Donghua Energy joined hands with CNNC to build a zero-carbon industrial park. The price of raw materials soared for half a year, and the net profit dropped by more than 80%.

Changjiang business news ● Changjiang Business Daily reporter Ming Hongze

Donghua Energy (002221.SZ), which constantly promotes the industrial layout, has made heavy moves again.

On the evening of September 6, Donghua Energy announced that the company will join hands with China National Nuclear Corporation to jointly promote the high-temperature gas-cooled reactor project, and it is estimated that the investment will exceed 100 billion yuan in the next five years to jointly build a zero-carbon industrial park. The two sides have also conducted in-depth cooperation in other areas.

Donghua Energy said that the above actions will be conducive to the company’s industrial transformation and upgrading, and greatly reduce the production cost of the process.

Donghua Energy was established in 1996. After more than 20 years of development, it has become one of the top 500 Chinese enterprises. The company’s main business was once dominated by trade, and it is the largest LPG trader in the world and the largest LPG importer in China. In recent years, the company has actively implemented industrial transformation, and now it has become the largest propane dehydrogenation manufacturer in the world.

In the past 10 years, Donghua Energy has achieved a continuous increase in net profit attributable to shareholders of listed companies, but since last year, net profit has declined. In the first half of this year, the company’s net profit was only 146 million yuan, down more than 80% year-on-year.

Donghua Energy explained that geographical conflicts, overlapping epidemics, soaring raw material prices and insufficient downstream demand led to a sharp drop in net profit.

Deep binding with CNNC

A paper announcement by Donghua Energy surprised the market.

According to the latest announcement, on September 6th, Donghua Energy and China National Nuclear Corporation (hereinafter referred to as "China National Nuclear Corporation") signed the Strategic Cooperation Agreement (hereinafter referred to as "Agreement"), which is valid for 10 years.

China National Nuclear Corporation (CNNC) is a super-large state-owned key enterprise directly managed by the central government and belongs to the industry giant.

According to the agreement, the two sides will jointly promote the high-temperature gas-cooled reactor project, and it is estimated that the investment will exceed 100 billion yuan in the next five years to jointly build a zero-carbon industrial park.

In addition, the two sides will jointly establish a hydrogen energy alliance, set up a hydrogen energy research institute and a pilot plant, focus on the thermochemical hydrogen production technology route in the preparation of green hydrogen, and develop solid-state storage materials and equipment for hydrogen.

At the same time, in order to build a hydrogen energy industrial chain and effectively deepen strategic cooperation, the two sides will actively promote CNNC or its member units to become strategic investors of Donghua Energy (accounting for 5%-15% of the shares), and appoint directors to participate in the management of Donghua Energy’s board of directors, so as to create a model of mixed ownership reform of "central enterprises+private enterprises". In addition, according to the principle of "giving priority to quality and price", Donghua Energy (Ningbo factory and Zhangjiagang factory) will be provided with economic and zero-carbon power supply.

The reporter of Changjiang Business Daily found that the cooperation between Donghua Energy and China National Nuclear Corporation not only involves a joint investment of 100 billion yuan in the next five years, but also involves a strategic investment in Donghua Energy, which is deeply tied with its equity relationship and has also made specific agreements on power supply. From this, it can be seen that the two are truly deepening comprehensive cooperation.

Investing 100 billion yuan in the next five years, if it is an enterprise of Donghua Energy, it is not generally difficult.

By the end of June this year, Donghua Energy’s total assets were 36.957 billion yuan, with a total market value of 15.748 billion yuan. With such a volume, it’s hard to imagine that you want to invest hundreds of billions. Holding hands with China National Nuclear Corporation, Donghua Energy will become impossible.

For the above cooperation, Donghua Energy said that the synergy effect on the company’s existing business is significant, which is conducive to the transformation and upgrading of the industry and is expected to greatly reduce the production cost of the process. If both parties cooperate on specific projects within the scope agreed in this agreement, it will have a positive impact on the company’s future performance.

Continuous large-scale investment is under financial pressure

Not only is it difficult to achieve a single investment of 100 billion yuan, but at present, Donghua Energy is also under greater financial pressure.

The semi-annual report shows that as of the end of June this year, Donghua Energy’s asset-liability ratio reached 66.43%. At the end of the period, although the company had 9.037 billion yuan of monetary funds on its books, its short-term debt reached 12.788 billion yuan, which showed obvious short-term debt repayment pressure.

Donghua Energy, originally engaged in trade business, is the largest LPG trader in the world and the largest LPG importer in China. In recent years, the company has actively implemented industrial transformation, and now it has become the largest propane dehydrogenation manufacturer in the world. Its industrial transformation is mainly implemented through investment construction and extended mergers and acquisitions.

In 2015, the first phase project of Zhangjiagang Yangzijiang Petrochemical Co., Ltd. was put into production, which is an important symbol of Donghua Energy’s strategic transformation, upgrading and layout of alkane resources comprehensive utilization industry. In that year, the production facilities of the 660,000-ton propane dehydrogenation to propylene project and the 400,000-ton/year polypropylene project were basically produced at full capacity.

Zhangjiagang Yangzijiang Petrochemical Department was established by Donghua Energy in 2011 with a capital contribution of 560 million yuan, with a shareholding ratio of 56%. In May 2015, the company acquired the remaining 44% equity at a price of 500 million yuan. From 2017 to 2019, Donghua Energy also successively acquired 100% equity of Baoying Jinfan, 100% equity of Polyentang Electronics, 100% equity of Tiansheng Port, and partial equity of Ningbo New Materials to carry out industrial transformation layout.

In 2019, the company announced that it would invest 16.67 billion yuan to build a comprehensive utilization project (Phase I) of alkane resources in Maoming. In order to strengthen the comprehensive utilization of hydrogen energy, in July last year, the company threw out acrylonitrile and its supporting projects to extend the industrial chain, with an estimated investment of more than 6.5 billion yuan.

At present, the company has three production bases in Zhangjiagang, Ningbo and Maoming, and some production capacity is still under planning and construction.

Donghua Energy said that the company will build the world’s largest olefin industrial base based on green chemicals, and plan 10 million tons of polypropylene and multi-copolymerization.

In recent years, the company’s investment cash flow has continued to flow out. From 2020 to the first half of this year, their net outflows were 1.054 billion yuan, 2.852 billion yuan and 1.911 billion yuan respectively.

Because of this, the company bears great financial pressure. In the next five years, the company and China National Nuclear Corporation will jointly invest 100 billion yuan, which will inevitably aggravate its financial pressure.

At one time, Donghua Energy showed strong profitability. In 2016, the company realized a net profit of 470 million yuan. From 2017 to 2020, its net profit increased slowly, but both exceeded 1 billion yuan. In 2021, its net profit dropped by 5.82% to 1.14 billion yuan.

However, in the first half of this year, the company’s performance fell sharply. The semi-annual report shows that its operating income was 15.192 billion yuan, up 6.54% year-on-year, the corresponding net profit was 146 million yuan, and the net profit after deducting non-recurring gains and losses was 95 million yuan, down 80.60% and 86.53% year-on-year.

Donghua Energy explained that geopolitical conflicts triggered international turmoil and superimposed global epidemics, which led to a sharp rise in propane prices. Downstream, due to the epidemic, construction was insufficient, and performance dropped significantly due to the squeeze at both ends.

Will Donghua Energy’s ability to resist risks be enhanced by accelerating industrial layout and financial pressure?

Reporting/feedback

"Enthusiasm" issued a new poster. Bo Huang and YiBo joined hands to perform hot youth


1905 movie network news The film officer announced the summer vacation and released the poster of "Hot Youth". The film is directed by, with Chen Zhixi as the chief producer and leading the street. The background of the poster is bright and colorful, like wanton youth and blood! Bo Huang and YiBo, the two leading actors, laughed shoulder to shoulder, and there was hope in their eyes. Let the audience can’t help but look forward to their stories.


The movie "Enthusiasm" tells the story of hip-hop mr. six Ding Lei (Bo Huang), who meets Chen Shuo (YiBo), a young boy who loves and pursues his dreams firmly. By chance, Chen Shuo joins the hip-hop troupe run by Ding Lei — — Exclamation mark, the master in the dance troupe is like a cloud, with different personalities, and Chen Shuo collides with different sparks and jokes. Chen Shuo enthusiastically pursued his dream and looked forward to the opportunity to play, only to find that everything was not as smooth as expected after entering the dance company. Ding Lei and Chen Shuo are facing their own difficulties in life. Can the unknown frustrations and blows make the mentoring and apprentices continue to join hands in the national competition? This mystery will be revealed after the film is released.


The poster of "Hot Youth" appeared in YiBo, Bo Huang, and the two men were blown up in the summer.


In the poster of "Hot Youth" released, the interaction of the two leading actors shoulder to shoulder caused netizens to speculate and discuss the relationship between the characters, and some netizens even used "being a teacher and a friend" to describe the status of the two characters. The background of the poster is gorgeous and unique, which belongs to the hot breath of summer, burning and warm, and you can feel youthful just by looking at the poster.


The fresh collocation of Bo Huang, a veteran actor, and YiBo, a young actor, has aroused the expectations of countless netizens for the film. One is mr. six, who has been a hip-hop coach for seven years, and the other is a new generation of actors. Their youthful "dislocation" collision in different times is bound to spark unexpected sparks.


Persistence in "enthusiasm" — — Is to pay tribute to every ordinary person who insists on loving.


The story of the film "Enthusiasm" is a gift from the master to every ordinary person who keeps loving life. Ding Lei’s persistence in winning the championship, Chen Shuo’s persistence in the stage, this kind of fighting spirit that seems to be "invincible Xiaoqiang", and his persistence in gritting his teeth in difficulties, truly pay tribute to everyone who works hard for love. Free and enthusiastic, hot and unrestrained is everyone’s attitude towards life. This story of breaking through all difficulties to pursue dreams is also a portrayal of thousands of ordinary people in Qian Qian who keep their love for their dreams.


Ding Lei and Chen Shuo met on their own dreams, and two different eras collided "enthusiastically". Survival and initial heart, friendship and reality finally gathered on one stage, and the stage of their youth never ended. Dreamcatchers of different generations encourage each other, making the film create new heights from all levels. This is exactly what director Dapeng wants to express. Youth never ends, and we will always be enthusiastic for love! Let’s meet the movie "Enthusiasm" in summer and blow it up together.


The movie "Enthusiasm" will be released in summer, so look forward to it!


[Ground Evaluation Line] Caiyun Online Review: Let the theme education release lasting effectiveness

  Duan Zongke, Special Commentator of Caiyun Online Review

  On January 8th, the educational summary meeting on the theme of "Do not forget your initiative mind, Remember Mission" was held in Beijing. General Secretary of the Supreme Leader attended the meeting and delivered an important speech. He stressed that the whole party should take this theme education as a new starting point, constantly deepen the party’s self-revolution, continue to promote the party’s Do not forget your initiative mind and keep in mind its mission.

  Summing up does not mean reaching the end, but starting a new journey on the basis of learning from experience. Theme education has a deadline, but Do not forget your initiative mind, keep in mind that the mission is never ending. General Secretary of the Supreme Leader pointed out that our party must always win the support and support of the people and write the great achievements of the Chinese nation for a thousand years, and must always bear in mind its initial heart and mission. This requires us to take Do not forget your initiative mind, bearing in mind the mission, as the eternal task of strengthening Party building, and the lifelong task of self-purification and promotion of cadres in party member, and make unremitting efforts for a long time to make the theme education release lasting effectiveness.

  Solidly summarize and improve the "storage battery"Under the strong leadership, deployment and promotion of the CPC Central Committee with the Supreme Leader as the core, and taking the lead in setting an example, the theme education of "Do not forget your initiative mind, Remember the Mission", a serious and profound baptism of party spirit, stirred up the whole party and achieved a series of major achievements. In order to release the lasting effectiveness of theme education, it is necessary to look back on the practical process in an all-round way and sum up successful experiences, so as to accumulate strong energy and lay a solid foundation for deepening the party’s self-revolution. Of course, summing up can’t be a complacent introduction of experience and a simple piling up of achievements, but should be refined and sublimated on the basis of summing up and summarizing. It is more important to look at the problem from a developmental perspective and a practical attitude. Only by constantly optimizing the measures of "keeping the original heart, taking the mission, finding the gap and grasping the implementation" can we inject lasting kinetic energy into the self-revolution.

  Ignite the long-term mechanism "engine"."Resolutely remove all factors that weaken the party’s advanced nature and damage the party’s purity, resolutely remove all cancers that breed on the party’s body, and resolutely guard against all dangers that violate the initial heart and mission and shake the party’s foundation." This is a long-term and systematic project, which must be done for a long time. It is inseparable from strong institutional guarantee to continuously promote the Do not forget your initiative mind of the whole party and keep in mind its mission. Although the theme education has come to an end, Do not forget your initiative mind’s mission needs not only immediate "immediate change", but also long-term management. Since the 18th National Congress of the Communist Party of China, the CPC Central Committee with the Supreme Leader as the core has attached great importance to institutional governance. At the Fourth Plenary Session of the 19th CPC Central Committee, it was proposed to establish a system of Do not forget your initiative mind and keeping the mission in mind. On the basis of summing up, establishing a simple, pragmatic and accurate long-term mechanism will undoubtedly ignite the engine of keeping the original heart and carrying out the mission.

  An "accelerator" to stimulate the vitality of the grassroots.General Secretary of the Supreme Leader pointed out that the mission of Do not forget your initiative mind and Mindfulness should be realized through the joint efforts of the whole Party. The key to running China well lies in the Party, and the most solid and active source of strength for the Party’s work lies in the grassroots. Doing a good job of summing up and upgrading is to start a new journey, build a long-term mechanism to promote going deep, going real and going far. Besides these, it is also essential to stimulate the vitality of the grassroots, give birth to Do not forget your initiative mind, and keep in mind the vivid and vivid grassroots innovation practice. "Bearing in mind the initial heart and mission, we must persist in serving the people wholeheartedly." Do not forget your initiative mind, whether the measures to keep in mind the mission are effective or not, and whether the results are remarkable or not, must be tested by the masses’ sense of gain. To this end, it is necessary to give full play to the initiative of grassroots innovation and creation, and to refuel and add strength to the release of lasting effectiveness of theme education with colorful grassroots practices.

  "You can’t expect to declare success through one or two educational activities. ‘ The revolution has not yet succeeded, and comrades still have to work hard ’ This sentence is always going on. " Ending is not ending, and summing up is not ending. "Do not forget your initiative mind, keep in mind the mission" is always on the road, so that the theme education will release lasting effectiveness, and our party will surely lead the great ship "China" to a brighter future.

Xinhua All Media+| It’s more fun to play ice and snow on campus during winter vacation.

  Xinhua News Agency, Changchun, January 29th Since the winter vacation, many places in Changchun and Shenyang have opened ice and snow custodians. Schools have built ice rinks and snow fields on campus, hired professional coaches, and provided all kinds of ice and snow sports courses for primary and secondary school students, so that students can enjoy ice and snow on campus during the winter vacation and welcome the Winter Olympics.

  In the cold winter, in the 2,400-square-meter ice rink of Pingquan Primary School in Nanguan District, Changchun City, the students learned from the skating coach in full swing.

  Students in the primary school of Changchun No.104 Middle School are learning to skate. Xinhua News Agency reporter dorri photo

  Song Haoxuan, a student in Class Two, Grade Five, Changchun No.104 Middle School, is learning skating for the first time. After three days, he has mastered the basic movements and can stand and walk on the ice. "Before the holiday, the class teacher said that there was ice and snow custody during the holiday, so I signed up. In the past, I could only do my homework at home during the holidays. It is so interesting to learn skating this time. " Song Yuxuan said.

  At the scene, the reporter saw that a shoe changing room was built around the skating rink, in which all the skating equipment was prepared for students, and each school was accompanied by leading teachers to ensure the safety of students.

  Sun Jingru, director of the Department of Physical Education, Sports, Arts and Health, Nanguan District Education Bureau, Changchun City, said that in order to create conditions for students to participate in ice and snow sports, Nanguan District Education Bureau poured an ice rink in Pingquan Primary School. Students in grades 4-8 of primary and secondary schools in the whole district took advantage of the winter vacation to participate in ice and snow custody for a total of 30 days, with about 600 participants every day. The total number of participants in the winter vacation is expected to be 18,000. The Education Bureau also hired seven professional coaches to guide students’ ice skills, so that students can master the basic skating movements and experience the fun of skating in a short period of time.

  Shoe changing room of Pingquan Primary School in Nanguan District, Changchun City. Xinhua News Agency reporter dorri photo

  In addition, other counties and cities in Changchun also provide various forms of ice and snow amusement activities for primary and secondary schools. Yushu city City, Jilin Province has poured 26 outdoor ice rinks in primary and secondary schools in towns and villages, and equipped students with PE teachers and skating equipment. Up to now, more than 10,000 people have participated in ice and snow custody.

  In the ninth primary school in Hunnan District, Shenyang City, Liaoning Province, ice and snow activities are another lively scene. The school’s snow machine makes snowflakes fly, and it is fun to have snowball fights, make snowmen and snowball. Two large indoor ski machines allow students to ski at zero distance, and more than 700 students who participate in the trusteeship can enjoy the fun of flying in the snow.

  Hou Mingfei, principal of the Ninth Primary School in Hunnan District, Shenyang, said that compared with summer classes, the school’s winter vacation trusteeship has increased the single and double snowboarding projects, and students can take skiing classes on campus.

  On the 120-square-meter indoor simulated ice rink of Heping Street No.1 Primary School in Heping District, Shenyang, the children were dressed in ice hockey equipment, and the teacher explained the technical points and basic sliding movements for the students. The slightly childish movements of the students added vitality and vitality to the winter campus.

  The school organized a winter vacation hosting service with the theme of "Harmony, Colorful Winter Holidays", and 80 students from different grades signed up to participate. The trusteeship classes were named "Bingdundun" class and "Snow Rongrong" class, and activities such as learning to sing winter Olympic songs and ice hockey experience were also carried out to cultivate students’ interest and skills in ice and snow sports.

  Students in the primary school of Changchun No.104 Middle School learn skating. Xinhua News Agency reporter dorri photo

  This school is a characteristic school of ice and snow sports on the national youth campus. Lin Yuheng, the director of teaching, said that ice hockey training in schools usually involves members of the school team, and not all students can master skills such as ice hockey and speed skating. There is plenty of hosting time in winter vacation, and for more than 80 students who participate, they can do no less than two hours of sports every day.

  In recent years, Shenyang has incorporated ice and snow projects into the teaching content of primary and secondary schools, and carried out ice and snow sports through physical education courses and comprehensive practical activities courses, and achieved remarkable results. Twenty-seven schools in the city were rated as "National Youth Campus Ice and Snow Sports Characteristic Schools" by the Ministry of Education, and 55 schools were named as municipal ice and snow characteristic schools. At present, more than 30% primary and middle school students in the city have mastered the basic skills of ice and snow. (Reporter: Li Shuangxi, dorri, Wang Ying, Wu Jiangmin)

Yuan Renguo, Chairman of Maotai Group: Integrating Internet thinking and big data into enterprise production.

  Cctv news (Reporter Liu Ying) On May 25th, China E-commerce Innovation and Development Summit opened in Guiyang. Yuan Renguo, chairman of China Kweichow Moutai Distillery Co., Ltd., delivered a speech at the opening ceremony. He said that integrating Internet thinking and big data into corporate strategy and production and operation, using 3-mdash; Five years to build big data Maotai, strengthen the seamless connection with consumers, and form a global big data platform such as manufacturing, trading and interactive industry chain and diversified expansion of Maotai, so that Maotai’s high-quality data can continue to be the most important data assets of the enterprise and continuously improve its core competitiveness, industrial competitiveness, brand influence and market share.

  The following is the full text of Yuan Renguo’s speech:

  Dear Governor Sun, distinguished leaders, distinguished guests, ladies and gentlemen, friends. As a leading enterprise in Guizhou Province and liquor industry, Maotai Group is honored to discuss the development of big data with industry leaders, experts, scholars and elites from the global big data field.

  Big data has brought changes to the manufacturing industry as much as the invention of steam engines and electricity has promoted the industrial revolution. In recent years, General Secretary of the Supreme Leader and Premier Li Keqiang have repeatedly given clear instructions on the implementation of the big data strategy and the internet plus Action Plan. The Guizhou Provincial Party Committee and the provincial government attached great importance to big data and made a decision to promote the strategic action of big data in the "Thirteenth Five-Year Plan". Big data has opened a brand-new era. Artificial intelligence, virtual reality technology, augmented reality technology, mixed reality technology, unmanned controllers and new sensors are on the rise. Everyone has a terminal, things can be sensed, and the Internet can be accessed everywhere. In real time, under the general trend of connected everything, data has become a valuable resource asset and production factor. The connection between Maotai and global consumers has increased the connection of big data on the basis of traditional connections, achieving zero distance from the world.

  Maotai’s craft is one of the living fossils of China’s manufacturing industry, and it is the representative of China’s traditional craftsman spirit. At present, world-renowned wine companies are carrying out big data reform, intelligent production, and informationization of the whole industry chain. Maotai deeply integrates big data, the Internet and the craftsman spirit, and leads Maotai’s innovative development with the big data revolution. First of all, Maotai built an Internet of Things cloud business platform to realize the data traceability of the whole industry chain. Maotai built the first comprehensive category trading platform integrating grassroots B2B2C, industrial financial services, collection and auction in the domestic liquor industry, and the trend of each bottle of Moutai can be quickly merged into the most valuable information of the company, which constitutes the big data of the whole industry chain of the company. At the same time, consumers can also know the production and sales links of each bottle of Moutai in their hands through the quality traceability system. We will interact with online and offline, actively and flexibly consume experiences and personalized needs.

  This year, Maotai used Internet technology to establish an information system for brewing production technology, from brewing to smart brewing. A bottle of Moutai has to go through 30 supply and demand and 165 technological links, and it will take at least five years. In the window of traditional enterprises facing the discovery and utilization of new growth drivers, under the background of Global Industry 4.0, Maotai has established an information system for collecting, counting and feeding back brewing production data.

  We will further promote the revolution and innovation of big data, better serve the global consumers from the traditional space to the Internet space, and extend the real-time interaction between service consumers and global consumers, and integrate Internet thinking and big data into corporate strategy and production and operation, using 3— Five years to build big data Maotai, strengthen the seamless connection with consumers, and form a global big data platform such as manufacturing, trading, interactive whole industry chain and diversified expansion of Maotai, so that Maotai’s high-quality data can continue to be the most important data assets of the enterprise and continuously improve its core competitiveness, industrial competitiveness, brand influence and market share. Data creates value, innovation drives the future, and the integration of knowledge and practice in Guiyang is the birthplace of philosophical thought. To make the flower of dreams bear the fruit of career, it depends on promoting knowledge with knowledge and promoting knowledge with action. Breaking can promote vitality, and innovation can promote the future. In 1995, Maotai left a much-told story in Panama. Because of breaking and innovation, Maotai has become a world-famous brand with the largest sales volume and the strongest leading ability in the world.

  Finally, welcome all of you to visit Maotai. You can appreciate the mellow taste of Maotai. Thank you!

Mila Tang Jian: Building ChatGPT in the field of life science and developing drugs with generative artificial intelligence.

"I have always been interested in biology. When I was in high school, my teacher told us that the 21st century was the century of biology. When I studied artificial intelligence, I believed that the 21st century was the century of artificial intelligence."

During the scientific lecture "Understanding the Future" hosted by the Future Forum, Tang Jian, an associate professor at the Research Center for Artificial Intelligence in Quebec, Canada (Mila) and a professor of artificial intelligence at the Canadian Institute of Advanced Studies (CIFAR), introduced the application of generative artificial intelligence in life sciences: how to build a "ChatGPT" in life sciences. He said, "Later, I felt that it might be the best choice if I could do something in the field where artificial intelligence and biology intersect."

Today, he is not only studying AI and biology at the same time, but also "left-handed scientific research and right-handed entrepreneurship". He said that he is a person who is willing to accept new things and challenges. From scientific research to entrepreneurship, many things are different, and it is difficult to carry out interdisciplinary cooperation, but this also reflects the value of doing these things.

Figure | Tang Jian (Tang Jian’s personal homepage)

According to reports, Tang Jian University studied geography at the beginning, transferred to the Department of Mathematics in his sophomore year, and successfully applied to the Department of Computer Science in his senior year. In his computer learning career, he first studied traditional machine learning, and in the last year of his doctoral degree, he turned to deep learning.

After graduating from the doctor’s degree, he officially embarked on the road of scientific research and made many achievements in the field of graphic representation learning. As one of the representative scholars in this field, his network representation learning method LINE (large-scale information network embedding) has been widely used, with more than 5,000 references.

"The double revolution of artificial intelligence and biotechnology broke out, and we are in the best era of doing research."

In 2018,Tang JianStart the research on the intersection of artificial intelligence and biology. At that time, he applied the graph representation learning technology to the research in the field of drug discovery, and did a lot of work in the prediction of three-dimensional structure of small molecules and the design of macromolecular proteins.

But a few years ago, only a few people devoted themselves to the research in this direction. In the past two years, more and more investment has been injected into this field. Tang Jian believes that the reason for this change is that artificial intelligence has brought great breakthroughs to the structural prediction and biological field in protein, and the spread of the COVID-19 epidemic has also aroused people’s focus on health and biomedicine.

"Now we are in the best era, because we are experiencing the dual technological revolution of artificial intelligence and biotechnology." Tang Jian said, "Therefore, we have seen great opportunities for generative artificial intelligence in the field of drug discovery, especially protein design."

Based on his accumulation in scientific research, he devoted himself to entrepreneurship and set up the artificial intelligence-driven biopharmaceutical company Baiao Geometry in 2022.

Build an AI macromolecular drug design platform to provide innovative drugs to save patients’ lives.

existTang JianIt seems that perhaps it is the entrepreneurial idea that has sprouted since childhood and the character of constantly seeking self-breakthrough that drives him to embark on the road of entrepreneurship.

The Baiao Geometry Company, founded by him, aims to develop a programmable protein by integrating the technologies of generative artificial intelligence and geometric deep learning, so as to overcome the problems of long cycle, high cost and low success rate of traditional macromolecular pharmacy and provide innovative drugs to save patients’ lives.

Tang Jian is mainly responsible for technical work in this company, and designs antibodies by building artificial intelligence models. As a new diffusion generation model, this model can model the amino acid sequence and three-dimensional structure of protein at the same time, and show the relationship between them, so as to generate protein with specific functions.

At present, the team has set up an AI macromolecular drug design platform, and is building a wet experiment verification platform for Qualcomm macromolecular drugs. At the same time, it also launched TorchProtein, an open source machine learning platform for macromolecules, in conjunction with companies such as NVIDIA, Intel and IBM.

"I hope that the technology I have made can really push several drugs into the clinic, solve more complicated diseases like cancer and save patients’ lives." Tang Jian said. In addition, he also said that with the development trend of intelligence, digitalization and automation in the biomedical field becoming inevitable, he expected to become a world-famous and international high-tech company in this field.

Based on generative artificial intelligence, build "ChatGPT" in life science field

In addition to starting a business, Tang Jian’s scientific research work at hand is also being carried out simultaneously. Based on generative artificial intelligence, he and his team have carried out research on three-dimensional structure prediction of small molecules and protein design of large molecules in the field of biomedicine.

In the prediction of the three-dimensional structure of small molecules, the team mainly modeled them based on the diffusion generation model. Specifically, a completely random structure is taken as the initial structure, and after several rounds of optimization, it finally converges to a stable protein structure. Each step of the optimization process is also called denoising. In addition, on the basis of expanding the research, the prediction of the complex structure was realized.

In the design of macromolecular proteins, the team proposed to design protein structure and sequence based on diffusion generation model, which not only realized the generation of antibody CDR Loop structure and sequence, but also designed α -helix transmembrane proteins with a specified number.

Not only that, the team also conducted research on antibody design and optimization. For example, it cooperated with the research team from Fudan University. Based on the antibody CR3022 obtained from newly crowned patients, it first designed the sequence with AI model, and then tested it on the wet experimental platform of Qualcomm, and finally successfully found the antibody molecule with strong affinity.

For generative artificial intelligence, its most critical ability is that it can generate new data. Then, if it is used in the biomedical field, it can help to generate a brand-new protein and help people find better drugs.

As a typical generative artificial intelligence model, ChatGPT has spread all over the world since it was introduced at the end of 2022. It can talk and communicate like a human being, and complete tasks such as writing papers and coding. "It is essentially a chat robot." Tang Jian said. As a large-scale pre-training language model, ChatGPT first pre-trains a large number of text and code data on the Internet, and then further optimizes it to enable it to be used for tasks such as dialogue.

The development of biotechnology, such as gene sequencing and gene synthesis, has brought a lot of data to the biomedical field. Therefore, Tang Jian believes that in the near future, people can also use these data to build ChatGPT in the field of life sciences.

Reporting/feedback

Vipshop will release the "2023 Beauty Awakening Trend": the trend of makeup first, refined demand and streamlined skin care is remarkable.

Wake up in the spring, and the mood of wanting to be beautiful grows wantonly in the new spring.
According to the data released by the National Bureau of Statistics, the total retail sales of social consumer goods reached 7,706.7 billion yuan in January and February 2023, a year-on-year increase of 3.5%. Among them, the total retail sales of cosmetics was 65.6 billion yuan, up 3.8% year-on-year, achieving the first positive growth since August 2022, and the cosmetics market showed obvious warming momentum.
Recently, Vipshop joined hands with many well-known beauty brands to launch a consumer survey called # Vipshop Beauty Awakening Plan #, and based on the platform sales data, brand feedback and nearly 1,500 netizens’ responses from platforms such as Weibo, Xiaohongshu, bilibili and Zhihu, it released the "2023 Beauty Awakening Trend" (hereinafter referred to as "Trend"). Trend shows that since the beginning of this year, the trend of making-up first, refined demand and streamlined skin care has been remarkable, which has brought new development space and growth point to the beauty market.
Trend 1: under the recovery of the market, make-up is the first to start.
In the vibrant spring, bright makeup makes people feel happier and more confident socially. Benefiting from the full liberalization of consumption and social scenes, makeup consumption took the lead in the first quarter of 2023, which sounded the clarion call for the recovery of the beauty market.
According to the data of Vipshop, from January to mid-March, 2023, the sales volume of platform makeup increased by 6.24% month-on-month, among which lip makeup and eye makeup products increased the most obviously, increasing by 15.3% and 18.6% month-on-month. In terms of brands, the sales of domestic beauty brands, such as Huaxizi, Kazilan and Tangduo, have increased significantly, with an increase of 17.1%, 24.9% and 20.6% respectively.
Geographically, the sales of beauty cosmetics in first-tier and new first-tier cities have increased significantly. For example, the sales of beauty cosmetics in Beijing, Shanghai, Guangzhou and Shenzhen increased by 20% to 40% month-on-month, and the growth rates of Chengdu and Chongqing, the "most beautiful cities", both exceeded 80%. Among the top ten cities in beauty sales, Xi ‘an increased by 101.9% month-on-month, ranking first in the country.
Trend 2: The consumer demand is refined, and the subdivided track is optimistic.
With the refinement of consumer demand, more and more beauty brands further expand their product lines and capture opportunities to segment the track. Taking Tangduo as an example, in 2022, innovative products, such as high-gloss capacity-repairing disk and ultra-fine eyeliner, were introduced in addition to the dominant categories such as eye shadow and blush, which formed a more perfect product layout and quickly seized the market segment.
At the same time, consumers’ awareness of cosmetics has improved rapidly, which puts forward higher requirements for the brand’s product strength. The person in charge of the Lancer brand pointed out that many "component parties" are even familiar with the basic formula and efficacy features of the products, and the beauty track will continue to "roll the efficacy" and "roll the research and development".
In addition, the refinement of demand is also reflected in the consumption scene+style. The person in charge of Maybelline brand said, "With the stratification, diversification and refinement of consumer demand, beauty care brands gradually break the circle boundary and expand brand influence through topic innovation with different emotions and scenes."
Trend 3: quality consumption prevails, and subtraction skin care becomes a hot spot.
# vipshop Beauty Awakening Plan # Consumer survey results show that nearly half of the consumers surveyed have reported that their consumption mentality has tended to be calm in the past three years, and their choices have become more rational, paying more attention to product quality. "I used to buy what I used to buy, but now I prefer to be short of it, and I will choose products that are of good quality and suitable for me."
The person in charge of Maybelline brand believes that consumers’ pursuit for the quality and details of beauty products reflects a typical attitude towards self-satisfaction.
The ever-changing lifestyle is reshaping the relationship between consumers and beauty care. A person in the beauty industry said, "Under the influence of environmental awareness and healthiness, consumers are increasingly favoring products with natural raw materials and safe ingredients. In terms of makeup, more consumers began to’ do subtraction’, praised natural and clean makeup, bid farewell to exaggeration and pursue originality. "
After more than half a year’s market downturn, the prosperity of the cosmetics industry has greatly increased. Cosmetics are selling well during Valentine’s Day 214 and Women’s Day 3.8 this year, which also makes brands optimistic about the next market trend.
The person in charge of the Orange Blossom brand said, "When the overall social mobility returns to normal, the vitality of the market is increasingly displayed. More importantly, we have seen more confidence in the industry, which comes from the supply chain, channels, consumers, and even more from various brands in the industry. This makes us look forward to the overall recovery of the beauty industry. "
The person in charge of Vipshop’s beauty cosmetics said: "As the original intention of the Spring Awakening Plan, Vipshop hopes to join hands with beauty brands in spring and start from spring."
Xinmin. com published this article for the purpose of transmitting information, and does not represent the views of this website.
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Where does RDN go to treat hypertension? Professor Guo Yifang: The future can be expected.

Renal artery denervation (RDN) is a hot topic in the field of hypertension in recent years. Although it has not been widely used in clinic, with the release of various clinical data, more and more industries focus on RDN.

RDN targets the sympathetic nervous system, which does play a role in raising blood pressure. Therefore, RDN selectively reverses a mechanism of hypertension. But hypertension is a multifactorial disease. Is it really enough to target a single pathogenic mechanism to produce effective and sustained blood pressure reduction in a large number of hypertensive patients? Yixin specially interviewed the vice president of Hebei Provincial People’s Hospital.Professor Guo Yifang, shared his views on the future prospects of RDN.

  One more proof of RDN’s long-term effect  

Recently, the three-year research results of RADIANCE-HTN SOLO test were published, which confirmed that the safety and effectiveness of ultrasonic RDN lasted for 36 months.

Patients with ambulatory blood pressure ≥135/85 mmHg and < 170/105 mmHg after 4 weeks of stopping antihypertensive drugs were randomly divided into ultrasound RDN group or sham operation group. The results of 36-month follow-up showed that the systolic blood pressure and diastolic blood pressure in RDN group decreased by 17.7 mmHg and 11.3 mmHg respectively compared with baseline. In terms of safety, there were no adverse events related to equipment or operation during the follow-up period.

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In response to this research result, Professor Guo Yifang pointed out that in recent years, the effectiveness and safety of RDN has been an important topic in the field of hypertension treatment, which has attracted extensive attention from scholars at home and abroad.Radiation-HTN solo research provides valuable new evidence for the instrument treatment of hypertension. However, Professor Guo is cautiously optimistic about the results of this study, considering the differences in the conclusions of several RDN studies published in recent years and the limitations of this study itself..

  The evidence-based road of RDN  

The basic principle of RDN is to block the afferent and efferent activities of sympathetic nerve around renal artery by radio frequency energy, ultrasonic energy or injecting heat into perivascular space, and reduce the influence of sympathetic nervous system on renal vascular resistance, renin release and sodium reabsorption. RDN blocks the signal conduction between the brain and sympathetic nerve to a certain extent, thus reducing the sympathetic nerve excitability of patients with hypertension. Theoretically, it can achieve long-term antihypertensive effect through a minimally invasive operation.

As early as 2009 and 2010, RDN completed two early clinical trials in Europe and Australia, namely Symplicity HTN-1 and HTN-2. The results of 3-year follow-up showed that the average systolic blood pressure and diastolic blood pressure of refractory hypertensive patients receiving RDN decreased by about 30 mmHg and 14 mmHg respectively, and there were no obvious adverse reactions and complications. More importantly, after three years of follow-up, these patients found no obvious signs of blood pressure rebound.

Because this is the first minimally invasive surgical technique that has been proved in history and can definitely lower patients’ blood pressure, RDN shines brilliantly after the above exploratory experiment, but the well-known sham-operated control experiment-Symplicity HTN-3 did not get positive results, which weakened people’s enthusiasm for RDN: although the research proved its safety, it did not significantly lower blood pressure compared with the control group.

On the basis of summarizing the research experience and lessons of SYMPLICITY HTN-3, the researchers subsequently carried out a new generation of randomized controlled trials, such as SPYRAL HTN-OFF MED, SPYRAL HTN-ON MED, SPYRAL HTN-OFF, etc. These studies used different techniques and methods to ablate the renal artery sympathetic nerve. The results showed that the ambulatory blood pressure and clinic blood pressure in RDN group decreased clinically regardless of whether antihypertensive drugs were used or not.

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Clinical research course of RDN

(Source: Nat Rev Cardiol. 2020 Oct; 17(10):614-628. )

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In different studies, compared with sham operation group, systolic blood pressure in RDN group decreased.

The REQUIRE study aims to evaluate the effectiveness and safety of ultrasound renal artery ablation system in controlling blood pressure in patients with refractory hypertension. 143 patients with refractory hypertension (office blood pressure ≥150/90 mmHg and 24-hour SBP≥140 mmHg) were randomly assigned to RDN or sham operation group. Three months after operation, there was no significant difference in the 24-hour ambulatory systolic blood pressure between the RDN group (-6.6 mmHg) and the sham operation group (-6.5 mmHg) (P=0.971). The difference of SBP between family self-measured blood pressure and clinic blood pressure was -1.8 mmHg(P=0.488) and -2.0 mmHg(P=0.511) respectively, and there was no difference. There was no significant difference in drug load between the two groups. No major adverse events related to the operation were found.

At the EuroPCR annual meeting in 2022, a number of research data of RDN were published: Global Symplicity Registry, SPYRAL HTN-ON MED, Radiation HTN Solo & Trio, which further confirmed the potential of RDN as an adjuvant therapy for hypertension, supplemented the existing first-line therapy, and thus changed the lifestyle and drug treatment.

  Professor Guo Yifang: RDN can be expected in the future  

The occurrence of hypertension is a complex process, involving many mechanisms, and it is not expected to solve all patients’ problems through one drug or technology. RDN only blocks renal sympathetic innervation, and may have no therapeutic effect on other mechanisms that cause and maintain hypertension. Moreover, the antihypertensive effect of RDN is moderate, which is only equivalent to taking an antihypertensive drug.

Professor Guo Yifang talked about the future prospect of RDN. He pointed out that RDN is still in the stage of research and exploration, and it can not be used as a mature treatment technology in clinical practice. From the pathophysiological mechanism, the sympathetic nervous system plays an important role in the occurrence and maintenance of hypertension, so in theory, RDN will definitely have an ideal effect on some hypertensive patients. butThe pathophysiological mechanism of hypertension in different patients is inconsistent, the renal artery structure in different patients is obviously inconsistent, the principle of different types of RDN technology and equipment is inconsistent, and the experience and technical level of different operators are inconsistent. These four "inconsistencies" will inevitably affect the effectiveness and safety of RDN treatment and its application value and clinical status in antihypertensive treatment..

On the whole,For patients whose blood pressure can’t be satisfactorily controlled after lifestyle intervention and adequate treatment with various antihypertensive drugs, patients with obvious sympathetic hyperactivity, or patients who can’t tolerate antihypertensive drugs, it is reasonable to carry out RDN treatment in mature medical centers.. It is believed that RDN will play a more important role in the field of hypertension treatment in the future with the progress of related technologies and the continuous improvement of treatment equipment.

Expert introduction

18681659483287032  

Guo yifang

People’s Hospital of Hebei Province

Chief physician/professor, doctoral tutor, currently vice president of Hebei Provincial People’s Hospital. He is also the vice chairman of the Hypertension Committee of Chinese Medical Doctor Association, the vice chairman of China Society Hypertension Branch, the executive director of China Hypertension Alliance, the chairman of the Geriatrics Branch of Hebei Medical Association, the chairman of the Hypertension Professional Physician Branch of Hebei Medical Association, and the chairman of the Medical Engineering Branch of Hebei Medical Association. And the editorial boards of Chinese Journal of Internal Medicine, Chinese Journal of Geriatrics, chinese journal of cardiology and Chinese Journal of General Practitioners, and the standing editorial boards of Chinese Journal of Hypertension and chinese journal of cardiovascular medicine. Enjoy the special allowance of the State Council.

references

1. David E. Kandzari, Raymond R. Townsend, George Bakris, et al. Renal denervation in hypertension patients: Proceedings from an expert consensus roundtable cosponsored by SCAI and NKF. Catheter Cardiovasc Interv. 03 August 2021. 

2 "China cardiovascular medical device industry innovation white paper 2021"

3. Nat Rev Cardiol. 2020 Oct; 17(10):614-628.

4. C. Venkata S. Ram. Renal Denervation Therapy for Hypertension: All That Glitters Is Not Gold. Medscape. https://www.medscape.com/viewarticle/976670_1

5. Ultrasound renal denervation meets primary efficacy endpoint in RADIANCE II study. Cardiovascularnews. 26th July 2022.

6. Florian Rader, Ajay J. Kirtane, Yale Wang, et al. Durability of blood pressure reduction after ultrasound renal denervation: three-year follow-up of the treatment arm of the randomised RADIANCE-HTN SOLO trial. DOI: 10.4244/EIJ-D-22-00305

Typesetting: Yixin Editorial Department

Lawyers interpret the ZhangJike storm: if you collude with creditors to extort Jing Tian, it will constitute an accomplice in extortion.

A few days ago, ZhangJike was exposed to a gambling debt dispute and spread private videos of others, which caused widespread concern. Seeing the rumors getting worse, ZhangJike issued a lawyer’s statement, claiming that some users’ comments had infringed on ZhangJike’s reputation, and investigation and evidence collection have been carried out. However, this did not stop the news from continuing. Well-known reporter Li Weiao subsequently published two articles, and the content of the news was more detailed and specific.

Li Wei ‘ao broke the news that the creditor who asked Jing Tian for money was sentenced. If the creditor asks Jing Tian for money by threatening the private video, and the person who gave the private video to the creditor is ZhangJike, does he need to bear legal responsibility in this case?

What kind of legal responsibility will it face to spread other people’s private videos? Will you be sentenced? If sentenced, how long will it take?

Can the celebrity accuse the gossip disseminator of infringement of his reputation right prove that the gossip spread is false? Is it true that the scandal will sue the right of reputation infringement, and the false will sue the crime of libel?

……

With these questions, I consulted lawyer Li Yang of Beijing Yingke (Shanghai) Law Firm and lawyer Liang Keli of Wanshang Tianqin (Shanghai) Law Firm.

You can’t repay your gambling debts, and you use your ex-girlfriend’s private photos to pay off your debts?

At the end of March, some netizens broke the news that ZhangJike had leaked private photos of himself and his predecessor, Jing Tian, to his creditors because he had not paid his gambling debts. After the creditor got the private photos, he asked Jing Tian for money on this matter. Then Jing Tian sued the creditor.

ZhangJike Studio first issued a statement on the 30th, saying: "Mr. ZhangJike has no debt disputes, and there is no case of damaging the privacy of others in order to protect himself. The rumor is purely fabricated."

On March 31, Li Weiao, the chief reporter of Economic Observer, wrote with his real name account: "From some judicial materials I saw and mastered a few years ago, ZhangJike passed on Ms. Jing’s private video to others. This is true." .

On the same day, ZhangJike Studio entrusted a lawyer to issue a statement, saying that some users’ remarks caused ZhangJike.Infringement of reputation rightAt present, investigation and evidence collection work has been carried out, and lawsuits will be filed against key infringing users who have repeatedly published or refused to delete infringing content and caused great adverse effects.

However, ZhangJike’s lawyer’s statement did not prevent Li Wei ‘ao from publishing a message again. Li Weiao then issued two more articles, and the content of the news was more detailed and specific.

Li Weiao revealed that the judicial materials showed that there were 3 private videos of Ms. Jing and 1 video screenshot. ZhangJike admitted that he had shown others a segment of the above video. In addition, ZhangJike was sued by his creditors (and his family) a few years ago. After the prosecution, after mediation, Zhang returned the creditor (and family) 1 million yuan. However, ZhangJike’s IOU is 5 million yuan, and that IOU is still in the hands of creditors (and family members). He also said that ZhangJike’s debt and video problems were not simply "gossip" of celebrities, but caused a serious criminal case. In this case, Ms. Jing is a complete victim. ZhangJike’s creditor, who asked her for money, later pleaded guilty and is still serving his sentence.

After Li Wei ‘ao broke the news again, some media reported that he had contacted ZhangJike himself. ZhangJike denied the debt and the photos. But when asked whether there was no debt or no photos, ZhangJike hung up.

On April 2, ZhangJike’s attorney responded to the media that this matter has actually been responded. One is that the studio has completely denied it. "Another, we are entrusted to investigate the facts of infringement and are ready to sue immediately."

Lawyer’s interpretation:

Winning the case of reputation right doesn’t mean that the gossip is false, and the fake star statement may also be infringing.

Under what circumstances should I bear legal responsibility for spreading other people’s private videos?Lawyer Li Yang said to the analysis that the dissemination of other people’s private videos may constitute an infringement of others’ privacy. If the content of private videos is sensitive and the scope of dissemination is wide, it may also constitute the crime of spreading obscene articles. According to Article 364 of the Criminal Law, whoever disseminates obscene books, periodicals, films, audio-visual images, pictures or other obscene articles, if the circumstances are serious, shall be sentenced to fixed-term imprisonment of not more than two years, criminal detention or public surveillance. "If it is a small-scale spread, it is basically necessary for the victims to call the police themselves. butIf it is a large-scale dissemination of obscene articles, the police may actively intervene if they find it at work. However, the latter is unlikely. Unless the perpetrator spreads the private video on the whole network. "Lawyer Li Yang told me.

According to reporter Li Wei ‘ao, he claimed that ZhangJike’s debt and video problems were not simply "gossip" of stars, but caused a serious criminal case. In this case, Ms. Jing is a complete victim. ZhangJike’s creditor, who asked her for money, later pleaded guilty and is still serving his sentence. At the same time, Li Weiao threw a question to ZhangJike: "What role did ZhangJike play in this case, and can he respond publicly?"

If Li Wei ‘ao’s news is true, does ZhangJike need to be responsible in this case? In this regard, lawyer Li Yang said to the analysis that the creditor was criminally held accountable for asking Jing Tian for money, which probably constituted the crime of extortion.ZhangJike’s responsibility depends on whether ZhangJike forms an accomplice relationship with the creditors."For example, if ZhangJike gave private materials to creditors and colluded with them (including consulting together and directing creditors, etc.) to extort Jing Tian, although he did not participate in the extortion, it would also constitute an accomplice in extortion; On the contrary,If ZhangJike only sold or otherwise gave the private information to the creditor, but did not participate in the extortion and did not collude with the creditor, it should not be considered that he should bear criminal responsibility for this crime. "However, it is not easy to judge whether it is collusion or not, unless the creditor can provide evidence such as recording. Or if the creditor confessed that he was colluding with Zhang, and ZhangJike himself admitted it.

ZhangJike Studio issued two statements in response to the storm. In the statement issued by the studio for the first time, it was responded that some infringing users made defamatory remarks about Mr. ZhangJike’s character and private life without any factual basis, slandering him for his involvement in gambling debt disputes, fund fraud and other illegal acts. He also said: "Mr. ZhangJike has no debt disputes, and there is no situation of damaging the privacy of others in order to protect himself. The rumor is purely fabricated." The statement issued by the second entrusted lawyer did not deny the relevant rumors, saying that evidence will be obtained for the infringement of reputation rights.

Many netizens are curious about whether the statement issued by the star studio has legal effect, and whether it is necessary to bear legal responsibility if there is anything contrary to the facts in the statement. In this regard, lawyer Li Yang told the analysis that,The statement issued by the studio is generally only regarded as a public explanation. If there are fabricated facts and other plots, which have adverse effects on others, it may also infringe on the right of reputation.

Others have questioned that ZhangJike is going to sue for infringement of reputation right instead of libel. Why do stars seldom mention criminal "libel" and take civil "infringement of reputation"?Is it true that the scandal will sue the right of reputation infringement, and the false will sue the crime of libel?In this regard, lawyer Liang Yan said to the analysis that this is actually not particularly related to the "true and false gossip", mainly because of the difference between the two. The criminal and civil conditions for filing a case are different, and the requirements for the consequences caused by "insulting" behavior are different. It can be simply understood that the severity of the consequences caused by most of these "celebrity gossip" is not enough to take the criminal "libel". For example, causing someone to go insane or commit suicide because of someone else’s "libel" behavior is a serious situation.

In addition, if the scandal is true, it may involve infringement of privacy rights, etc. It should be noted that we can’t say that "if the privacy infringement is mentioned, it will prove that the scandal is true", but it still depends on the specific case.

butCan it be proved that the gossip spread is false when the star accuses the gossip disseminator of infringement of his reputation right?Lawyer Liang Yan told me that, generally speaking, when a star sues someone for infringement of his reputation, there are two main aspects, namely, whether there is slander or whether there is insult.

Even if the actor provides sufficient evidence to prove that he is spreading the true "facts", he may lose the case because of insulting behavior.At the same time, it may also involve infringing on the privacy rights of others, such as publicizing the physical defects or illness of others.

Although "winning the case of infringement of reputation right" can help us to judge the truth of "the spread scandal" to some extent. However, we can’t simply equate "winning the case" with "the gossip being spread is false", and we need to further analyze and judge rationally.

This year, over 30 cities have adjusted the property market purchase restriction policy: "high-frequency small-step optimization" will become a feature.

  "Cancel the recognition of housing and loan" and "encourage the elderly to buy houses with relatives" …… On March 1 this year, after Zhengzhou became the first city in China to relax the purchase restriction policy, many cities followed up and adjusted the purchase restriction policy.

  Over 30 cities adjust the purchase restriction policy

  According to the incomplete statistics of The Paper, this year, it includes Zhengzhou, Qinhuangdao, Fuzhou, Quzhou, Lanzhou, Shaoxing, Foshan, Shenyang, Huizhou, Zhongshan, Dongguan, Jurong, Changsha, Yangzhou, Hefei, Shenyang, Hangzhou, Huzhou, Yinchuan, Dalian, Harbin, Tangshan, Wuxi, Jiangmen, Guangzhou, Jiujiang, Nanjing, Wuhan.

  In these cities, some announced the abolition of the original restrictive measures, some announced the narrowing of the scope of purchase restrictions, some lowered the threshold of purchase restrictions, and some cities made it clear that families with many children and relatives could increase the number of places to buy houses.

  Take Tianjin as an example. On September 16th, according to "Tianjin Housing and Urban-Rural Development", the Tianjin Municipal Housing and Urban-Rural Development Committee and other seven departments jointly issued the Notice on Further Improving the Real Estate Regulation Policy to Promote the Healthy Development of the Real Estate Industry (hereinafter referred to as the Notice). The Notice mentioned that new citizens and college graduates who are not registered in this city and are employed in this city can buy in Tianjin with social insurance or personal income tax certificates for six consecutive months.

  According to the "Implementation Opinions on Deepening the Regulation of the Real Estate Market in Tianjin" issued by Tianjin on March 31, 2017, families with non-Tianjin household registration who purchase houses in this city need to provide proof of continuous payment of social insurance or personal income tax for more than 2 years in Tianjin within 3 years.

  In terms of supporting the demand for improved housing, the Notice proposes that families with members aged 60 and above and families with many children who have two or more children can purchase another set of housing on the basis of the original housing purchase restriction policy in Tianjin with the household registration book.

  Guan Rongxue, an analyst at Zhuge Housing Data Research Center, pointed out that in the original policy, it was clear that non-Tianjin registered residents were required to provide proof of continuous payment of social insurance or personal income tax for more than two years within three years in this city, and now it is adjusted to only provide social insurance or individual income tax for six consecutive months, which lowered the threshold for buying a house; Secondly, for families with members aged 60 and above and families with many children who have two or more children, one set can be purchased, which fully considers the housing needs of different age groups and reasonably relieves the contradiction between supply and demand.

  The policy of Suzhou and Qingdao is now "one-day tour"

  However, in the above-mentioned cities that announced the adjustment of the purchase restriction policy, there have also been cases in which policies have been introduced and adjusted.

  Taking Qingdao as an example, on September 15th, WeChat official account, the official WeChat of Qingdao Urban and Rural Construction Bureau, released "Dynamic Improvement of Real Estate Policy in Qingdao". The New Deal is clear, and the purchase restriction policy will continue to be implemented in Shinan District and Shibei District (except the original Sifang District).

  At the same time, continue to clarify the purchase of housing. For new commercial housing in the restricted area, local residents are restricted to purchase 2 sets, families with two children and three children can purchase 1 set, and foreign residents can purchase 1 set after living for half a year; Second-hand housing is no longer restricted.

  However, on the same day, Qingdao Housing and Urban-Rural Development Bureau deleted the statement that "second-hand housing is no longer restricted".

  On the afternoon of September 16th, the relevant staff of Qingdao Housing and Urban-Rural Development Bureau told The Paper that in the new policy, the restricted purchase area of second-hand houses has been adjusted, and the restricted purchase policy is still implemented for first-hand houses and second-hand houses in Shinan District and Shibei District, while the restricted purchase is released for first-hand houses and second-hand houses in other areas.

  On September 14th, market news came out that Suzhou City, Jiangsu Province has made adjustments to the purchase restriction policy, and non-Suzhou local residents can directly purchase the first suite without providing proof of social security payment.

  According to the New Deal, the six districts in Suzhou (including Xiangcheng District, gusu district District, Wuzhong District, Wujiang District, Industrial Park and High-tech Zone) have adjusted the policies for foreigners to buy the first suite, and it is no longer necessary to show social security certificates or tax certificates.

  Subsequently, The Paper confirmed from the real estate departments in various districts that the above policies were indeed adjusted. However, on September 16th, The Paper learned from the real estate departments of gusu district, Xiangcheng District, Wuzhong District, High-tech Zone and Industrial Park in Suzhou City, Jiangsu Province that the purchase restriction policies of gusu district, Xiangcheng District, Wuzhong District, High-tech Zone and Industrial Park for non-registered households have been restored to the original policy, that is, the conditions for non-registered households to purchase houses are to pay social security for six consecutive months in Suzhou within three years.

  Chen Wenjing, director of market research in the Index Division of the Central Finger Research Institute, believes that under the guidance of the central government’s orientation of "housing and not speculating", the efforts of policy optimization in first-and second-tier cities are generally weak, and high-frequency small-step optimization in various places has become a major feature of real estate policy adjustment this year.

  Chen Wenjing pointed out that the recent cancellation of the purchase restriction policies in Suzhou and Qingdao has been withdrawn, which further shows that "no speculation in housing" is still the bottom line of the policies. Among all kinds of restrictive policies, the restriction on the purchase of foreign household registration is an important firewall for core cities to achieve "housing and not speculation". In the short term, it is unlikely that hot second-tier cities will completely cancel the restriction on purchases. It is expected that more cities will gradually advance by giving priority to relaxing the restrictions on purchases in suburbs. At the same time, combined with the National Standing Committee at the end of August, "Allow local &lsquo; One city, one policy &rsquo; From the expression of "flexible use of credit and other policies", it is more likely that second-tier cities will reduce the down payment ratio and optimize the "recognition of housing and loans" in the future.

  From a national perspective, Chen Xiao, a senior analyst at Zhuge Housing Search Data Research Center, pointed out that from the perspective of policy trends, policy loosening has gradually shifted from the initial stage of mild relaxation such as initial housing subsidies and relaxation of provident fund loans to a more in-depth stage, that is, the policy loosening is stronger, the coverage is deeper, and the influence is more profound. At present, many cities have released policies to loosen restrictions on purchases, including some hot second-tier cities, and the degree of loosening has gradually expanded, which will play a substantial role in boosting the property market.

  According to the monitoring data of Zhuge Housing Search Data Research Center, the sales area of new houses in 40 cities monitored in August was 14,882,000 square meters, down 10.08% from the previous month and 24.53% from the same period last year. 59,721 sets of second-hand houses were sold in 10 key cities, down 9.23% from the previous month and up 21.27% year-on-year.