’t follow the modernization road of western developed countries’ internal oppression and exploitation, foreign aggression and plunder, and create an unequal international political and economic order. Instead, it puts more emphasis on the people-centered development thought and the international relations concept of the community of human destiny, and embarks on a socialist modernization road with China characteristics.

  The essential requirements of Socialism with Chinese characteristics and the unique and arduous modernization of China make it particularly important to uphold the leadership of the Party. We must uphold and strengthen the Party’s overall leadership, lead the way for China’s modernization, create a stable and United political situation, maintain the stability and continuity of the country’s major policies, mobilize the people’s enthusiasm and creativity in participating in national construction and governance, and concentrate the strength of the whole party and society to continue their struggle to realize the Chinese dream of becoming a socialist modernization power and the great rejuvenation of the Chinese nation.

  Adhere to the fundamental purpose of people first, and clarify the people-centered development thought and the essential attribute of modernization with human modernization as the core.

  "China’s modernization is a modernization with a huge population and the common prosperity of all the people", which shows the socialist nature of Chinese modernization. Chinese-style modernization insists on the supremacy of the people in its fundamental purpose, people-centered in its fundamental position, constantly promoting the all-round development of people and realizing the common prosperity of all people, which embodies the essential attribute of Chinese-style modernization with human modernization as its core and the social nature of socialism.

  The supremacy of the people is a valuable experience of the Communist Party of China (CPC)’s century-long struggle, and it is the root of the great achievements of Chinese modernization. The foundation of Chinese modernization lies in the people, the subject lies in the people and the strength lies in the people. Chinese modernization always insists on development for the people, development depends on the people, and development results are shared by the people. General Secretary of the Supreme Leader pointed out: "The people are both creators and witnesses of history, and they are both historical &lsquo; People in the play &rsquo; And historical &lsquo; The playwright &rsquo; " . The Communist Party of China (CPC)’s revolution, construction and reform are all realized in the process of maintaining flesh-and-blood ties with the people and relying on them closely. The people are the main body and source of strength for Chinese modernization. The Fifth Plenary Session of the 18th CPC Central Committee clearly put forward that we should adhere to the people-centered development thought, and take enhancing people’s well-being, promoting people’s all-round development and making steady progress towards common prosperity as the starting point and the end result of economic development. Chinese modernization takes the people as the center, emphasizes the people’s position, and always puts the promotion of people’s free and all-round development in the primary position of modernization, which is the most fundamental value orientation of Chinese modernization.

  Chinese modernization emphasizes the people’s stand and adheres to the people-centered development thought, which fundamentally opens up the consistency between human modernization and the fundamental purpose of people first. Marxism holds that man is the main body of social practice, which is shaped by the real society and realizes his own development in promoting social progress. What kind of modernization to build and what kind of goals to achieve are determined by people. The overall modernization of society cannot be separated from the modernization of people, who is the core content of the overall modernization of society. People are not only the subject of modernization practice, but also the subject of modernization value and the ultimate goal of modernization. The practice of world modernization proves that human modernization is more important than material modernization. Once people’s modernization is ignored or hesitated or lagged behind on this issue, it will inevitably bring great harm and disaster. Socialism with Chinese characteristics, not only bears the heavy responsibility of the times for the overall modernization of society, but also bears the historical mission of continuously promoting human modernization and promoting human all-round development. Comrade Supreme Leader wrote in Zhijiang Xinyu: "People are essentially cultural people, not &lsquo; Materialization &rsquo; People; Is a dynamic and comprehensive person, not a rigid, &lsquo; One-dimensional &rsquo; People. " The value pursuit of the people’s subject established by Chinese modernization is essentially the same as Marx’s theory of all-round development of human beings, which is a reaffirmation and creative development of the proletarian as the subject of liberation.It is also a vivid embodiment of our party’s fundamental purpose of serving the people wholeheartedly.

  Adhere to Socialism with Chinese characteristics’s fundamental system, basic system and important system, and clarify the institutional guarantee and institutional advantages of Chinese modernization.

  Socialism with Chinese characteristics system is a scientific system composed of fundamental system, basic system and important system, and it is the most important system regulation, system guarantee and system advantage of Chinese modernization. Socialism with Chinese characteristics’s fundamental system includes the fundamental system of the Party’s leadership, the fundamental system of the people’s democratic dictatorship, the fundamental system of the people’s congresses, the fundamental system of Marxism’s guiding position in the ideological field, and the fundamental system of the Party’s absolute leadership over the people’s army. It plays a "main beam" and "pillar" role in China’s national system and national governance system, and fundamentally embodies Socialism with Chinese characteristics’s institutional advantages. Socialism with Chinese characteristics’s basic systems are those that embody the socialist nature of our country, stipulate the basic principles of the country’s political life and economic life, and have a great influence on the country’s economic and social development. Socialism with Chinese characteristics’s important system is the subjective system of state governance in all fields derived from Socialism with Chinese characteristics’s fundamental system and Socialism with Chinese characteristics’s fundamental system. Specifically, it is the subjective system of legal rule, administrative management, cultural construction, people’s livelihood security, social governance, ecological civilization, "one country, two systems", foreign affairs, party and state supervision and so on. These fundamental systems, basic systems and important systems are the institutional guarantee and obvious institutional advantages of Chinese modernization.It is the fundamental reason why Chinese modernization has maintained its socialist nature and made great achievements.

  After more than 70 years of rich practice in New China, the Party led the people to create and develop the Socialism with Chinese characteristics system. Since the 18th CPC National Congress, Socialism with Chinese characteristics’s system has been further consolidated and improved, and Socialism with Chinese characteristics’s institutional advantages have been further highlighted and strengthened. The historical achievements of the founding of New China for more than 70 years fully prove that the Socialism with Chinese characteristics system is the fundamental guarantee for the great achievements of Chinese modernization. Socialism with Chinese characteristics system is a scientific system formed by the Party and the people in the long-term practice and exploration. It not only reflects the historical achievements made by the Communist Party of China (CPC) in establishing and perfecting the socialist system, forming and developing various systems, but also reflects that since the founding of New China for more than 70 years, our Party has been able to unite and lead the people to promote and expand Chinese modernization, lay a material foundation for the great rejuvenation of the Chinese nation, generate spiritual strength, create social conditions, and usher in a period from standing up to becoming rich and strong. To take the new journey of building a socialist modern country in an all-round way and achieve the goal of the second century as scheduled, we must strengthen the linkage between the fundamental system, the basic system and the important system, promote the Socialism with Chinese characteristics system to be more mature and stereotyped, continuously inject new kinetic energy into Chinese modernization, and promote Chinese modernization with efficient state governance.

  Adhere to the global vision of the new form of human civilization, and clarify the epoch-making significance of Chinese modernization in the history of China modernization, world modernization, world socialist development and human civilization development.

  Chinese-style modernization is a great change in the continuation, iteration and innovation of civilization. It not only depicts the special law of the continuation of Chinese civilization for 5,000 years, but also explores the universal law of the revival of human civilization, especially in developing countries, and the universal pattern of exchanges and mutual learning between different civilizations in the same time and space environment, creating a new form of human civilization, showing Socialism with Chinese characteristics’s remarkable advantages and strong vitality, and fundamentally surpassing the "clash of civilizations" and "western-centered theory" and.

  On the one hand, Chinese-style modernization is the independent road of the nation-state. No nation or country in human history can achieve modernization by relying on external forces, copying foreign models and following others. Chinese-style modernization insists on putting the development of the country and the nation on the basis of its own strength, firmly holding the destiny of China’s development and progress in its own hands, and always proceeding from China’s national conditions, exploring and forming the correct road in line with China’s reality.

  On the other hand, Chinese modernization is an open and inclusive modernization rather than a closed and exclusive modernization, which shows the openness and cosmopolitan nature of civilization. Chinese modernization takes socialism as its essential attribute, takes the common values of peace, development, fairness, justice, democracy and freedom as its value orientation, and adheres to the basic concepts of win-win cooperation and mutual benefit. It is firmly rooted in the soil of China, based on the logic of Chinese civilization development, and firmly follows the law of modern civilization construction. On the basis of conforming to the development trend of the times, it insists on exchanges and mutual learning among civilizations, finds consensus in exchanges, realizes development in mutual learning, and shows a distinct openness.

  Chinese modernization, based on China’s basic national conditions and development practice, conforms to the development trend of the times, opens a successful path for the great rejuvenation of the Chinese nation, transcends the logic of western modernity, breaks the uniqueness of western modernization model, drives developing countries to realize "group rise", promotes the image of socialism and promotes the progress of human civilization, which is of great significance in the history of China modernization, world modernization, world socialism development and human civilization development. In the history of China’s modernization, the Chinese-style modernization road has solved the perplexed and tortuous problem of China’s modernization road since modern times, and combined Socialism with Chinese characteristics with the Chinese-style modernization road, the great rejuvenation of the Chinese nation has shown an unprecedented bright future. In the history of world modernization, the Chinese modernization road has surpassed the western modernization model, provided a new choice different from the western modernization model, and opened up a new road for developing countries to modernize. In the history of world socialist development, the Chinese-style modernization road has overcome the defects of the traditional socialist model, opened up a new realm of socialist modernization road, and made it possible for socialism to revive, prosper and develop continuously in the world. In the history of human civilization development, Chinese-style modernization road has made new contributions to human exploration of modernization road, created new forms of human modern civilization, and demonstrated the diversity of human civilization development.

Thought it was excessive internal heat, it turned out to be Guangdong cancer, and its pathogenic virus infected more than 90% people.

Guangdong, a place easy to get angry.

For Cantonese people,

If you have a nosebleed

Nine times out of ten, it is getting angry.

Especially now when the weather is dry and things are dry.

Cantonese will remind you to drink herbal tea at once.

If there is a long-term nosebleed,

And it’s when there’s blood in the tears

We are about to start to be vigilant.

This could beGuangdong cancer!

nasal pharyngeal cancerIt is a malignant tumor located in the nasopharynx, also known asGuangdong cancerAccording to the statistics of the World Health Organization, there are80%Nasopharyngeal carcinoma (NPC) occurred in China, especially in Guangdong. The cancer detection data of our province released by Guangdong Provincial Center for Disease Control and Prevention in 2019 shows that at present, nasopharyngeal carcinoma ranks eighth among residents in Guangdong Province, with an incidence rate of 14.84/100,000.Far higher than the national average.

Speaking of nasopharyngeal carcinoma,

I have to mention

Epstein-Barr virus closely related to nasopharyngeal carcinoma

"Reasonable Inspection" Series No.twenty-eightperiod

Let’s have a chat.

Nasopharyngeal carcinoma and EB virus

epstein barr virus

"Good friend" of nasopharyngeal carcinoma, EB virus

Epstein-Barr virus is considered to be the strongest pathogenic factor of nasopharyngeal carcinoma at present. Epstein-Barr virus (EB virus) is one of the most widely infected herpes viruses. It is highly contagious and can be spread through droplets, kissing, sharing tableware and other behaviors, as well as through blood and semen during sexual contact, blood transfusion and organ transplantation. Epstein-Barr virus infection is very common in normal people. It is reported that more than 90% people have been infected with Epstein-Barr virus, and once infected, the antibody of Epstein-Barr virus will be carried for life.

Note: Autumn is the high incidence period of EB virus infection, so try to avoid going to crowded places to avoid cross-infection. Wear a mask when going out and take protective measures.

Then the problem is coming.

EB virus positive = nasopharyngeal carcinoma?

Epstein-Barr virus detection usually includes early antigen IgA antibody detection of Epstein-Barr virus, Rta-IgG detection of Epstein-Barr virus, and qualitative detection of Epstein-Barr virus DNA.

When EB virus antibody is positive, nasopharyngeal carcinoma can not be diagnosed. More than 90% of adults have been infected with EB virus, and only about 3%-10% of people with EB virus antibody positive will turn into nasopharyngeal carcinoma patients, indicating that the occurrence of tumors is not caused by EB virus alone, but by genetic and environmental factors.

(Source: Healthy Guangdong)

Don’t panic when you find EB virus positive in physical examination. Consult your doctor as soon as possible. The doctor can judge whether you are a high-risk patient by asking about your place of origin, family history, living habits and whether you have symptoms. According to the doctor’s advice, you may have an imaging examination for further confirmation. The 5-year survival rate of early nasopharyngeal carcinoma can reach 97%, so early detection is very important!

Epstein-Barr virus is indeed closely related to nasopharyngeal carcinoma. Accurately speaking, Epstein-Barr virus is a related substance of nasopharyngeal carcinoma, not a marker of nasopharyngeal carcinoma.

epstein barr virus

If you have the following symptoms, you should be alert to nasopharyngeal carcinoma.

VCA-lgA titer ≥ 1: 80;

All the EB virus indexes were positive;

Check the EB virus index, any one continues to rise.

When EB virus is positive, nasal congestion occurs; Reflux nasal discharge with blood; Vision loss and ghosting; Cervical lymph node enlargement; Ear buzzing and hearing loss; Headache; Facial numbness, etc., need more attention.

(Source: Healthy Guangdong)

epstein barr virus

What are the high risk factors for nasopharyngeal carcinoma?

At present, the pathogenic factors of nasopharyngeal carcinoma are not clear, except EB virus infection, which may be related to genetic factors, environmental factors, dietary factors and other factors.

01

Gender:

Nasopharyngeal carcinoma is more common in male population, which is 2~3 times higher than that in female.

02

Race:

Nasopharyngeal carcinoma is common in China, Southeast Asia and parts of North Africa. Inuit people also have a higher risk of nasopharyngeal carcinoma than other ethnic groups.

03

Region:

Guangdong, Guangxi, Fujian, Hunan, Jiangxi and other places in South China and East China belong to areas with high incidence of nasopharyngeal carcinoma, among whichPearl River DeltaThe area is particularly obvious.

04

Age:

May occur in any age group, butMostly in 30~50 years old..

(Source: Healthy Guangdong)

05

Diet:

Love foodPreserved foodSome people will also increase the incidence of nasopharyngeal carcinoma. Pickled food contains a lot ofAmmonium nitrite compoundLong-term intake can increase the incidence of nasopharyngeal carcinoma by 2~7 times.

06

Alcohol and tobacco:

manysmokeanddrink wine/alcoholIt will also increase the risk.

07

History of sinusitis and family history:

If someone in the family suffers from nasopharyngeal carcinoma, especiallydirect relativeThe risk of illness will also increase.

People who meet one or more of the above conditions are at high risk of nasopharyngeal carcinoma, so it is necessary to screen nasopharyngeal carcinoma.

epstein barr virus

Prevention: early detection+self-discipline is the key!

How to prevent nasopharyngeal carcinoma?

Quit smoking and drinking, eat less pickled food;

● Epstein-Barr virus is mainly transmitted through saliva, and infants should not be fed mouth to mouth;

● Maintain good hygiene habits: wash your hands before meals, do not spit everywhere, and advocate the use of public chopsticks;

● If you get up every day and find that you often have a runny nose and are accompanied by bloodshot or bleeding symptoms, you must be vigilant;

(Source: Healthy Guangdong)

● In areas with high incidence of nasopharyngeal carcinoma, people with family history of nasopharyngeal carcinoma, and middle-aged and elderly people, EB virus detection should be taken as a necessary item for physical examination.

reference data

What the hell is EB virus?

https://mp.weixin.qq.com/s/I3I9u_1fsRufBIszp8OoEw

EB virus positive = nasopharyngeal carcinoma?

https://mp.weixin.qq.com/s/Z7iweJudIY9U_35Wla2Rkg

Health Science | Did you "catch" nasopharyngeal carcinoma when the physical examination found that "EB virus" was positive?

https://mp.weixin.qq.com/s/ygn4166PoefdHYrVFwHyrQ

Epstein-Barr virus positive means "Guangdong cancer"? Pay more attention to these daily situations!

https://mp.weixin.qq.com/s/6GB99I0DGXc1eX6YOEvl2A

Nosebleeds, tinnitus, neck mass, beware of "Guangdong cancer"

https://mp.weixin.qq.com/s/_YAKZlbGjfLyxNSHpfRH5w

Source | First Health Group

Editing | First Health Group

Please contact First Health Group for reprinting.

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