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Have you ever paid attention to carcinogens around you? Recently, the topic of "super carcinogen Aspergillus flavus around us" has attracted attention in Weibo.

Aflatoxin is a strong carcinogen produced by Aspergillus flavus! As early as 1993, aflatoxin was classified as a class 1 carcinogen by the World Health Organization, with its toxicity 68 times that of arsenic, 10 times that of potassium cyanide, and 70 times that of dimethylnitrosamine, which is extremely destructive to liver tissue. Regular intake may increase the risk of liver cancer. [1]

In addition to aflatoxin, there are actually some "carcinogens" around us, which are likely to enter the diet and life every day.

1. Aflatoxin: moldy grain and nuts.

Among moldy foods, one kind of mildew comes from Aspergillus flavus, especially in grain. In 2007, an assessment of dietary exposure of Chinese aflatoxin published in China Journal of Food Hygiene pointed out that corn and rice were the main contribution foods to dietary exposure of Chinese aflatoxin. [2]

Reproduction and use of copyright pictures in the gallery may lead to copyright disputes.

In addition, peanuts and peanut oil may also contain aflatoxin.

Common sources of aflatoxin

Moldy corn, rice

Moldy, especially in foods with high starch content, such as corn and rice.

Deteriorated nut

When you eat bitter nuts, you must spit them out immediately and rinse your mouth.

Broken and unclean bamboo and wood chopsticks

Chopsticks themselves will not grow Aspergillus flavus, and starch is easily hidden in unwashed chopsticks, which poses a risk of mildew.

Inferior sesame paste

Using inferior and deteriorated sesame seeds and peanuts as raw materials, aflatoxin may exist in peanuts.

Earth-pressed peanut oil

Some "earth-squeezed oil" or self-squeezed oil has no quality control, and the equipment is not easy to be thoroughly cleaned, and the residual oil stains and grain residues are easy to mildew. [3]

2. benzopyrene: food that has been roasted and fried at high temperature.

Pan Zhanhe, deputy chief physician of the Oncology Department of Zhongshan Hospital affiliated to Xiamen University, said in the Health Times article in 2017 that heterocyclic amines and polycyclic aromatic hydrocarbons may be produced in the production process by barbecue or smoking, among which the most well-known one is benzopyrene, which may be contained in many baked and smoked foods. [4]

A study published in Jinan University in 2018 found that the intake of polycyclic aromatic hydrocarbons in the barbecue process was: eating barbecue food > skin contact > lung inhalation.

This means that during barbecue, the skin absorbs more carcinogens than the lungs inhale. [5]

Common sources of benzopyrene

roast

It may be produced during barbecue or smoking.

High temperature fried food

Cooking oil will produce a lot of benzopyrene at high temperature, and the higher the oil temperature, the more it will be produced.

Cooking oil fume

The cooking fume will also carry benzopyrene, so don’t wait for the oil in the pot to smoke before putting the food. [6]

3. nitrosamines: smoked and pickled food.

Zhang Qin, vice president of Jiangsu Cancer Hospital, said in the program "Meeting a Famous Doctor" on Jiangsu City Channel in 2019 that smoked bacon food contains a lot of nitrosamines, and the incidence of some digestive system tumors, such as esophageal cancer, is related to the intake of nitrosamines in the diet. When smoked food and wine are ingested together, the harm of nitrosamines to human health will multiply. [7]

Reproduction and use of copyright pictures in the gallery may lead to copyright disputes.

Pickled products often contain more nitrite. Although nitrite itself does not cause cancer, it will combine with protein to form nitrosamines when it enters the body. In addition, some nitrosamine compounds, such as nitrosodimethylamine, will be produced in the process of dehydration of Chinese salted fish, which are carcinogenic. [8]

Common sources of nitrosamines or nitrites

Processed meat products

Nitrite is added to some processed meat products such as sausages, ham and bacon.

Overnight dish

Overnight vegetables, especially overnight green leafy vegetables, will produce nitrite, and the nutrition will be discounted.

Smoked and cured food

Pickles, salted fish, bacon, high-salt pickled and smoked foods contain nitrite. For example, the most nitrite in pickles is between two or three days and ten days after the start of pickling. [9]

4. Tobacco tar: inhaled by tobacco burning.

Smoking and second-hand tobacco smoke are classified as Class 1 carcinogens. During the burning process of cigarettes, nearly 4000 new chemicals are formed. Most of these substances are harmful to people, among which nicotine, nitric oxide and tobacco tar are the most harmful, and the latter is the chief culprit of cancer. [10]

Moreover, smoking is not only a kind of cancer that causes lung cancer, but also closely related to the occurrence of nasopharyngeal carcinoma, oral cancer, esophageal cancer and other related cancers.

5. Acetaldehyde: an intermediate product produced after drinking.

The main component of wine is ethanol, which is oxidized into acetaldehyde after entering liver cells. The latter is hepatotoxic and carcinogenic, and excessive accumulation in the body will cause serious harm to the liver. [11]

Reproduction and use of copyright pictures in the gallery may lead to copyright disputes.

Acetaldehyde related to the intake of alcoholic beverages is classified as a class 1 carcinogen. According to the statistics in the 2014 World Cancer Report, 3.5% of cancers are caused by alcohol, and one in every 30 cancer deaths is caused by alcohol. [12]

Although there are various carcinogens around us, carcinogens can cause some cancers, which refers to a possibility after long-term and excessive intake. If you only eat a little occasionally or touch it occasionally, don’t worry, it’s still safe.

Original title: "Five super carcinogens hidden around you, see if you eat them often! 》

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    Xinhua News Agency, Beijing, January 17th (Reporter Pan Jie, Han Jianuo) According to the data released by the National Bureau of Statistics on the 17th, the gross domestic product (GDP) in 2024 was 134,908.4 billion yuan, an increase of 5.0% over the previous year at constant prices.

    "In 2024, China’s economy overcame various difficulties and challenges brought about by the complex internal and external environment, successfully achieved the main expected goals and tasks, and promoted the effective improvement of economic quality and reasonable growth of quantity. The high-quality development was full of color and the results were not easy." Kang Yi, director of the National Bureau of Statistics, said at the press conference of the State Council Office that day.

    Under the conditions of increasing external pressure and internal difficulties, China’s economic aggregate reached a new level in 2024, surpassing 130 trillion yuan for the first time, ranking second in the world in scale. Globally, China’s 5% economic growth rate ranks among the top in the world’s major economies and continues to be an important power source for world economic growth.

    Quarterly, GDP increased by 5.3% in the first quarter, 4.7% in the second quarter, 4.6% in the third quarter and 5.4% in the fourth quarter. From the ring comparison, GDP increased by 1.6% in the fourth quarter.

    Kang Yi said that in view of the slowdown of China’s economic growth in the second and third quarters of 2024, the CPC Central Committee strengthened macro-control according to the situation, and a package of policies was issued in time, which effectively boosted social confidence and promoted an obvious economic recovery. In the fourth quarter, the growth rates of industrial added value above designated size, service added value and total retail sales of social consumer goods in China were 0.7, 1.0 and 1.1 percentage points faster than those in the third quarter, respectively.

    In the past year, China’s high-quality development has achieved new results, ensuring and improving people’s livelihood has been solidly promoted, grain output has reached a record high, and risks in key areas have been effectively resolved in an orderly manner. In 2024, the proportion of the added value of high-tech manufacturing and equipment manufacturing industries above designated size in the added value of industrial enterprises above designated size rose to 16.3% and 34.6% respectively, up by 0.6 and 1.0 percentage points respectively over the previous year. The national urban survey unemployment rate averaged 5.1%, down 0.1 percentage points from the previous year; The per capita disposable income of residents increased by 5.1% in real terms, keeping pace with economic growth.

    "We must also be soberly aware that the adverse effects brought about by the external environment are deepening, domestic demand is insufficient, some enterprises have difficulties in production and operation, and people’s employment and income are under pressure. There are still many hidden dangers, and it takes hard work to promote economic recovery." Kang Yi said: in the next stage, we should face up to difficulties, strengthen our confidence and take the lead, turn all favorable factors into development achievements, and constantly promote the sustained economic improvement in accordance with the decision-making arrangements of the Central Economic Work Conference.

() The operating comments of the Board of Directors in 2023 are as follows:

　　I. The industry in which the company is located during the reporting period.

　　During the reporting period, the company mainly engaged in LED, semiconductor memory new generation information technology business, comprehensive energy service business and advertising media business, providing customers with customized and integrated solutions.

　　(a) the new generation of information technology business in the industry

　　1. LED industry

　　China has written its strong support for the development of the third-generation semiconductor industry into the Tenth Five-Year Plan. LED is an important industry field of the third-generation semiconductor and has been widely used in many application scenarios such as lighting, backlight and display. 2023 is a year in which challenges and opportunities coexist: the downward pressure on the global economy has not diminished, the impact of global public health events has weakened, the macro economy has gradually recovered, and the overall market is still full of vitality; New challenges, new opportunities, new technologies and new applications coexist, and the LED industry as a whole is under pressure to repair. During the reporting period, the concentration of packaging links continued to increase and the competition became increasingly fierce; The overall revenue of the packaging industry is under pressure, and the sub-sectors such as automotive electronics and MiniLED are growing rapidly; The demand recovery of overseas lighting market has accelerated and exports have accelerated; Domestic market segments such as municipal lighting, commercial lighting and educational lighting are picking up, driving the LED industry forward.

　　2. Semiconductor memory industry

　　The semiconductor memory industry naturally has a strong periodic property. Since the second half of 2022, the unbalanced state of oversupply in the storage market caused by sluggish terminal demand and high inventory of enterprises has led to the decline of NANDFlash and DRAM prices for four consecutive quarters from Q3 2022 to Q2 2023. During this period, the original storage factories started to reduce production and continued to reduce production, drastically reducing supply, trying to slow down the downward trend of prices and reduce inventory pressure; However, the production reduction effect has a time limit, and the continuous decline of this price has caused huge performance losses to the original storage factory, and the continuous decline will even affect the medium and long-term technology investment and capacity planning. As a result, under the change of strategy of giving up the market share and turning to restoring profitability as the primary goal, the original storage factory began to strongly increase the storage price from the third quarter of 2023. The storage market became a de facto low point in the second quarter of 2023. In the third quarter, the prices of some products diverged, and in the fourth quarter, the storage prices rose in an all-round way. In the second half of 2023, the storage price rebounded, breaking the downward trend since the third quarter of 2022, and the price returned to the upward track.

　　According to the data of CFM flash memory market, the global storage market scale decreased by 20%, increased by 9% and increased by 16% in the first quarter, the second quarter and the third quarter of 2023, respectively. It is expected to maintain the double-digit growth rate in the fourth quarter and resume the year-on-year growth, but the storage market scale in 2023 will still decrease by 38% to 86.8 billion US dollars year-on-year. In 2023, eSSD, with enterprise/server as the main application field, consumed about 29% of the global NANDFlash production capacity, Mobile products with smart phone applications as the main consumption capacity, and cSSD with PC applications as the main consumption capacity.

　　Affected by the continuous production reduction of the original factory, the rising wafer price, the month-on-month warming of the three major storage application markets of PC, mobile phone and server in the second half of 2023, and the acceleration of artificial intelligence, the income change of storage application manufacturers showed a trend of first restraining and then rising, and it became a low performance in the first quarter of 2023. Stimulated by the rebound of storage prices in the third quarter, the market demand for stocking increased rapidly, which led to the gradual increase of storage application manufacturers’ income and the rebound of operating profit margin.

　　(2) Comprehensive energy industry

　　In essence, comprehensive energy service is to change the previous mode of separate planning, design and operation of electricity, gas, cold and heat, and coordinate and optimize the distribution, conversion, storage and consumption of all kinds of energy in operation by means of information technology, intelligent technology and management improvement. Its core value lies in improving energy utilization efficiency and realizing energy conservation and emission reduction.

　　Energy conservation and emission reduction is an inevitable requirement to achieve the policy goal of "carbon neutrality". Under the background of "carbon neutrality" policy, the country has successively introduced the policy of "double control of energy consumption" in terms of total energy consumption and intensity, and gradually turned to the policy of "double control of carbon emission", further highlighting the value of energy-saving services. The development of energy-saving service industry promotes the demand for comprehensive energy services.

　　(3) Advertising media industry

　　In 2023, with the outbreak of AI big model, the rise of small program games and micro-short plays, China’s Internet advertising industry has significantly demonstrated the characteristics of diversification, innovation and intelligence. According to China Internet Advertising Data Report 2023, the scale of Internet advertising market in China is estimated to be 573.2 billion yuan in 2023, an increase of 12.66% compared with 2022, and the growth rate tends to be flat and the competition is intensified. With the further increase in the proportion of Internet advertisements, short video advertisements and effect advertisements, TV advertisements, long video advertisements and brand advertisements are on the decline, and TV advertisements and long video advertisement service providers are facing the challenges of shrinking market demand, fierce competition and transformation and upgrading.

　　II. Main businesses of the Company during the reporting period

　　(A) a new generation of information technology services

　　1. LED business

　　The company is mainly engaged in the midstream packaging and downstream application business of the LED industry. It is a comprehensive provider and service provider of high-end LED light source device packaging, LED lighting application products and LED lighting engineering integrating R&D, design, production, sales and construction, providing customers with customized and integrated solutions.

　　The company’s LED light source device packaging mainly includes SMD, LAMP, IRM and large-size backlight products, which are widely used in consumer electronics, TV backlight, fire protection and security, automotive electronics and smart home. LED lighting products mainly include three-proof lamps, street lamps, industrial and mining lamps, panel lamps, lamp tubes and advertising identification modules, lamp strips, straight lamps, blackboard lamps and classroom lamps, which can be used in the fields of rail transit lighting, municipal lighting, sign lighting, commercial lighting and educational lighting.

　　2. Semiconductor memory service

　　The main body of the company’s semiconductor memory business is Wanrun Semiconductor, a holding subsidiary. During the reporting period, Wanrun Semiconductor mainly focused on the design, research and development and sales of semiconductor memory in accordance with the idea of R&D and sales first. Since its establishment, Wanrun Semiconductor has adhered to the market demand, and formed a product matrix with solid state disk (SSD) and embedded storage (eMMC) as the main forms, which can be applied to storage application scenarios such as consumer, industrial and enterprise.

　　During the reporting period, Wanrun Semiconductor mainly focused on the design, research and development and sales of semiconductor memories; Adhere to market demand guidance, conduct product design, R&D and material selection through research and testing of storage medium characteristics, development of storage application technology, etc. According to different market demands, purchase wafers or chips, master control chips and other main and auxiliary materials from suppliers, entrust packaging, testing and other links, and then sell them to domestic and foreign customers through direct sales or distribution. Under the distribution mode, it is buyout sales. In order to cultivate the core competitiveness of testing technology, the company invested in the construction of R&D testing line to conduct automatic testing of solid state hard disk (SSD).

　　(2) Comprehensive energy business

　　The company’s comprehensive energy business mainly focuses on cultivating comprehensive energy services such as public buildings and industries, and new energy services such as distributed photovoltaic and wind power.

　　(3) Advertising media business

　　The company is mainly engaged in TV advertising content marketing and Internet digital marketing advertising media business, and the implementation subjects are mainly wholly-owned subsidiaries Xinli Media and Billion Wireless.

　　Third, the core competitiveness analysis

　　1. Advantages of State-owned mixed ownership listed companies

　　The controlling shareholder of the company is Changjiang Industry Group, and the actual controller is the State-owned Assets Supervision and Administration Commission of Hubei Province. Changjiang Industry Group focuses on the national strategy and the construction of modern industrial clusters in Hubei Province, and performs the functions of investment operation subject of provincial strategic emerging industries and investment management subject of provincial industrial investment funds, focusing on building six major industrial sectors, including information technology, biomedicine, modern chemicals, automobiles and parts.

　　As a mixed-ownership listed company controlled by the State-owned Assets Supervision and Administration Commission of Hubei Province and controlled by Changjiang Industry Group, the resource advantages of Changjiang Industry Group in the field of industry and funds will empower and help the company to extend the chain and strengthen the chain, and make it bigger and stronger.

　　2. Technical advantages and qualification advantages

　　Companies adhere to the supremacy of technology, technology is paramount, and constantly pursue technological innovation and progress. During the reporting period, the company established a multi-level scientific and technological innovation management system by selecting and appointing the "Vice President of Science and Technology", introducing the "Chief Engineer" and establishing the "Science and Technology Innovation Department" to enhance its scientific and technological innovation capability and technical strength.

　　During the reporting period, Hengrun Optoelectronics obtained the re-examination of the certificate of high-tech enterprise, was rated as a specialized and innovative small and medium-sized enterprise in Guangdong Province, and was recognized by Dongguan Intelligent Vehicle Internal and External Display and Lighting Engineering Technology Research Center; The qualification certification of light source and lighting products has been strengthened, and some products have passed LM-80, AEC-Q102 or CE, ENEC, CCCF and other certifications. Obtained a number of utility model and design patents; Develop products such as automotive electronic interior lights, infrared invisible light, POBMiniLED and rail transit lighting, enrich product matrix and improve product competitiveness. Rishi Optoelectronics obtained the re-examination of high-tech enterprises and was awarded as a specialized and innovative small and medium-sized enterprise in Shenzhen; Improve the market access qualification of educational lighting products, and the blackboard lamp and classroom lamp series products have passed the standard test; Obtained an American invention patent and a number of utility model and design patents; Actively participate in the formulation of industry standards, and it is an outstanding unit in drafting the White Paper on Education Lighting Industry in China in 2022 and the Group Standard for Energy Efficiency Rating in LED strip. Zhongzhu Tianyou and Wanrun Wisdom were rated as specialized and special new SMEs.

　　The company’s TV advertising business has always been the core agent and deep partner of Zhejiang Satellite TV and Hunan Satellite TV, providing advertising services for advertisers in popular variety shows; Mobile Internet advertising media business has achieved mainstream channel coverage, and it is an important partner of today’s headline, huge amount of Sichuan, Guangdiantong, Interesting Headline, Aauto Quicker, bilibili and other channels. During the reporting period, the company improved the precision delivery and marketing effect and enhanced its core competitiveness by increasing the investment in content creativity and material production, and strengthening the digital and intelligent technology delivery and operation capabilities. During the reporting period, Billion Wireless became the highest A1 agent in today’s headline industry. It was listed in the Qingyun Cup-South China Championship with its "optimized service power", and was successfully selected into the "China Digital Marketing Ecology Map (2023 Edition)" with three major tracks: media agency, creative agency and case agent, and won the 10th TMA mobile marketing award-influence service provider.

　　3. Advantages of industrial chain synergy.

　　The LED business of the company has now formed a collaborative layout of the middle and lower reaches industrial chain integrating packaging, lighting, contract energy management, landscape lighting design and construction. The LED lighting lamps produced by Hengrun Optoelectronics and Rishang Optoelectronics can be combined with the comprehensive energy-saving service of Wanrun New Energy, and applied to the landscape lighting and lighting project of Zhongzhou Tianyou, which has good synergy advantages in cost, delivery, quality assurance and customer service. Hengrun Optoelectronic Co., Ltd. and Sunrise Optoelectronic Co., Ltd. can provide a full range of products for rail transit lighting projects, from station halls to inspection pits, from advertising light boxes to guiding signs, and provide customers with a complete set of solutions.

　　4. Brand and customer advantages

　　After 20 years of development and accumulation, the company has formed a unique brand of LED packaging and lighting application, and its products have been welcomed by the high-end market in terms of technology, quality and customer service. The company has a high brand awareness in the fields of 3C electronic display instructions, TV backlighting, smart home, fire protection and rail transit lighting, advertising logo lighting, etc. It is in the first echelon of the industry, and its customers are mainly listed companies or their subsidiaries, large enterprise groups, brand enterprises, specialized and innovative industries.

　　The company has been an in-depth partner of mainstream TV media such as Zhejiang Satellite TV and Hunan Satellite TV for many years, providing TV advertising content marketing services for advertisers of automobiles, household appliances and consumers, and its main customers include (), () and (). The company’s Internet advertising and marketing services mainly focus on the industry’s head customers in the fields of Internet services and online social interaction. With good brand and operation ability, the company deepened cooperation with the media, obtained credit from the media, and reduced financial pressure.

　　Fourth, the main business analysis

　　1. Overview

　　According to the company’s strategic plan for 2022-2025, the key operations in 2023 are as follows:

　　First, implement the main strategy of the new generation of information technology and consolidate the main business:

　　(1) LED business:

　　During the reporting period, combined with the global macroeconomic and social environment and the development of LED industry in the middle and lower reaches, the company adhered to market demand guidance, dug deep into stock business and actively expanded incremental business, including:

　　1. LED light source device packaging field: adhere to the differentiated market segmentation strategy, actively optimize the customer and product structure, consolidate and dig deep into the LED component market such as consumer electronics, backlight, fire protection and security, smart home, dig deep into the incremental demand of old customers such as (), and actively expand new customers in the home appliance and office application market; Vigorously develop the LED automotive electronics market and achieve effective results. We won the bid for four projects: Hanwang, Wangwang, Tengshi and Destroyer, and newly developed a number of customers to achieve double growth in revenue and profit.

　　2. LED lighting application field: Deeply cultivate the rail transit lighting market, give full play to the advantages of "the first echelon", and win the bid for many projects such as Shenzhen Metro Line 11 and Chengdu Metro Line 30, so as to speed up the delivery of Suzhou Metro and Shenzhen Metro. On the basis of stable identification module, actively lay out strip lighting, increase product research and development, equipment automation and market investment, and realize rapid growth of strip lighting revenue; Make efforts to educate the lighting market, increase investment in product research and development, qualification certification and sales team building, and win the bid and deliver the educational lighting projects of many schools such as Sichuan and Hainan; Strengthen the construction of distribution channels at home and abroad, expand the market coverage, and increase the promotion of product business at home and abroad. It has successively appeared in the 15th Shanghai International Automobile Lamps and Vehicle Lighting Technology Exhibition, the 6th China China International Import Expo(CIIE), the 25th Hong Kong Autumn Lighting Exhibition and other large-scale exhibition activities, and actively went to Europe, America, Southeast Asia and other overseas countries or regions to conduct on-the-spot market research and visit customers.

　　3. LED lighting engineering field: Efforts have been made to develop LED lighting engineering business in relatively developed areas and cities and increase the collection of creditor’s rights. However, due to the macroeconomic environment, the progress of contracted projects, the landing of new projects and the collection of creditor’s rights are less than expected.

　　(2) Semiconductor memory business:

　　The main body of the company’s semiconductor memory business is Wanrun Semiconductor, a holding subsidiary. During the reporting period, Wanrun Semiconductor achieved an operating income of about 128 million yuan, and its main work is as follows:

　　1. Due to the recovery of the downstream application market demand and the reduction of the upstream wafer factory to accelerate the destocking of the industrial chain, the semiconductor memory industry gradually entered the upward cycle in the second half of 2023, and Wanrun Semiconductor seized the market opportunity and vigorously explored the market;

　　2. Strengthen the construction of talent team, introduce professional talent teams in R&D technology, supply chain development and market channels, implement the employee stock ownership plan, and stimulate the entrepreneurial motivation of the officers;

　　3. Intensify research and development, focusing on testing technology and gradually improving firmware technology; Building a research and development laboratory; In product research and development, it has the independent hardware design ability of storage module; In testing, the solid state hard disk (SSD) test line has been built, the internal test specifications of various storage products have been formulated, the development of automatic test equipment and mass production test software has been carried out, and the mass production aging tester and sample tester have been successfully developed; In the R&D test, research and develop flash memory chip test technology with Huazhong University of Science and Technology to create an independent and controllable flash memory particle screening technology; Since its establishment at the end of 2022, 39 new products have been developed, involving storage application scenarios such as consumer, industrial and enterprise. Some products have completed CE, FCC, RoHS certification or professional platform certification such as Loongson and Haiguang, and entered the stage of mass production sales or small batch trial production; Declare and obtain invention patents and software copyrights; Obtained ISO9001:2015 quality system certification;

　　4. Accelerate the channel construction. The company adopts the sales practice of semiconductor memory industry, sells to domestic and foreign customers such as China Mainland, Hong Kong, China, Taiwan Province and Japan through direct sales and distribution channels, and establishes partnerships with many distribution channels to accelerate market development;

　　5. Accelerate the brand building of MasonSemi: register the trademark of "Changjiang Wanrun"; By building websites and making product manuals to promote enterprises and products, by holding a sub-forum on the development of storage semiconductor industry in the Science and Technology Innovation Week of Changjiang Industry Group to release new products and technical cooperation, and by participating in large-scale activities such as the exhibition of domestic storage products in China International Import Expo(CIIE), Shanghai, the visibility and influence of Wanrun Semiconductor and its product brands will be improved.

　　The second is to implement the sub-strategy of comprehensive energy services and stabilize the chassis:

　　During the reporting period, the company successfully acquired 100% equity of Fuxin Kaidi New Energy Development Co., Ltd. and Heping Lukaidi New Energy Development Co., Ltd., and quickly cut into the new energy field of wind power; The completion of the () 5.99MW distributed photovoltaic project under the controlling shareholder has enhanced the company’s profitability, stabilized the company’s development chassis, and laid a solid foundation for the promotion of "main industry".

　　Third, promote the advertising media business to upgrade to integrated service providers and promote high-quality development:

　　First, shut down the advertising media business with losses and weak profitability in time to reduce costs and increase efficiency; The second is to increase investment in the production and intelligent operation of content materials, upgrade to comprehensive service providers of creative planning and technical operation, and improve the added value of services; Third, actively optimize the customer and product service structure, increase the development efforts of head customers, brand customers and direct sales customers, and improve the ability to resist risks and profitability; Fourth, constantly enrich the media channels, dig deep into the needs of customers for multimedia advertising, and improve customer stickiness.

　　Fourth, deepen the reform and improve the quality and efficiency of operation and management;

　　According to the action deployment requirements of "year of improving management efficiency" and "year of deepening reform", we have taken various measures to promote deepening reform by making a list of key tasks, organizing special seminars, and investigating and communicating with grass-roots units, and achieved remarkable results in operational management. First, strengthen business scheduling and empower subsidiaries to develop; Second, strengthen overall financing management, broaden financing channels and reduce financial expenses; The third is to fully launch the financial Kingdee system to improve financial management and control capabilities and work efficiency; The fourth is to establish and improve the innovation incentive mechanism to stimulate the entrepreneurial atmosphere of the officers.

　　Fifth, lose weight and keep fit, and achieve practical results in the disposal of assets:

　　Firmly implement the strategic plan, shut down and transfer the low-quality and inefficient subsidiaries, businesses and projects with small revenue scale, long-term losses and lack of development prospects, further improve the efficiency of asset allocation, and achieve slimming and fitness, reducing burdens and increasing efficiency. First, shut down the loss-making advertising media business in time to reduce expenses; The second is to transfer the comprehensive energy subsidiary whose development is restricted to realize efficiency improvement and capital recovery; The third is to actively revitalize idle real estate to generate income and increase efficiency.

　　Sixth, strengthen the responsibility to ensure a stable and orderly production safety;

　　In strict accordance with the principle of "safety must be managed in the industry, safety must be managed in the business and safety must be managed in the production and operation", the company will do the work of safety production in detail, and the overall safety situation of the company in 2023 will be stable and orderly.

　　V. Prospect of the Company’s Future Development

　　(A) the industry pattern and trends

　　1. Semiconductor memory industry

　　Integrated circuit industry is one of the basic and core industries of modern information industry. Semiconductor storage is an important branch of integrated circuit industry, which is widely used in artificial intelligence, cloud computing, automotive electronics, industrial control, data center, consumer electronics and other fields. The downstream application scenarios of industrial chain are rich and the market demand is broad. According to the forecast of CFM flash memory market, on the basis of improved demand and price recovery, the global storage market will rebound strongly by 48% in 2024, returning to the level of 2020 (US$ 128 billion). Among them, the growth rate of DRAM will exceed that of NANDFlash, which will drive the growth of the whole market.

　　With the accelerated evolution of the world’s unprecedented great changes in the past century, the central government and the Hubei provincial government have paid more and more attention to the development of the integrated circuit industry, and have launched a series of industrial support policies to achieve independent security and controllability. Among them, the Ministry of Industry and Information Technology and other six departments jointly issued the Action Plan for High-quality Development of Computing Infrastructure, encouraging the use of independent storage devices in key information infrastructures, and promoting the localization application of key storage components through all-flash storage machines; The Hubei Provincial Government issued the Action Plan for Accelerating the Construction of "Optical Valley of the World", proposing to develop memory chips with the focus on national memory bases, accelerate the domestic substitution process of key equipment, basic raw materials and core components, and gradually establish an independent and controllable industrial chain and supply chain system to promote the overall improvement of domestic semiconductor manufacturing level and accelerate the construction of "World Storage Capital". The domestic semiconductor memory industry will usher in great development opportunities, and domestic semiconductor memory manufacturers will have broad growth space.

　　2. LED industry

　　According to TrendForce Jibang Consulting’s "2024 Global LED Lighting Market Analysis -1H24", it is predicted that in 2024, 5.788 billion LED light sources and lamps will be retired after reaching the service life limit, which will bring considerable demand for secondary replacement. It is estimated that the global LED lighting market is expected to grow by 4% to 60.9 billion US dollars in 2024. As the largest producer and exporter of global LED industry, there will be many opportunities in China’s LED lighting market. In addition, at present, the overall development of LED industry has entered a critical period of phased transformation, and leading enterprises in the industry continue to increase investment in research and development of new technologies and new products to seize emerging and fast-growing markets. With the development of LED technology and the improvement of technical performance, energy efficiency ratio and cost performance of LED products, LED application scenarios are constantly expanding, and the market segments such as automotive LED electronics, infrared invisible light and MiniLED will accelerate their growth, and the product penetration rate is expected to continue to increase, providing more development opportunities for the industry.

　　3. Comprehensive energy industry

　　The energy-saving and environmental protection industry has been recognized as a strategic emerging industry by the state. There are a large number of energy-saving needs in manufacturing, smelting, petrochemical and other industrial enterprises, and there is also a large space for energy-saving transformation in public institutions such as the government and buildings and facilities in commercial or civil fields.

　　At present, comprehensive energy services are still in the initial stage in China. With the change of economic situation and the expansion of service targets, the demand for comprehensive energy services will be more and more extensive, and the market potential will be gradually released.

　　4. Advertising media industry

　　Science and technology development and data drive are two carriages that drive the development of digital marketing industry. With the continuous development of artificial intelligence, big data, Internet of Things and other technologies, the advertising industry will be further digitized and intelligent, and artificial intelligence, big data and other technologies will be used to improve the advertising effect and delivery accuracy. At the same time, influenced by the new model, new ecological development and changes in consumer behavior, the advertising industry will show the development trend of cross-border integration and integrated marketing.

　　(II) Company development strategy

　　The company will firmly implement the "14th Five-Year Plan" development strategy, vigorously develop a new generation of information technology "main industry" with LED and storage semiconductor electronics industries as the core, cultivate and develop a "subsidiary industry" of comprehensive energy services, build a new development pattern of "one master and one deputy" representing new quality productivity, adhere to the basic policy of making excellent stocks and expanding increments, and coordinate and integrate through "one investment, two turns to three development", two-wheel drive of industry and capital, and resource sharing. Realize the kinetic energy conversion and high-quality development of old and new industries, enhance core competitiveness, expand income scale and improve profitability, so that the company will become a new generation of scientific and innovative listed companies with industry influence in the field of information technology.

　　(3) Main business plan

　　1. Adhere to strategic focus and strengthen investment in mergers and acquisitions.

　　In 2024, the company will maintain strategic strength, adhere to strategic focus, and strengthen investment and mergers and acquisitions in the field of new quality productivity of LED automotive electronics and semiconductor memory. The company will actively tap resources such as Wanrun Technology and the controlling shareholder system, the Yangtze River Economic Belt, Guangdong-Hong Kong-Macao Greater Bay Area and so on through two junior college classes of LED automotive electronics and semiconductor memory, give full play to the platform role of Hubei state-owned holding and market-oriented listed companies, and realize the extension of LED and semiconductor memory main industries through endogenous investment and/or outreach mergers and acquisitions, make them bigger and stronger, realize the transformation and upgrading to a new generation of information technology main industries, and effectively promote the strategic planning.

　　2. Insist on promoting stability by making progress, and strive for development after establishing first.

　　In 2024, the company will speed up the adjustment of business structure and enhance profitability by striving for progress in stability, promoting stability in progress, advancing with multiple heads, and breaking first.

　　(1) Deeply cultivate LED market segments and make LED business bigger and stronger.

　　LED light source device packaging field: adhere to the strategy of mid-to-high-end, differentiated market segmentation, and on the basis of consolidating the first echelon of 3C market, first, increase investment in automotive electronic product lines and related supporting facilities, establish industry-leading automotive electronic product production lines and management systems, and achieve breakthrough growth in automotive electronic product revenue; The second is to dig deep into the infrared invisible light market, focus on the fire security and smart home market, and open up more new application fields at the same time; Third, actively expand new mid-to high-end market segments and accelerate the development and mass production of new products such as POBMiniLED and equipment visual inspection.

　　LED lighting application fields: First, strengthen the construction of domestic and foreign brands and marketing channels, explore the "Belt and Road" market through going out and bringing in, expand the sales scale, especially the ODM channel, focus on developing large customers and industry-leading customers, and improve market coverage; Second, focus on 3C electronics, robots, elevators, automotive electronics and other high value-added applications in the fields of sign lighting and linear lighting, and focus on developing large-scale projects to provide customers with mid-to-high-end, customized integrated solutions to enhance profitability; The third is to upgrade and improve the qualification of educational lighting, optimize and enrich eye protection lighting products such as classroom lights and blackboard lights, enhance the market competitiveness of products and expand the business scale; Explore the application markets of municipal lighting, educational lighting and rail transit lighting within the controlling shareholder system and in Hubei, give play to the synergistic integration effect, and expand the market share in Hubei.

　　LED lighting engineering field: Give full play to the advantages of lighting engineering, take Guangdong-Hong Kong-Macao Greater Bay Area, Chengdu-Chongqing Economic Circle and Central China as key areas for business development, and focus on and tap the lighting update needs of cities and cultural tourism involved in major events such as the 2025 Bay National Games; Actively expand professional lighting and intelligent lighting engineering business; Tap the market demand and project resources within the controlling shareholder system and Hubei area, give play to the synergistic integration effect, and expand the lighting engineering and electromechanical engineering business.

　　(2) Accelerate the layout of semiconductor memory business and cultivate performance growth points.

　　Improve product layout and enrich product matrix: focus on providing high-quality storage solutions, promote the update iteration of original flash memory consumer products, and improve product competitiveness; Accelerate the design, development, testing and certification of industrial, enterprise and vehicle code products of flash memory, expand application scenarios and enrich product matrix; At the same time, adhere to market demand guidance, make full use of channels and technical resources, add DRAM business, and cultivate new growth points.

　　Strengthen brand and channel construction: establish a brand planning department, promote the construction of Yangtze River Wanrun Semiconductor’s own brand and channel by increasing the construction of direct sales and distributors, expanding the independent seaport, and () linkage, increase the market development of products and increase the market share.

　　Strengthen R&D technical ability and cultivate core competitiveness: build core testing technology and promote the construction of high-reliability flash memory laboratory; Continue to promote flash memory characteristics research and particle testing projects, focusing on sub-projects such as memory simulation software development and memory protocol tester development; Accelerate the introduction of mass production of self-developed test equipment; Increase investment in R&D of vehicle regulation products; Strengthen the declaration of intellectual property and high-tech enterprises.

　　(3) tap the potential of existing projects and increase the development of comprehensive energy business.

　　By establishing and perfecting the system, improving the process and emergency solutions, we will do a good job in diagnosis and investigation in time, improve the operation and management capabilities of existing wind power and photovoltaic projects, reduce production and operation costs, and improve production efficiency and benefits; Increase the development and collaborative integration of comprehensive energy services such as public buildings and industries within Wanrun Technology and the controlling shareholder system.

　　(4) The advertising media business keeps the stock stable and improves the quality.

　　First, steadily promote the cooperation of stock head customers such as Dongyangguang, Xilinmen and () in Hunan Satellite TV, Zhejiang Satellite TV and other TV platforms and mobile Internet media platforms, and dig deep into the multimedia advertising demand of stock customers; The second is to further improve the matching degree between media resources and customer needs, and improve customer satisfaction and stickiness around new head channels such as Youku and iQiyi. The third is to continuously improve the content creative planning and technical operation capabilities, and improve the service effect and added value; Fourth, strengthen risk prevention and control in the whole process of business, and do a good job in credit management and debt collection management.

　　3. Strengthen the collection of creditor’s rights, and compact the responsibility to control risks.

　　First, strengthen the efforts to collect overdue creditor’s rights: classify overdue creditor’s rights in detail, manage the overdue creditor’s rights by one enterprise, one policy and one list, compact the responsibility to individuals, and adopt the method of promoting talks by fighting and combining talks with fighting to fully collect debts and reduce risks; Second, do a good job in the management of accounts receivable: strengthen the early warning before maturity, grasp the rhythm of payment, shorten the account period, collect more early, and strictly control the incremental overdue risk; The third is to strengthen incentives and constraints. By strengthening the responsibility of creditor’s rights collection, the effect of creditor’s rights collection will be linked to the management assessment of subsidiaries, and the responsibility of each collection subject will be further compacted to complete the annual collection task.

　　4. Strengthen scientific research and innovation, and work hard to add vitality.

　　Establish and improve the system and mechanism of scientific and technological innovation, focus on strengthening the scientific and technological innovation of new productivity in the fields of LED and semiconductor memory, increase investment in research and development, strengthen the declaration of intellectual property rights, and stimulate the vitality of high-quality development. In the field of LED light source devices, we will focus on the development of LED automotive electronic interior and exterior decoration display instructions and lighting, POBMiniLED and infrared invisible light products; LED lighting application field, focusing on mainstream lighting products, in-depth development in smarter, healthier and more environmentally friendly fields; In the field of semiconductor memory, we will build core competitiveness such as hardware design capability, flash memory chip testing capability and intelligent mass production testing technology, strengthen cooperation with Industry-University-Research, accelerate the transformation of scientific and technological achievements, and become a scientific and innovative listed company with industry influence.

　　5. Enhance coordinated development and promote integration through up-and-down linkage.

　　Focusing on the development strategy and business resources of controlling shareholders, we will accelerate the coordinated development of related industries with controlling shareholders. First, strengthen the functions of the second headquarters in Wuhan, gradually transfer some headquarters management functions to the Wuhan office center, and strengthen communication and linkage within the system; The second is to strengthen the coordinated development of industries, strengthen the docking with resources in Hubei Province, deepen the cooperation with enterprises in the controlling shareholder system in the fields of LED, semiconductor memory, comprehensive energy and automotive electronics, and increase revenue and efficiency through collaborative integration; The third is to promote the interaction between industry and finance, strengthen cooperation with fund companies and investment companies within the controlling shareholder system, and help the development of real industries with industrial investment.

　　6. Deepen fine management and take measures to increase benefits.

　　Firmly establish the "benefit-centered" business philosophy, adhere to the simultaneous promotion of tapping potential and increasing efficiency, increasing revenue and reducing expenditure, and comprehensively improve operational efficiency and quality. First, strengthen operation scheduling: take solving practical problems as the guide, improve the operation scheduling mechanism, find and solve problems in time through on-site coordination and regular supervision, and fully empower subsidiaries; The second is to optimize the control process and establish a hierarchical and classified "one enterprise, one policy" control list to improve the control efficiency; Third, comprehensively strengthen cost control, improve the cost control system, strengthen budget cost control, set the total limit and single limit of cost control, strictly control expenses and unnecessary expenses, and explore the incentive mechanism of cost reduction.

　　7. Adhere to compliance management, prevent risks and build safety.

　　First, improve the risk control system, improve the business risk control mechanism and process, resolve the stock risk and strictly control the incremental risk; Second, strengthen fund management, do a good job in fund scheduling and long-term and short-term fund use planning, expand financing channels and reduce the cost of funds; The third is to strengthen safety management, do a good job in safety production strictly from reality to detail, and build a safe defense line; The fourth is to improve the institutional process system to ensure that there are systems to follow, operate according to processes, and operate in compliance.

　　(4) Possible risks and countermeasures

　　1. Supply chain risk and market competition risk brought about by changes in global macroeconomic and social situation.

　　With the global economic and trade frictions, geopolitical conflicts and other uncertainties and uncertainties in the global macroeconomic and social situation, the normal circulation of the supply chain of the semiconductor electronic industry chain faces certain risks, which may lead to unstable supply of raw materials and large price fluctuations, thus adversely affecting the development of China’s semiconductor industry. If the macroeconomic and social development is less than expected, it will further intensify the market competition in the LED industry, semiconductor memory industry and advertising media industry where the company is located, which may lead to a decline in gross profit margin.

　　The company will closely follow the changes in the supply chain of the global semiconductor electronics industry chain and take appropriate measures in a timely manner to reduce the risks in the supply chain of the industry chain; Focus on high-end differentiated segments, increase product research and development, improve the level of automation and intelligence, and enhance profitability; Strengthen brand and market channel construction and broaden business sources.

　　2. Risk of accounts receivable recovery

　　The customers of the company’s LED lighting projects are mainly government units and institutions. Due to the macroeconomic environment, there is a risk that some "old-fashioned" customers’ accounts receivable cannot be recovered, which is not conducive to the promotion of old projects and the undertaking of new projects, thus affecting their performance. The advertising media business is affected by industry policies and development, customer operating conditions, etc., and there may be risks that individual accounts receivable cannot be recovered on schedule, which will adversely affect performance.

　　The company will strengthen the collection of creditor’s rights, and control the risk of accounts receivable recovery by strengthening the collection, doing a good job in accounts receivable management and strengthening incentives and constraints.

　　3. The development of semiconductor memory business is less than expected.

　　The company has entered the field of storage semiconductors for a short time, and is still in the initial stage of capacity building of products, supply chains, channels and brands. In the course of operation, it may face a series of risks, such as industry development falling short of expectations, unstable supply of main raw materials and price fluctuations, supply chain development and integration, iteration of technological innovation and product upgrading, and brain drain. The company will give full play to the advantages of Hubei State-owned listed company with mixed ownership, located in Guangdong-Hong Kong-Macao Greater Bay Area, tilt its capital, policies, talents and other resources to Wanrun Semiconductor, and support it to effectively expand and strengthen its semiconductor memory business, making it a new generation of information technology main industry of the company.

　　4. Risk of exchange rate fluctuation

　　The company’s lighting business mainly focuses on overseas exports. At present, the RMB exchange rate is subject to a floating exchange rate system, and the company’s international business is settled in foreign currency. The price change of RMB to US dollars and other currencies may bring uncertain influence to the company’s product price competitiveness and income.

　　The company will pay close attention to the exchange rate changes, and reduce the adverse impact of exchange rate fluctuations on the company’s performance by improving product technology innovation and service level and reasonably controlling foreign exchange risk exposure.

　　5. Risk of policy change

　　New energy and comprehensive energy businesses such as wind power and photovoltaic are greatly influenced by industry policies, and the risk that the operating performance of this part of the company fluctuates greatly due to the adjustment and change of industry policies is not ruled out. The company will pay close attention to policy trends, adjust business strategies in a timely manner, cultivate business sectors with policy-oriented layout, and actively participate in the policy formulation process to strive for a favorable industry development environment.

　　6. Risk of impairment of goodwill

　　If the macro-economy and the development of the industry in which the company acquired the enterprise are still less than expected, the operating performance of the company acquired the enterprise may also be less than expected, which will lead to the risk of goodwill impairment and adversely affect the overall operating performance of the company.

　　The company will strengthen its operation and management, empower the development of acquired enterprises, and promote the expansion of its business scale and the improvement of its profitability through measures such as resource coordination, risk control and financial support.

　　Investors are requested to invest rationally and pay attention to risks.

At 9: 00 pm on July 29, 2018, in the courtyard of No.398 Mafangsi, Chaoyang District, Beijing, a man entered the Tianyikang pedicure shop with pornographic services. The store has online promotion and enterprise certification in 58 cities.

58 City, WeChat applet has become a channel for pornographic businesses to attract customers, authentication accounts can be bought for money, and pornographic service businesses have launched multiple platforms.

One-click booking of mobile APP, home-to-home services such as manicure and beauty, laundry and cooking, mobile phone repair and home appliance repair are becoming more and more popular and practical. This business model of online booking and offline experience has attracted many consumers. Health massage and SPA conditioning, which have always been called "the hardest hit area for pornographic services", have also entered the online and offline operation mode, and technicians can be booked to come to the door or to the store with one phone call. The Beijing News reporter’s investigation found that although the police have always maintained a high-pressure crackdown on pornography, some illegal health care and SPA shops secretly conduct pornographic transactions through online and offline modes in an attempt to escape the crackdown.

After opening the WeChat applet or 58 City, the promotion of many SPA merchants seems to be the same as the business introduction of regular clubs. However, after further contact, many merchants actively promote their "special services" in addition to providing regular massages, and even some stores directly recommend "Wan-style services". Through online contact and offline unannounced visits, the Beijing News reporter found that many pornographic dens in Beijing all used this business model to conduct "home-to-home" or "shop-to-shop" pornographic transactions, and the price of each transaction ranged from 800 yuan to 2,400 yuan.

58 merchants in the same city hide foreign female "technicians"

"Men’s private SPA, health massage, kidney care … professional techniques and thoughtful service, welcome to make an appointment by phone", which is not uncommon in 58 cities. Enter "SPA Health Care", and the system shows that there are 1668 businesses engaged in SPA services that can be contacted. But there is no more information except a short text introduction and a few pictures of female technicians.

"It looks the same, but the actual content is still different." One of the merchants told the reporter that every merchant has a phone number, and he has to ask himself to know the service content inside. On July 22, the reporter randomly dialed a number of SPA merchants provided by 58 cities, among which three merchants made it clear that "female technicians" can provide pornographic services at will.

"Big job, one hour in 800 yuan; Small work, 30 minutes in 400 yuan. " At the other end of the phone, the woman who claimed to be "Sister Chen" said.

The reporter asked whether it was possible to provide on-site service, and the other party said that they could only go to the store. As for the specific location, "Sister Chen" only revealed that it was near Shuangjing subway station, "Call me when you arrive". Twenty minutes later, the reporter finally saw "Sister Chen" in a residential building in R&F City.

Although the information released by Sister Chen in the same city in 58 shows that she has passed the "enterprise certification", there is no trace of any storefront here. "The house is rented, 20,000 yuan per month." Sister Chen said. On the sofa in the living room, two women with little clothes are waiting to meet guests. "There are four of us, and one is ringing the clock." Sister Chen pointed to one of the rooms and said.

After introducing the service items in detail again in the room, Sister Chen began to urge the reporter to experience it and hinted that another guest had arrived. When the reporter said that there was no suitable candidate to leave, he saw a man waiting in the living room.

Another SPA merchant, also from 58 cities, is more cautious. Before and after the transaction, guests can only see the "technicians" who have sex with them.

On July 23, the reporter once again contacted a merchant who claimed to provide pornographic transactions through 58 cities. The other party said that it was inconvenient on the phone, and then added the reporter’s WeChat. On WeChat, the other party introduced that they have three stores, which are located in Jianguomen, Dongzhimen and Beishatan, and "all technicians are from abroad".

"Pick a good technician first, so I can arrange it for you." The other party sent personal introductions and prices of 10 "technicians" from different countries, once in 800 yuan. After selecting the technician, the other party gave a room number of an apartment in Dongzhimen. In this room, the reporter saw a female "technician" who claimed to be Russian. In the room, the reporter did not see anyone else.

The club recommended "Wan-style service"

In addition to the "scattered camp" mode of residential buildings or apartments, there are also SPA clubs in 58 cities to provide pornographic services.

Just after 9: 00 p.m. on July 20, at the entrance of No.398 courtyard of Mafang Temple, women with heavy make-up came by car and then walked into the courtyard. This is the common address of an apartment, a car sales company and an auto parts city. However, little known is that a club named "Tianyikang SPA" is also hiding in it. On the right side of the gate, on a piece of ordinary a4 paper, the unremarkable word "Tian Yikang" doesn’t seem to attract too much attention. Turn right at the gate, then turn left, and walk for about 5 minutes before you can find this club. "In the final analysis, it is still for safety." The club’s season manager told reporters.

The contact person of the club had previously told reporters that there are two kinds of pornographic services provided in the store, one is 40 minutes, 1000 yuan; One is 90 minutes, 1500 yuan, "all have big jobs, one-stop service."

After arriving at the store, manager Ji first produced a price list, which only included the price and introduction of foot bath, massage and other items.

"Is there no other service?"

"No more."

"Didn’t you say that there is a Wan-style service?"

"That’s all for now."

However, when the reporter told the name of the contact person and the quotation of the specific project on the 58 th floor where the association was located, the other party immediately changed its mouth: "I will arrange it for you right away." "For strangers, we generally don’t provide these items. If you hadn’t contacted at 58, we wouldn’t have picked them up. Recently, the investigation was strict." Manager Ji said with a smile in a low voice.

Subsequently, a person in charge who claimed to be surnamed Gu took the reporter to a room on the second floor. The room looks not much different from an ordinary hotel room, but the red gauze on the bed, the rotating laser lamp and the decoration of the semi-naked female image all reveal its special atmosphere.

After a while, the person in charge of Gu took a woman into the room and asked the reporter if he was satisfied. The technician also confirmed that he could provide pornographic services.

Another female technician in the store told reporters that the club named "Tianyikang SPA" has been open for about half a year, and the business has been good. There are six or seven women who provide pornographic services. They usually live in a dormitory building in the compound.

According to industrial and commercial information, the club is affiliated to Beijing Tianyikang Health Management Co., Ltd., and its legal representative is Ji Zhitong. It was established in December 2017 with a registered capital of 500,000 yuan.

58 enterprise certification account number: 20 yuan.

Regardless of whether there is a physical storefront or not, on the 58-city APP, the above-mentioned massage businesses involved in pornography all show "passed the enterprise certification", but no specific enterprise information can be seen.

"Although users can’t see it, we will review their corporate qualifications in the background. Only after the approval will it be marked as having passed the enterprise certification. "

On July 23, a staff member in charge of certification in 58 cities introduced that there are more than 1,000 spas or pedicure shops in Beijing in 58 cities. "Basically, they have passed the enterprise certification, which will increase the trust of users." The promotion price is divided into four grades, 4800, 5800, 6800 and 12800 yuan, with a minimum period of one year.

"The first few pages you found were promoted and the effect was very good. 200 items are pushed first, and 200 items are refreshed first. The number of stores ranked first is between 15 and 30 through 58 orders per day. " The above staff said.

Can unqualified businesses pass enterprise certification? The other party replied that the audit was very strict and this would not happen.

In 58 cities, there are four ways to pass enterprise certification, and a series of vouchers need to be uploaded. For example, online real-time authentication of enterprise legal person, authentication of corporate account, photo authentication of legal person’s identity document, etc., but the simplest authentication is ordinary business license, which only needs to upload the company’s business license and fill in the relevant information of the enterprise.

The reporter’s investigation found that many "number merchants" turned the enterprise certification of 58 cities into a kind of business, and 20 yuan could buy a 58 account that passed the enterprise certification.

Lynne (a pseudonym) is one of them. His business is divided into two types, selling 58 accounts that have passed the enterprise certification, each 20 yuan; Enterprise certification accounts in designated regions and industries, each in 60 yuan, should be made according to customer requirements.

The reporter bought three 20 yuan accounts at random, and after logging in normally, it was found that all three accounts had passed the enterprise certification. Lynne told reporters that the audit of 58 cities is not perfect, and the same company can also register multiple accounts. As for how these accounts passed the authentication, Lynne only revealed that "some technology is needed".

In addition to Lynne, entering "58 Enterprise Certification" can retrieve many "number merchants" engaged in the same business.

The small program "door-to-door SPA" hides pornographic services

In addition to 58 cities, there are also businesses that provide pornographic services in the name of "home SPA" on the WeChat applet.

Enter keywords such as "SPA" and "door-to-door" in the column of small programs, and you can see many related small programs. The reporter randomly opened a small program named "Massage SPA on the Upper Gate of Bali Island in Beijing". In the interface introduction, the price of the meridian SPA from 399 yuan to the personal tailor SPA of 1299 yuan varies, and the home page of the small program is marked with "door-to-door service" and the contact information of the customer service of the store.

After adding WeChat, the other party sent photos of a number of female technicians to the reporter to choose from. When the reporter directly asked if his shop had pornographic services, the other party said that "these technicians who sent photos to you only did small jobs, not big ones". Later, another photo was sent to the reporter, saying that the technician in the picture can do "big work" and the price is 1699 yuan.

The customer service staff clearly told him that there is no physical storefront in his home, and he only does on-site service, which is "safer". He also reminded that it is impossible to place an order directly in the WeChat applet. Then the reporter added their WeChat WeChat official account "Beijing Home Conditioning" according to its instructions, and then made an appointment for technicians to come to the house from WeChat official account.

The company behind "Beijing Home Conditioning" is called Beijing Yunfeifan Health Management Co., Ltd.. According to public information, the company’s business scope includes health management, health consultation, education consultation, organization of cultural and artistic exchange activities, conference services and so on.

Xiaoli, a technician of "Beijing Home Conditioning", told the reporter that after placing an order on the platform, users will share it with the store "46%", such as a single 500 yuan, they can get 300 yuan, and the other 200 is the draw of the store. However, if it is after meeting the guests, other newly added projects are simply the income of the technicians themselves.

Xiaoli told reporters that when she was on-site service, the small job was generally 698 yuan, and the middle job was 998 yuan.

"Pornographic health preservation" only does "home"

In another small program called "Beijing Men’s Health SPA", we can see that there are five services to choose from, and the price ranges from 298 yuan to 698 yuan. There are also the store’s mobile phone number and micro-signal on the page for diversion.

After the reporter added the other party’s micro-signal, the other party sent a price list to the reporter, and told the reporter that he could choose technicians online, and then sent nine photos of female technicians to the reporter for selection.

The other party told the reporter that the technology of the applet is not mature enough to place an order online. At present, it mainly plays the role of online promotion. Later, it sent the reporter a link in 58 cities for the reporter to place an order, and arranged for technicians to come to the door for service. The reporter noticed that in its 58-city link, the name of the store was "Bali Romantic Theme SPA Club".

In the WeChat chat, the merchant insisted that only regular SPA massage services were provided in the store. "Other projects need to be discussed with technicians." The reporter then made an appointment for a SPA massage in the store. When the technician came to the door, she said that she could also provide pornographic services, and the price ranged from 1,200 yuan to 2,000 yuan. The technician said that he worked part-time in the store and only provided on-site service. As for how to divide the charges with the store, the technician was very cautious and refused to disclose.

The reporter contacted the customer service of the store and said that he hoped to go to the store for consumption. The other party said that "the recent investigation was tight, and we didn’t do anything in the store. Many technicians went home on holiday and had to go to the door." Later, the other party told the reporter that his store was located next to Sihui subway station, but he refused to tell the specific location.

The reporter found out in his "Bali" applet that the actual name of the merchant is Beijing Miaoshou Liren Fitness and Leisure Center, and its business place is No.16, 2nd Floor, Jingbei Street, Jinding Town, Balizhuang Village, Gaobeidian Township, Chaoyang District, Beijing.

Subsequently, the reporter came to his business address, and he could see a broken signboard with the words "pedicure" on the registered address, but there was no store. The merchant next to him told the reporter that the pedicure store had been moved about half a year ago.

Enter keywords such as "applet" in Taobao, and you can see that many shops are selling applet authentication accounts, and the price ranges from tens to hundreds of yuan. One of the customers said that they sold small program accounts that had passed the enterprise certification for 300 yuan each. "These accounts are randomly obtained from different companies, and they are also randomly sent to you. If we need help to make the corresponding applet, we can do it." The other party said that if the simplest applet is needed, it usually takes five days from design to online, and the price depends on the customer’s requirements for the applet.

The reporter found that since the launch of the applet, some applets have been repeatedly exposed for selling fake goods and suspected pornographic services. In early February this year, the WeChat applet team responded that it has been cracking down on the exposed applets, such as "high imitation, fake goods", "pornography and vulgarity". Hundreds of pornographic applets have been permanently closed before, but some illegal applets have maliciously confronted the platform, for example.

The platform shall perform the duties of user’s real name registration and review.

In response to pornographic services, Pan Xiang, a partner of Guangdong Zhongan Law Firm and an arbitrator of Shenzhen Arbitration Commission, said that according to the Law on Public Security Administration Punishment, prostitutes and prostitutes are detained for more than 10 days and less than 15 days, and may be fined less than 5,000 yuan; If the circumstances are minor, they shall be detained for not more than five days or fined not more than five hundred yuan. Whoever soliciting prostitutes in public places shall be detained for not more than five days or fined not more than 500 yuan. According to the provisions of the Criminal Law, those who organize others to engage in prostitution shall be sentenced to fixed-term imprisonment of not less than five years but not more than ten years and fined; If the circumstances are serious, he shall be sentenced to fixed-term imprisonment of not less than 10 years or life imprisonment, and shall also be fined or confiscated.

Illegal merchants launch pornographic services through 58 cities and WeChat network platforms. Does the platform need to be held responsible? Lawyer Pan believes that according to the provisions of the Cyber Security Law, online platforms should register users with their real names. That is to say, the backstage real name, the front desk is voluntary, and the front desk can use a virtual name. The online platform should fully implement the regulations on the registration of users’ real names, so that when users use the platform to publish illegal information about soliciting prostitutes, they will be afraid of the mouse, and the public security organs also have evidence to check.

If the network platform fails to perform the duty of reviewing the real-name registration of users, or the network platform knows or should know that users publish such illegal information on the platform, but the operator of the network platform fails to take timely measures to block and disconnect links, the network platform should bear corresponding legal responsibilities according to relevant laws and regulations.

　　It has been half a month since the normalization of nucleic acid screening in various places. As the weather turns hot, the work of nucleic acid sampling and sample transportation becomes more difficult. Experts said that although the working environment is even worse, especially for some outdoor sampling points, the sample collection, storage and transshipment work should still be carried out in accordance with the specifications and should not be slack.

　　Battery car transfer sample

　　June 15th is the first hot day since Shanghai entered Mei, with the temperature climbing to 36 degrees and the outdoor ground temperature even higher. The first financial reporter saw in an open-air nucleic acid detection point in Shanghai that the temporary tent could not stop the scorching sun, and the sampling personnel wore protective clothing, and their faces were sweating, while there were no electric fans or cooled ice cubes outdoors. Also exposed to the scorching sun are tubes of nucleic acid reagent samples being collected.

　　The sampling time at this sampling point is from 1: 00 to 4: 00 in the afternoon. After the sampling stopped at 4: 00, the staff put the last batch of samples into a suitcase-sized small refrigerator, which was close to 4: 30. A courier arrived at the testing point by car battery car, ready to take them away.

　　I saw that the picker opened the refrigerator and hastily stuffed nearly 20 tubes of nucleic acid reagents in sealed bags into black shoulder bags, while the battery car was filled with yellow medical waste bags collected from multiple inspection points.

　　Now he will carry the samples and medical wastes to a nearby "transfer station", and then these uniformly collected samples will be transferred to the designated testing laboratory by special vehicles. He claimed that this was the sixth time he had transshipped samples today, three times in the morning and three times in the afternoon, thus ending the six-hour working day agreed in the contract.

　　According to the transshipman, the point where he collects samples every day is not completely fixed, and sometimes an extra sampling point is added temporarily, which leads to the delay of his arrival at the next point, so the actual working time is more than 6 hours.

　　A sampler of normalized nucleic acid kiosks told the First Financial Reporter that in principle, a batch of samples will be transported away every hour, but in practice, the time is not so fixed, mainly depending on whether there are enough people to transport them. Their main tool is a battery car, which transports the reagents collected from several nearby testing points to the assembly point and then sends them to the testing laboratory by special car.

　　However, for the above process, an infectious disease expert with rich field sampling experience said that this sample processing method is worrying, and the sample storage and transshipment are very inconsistent with the basic norms.

　　"We who do infectious diseases know that the most important thing is that all operations must be carried out in strict accordance with norms and standards. The storage temperature and transfer time of nucleic acid samples have strict standardized processes, which is definitely not convenient." The above experts told the First Financial Reporter.

　　The guide has clearly stipulated.

　　The Implementation Guide for COVID-19 Nucleic Acid Testing Organization (Second Edition) clearly stipulates the preservation and transportation of samples, which should be kept at low temperature (2-8 degrees Celsius). In principle, samples should be collected every 2 hours for transportation, and the samples should be delivered to the laboratory 4 hours after collection.

　　On the basis of the above guidelines, Shanghai has further put forward "126" requirements for nucleic acid testing institutions, that is, collecting and transporting a batch of samples every hour, transporting the samples to the testing institutions in 2 hours by vehicles, and completing the testing in the laboratory within 6 hours. In terms of sample transfer, the time requirement is reduced by half compared with the guideline, but in fact, it is very difficult to achieve such a goal. If the sample is not transferred in time, it will not only affect the quality of the sample, but also affect the waiting time for detection.

　　In this regard, the above-mentioned infectious disease experts told the First Financial Reporter: "Since there are norms, it should be strictly implemented in accordance with the norms. For example, it is stipulated that samples should be shipped every hour or two, and someone should come to pick them up when they arrive, instead of seeing that there are enough people to pick them up. If not, just wait."

　　The expert also warned that as the weather gets hotter, if the nucleic acid reagent cannot be stored at low temperature in time during transportation, or exposed to the sun for a long time, it will increase the risk of inaccurate nucleic acid test results.

　　He told the First Financial Reporter: "You should know that ribonuclease is ubiquitous. It exists in the air and anywhere. When you open the lid of the nucleic acid test tube, it may enter the test tube. At the temperature above 37 degrees, Rnase will easily degrade RNA, and the whole process only takes 10-15 minutes. If there is a very low virus load in the test tube, it will be diluted after ten mixes.

　　According to the observation of the first financial reporter at some nucleic acid detection points, in some mixed-tube tests, the actions that do not meet the operating standards include picking a person without screwing on the cover, which also increases the risk of exposing the sample to the air.

　　The above experts added that although adding some components, such as diethyl pyrocarbonate (DEPC), to the reagent can help to inhibit Rnase, these components will increase the cost of the reagent, and standard nucleic acid reagents are generally not added. "The easiest way is to keep it at low temperature and transport it in time. Even using ice cubes to cool down is helpful. Ice cubes have no cost and can be reused." He told the first financial reporter.

　　He also stressed that the basic operation in transferring samples is to put the samples into two-layer sealed packages and avoid the test tubes from tipping, so as to prevent the reagent from leaking and polluting other samples because the cover is not tightened.

　　Professor Lu Hongzhou, president of Shenzhen Third People’s Hospital, told the First Financial Reporter: "The best way to solve this problem is to collect samples regularly."

　　Professor Shen Hanming, an expert in cell biology at the University of Macau, told CBN: "In theory, there is a protective solution in nucleic acid reagents, and some components can inhibit RNA degradation to a certain extent, but even so, in principle, reagents should not be stored at room temperature and high temperature for a long time."

　　In order to activate the new kinetic energy of high-quality development of township economy, and further consolidate the effective connection between the achievements of poverty alleviation and rural revitalization, Nankang District of Ganzhou City takes "a prosperous town for the people" as the goal, takes economic development as the main line, takes the development of private economy as the starting point, and focuses on key tasks such as enterprise cultivation, industrial transformation and upgrading, and financial system reform, so as to give full play to the positive role of fiscal policy, fully improve the level of township economic development, and promote the sustained, rapid and healthy development of township economy.

　　First, focus on supporting and promoting the first industry.Focusing on the first industry of modern home furnishing, we will improve quality and efficiency, play a positive role in fiscal policy, better guide all towns (streets) to adhere to standards guidance and innovation drive, manage and operate furniture gathering areas, actively promote the overall improvement of environmental protection, fire protection and safety production in the region, and further promote the transformation and upgrading of the first industry of home furnishing.

　　The second is to vigorously cultivate and expand market players.Support each township (street) to cultivate new leisure agriculture such as industrial enterprises above designated size and farmhouse music based on local characteristics. Strengthen departmental cooperation, increase policy propaganda, optimize the approval process, actively guide foreign business workers to return home to start businesses, and continuously enhance the new kinetic energy of town economic development.

　　The third is to deepen the pilot reform of the township financial system.Implement the relevant arrangements for the reform of the financial system below the provincial level, in accordance with the principle of "checking revenue and expenditure, striving for self-balance, and encouraging development", and on the basis of scientifically delineating the base of township financial revenue and expenditure, further clarify the scope and sharing ratio of district and township income, standardize the sharing of surplus income, give full play to the financial enthusiasm of district and township levels, and strengthen the guarantee ability of financial assistance to township economic development.

　　In addition, policies and measures should be refined in promoting new urbanization, and performance appraisal should be increased to ensure the sustained and healthy development of township economy.

On July 26th, the symposium of responsible comrades of the national industrial and information technology authorities was held in Beijing.

The meeting pointed out that the Third Plenary Session of the 20th CPC Central Committee was a very important meeting held in the critical period of comprehensively promoting the construction of a strong country and the great cause of national rejuvenation with Chinese modernization. The meeting deliberated and adopted "the Central Committee of the Communist Party of China’s Decision on Further Comprehensively Deepening Reform and Promoting Chinese Modernization", which made systematic arrangements for further comprehensively deepening reform, and defined the guiding ideology, theme, general goal, major principles, major measures and fundamental guarantee for further comprehensively deepening reform. It is not only a continuation of the practice of comprehensively deepening reform since the Third Plenary Session of the 18th CPC Central Committee, but also a new chapter in the era of promoting Chinese modernization in the new journey.

Put forward the work in the second half of the year:

It is necessary to promote the high-quality development of the industry, consolidate and enhance the competitive advantage and leading position of the information and communication industry, strengthen the construction and application of new information infrastructure, deepen the regulatory reform of the information and communication industry, and strengthen the network and data security capabilities.

We should make every effort to promote the steady growth of industrial economy, continue to give play to the leading role of key industries and regions, actively expand domestic demand, focus on stabilizing the export of industrial products, and strengthen the monitoring and dispatching of industrial economic operation.

It is necessary to solidly promote the digital transformation of manufacturing industry, carry out the digital transformation of manufacturing industry and the special action of artificial intelligence to empower new industrialization, accelerate the large-scale application of industrial Internet, and build an open source system in China with high quality.

It is necessary to speed up the cultivation of new pillars and new racetracks, seize the opportunity of a new round of scientific and technological revolution and industrial transformation, and focus on intelligent networked automobiles, new materials, bio-manufacturing, hydrogen energy, humanoid robots, metauniverse, brain-computer interface, quantum information, low-altitude economy, commercial aerospace and other fields to make precise efforts to accelerate development.

　　Changsha Evening News (all-media reporter Peng Fang correspondent Chloe Wang Zeng Fan) Ms. Li, 50, has the greatest pleasure of cooking a sumptuous dinner for her family after work every day. A few days ago, Ms. Li participated in the physical examination of the unit. The results of low-dose spiral CT showed that "the space-occupying lesion of the upper lobe of the right lung does not rule out malignant lesions", and she was subsequently diagnosed as peripheral lung cancer in Hunan Cancer Hospital. Ms. Li wondered how she and her family could get lung cancer because they don’t smoke, and they usually have a healthy diet and a regular schedule. Wang Wenxiang, director and chief physician of the Second Department of Thoracic Surgery, Hunan Cancer Hospital, pointed out that in recent years, more and more patients with peripheral lung cancer were found in physical examination, and most of them were female patients who did not smoke. The academic circles thought it was related to their long-term exposure to high-temperature kitchen fumes.

　　Some surveys have found that women’s long-term exposure to high-temperature fumes will increase their risk of lung cancer by 2-3 times. Among non-smoking female lung cancer patients, more than 60% have long-term exposure to kitchen fumes; 32% women like to fry food in high-temperature oil when cooking, and the kitchen doors and windows are closed or poorly ventilated.

　　Wang Wenxiang pointed out that different cooking oils have different smoke points, and the higher the smoke point, the healthier the cooking oil. Among the commonly used edible oils, camellia seed oil has a high smoke point and can be used as a healthy first choice for cooking. In the cooking process, try to use medium fire, and control the temperature when cooking, so as not to smoke as the limit, which can not only reduce the damage of fatty acids and vitamins caused by high temperature, but also minimize the generation of smoke; Try to choose a pot with a thick bottom for cooking, so as to reduce a lot of oil smoke generated by the sharp rise of temperature in the wok; Try to use cooking methods such as steaming, boiling and stewing to reduce the oil smoke caused by frying; Ensure good ventilation in the kitchen, clean the range hood regularly, and wear a mask when necessary to reduce the smoke inhalation.

　　Wang Wenxiang reminded that the clinical cure rate of early lung cancer is over 80%, especially for women’s early lung cancer, most of which are peripheral lung cancer. Thoracoscopic surgery can achieve radical cure of lung cancer through 1 ~ 3 keyhole-sized operation incisions, and the curative effect is not inferior to that of large incision open surgery.

CCTV News:Tomorrow (June 22nd) is the Dragon Boat Festival holiday. The reporter learned from china tourism academy that this year’s Dragon Boat Festival holiday, the number of tourists is expected to exceed the level of the same period in 2019, reaching 100 million, and the holiday trips will mainly focus on Zhou Bianyou and short-distance tours.

Following the unexpected release of the "May Day" labor holiday tourism demand, the market demand for Dragon Boat Festival holiday tourism is in a warm period. The reporter learned from a number of platforms that during the Dragon Boat Festival holiday this year, the average price of hotels and air tickets in China and many popular destinations will be lower than that during the May Day holiday. Beijing, Hangzhou, Guangzhou, Chengdu and Qingdao will become popular tourist destinations in China.

Dai Bin, Dean of china tourism academy:We predict that there will be 100 million people traveling during the Dragon Boat Festival holiday this year, and there will be 37 billion yuan in tourism consumption. What does this data mean? This means that compared with the same period last year, the number of tourists will increase by 30%, while tourism consumption will increase by 43%.

China tourism academy predicted that tourists from Guangdong-Hong Kong-Macao Greater Bay Area, the Yangtze River Delta, Beijing-Tianjin-Hebei, the middle reaches of the Yangtze River and Chengdu-Chongqing urban agglomerations will circulate and interact, and a "three-hour golden tourism circle" will be formed around major tourist cities, and the popularity of tourist resorts such as Beidaihe, Songshan and Conghua will gradually become apparent.

Dai Bin, Dean of china tourism academy:Because (Dragon Boat Festival holiday) only lasts for three days, compared with "May 1" Labor Day (holiday), it is mainly short-distance travel, mainly in Zhou Bianyou; Self-driving, individual travel, family, parent-child, study and summer vacation will become the key words of holiday travel.

Shunde, Guangdong: Colorful boats compete for beauty to welcome the Dragon Boat Festival "Night Dragon Tour"

It is also a traditional festival of Dragon Boat Festival, with dumplings and dragon boat races, which has long been a lively scene all over the country. This year, the dragon boat race held in Shunde is unique and eye-catching. What kind of dragon boat race is it? Now let’s take a look with the reporters at the reception desk.

General Station reporter Qu Baiyu:This is Ronggui Street in Shunde, Guangdong. Usually, people watch dragon boats faster than others. Today, I want to show you Bimei.

At the competition site, gongs and drums were loud, waves splashed and dragon boats fought brightly. Ten dragon boats from various clubs in Rong Gui decorated their bodies with gongs and drums, umbrellas and colored lights, and they "dressed up" for a trip to show their slender posture. "Night Dragon Tour" is rare in Guangdong, which is a unique feature of traditional dragon boat culture in Rong Gui. Different from the traditional Youlong, the night dragon with lights in Rong Gui not only retains traditional elements such as gongs, drums and umbrellas, but also uses LED lights to decorate the dragon boat, innovating the form of dragon boat competition, and skillfully blending water, lights and music.

Putian, Fujian: colorful folk customs of "dragon boat climbing" at sea welcome the Dragon Boat Festival.

As the Dragon Boat Festival approaches, Fujian will carry out special folk activities in many places. These two days, in Dongpu Town, Putian City, a huge sea dragon boat race was staged.

In Putian, Fujian, dragon boat racing is also called "dragon climbing boat". On the morning of 19th, Jicheng Village, Dongpu Town, Putian City ushered in a lively Dragon Boat Climbing. On the sea, the dragon boat players follow the rhythm of drums and raise their arms to paddle hard. On the beach, citizens and tourists shouted for fun, and the scene was crowded and lively.

Tourist Liao Kajia:I like watching the Dragon Boat Festival in China very much, because it is very lively and crowded, and it is very comfortable to watch together.

According to reports, during the Dragon Boat Festival, in addition to the dragon boat race at sea, villagers in Jicheng Village will also hold dragon dances and flower drums, and the folk performance team consisting of thousands of people will stretch for miles, which is very spectacular.

Putian citizen Li Jianhuang:We rushed back to our hometown from Yunnan for the traditional Dragon Boat Festival, and we were very happy. One is to unite everyone’s cohesion, and the other is to carry forward traditional culture.

It is understood that Putian has a wide range of rivers and waters, and the Dragon Boat Festival is the most important local folk activity every year. This year, Putian Dragon Boat Race Folk Games will span many counties and districts and will last until the beginning of July.

Henan Dragon Boat Festival: Drum-beating and Paddling Dragon Boat Race for the Dragon Boat Festival.

With the approach of the Dragon Boat Festival, a Dragon Boat Culture Festival was held in Zhumadian City, Henan Province these days, and everyone welcomed the Dragon Boat Festival by way of dragon boat race.

At the Dragon Boat Culture Festival in Zhumadian City, Henan Province, the 200-meter straight race and the 300-meter straight race were set up in the dragon boat competition. On the field, drums were rumbling and cheering, and Qi Xin, a 12-player dragon boat team, joined forces to paddle and cut waves and compete. The dragon boat race attracted many citizens and tourists to watch it. People took pictures by video and recorded wonderful moments.

Meng Xin ‘ai, a citizen of Zhumadian, Henan:Everyone wants to stick to the traditional culture, so everyone is very supportive of this movement and hopes to hold more such activities in the traditional culture in the future.

Cancer, as one of the most common diseases with high mobility and high mortality in the world, the clinical treatments for its tumors generally include surgery, chemotherapy and radiotherapy. Due to the shortcomings of chemical drugs and various toxic and side effects, people have been committed to developing more effective drug delivery systems for cancer treatment, with the aim of reducing side effects and ensuring its efficacy.

With the progress and maturity of nanotechnology, its advantages are gradually reflected.

Introduction of nano-drugs

Diagram of sustained release process of nano-drugs

Nano-drug and its delivery system

Nano-medicine refers to nanoparticles or nano-carriers, which is a new product produced by the combination of nano-technology and medicine.

Nano-drug delivery system refers to the integration of small drug molecules into nano-materials by means of encapsulation or adsorption.

Advantages of nano-drugs

First, improve the solubility and absorption of drugs.

Nano-sized drugs are different from most chemotherapy drugs. Nano-sized drugs have larger specific surface area, better solubility, faster dissolution, improved absorption properties and better therapeutic effect.

At the same time, due to better solubility, the dosage of patients can also be appropriately reduced.

Second, prolong the drug’s circulation time in vivo, and enrich it to the focus.

Through some modification and treatment on the surface of nano-drugs, the circulation time of drugs in human body can be prolonged, which is beneficial for drugs to reach the lesion site, and special modification may make drugs more concentrated in the tumor site, resulting in better selectivity and targeting properties.

Nano-drugs can enter the tumor tissue through the porous blood vessels of the tumor, and achieve a high degree of penetration and retention in the tumor. Therefore, nano-preparation has excellent properties of high drug loading rate, passive targeting and controlled drug release.

Clinical application of nano-preparation.

Paclitaxel albumin nanoparticles

Paclitaxel is a commonly used anticancer drug in clinic. Here is a brief introduction to the nano-preparation of paclitaxel:

Paclitaxel, a commonly used anticancer drug

Albumin nanoparticles

Albumin nanoparticles are nano-particles based on albumin.

Albumin is an endogenous natural product with the advantages of safety, non-toxicity, non-immunogenicity, biodegradability and good biocompatibility. Moreover, the nanoparticle carrier system has unique targeting, sustained and controlled release characteristics and drug protection.

By high-pressure homogenization, paclitaxel and human serum protein preparation were made into nanometer freeze-dried powder, which can improve the solubility, avoid a large number of paclitaxel nanoparticles aggregation, and help the drug to be absorbed into tumor cells and give full play to its role.

Pharmacological action of paclitaxel

Paclitaxel is an anti-microtubule drug, which can stabilize microtubules by promoting the polymerization of tubulin dimer and inhibiting its depolymerization, thus inhibiting the normal dynamic reorganization of microtubule network during interphase and mitosis.

In addition, paclitaxel can lead to abnormal arrangement of microtubule "bundles", affect the division of tumor cells and promote tumor cell apoptosis during the whole cell cycle and cell mitosis.

indication

The application of albumin nanoparticles in the in vivo delivery of paclitaxel and cancer treatment has become a hot topic in recent years.

Albumin paclitaxel nanoparticles are mainly suitable for the treatment of metastatic breast cancer that failed in combination chemotherapy or breast cancer that recurred within 6 months after adjuvant chemotherapy.

Unless there are clinical contraindications, an anthracycline anticancer drug should be included in previous chemotherapy.

matters need attention

In the process of using paclitaxel albumin nanoparticles, it should be noted that paclitaxel for injection (albumin binding type) also has adverse drug reactions and must be used under the guidance of a doctor with chemotherapy experience.

Only with perfect diagnosis and treatment facilities can the complications and adverse reactions caused by drugs in treatment be effectively controlled.

references

[1] Jie Chen, Cao Ye, Li Shuangshuang, Luo Lailong, Yu Peng, Li Mingyuan. Research progress of novel nano-drug delivery system for tumors [J]. China Journal of Pharmacy, 2020,55(21):1749-1756.

Xin li, Zhu Dandan, Chen Yu, Lin Shuting, Han Lili, Li Ying, Liu Xiaoxuan. Research progress of nano-drug delivery system in promoting deep penetration of tumor [J]. Zhongnan Pharmacy, 2020,18(12):2009-2018.

Zhao Shuang, Zhang Shaofang, Mu Xiaoyu. Research progress of nano-drugs [J]. Tianjin Pharmacy, 2020,32(02):57-61.

Chen Dongxiao, Zhang Juanmei, Li Jianye, Xu Tianhong, Dong Yaqin, Pu Xiaohui. Research status and progress of paclitaxel albumin nanoparticles [J]. Journal of Henan University (Medical Edition), 2017,36(04):296-300.

[5] Chen Kang. Analysis of the research progress of paclitaxel pharmaceutical preparations [J]. Heilongjiang Medicine, 2019,32(06):1390-1392.

Contributed by: Song Haolin (Ruijin Intern Pharmacist)

Original title: "How do nano-warriors fight cancer-do you understand? 》

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