On July 26th, the symposium of responsible comrades of the national industrial and information technology authorities was held in Beijing.

The meeting pointed out that the Third Plenary Session of the 20th CPC Central Committee was a very important meeting held in the critical period of comprehensively promoting the construction of a strong country and the great cause of national rejuvenation with Chinese modernization. The meeting deliberated and adopted "the Central Committee of the Communist Party of China’s Decision on Further Comprehensively Deepening Reform and Promoting Chinese Modernization", which made systematic arrangements for further comprehensively deepening reform, and defined the guiding ideology, theme, general goal, major principles, major measures and fundamental guarantee for further comprehensively deepening reform. It is not only a continuation of the practice of comprehensively deepening reform since the Third Plenary Session of the 18th CPC Central Committee, but also a new chapter in the era of promoting Chinese modernization in the new journey.

Put forward the work in the second half of the year:

It is necessary to promote the high-quality development of the industry, consolidate and enhance the competitive advantage and leading position of the information and communication industry, strengthen the construction and application of new information infrastructure, deepen the regulatory reform of the information and communication industry, and strengthen the network and data security capabilities.

We should make every effort to promote the steady growth of industrial economy, continue to give play to the leading role of key industries and regions, actively expand domestic demand, focus on stabilizing the export of industrial products, and strengthen the monitoring and dispatching of industrial economic operation.

It is necessary to solidly promote the digital transformation of manufacturing industry, carry out the digital transformation of manufacturing industry and the special action of artificial intelligence to empower new industrialization, accelerate the large-scale application of industrial Internet, and build an open source system in China with high quality.

It is necessary to speed up the cultivation of new pillars and new racetracks, seize the opportunity of a new round of scientific and technological revolution and industrial transformation, and focus on intelligent networked automobiles, new materials, bio-manufacturing, hydrogen energy, humanoid robots, metauniverse, brain-computer interface, quantum information, low-altitude economy, commercial aerospace and other fields to make precise efforts to accelerate development.

Cancer, as one of the most common diseases with high mobility and high mortality in the world, the clinical treatments for its tumors generally include surgery, chemotherapy and radiotherapy. Due to the shortcomings of chemical drugs and various toxic and side effects, people have been committed to developing more effective drug delivery systems for cancer treatment, with the aim of reducing side effects and ensuring its efficacy.

With the progress and maturity of nanotechnology, its advantages are gradually reflected.

Introduction of nano-drugs

Diagram of sustained release process of nano-drugs

Nano-drug and its delivery system

Nano-medicine refers to nanoparticles or nano-carriers, which is a new product produced by the combination of nano-technology and medicine.

Nano-drug delivery system refers to the integration of small drug molecules into nano-materials by means of encapsulation or adsorption.

Advantages of nano-drugs

First, improve the solubility and absorption of drugs.

Nano-sized drugs are different from most chemotherapy drugs. Nano-sized drugs have larger specific surface area, better solubility, faster dissolution, improved absorption properties and better therapeutic effect.

At the same time, due to better solubility, the dosage of patients can also be appropriately reduced.

Second, prolong the drug’s circulation time in vivo, and enrich it to the focus.

Through some modification and treatment on the surface of nano-drugs, the circulation time of drugs in human body can be prolonged, which is beneficial for drugs to reach the lesion site, and special modification may make drugs more concentrated in the tumor site, resulting in better selectivity and targeting properties.

Nano-drugs can enter the tumor tissue through the porous blood vessels of the tumor, and achieve a high degree of penetration and retention in the tumor. Therefore, nano-preparation has excellent properties of high drug loading rate, passive targeting and controlled drug release.

Clinical application of nano-preparation.

Paclitaxel albumin nanoparticles

Paclitaxel is a commonly used anticancer drug in clinic. Here is a brief introduction to the nano-preparation of paclitaxel:

Paclitaxel, a commonly used anticancer drug

Albumin nanoparticles

Albumin nanoparticles are nano-particles based on albumin.

Albumin is an endogenous natural product with the advantages of safety, non-toxicity, non-immunogenicity, biodegradability and good biocompatibility. Moreover, the nanoparticle carrier system has unique targeting, sustained and controlled release characteristics and drug protection.

By high-pressure homogenization, paclitaxel and human serum protein preparation were made into nanometer freeze-dried powder, which can improve the solubility, avoid a large number of paclitaxel nanoparticles aggregation, and help the drug to be absorbed into tumor cells and give full play to its role.

Pharmacological action of paclitaxel

Paclitaxel is an anti-microtubule drug, which can stabilize microtubules by promoting the polymerization of tubulin dimer and inhibiting its depolymerization, thus inhibiting the normal dynamic reorganization of microtubule network during interphase and mitosis.

In addition, paclitaxel can lead to abnormal arrangement of microtubule "bundles", affect the division of tumor cells and promote tumor cell apoptosis during the whole cell cycle and cell mitosis.

indication

The application of albumin nanoparticles in the in vivo delivery of paclitaxel and cancer treatment has become a hot topic in recent years.

Albumin paclitaxel nanoparticles are mainly suitable for the treatment of metastatic breast cancer that failed in combination chemotherapy or breast cancer that recurred within 6 months after adjuvant chemotherapy.

Unless there are clinical contraindications, an anthracycline anticancer drug should be included in previous chemotherapy.

matters need attention

In the process of using paclitaxel albumin nanoparticles, it should be noted that paclitaxel for injection (albumin binding type) also has adverse drug reactions and must be used under the guidance of a doctor with chemotherapy experience.

Only with perfect diagnosis and treatment facilities can the complications and adverse reactions caused by drugs in treatment be effectively controlled.

references

[1] Jie Chen, Cao Ye, Li Shuangshuang, Luo Lailong, Yu Peng, Li Mingyuan. Research progress of novel nano-drug delivery system for tumors [J]. China Journal of Pharmacy, 2020,55(21):1749-1756.

Xin li, Zhu Dandan, Chen Yu, Lin Shuting, Han Lili, Li Ying, Liu Xiaoxuan. Research progress of nano-drug delivery system in promoting deep penetration of tumor [J]. Zhongnan Pharmacy, 2020,18(12):2009-2018.

Zhao Shuang, Zhang Shaofang, Mu Xiaoyu. Research progress of nano-drugs [J]. Tianjin Pharmacy, 2020,32(02):57-61.

Chen Dongxiao, Zhang Juanmei, Li Jianye, Xu Tianhong, Dong Yaqin, Pu Xiaohui. Research status and progress of paclitaxel albumin nanoparticles [J]. Journal of Henan University (Medical Edition), 2017,36(04):296-300.

[5] Chen Kang. Analysis of the research progress of paclitaxel pharmaceutical preparations [J]. Heilongjiang Medicine, 2019,32(06):1390-1392.

Contributed by: Song Haolin (Ruijin Intern Pharmacist)

Original title: "How do nano-warriors fight cancer-do you understand? 》

Read the original text

Suggestions: Suggestions on vigorously improving the local matching rate of automobile parts and enhancing the overall competitiveness of automobile industry chain.

Automobile industry is an important industry in Guangxi and a pillar industry in Liuzhou. Liuzhou is one of the important automobile industry gathering places in China, with four automobile enterprises including SAIC-GM-Wuling, Dongfeng Liuqi, faw liberation Liuzhou Branch and Guangxi Automobile Group. In 2021, the estimated output value will exceed 175 billion yuan, and the automobile production and sales will reach 1.88 million and 1.89 million respectively, among which the output of new energy vehicles will exceed 480,000, up 157.6% year-on-year.

At present, the automobile industry is facing an unprecedented change in a hundred years, and the automobile industry chain in the whole region is facing great challenges:

1. The layout of the "Three Electricity" industrial chain of new energy vehicles in Guangxi is not perfect, and the supporting system and R&D capability of the whole industrial chain of vehicles have not been upgraded. There are shortcomings in supporting local intelligence, networking, domestic chip components and intelligent driving control systems. For example, in 2021, leading enterprises in Guangxi’s new energy automobile industry, such as SAIC-GM-Wuling and Dongfeng Liuqi, are facing the problem of strong market demand but shortage of core components (control chips, power batteries, engines, etc.), and the satisfaction rate of SAIC-GM-Wuling core chips is only 30%.

Second, the core industrial chain is underdeveloped, and the localization, research and development and manufacturing capabilities of core components such as high-performance engines for passenger cars, automatic transmissions, and new energy vehicles "Three Electricity" need to be improved. The intelligent manufacturing level of local supply chain is not high, and the production operation efficiency can not meet the future competition. Take SGGM-Wuling as an example, the automation rate of its supporting suppliers in Liuzhou is about 30%, which is half that of supporting suppliers in Chongqing; The completion rate of digital factory transformation is less than 10%.

4. In recent years, Liuzhou City has successfully explored the "Liuzhou Model" for the promotion and application of new energy vehicles through the linkage between government and enterprises. In 2021, the autonomous region also introduced relevant policies for the promotion of new energy, but the promotion and application of new energy passenger cars and commercial vehicles in other cities still need to be further strengthened.

5. The competition in the new energy automobile industry will be more intense. The number of new energy automobile main engine plants has reached more than 76, and the traditional automobile giants have launched brand-new new energy vehicles. At the same time, the electric replacement models and hydrogen battery models of commercial vehicles of major automobile enterprises have also appeared. It is estimated that the output of new energy vehicles will reach 5 million in 2022.

The new energy automobile industry has become the key field of the future competition of the world automobile industry. Promoting the transformation and upgrading of the automobile industry in Guangxi is particularly important for the development of Guangxi during the "Tenth Five-Year Plan" period. It is urgent to introduce more key projects, create more competitive parts products, maintain the stable operation of the industrial chain, improve the local matching rate of automobile parts and enhance the overall competitiveness of the automobile industry chain.

To this end, it is suggested that:

First, make the industry leader bigger and stronger, and improve the driving ability and efficiency. Give full play to Liuzhou’s role as a pioneer of high-quality industrial development in the whole region, and relevant departments of the autonomous region will increase policy support and land use security to promote the strong chain, supplementary chain and extension of Liuzhou’s new energy automobile industry chain. We will increase the layout of the independent controllable capacity of the automobile industry chain led by SAIC-GM-Wuling and Dongfeng Liuqi, support the accelerated development of new energy vehicle projects, and constantly improve new energy platforms, large and medium-sized logistics vehicles, HEV energy-saving vehicles, commercial vehicles, trams and hydrogen energy commercial vehicles, enhance local basic process design, research and development capabilities and manufacturing capabilities, and consolidate the foundation of the automobile and equipment manufacturing industry chain. In five to eight years, the local matching rate will gradually increase by more than 15%, the output value of new energy automobile industry will increase by 50 billion yuan, the output value of high-tech and high value-added supply chain will increase by more than 20 billion yuan, and the total automobile production and sales will increase by 5% every year, and the market share in the country will reach more than 10%, and the total output value will increase by more than 100 billion yuan.

Second, relying on the leader to promote the gathering of industrial chain elements of the new four modernizations. In combination with the 14th Five-Year Plan of Guangxi Automobile, the relevant departments of the autonomous region, aiming at the weak points of the "new four modernizations" industrial cluster, have issued targeted policies and measures for attracting investment, carried out precise investment and special investment, attracted leading enterprises in the new energy automobile industry to settle in Liuzhou, strived to introduce a number of "three power" and intelligent networked supply chains, planned chip packaging, testing and application localization projects synchronously, and gradually built a new four modernizations with complete elements.

Third, improve the level and support the digital and intelligent upgrading of the industrial chain. Strengthen the cooperation of the government, scientific research institutions, enterprises and other parties, build leading enterprises, promote the intelligent upgrading of the industrial chain, focus on cultivating core enterprises such as SEEK Technology, focus on the upgrading of intelligent workshops and smart factories, accelerate the construction of industrial Internet, deepen the cost reduction and quality improvement of the automobile industrial chain, and enhance the competitiveness of the existing local parts market; Vigorously build a public service platform for intelligent manufacturing, support enterprises to carry out technological innovation, mechanism system innovation and business model innovation, and stimulate enterprise innovation and creativity.

Fourth, strengthen the promotion of new energy vehicles and cultivate the development environment of new energy vehicles in Guangxi. Pilot application of "Liuzhou Model for Promotion and Application of New Energy Vehicles" in various cities in the whole region, and promote and apply new energy commercial vehicles, urban logistics vehicles, special vehicles and other vehicles in ports, factories and mines and long-distance trunk transportation in conjunction with Guangxi Automobile Group, Dongfeng Liuqi and Heavy Duty Truck Transportation; Promote the application of new energy sanitation vehicles in urban and rural areas; Introduce financial leasing companies and other models, start commercialization pilots, and promote the application of new energy logistics vehicles in the fields of postal services, express delivery, and e-commerce terminal logistics; Give full play to the advantages of intelligent new energy vehicles and actively promote the transformation and upgrading of new energy commercial vehicles and special vehicles to participate in the intelligent transformation of ports, factories and mines.

Five, the implementation of the policy, increase the introduction and cultivation of high-end talents such as the "new four modernizations". Support, guide and encourage OEMs to strengthen the construction of innovative teams, implement the talent strategy of "going out" and "bringing in" in parallel, and continuously consolidate the stability and development of talent teams. On the one hand, we will build talent enclaves and R&D enclaves, break geographical restrictions, and gather industry elites to contribute to industrial chain construction. On the other hand, we will further optimize the talent introduction and education policy, improve the talent development environment, improve the talent care and protection policy, and strive to build a high-end innovative talent team with key core technologies, lead the industrial development, and promote the transformation and upgrading of the industrial chain, and strive to maintain the stability of high-end and special talents in enterprises.

Organizer: sponsored by the Department of Industry and Information Technology of the Autonomous Region, assisted by the Liuzhou Municipal People’s Government, the Science and Technology Department of the Autonomous Region and the Investment Promotion Bureau of the Autonomous Region.

Handling the reply:

Liuzhou Municipal People’s Government on the 12th CPPCC Autonomous Region

Letter of opinions of the fifth meeting on proposal No.20220291

Department of Industry and Information Technology of the Autonomous Region:

Now, we will inform you of the handling of the suggestions put forward in Proposal No.20220291 of the Fifth Session of the 12th CPPCC Autonomous Region on vigorously improving the local matching rate of auto parts and enhancing the overall competitiveness of the automobile industry chain. Please reply to the proposer together after synthesis.

I. Production and Marketing of Automobile Products in Liuzhou City

In 2021, the city’s vehicle production and sales were 1.895 million and 1.882 million respectively, up by 8.2% and 4.7% year-on-year. The growth rate of production and sales was 4.8 percentage points and 0.9 percentage points higher than that of the whole country, and the sales growth rate outperformed the national market. Among them, the production and sales volume of new energy vehicles all reached 482,000, up by 157.6% and 158.7% respectively year-on-year, and the sales volume of new energy vehicles produced in Liuzhou accounted for 13.7% of the national sales volume of new energy vehicles.

II. Answers to the suggestions made in the proposal

(A) on the "bigger and stronger industry leader, improve the driving ability and efficiency" proposal.

In recent years, the autonomous region and Liuzhou City have continuously optimized the industrial development environment, improved the policy support system, enriched the service methods of enterprises, fully supported the transformation and development of the automobile industry, and made the leading enterprises bigger and stronger. Liuzhou actively supports SAIC-GM-Wuling, Dongfeng Liuqi and other automobile main engine plants to increase the research and development of new products, and supports SAIC-GM-Wuling to implement the "two million" new energy platform project and the research and development of E-series and Hongguang MINI new energy vehicles; Support Dongfeng Liuqi to develop T5EVO, yacht, S50EV, hydrogen fuel commercial vehicle and pure electric commercial vehicle; Support the research and development of G100 new energy logistics vehicle of Guangxi Automobile Group. Actively promote the construction of the national automobile quality inspection center (Guangxi) intelligent networked automobile closed test site and Liuzhou automobile networking pilot area, and support the transformation and upgrading of automobile products of automobile OEMs. At the same time, actively assist leading automobile enterprises to explore overseas markets, the new energy automobile market in Guangxi and the northern market.

Focusing on the leading enterprises in the automobile industry, we will increase the layout of independent and controllable capabilities in the automobile industry chain. The autonomous region issued the Work Plan for Promoting the Transformation, Upgrading and Development of the Automobile Industry, the Notice on Improving the Local Matching Rate of Automobile Parts, the Notice on Printing and Distributing the Work Plan for Making SAIC-GM-Wuling Leading Enterprises Form the Whole Industry Chain of Liuzhou Automobile, and the Notice on Printing and Distributing the Work Plan for Making Dongfeng-Liuzhou Leading Enterprises Form the Whole Industry Chain of Liuzhou Automobile. Liuzhou has issued such policy documents as Implementation Plan for Transformation and Upgrading of Liuzhou Automobile Industry, Several Measures for Promoting the Development of Mould Industry in Liuzhou City and Several Measures for Promoting the Development of Casting and Forging Industry in Liuzhou City, which strongly support the construction of strengthening, supplementing and extending the chain of Liuzhou automobile industry chain.

In recent years, Liuzhou’s automobile industry has overcome the adverse effects of rising raw materials, repeated epidemics, chip shortage and power shortage, and gradually realized the transformation from traditional fuel vehicles to new energy vehicles. The production and sales volume have rebounded year by year, and the automobile production and operation of the OEM have achieved good results. In 2021, SAIC-GM-Wuling produced 1.672 million vehicles, up 8% year-on-year, of which 458,000 new energy vehicles were sold, up 157.5% year-on-year. Dongfeng Liuqi produced 200,000 vehicles in 2021, up 11.2% year-on-year, including 125,000 passenger vehicles, up 35.6% year-on-year. At present, there are E100/E200/E300 new energy automobile products produced in Liuzhou.

/E300Plus/ Hongguang MINI EV, S50EV, G100 logistics vehicles, Dongfeng Liuqi new energy power exchange vehicle, Dongfeng Liuqi hydrogen fuel commercial vehicle and other new energy vehicle products, and the products are gradually serialized.

Liuzhou plans to build a well-known domestic R&D and production base for the whole industrial chain of new energy vehicles in about five years, and build a well-known domestic new energy automobile city in Guangxi, with a production and sales scale of over 2 million vehicles and an output value of over 170 billion yuan. The production technology of complete vehicles and main parts enterprises has reached the domestic leading level. In the next step, several key projects will be implemented in the new energy automobile industry: First, the "two million" new energy automobile platform project of SAIC-GM-Wuling. Invest 30 billion yuan to build two platforms of millions of new energy vehicles, pure electric vehicles and hybrid vehicles, accelerate the localized production of the industrial chain of new energy vehicles, and realize the new output value of more than 100 billion yuan. Second, Dongfeng Liuqi new energy transformation project. Invest 4.3 billion yuan, strive to sell more than 10,000 new energy vehicles such as hydrogen fuel heavy trucks, and realize the new output value of new energy heavy trucks of more than 12 billion yuan. The third is the transformation project of new energy vehicles of Guangxi Automobile Group. Invest 3 billion yuan to develop the new energy logistics vehicle market, form three major product series of passenger cars, trucks (modified vehicles) and off-road vehicles, and at the same time promote the OEM plan of new energy passenger cars, achieving an additional output value of more than 10 billion yuan. Fourth, the new energy automobile industry chain extension and chain repair project. Invested 12 billion yuan, introduced Qingshan Ruipu power battery, United Automotive Electronic New Energy Vehicle Controller, Wuhan Yuanfeng ABS Controller and other projects, with an added output value of more than 50 billion yuan.

(B) on "relying on leading enterprises to promote the new four industrial chain elements gathering" proposal.

Liuzhou insists on promoting the electrification, intelligence and networking development of the automobile industry as an important direction to promote the transformation and upgrading of the automobile industry. Relying on the continuous improvement of the new energy automobile product market of SAIC-GM-Wuling and Dongfeng Liuqi, Liuzhou has carried out accurate investment promotion and accelerated the layout of supporting industrial chains. Liuzhou Guoxuan Hi-Tech New Energy Battery 5 GWh Project, Huating Power Battery Pack Production Line and Liuzhou Shuanglin New Energy Motor Project were completed and put into operation, SAIC-GM-Wuling built the first automobile controller production line, Sykes hybrid engine was developed, Penghui new energy storage project and Sykes Ruipu new energy battery project started construction, and the United Electronics Phase III new energy electric control drive project and Nexter new energy parts project were signed. Taking the construction of the car networking pilot area as an opportunity, we will increase investment attraction and introduce 8 industrial projects related to intelligent networking. The industrial chain construction of new energy vehicles has achieved good results, and various major core components have been put into production one after another. At present, local production of major components such as new energy power batteries, drive motors, bridges and controllers has been realized.

In the next step, in accordance with the relevant requirements of investment promotion of key industrial chains in the autonomous region and Liuzhou, we will continue to further promote the project of supplementing and strengthening the chain, especially for the upstream of new energy vehicles and intelligent network connection, and gradually build a new four-oriented industrial chain with complete elements.

(C) Suggestions on "upgrading the level and supporting the digital and intelligent upgrading of the industrial chain"

Liuzhou steadily promotes the construction of key industry platforms, with automobiles and construction machinery as the main line, and government and enterprises work together to support leading enterprises in the industry to build industry-level industrial Internet platforms and promote the digital transformation of upstream and downstream enterprises in the industrial chain. SAIC-GM-Wuling digital supply chain collaborative intelligent industrial Internet platform has been included in the pilot demonstration project of the Ministry of Industry and Information Technology for three consecutive years, and has been popularized and applied in more than 700 parts enterprises. More than 900 enterprises have carried out procurement collaboration on Guangxi machinery industry Internet platform built by Liugong. The Cheheyun Industrial Internet Platform built by Guangxi Automobile Group has been applied by more than 700 suppliers.

(D) Suggestions on "Strengthening the promotion of new energy vehicles and cultivating the development environment of new energy vehicles in Guangxi"

Liuzhou actively supports the local automobile main engine factory to carry out the promotion and application of new energy vehicles, and has formed the "Liuzhou model" for the promotion and application of new energy vehicles. In 2019, Liuzhou City and 13 other cities in Guangxi jointly launched the "Guangxi New Energy Vehicle Promotion and Exchange Series" to jointly explore and practice the "Guangxi Model" for the promotion and application of new energy vehicles, cultivate and expand the new energy vehicle market in Guangxi, and achieved remarkable results. By the end of March 2022, the total output of various new energy vehicles was 935,000 and the total sales volume was 916,500; The number of new energy vehicles is 122,700, accounting for 12.31%; Built 1016 charging pile sites and 11378 charging piles (2032 fast charging piles and 9346 slow charging piles); 530 public charging socket stations, 7041 public sockets and 17357 personal sockets have been built.

In the next step, Liuzhou will continue to accelerate the development of the new energy automobile industry, encourage SAIC-GM-Wuling and Dongfeng Liuqi to speed up the development and listing of new energy products, realize the increase in sales of new vehicles as soon as possible, and at the same time seize the favorable opportunity of the national new energy vehicles going to the countryside, accelerate the construction of charging infrastructure in counties and townships under the jurisdiction of Liuzhou, create a favorable environment for the promotion of new energy vehicles in counties and townships, and promote the extension of the promotion and application of new energy vehicles to counties and townships. At the same time, actively strive for the support of the autonomous region, increase the promotion and application of the "Liuzhou model" in the whole region, and create a good environment for the promotion and application of new energy vehicles produced in Liuzhou.

(V) Suggestions on "implementing policies and increasing the introduction and cultivation of high-end talents such as the" new four modernizations "

Liuzhou has issued some policy documents, such as "Several Measures for Accelerating the Gathering of Talents in the New Era in Liuzhou" and "Detailed Rules for the Classification of Talents and the Implementation of Incentive Subsidies in Liuzhou (Trial)", to increase the introduction of talents. From October 1, 2018, the city will achieve the goal of total talents exceeding 1 million in five years, including 100 high-end talents, 3,000 senior management talents, 3,000 doctors and masters, and high-skilled talents. According to different levels of talents, preferential treatment is given from salary, living allowance, housing purchase (rental) allowance, children’s enrollment and other aspects.

In 2022, Guangxi New Energy Automobile Laboratory settled in Liuzhou. Through joint innovation of politics and Industry-University-Research, it focused on five major sectors, namely, technical research, product development, intelligent manufacturing, industrial chain and ecological construction, and built the highest level and level of scientific and technological R&D innovation platform in Guangxi, creating a whole-chain R&D innovation base, a new highland for industrial talents training and a source of industrial ecological model in the whole region, and accelerating the "double-chain" integration of industrial chain in innovation chain. At the same time, in the process of layout of science and technology projects, guide local car companies to carry out joint research with universities, research institutes, key laboratories and other units, set up talent cultivation indicators, strengthen the construction of talent teams, and enhance the R&D and innovation capabilities of enterprises. In the introduction of high-level talents, we should pay more attention to the accurate introduction of talents, pay attention to the introduction of high-end innovative and entrepreneurial talents, achieve a benign interaction between talents and industries, and achieve a win-win situation for the development of talents and industries and enterprises. At present, four high-level talent projects in the automobile industry have been introduced to Liuzhou, including two B-type talent projects, one D-type talent project and one E-type talent project.

I am writing this letter.

the peopl citye’s government of liuzhou

June 24, 2022

Every time you get a ticket, you have to go to the tax service hall.

The journey takes a long time.

Also bring the tax controller, ID card and special seal for invoice.

It’s easy to leave things behind if you’re not careful

Now these troubles can be solved.

Since June 1, 2020

Beijing Economic Development Zone Taxation Bureau

It will be a normal ticket-using enterprise in the region.

Provide through the "e-ticket delivery" mode

Free mail delivery service for receiving invoices

Yifen

How to operate this "ticket e delivery"?

Xiaoye

Xiaoye has prepared a detailed tutorial for everyone. Let’s take a look!

Detailed operation manual of "ticket e delivery"

"Ticket e-delivery" is a convenient service project of online invoice collection launched by logistics service unit entrusted by Beijing Taxation Bureau of State Taxation Administration of The People’s Republic of China. It aims to solve the problems of long journey, long time-consuming and difficult queuing for taxpayers to go to the tax service hall, and realizes the one-stop invoice collection service of "online application of taxpayers, automatic processing on cloud platform, and limited logistics delivery to the door".

one

"e-ticket delivery" feature

1. All year round, 365*24 hours service;

2. Express delivery to your door within 24 hours;

3. Coverage of the whole city, which can be delivered in Beijing area;

4. tax express through train, unlimited number of non-traffic jams;

5. Professional support team, 24-hour service hotline 4006289911 to provide follow-up guarantee;

two

Ticket e delivery qualification requirements

1. The tax registration status is business;

2. VAT taxpayers (except taxpayers who declare VAT on a per-time basis and general VAT taxpayers during the counseling period);

3. It has been included in the upgraded version of the VAT invoice system;

4. There is no internal investigation information about invoices;

three

Ticket e delivery invoice type

Five categories and seven versions of invoices can be applied for online: "two-copy and five-copy versions of general VAT invoices, three-copy and six-copy versions of special VAT invoices in Chinese, unified invoices for motor vehicle sales (computer version), roll-type invoices for taxi passengers and electronic general VAT invoices".

four

Application for online ticket collection qualification

1. Taxpayers log in to State Taxation Administration of The People’s Republic of China Beijing Electronic Taxation Bureau.

2. Click Login, enter State Taxation Administration of The People’s Republic of China Beijing Electronic Taxation Bureau, and click the "Invoice Use" module under the "I want to do tax" directory.

3. Taxpayers enter the "invoice collection" and click the "invoice distribution (e-delivery)" button to enter the "e-delivery" qualification application page (note: if you are qualified to apply for invoices online, you will directly enter the invoice application page, otherwise you will enter the online invoice application qualification application page).

4. You need to submit a qualification application for the first use. Fill in the real contact person and mobile phone number, and confirm that "our company (or individual) confirms to voluntarily use the" ticket e-delivery "service", and click the submit application button.

five

Steps to apply for invoices online

1. Taxpayers enter State Taxation Administration of The People’s Republic of China Beijing Electronic Taxation Bureau;

2. Select "Invoice Business" in the navigation bar and click "Invoice Distribution (Ticket E Delivery)" to enter the "Ticket E Delivery" page;

Step 3 fill in the application form

Enter the invoice application page and click the "New Application" button on the right side of the page.

Note: This button will only appear after the last invoice application order has been accepted successfully.

The application form is as follows. You need to fill in the number of applications, the name of the ticket holder, the mobile phone number, the location, the detailed address and the postal code. Among them, the number of applications must be an integer multiple of 5 and cannot be greater than the number of applications.

After filling out the application form, click the "Save" button. The table can be modified before it is submitted again.

4. Submit the application form

Please submit this application form when you are sure that the information filled in is correct. ("Submit" button in the action bar of the list page) After the submission is successful, please wait for the tax authorities to accept your application.

When submitting, you need to check the "Ticket E Delivery" service use confirmation form, otherwise it cannot be submitted.

5. Print the bill receipt

When the "Business Status" changes to "Package Picking Completed, Delivery Started", you can print the "Invoice Receipt Form for Online Collecting of Beijing Taxation Bureau" through the button in the operation bar of the page. The printed bill receipt needs to be stamped with official seal or special seal for invoice. When distributing the invoice, you need to receive the ticket with this receipt.

6. Sign the physical invoice

The delivery staff will contact you through the mobile phone number when submitting the application. When signing, please show the Invoice Receipt Form for Online Receipt of Invoice from Beijing Taxation Bureau, and check the invoice code and invoice number of the physical invoice. After confirmation, please give the stamped ticket receipt to the delivery staff.

END

This article was published by Yizhuang, Beijing.

Please indicate the source for reprinting.

The news comes from Beijing Economic Development Zone Taxation Bureau.

Original title: "From June 1st, tax invoices can be delivered home free of charge without queuing"

Read the original text

　　The the Political Bureau of the Communist Party of China (CPC) Central Committee Conference held a few days ago emphasized that "consumption should play a leading role in the economic cycle", which is an important work deployed on the basis of a comprehensive analysis of the economic situation. In connection with the "Opinions on Further Releasing Consumption Potential and Promoting Sustainable Recovery of Consumption" issued by the General Office of the State Council not long ago, 20 key measures in five aspects were put forward. The "combination boxing" to promote consumption in order to consolidate and develop the market of more than 1.4 billion people has aroused widespread concern at home and abroad.

　　From the perspective of national economic operation, consumption has a lasting driving force for economic development, is an important engine to smooth the domestic cycle, and is also a key link to form a higher level dynamic balance between demand and supply, which is related to the national economy and people’s livelihood. Judging from the current economic situation in China, the triple pressures of demand contraction, supply shock and expected weakening have not changed, and some unfavorable factors are still evolving in a complicated way, and the new downward pressure has further increased. In the face of the situation, tasks and severe tests, we should not only have a full understanding, but also have countermeasures. It is undoubtedly crucial to do everything possible and comprehensively implement policies to release consumption potential and promote sustained recovery of consumption.

　　Statistics from the National Bureau of Statistics show that in 2021, the contribution rate of China’s final consumption expenditure growth to economic growth is 65.4%, which is higher than the contribution rate of total capital formation, and it is the main driving force for the stable recovery of the national economy, and the "ballast stone" role of consumption is prominent. In the first quarter of this year, thanks to the transformation and upgrading of traditional consumption, the release of new consumption potential and the strong "blood supplement" of online consumption, the overall market sales maintained steady growth. However, since March, domestic epidemics have occurred frequently, which has had a great impact on the consumer market. In March, the total retail sales of social consumer goods decreased by 3.5% year-on-year. Residents’ trips have been significantly reduced, and contact and aggregate consumption have been greatly affected. The foundation for sustained recovery of consumption still needs to be consolidated.

　　Among the key measures put forward in the Opinions, the first one is "increasing efforts to help enterprises bail out the difficulties around the main body of the insurance market", which is a key to promoting the orderly recovery and development of consumption and thus stabilizing the basic economic disk. As the COVID-19 epidemic directly impacts the consumer, small and medium-sized enterprises and individual industrial and commercial households, it has a great impact on low-income groups and basic people’s livelihood. At present, there are more than 150 million market players in China, carrying hundreds of millions of people to find jobs and start businesses. If you keep the market players, you can keep employment; If there is employment, there will be income and consumption, which will promote economic growth. The central and local governments have introduced relief measures such as tax reduction and fee reduction, and deferred payment of social insurance premiums. Some related companies such as take-away platforms have also responded positively, helping small and medium-sized businesses tide over the difficulties by reducing commissions.

　　Practice shows that reducing taxes and fees is a direct and effective way to help enterprises get rid of difficulties. All localities should, in light of the actual situation, introduce effective measures such as tax reduction and exemption according to law, so that the intensity of tax reduction and fee reduction will only increase, so as to stabilize market expectations. In addition, the financial system should also make profits to the real economy by reducing interest rates, reducing fees and other measures, and provide financing support to enterprises in industries seriously affected by the epidemic to avoid industrial loan restriction, loan withdrawal and loan suspension.

　　Stabilizing consumption growth and promoting consumption upgrading is a systematic project. Doing a good job in ensuring the supply and price stability of basic consumer goods, promoting the upgrading of physical consumption, continuously expanding cultural tourism consumption, fully tapping the consumption potential of counties and towns, reasonably increasing public consumption, and creating a safe, secure and honest consumption environment are all important tasks to increase the weight of consumption.

　　It should be noted that the impact of the epidemic on consumption is phased. With the effective control of the epidemic and the gradual emergence of policy effects, the normal economic order will be quickly restored and consumption will gradually pick up. China has a population of more than 1.4 billion, the largest domestic market with middle-income groups in the world, and the policy support and work deployment with both far and near, and the fundamentals of long-term positive consumption will not change. We should have full confidence in this. (This article Source: Economic Daily Author: Jin Guanping)

CCTV News:Another feature of Mid-Autumn Festival tourism this year is that cultural leisure tourism is favored. All localities combine the activation of intangible heritage with immersive experience to improve people’s sense of participation and identity with intangible heritage. Many places have also launched theme tourist routes such as Mid-Autumn Festival custom experience, attracting a large number of tourists. According to the data of special survey in china tourism academy, 94.1% of tourists participated in cultural leisure during holidays, and 24.8%, 35.6% and 25.6% visited historical and cultural blocks, museums, art galleries and art galleries respectively.

Traditional culture stimulates the consumption of cultural tourism in Mid-Autumn Festival holiday.

In flying tigers Scenic Area, Zaozhuang, Shandong, a group of children, dressed in Hanfu, listened to the historical story of wickerwork’s craft, made strips with straw ropes by themselves, and wound them around wicker baskets ring by ring, patiently weaving a beautiful yearning for the future.

During the Mid-Autumn Festival holiday, in Shanghai Haichang Ocean Park, a round of "bright moon" rippled in the water. Professional synchronized swimmers dressed in ancient costumes performed a series of underwater "the Goddess Chang’e flying to the moon" cultural feasts for the audience. In addition to "the Goddess Chang’e flying to the moon", there is also a cruise full of national trends, which attracts many tourists.

Characteristic cultural activities promote "night economy"

In addition to traditional cultural tourism, immersive moon viewing has also brought fire to urban night tours. Night tourism projects such as theme park night tours, river night tours and city night sightseeing have attracted many tourists.

According to the special survey data of china tourism academy, 29.3% of tourists experienced night tours during the Mid-Autumn Festival holiday.

Topic: Commemorating the 88th anniversary of the founding of the Communist Party of China (CPC).

Chart: By the end of 2008, there were 75.931 million Xinhua News Agency in members of the Communist Party of China (CPC).

Chart: party member’s age by Xinhua News Agency.

Chart: party member’s time to join the party was issued by Xinhua News Agency.

Chart: party member’s Career Xinhua News Agency

　　Xinhuanet Beijing July 1 ST

　　The Communist Party of China (CPC) inner-party statistical bulletin in 2008

　　Organization Department of the CPC Central Committee

　　By the end of 2008, the total number of members of the Communist Party of China (CPC) was 75.931 million, a net increase of 1.778 million over the previous year.

　　There are 3.718 million grass-roots organizations in the Communist Party of China (CPC), a net increase of 55,000 over the previous year, including 179,000 grass-roots party committees, 229,000 general branches and 3.310 million branches.

　　I. Team structure in party member

　　Gender, ethnicity and education in party member. There are 15.969 million women in party member, accounting for 21.0% of the total number in party member, with an increase of 0.6 percentage points over the previous year. There are 4.944 million ethnic minorities in party member, accounting for 6.5% of the total number of party member, which is basically the same as last year. There are 25.833 million party member with college education or above, accounting for 34.0% of the total number of party member, an increase of 1.6 percentage points over the previous year.

　　Party member’s age. There are 17.855 million party member under the age of 35, accounting for 0.2 percentage points higher than the previous year; There are 17.19 million party member between the ages of 36 and 45, accounting for 0.3 percentage points lower than the previous year; There are 22.22 million party member people aged 46 to 59, accounting for 0.4 percentage points lower than the previous year; There are 18.666 million party member people over 60 years old, accounting for 0.6 percentage points more than the previous year.

　　Party member’s time to join the Party. 733,000 people who joined the party before the founding of the People’s Republic of China; 7.996 million people joined the Party after the founding of the People’s Republic of China and before the Cultural Revolution: 12.309 million people joined the Party during the Cultural Revolution; Crushed the Gang of Four to 38.036 million people who joined the Party before the 16th Party Congress; 16.856 million people have joined the Party since the 16th National Congress of the Communist Party of China.

　　Party member’s occupation. There are 7.336 million workers, 23.612 million farmers, herdsmen, 6.208 million staff of party and government organs, 16.876 million managers and professional technicians of enterprises and institutions, 2.014 million students, 14.282 million retirees and 5.601 million other occupations.

　　There are 3,582,000 employees in non-public units in party member, including 1,635,000 workers and 1,947,000 managers and professional technicians.

　　Second, the development of party member.

　　In 2008, 2.807 million party member people were developed, 25,000 more than the previous year, with an increase of 0.9%.

　　Develop gender, ethnicity, age and education in party member. There are 1.023 million women in party member, accounting for 36.4% of the total number of developing party member, an increase of 0.7 percentage points over the previous year. There are 198,000 ethnic minorities in party member, accounting for 7.1% of the total number of developing party member, an increase of 0.4 percentage points over the previous year. There are 2.268 million people under the age of 35 in party member, accounting for 80.8% of the total number of developing party member, an increase of 0.7 percentage points over the previous year. There are 862,000 party member with college education or above, accounting for 30.7% of the total number of developing party member, down 0.4 percentage points from the previous year.

　　Develop party member’s career. In the developed party member, there are 209,000 workers, 559,000 farmers, herdsmen, 123,000 staff of party and government organs, 581,000 managers and professional technicians of enterprises and institutions, 1.067 million students and 268,000 other occupations. Among them, the number of developing students in party member increased most obviously, with an increase of 71,000 over the previous year, accounting for 2.2 percentage points of the total number of developing party member.

　　There are 126,000 employees in party member in non-public units, including 47,000 workers and 79,000 managers and professional technicians.

　　Develop 1.291 million party member in the front line of production and work; 25,000 people in party member were developed under special circumstances such as earthquake relief.

　　Iii. commendation within the party

　　In 2008, Party organizations at all levels commended 311,000 advanced Party organizations, 1.526 million outstanding Communist party member and 246,000 outstanding Party workers. Among them, 3,000 advanced party organizations, 14,000 outstanding Communist party member and 487 outstanding party workers were commended for their outstanding performance in resisting ice and snow disasters; Commend 14,000 advanced party organizations, 55,000 outstanding Communist party member and 30,000 outstanding party workers for their outstanding performance in earthquake relief; There are 2000 advanced party organizations, 10000 outstanding Communist party member and 635 outstanding party workers who have made outstanding achievements in the Olympic and Paralympic Games.

　　Related links: